{"id":"https://openalex.org/W4407196136","doi":"https://doi.org/10.3390/jcm14031034","title":"Immune Checkpoint Inhibitor in Hepatocellular Carcinoma: Response Rates, Adverse Events, and Predictors of Response","display_name":"Immune Checkpoint Inhibitor in Hepatocellular Carcinoma: Response Rates, Adverse Events, and Predictors of Response","publication_year":2025,"publication_date":"2025-02-06","ids":{"openalex":"https://openalex.org/W4407196136","doi":"https://doi.org/10.3390/jcm14031034","pmid":"https://pubmed.ncbi.nlm.nih.gov/39941701","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11818670"},"language":"en","primary_location":{"id":"doi:10.3390/jcm14031034","doi":"https://doi.org/10.3390/jcm14031034","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm14031034","pdf_url":"https://www.mdpi.com/2077-0383/14/3/1034/pdf","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2077-0383/14/3/1034/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073316321","display_name":"Shekhar Swaroop","orcid":"https://orcid.org/0000-0001-7792-6846","observed_orcids":["https://orcid.org/0000-0001-7792-6846"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shekhar Swaroop","raw_affiliation_strings":["Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India"],"raw_orcid":"https://orcid.org/0000-0001-7792-6846","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034400990","display_name":"Sagnik Biswas","orcid":"https://orcid.org/0000-0003-3487-4921","observed_orcids":["https://orcid.org/0000-0003-3487-4921"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sagnik Biswas","raw_affiliation_strings":["Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India"],"raw_orcid":"https://orcid.org/0000-0003-3487-4921","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101388634","display_name":"Shubham Mehta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shubham Mehta","raw_affiliation_strings":["Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043470831","display_name":"Arnav Aggarwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arnav Aggarwal","raw_affiliation_strings":["Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056766351","display_name":"Umang Arora","orcid":"https://orcid.org/0000-0002-4366-0776","observed_orcids":["https://orcid.org/0000-0002-4366-0776"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Umang Arora","raw_affiliation_strings":["Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India"],"raw_orcid":"https://orcid.org/0000-0002-4366-0776","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019317520","display_name":"Samagra Agarwal","orcid":"https://orcid.org/0000-0002-2053-2069","observed_orcids":["https://orcid.org/0000-0002-2053-2069"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Samagra Agarwal","raw_affiliation_strings":["Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India"],"raw_orcid":"https://orcid.org/0000-0002-2053-2069","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110948539","display_name":"Amitkumar Chavan","orcid":"https://orcid.org/0000-0002-7670-2792","observed_orcids":["https://orcid.org/0000-0002-7670-2792"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amitkumar Chavan","raw_affiliation_strings":["Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India"],"raw_orcid":"https://orcid.org/0000-0002-7670-2792","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024739498","display_name":"Baibaswata Nayak","orcid":"https://orcid.org/0000-0003-2238-6015","observed_orcids":["https://orcid.org/0000-0003-2238-6015"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Baibaswata Nayak","raw_affiliation_strings":["Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India"],"raw_orcid":"https://orcid.org/0000-0003-2238-6015","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071416215","display_name":"S. Shalimar","orcid":"https://orcid.org/0000-0003-1247-437X","observed_orcids":["https://orcid.org/0000-0003-1247-437X"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Shalimar","raw_affiliation_strings":["Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India"],"raw_orcid":"https://orcid.org/0000-0003-1247-437X","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi 110029, India","institution_ids":["https://openalex.org/I63739035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071416215"],"corresponding_institution_ids":["https://openalex.org/I63739035"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":2.7722,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.90089267,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"14","issue":"3","first_page":"1034","last_page":"1034"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/atezolizumab","display_name":"atezolizumab","score":0.9300000071525574},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":1.0},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.6850000023841858},{"id":"https://openalex.org/keywords/overall-response-rate","display_name":"overall response rate","score":0.7910000085830688},{"id":"https://openalex.org/keywords/predictors-of-treatment-response","display_name":"predictors of treatment response","score":0.6320000290870667},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7419999837875366},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9430000185966492},{"id":"https://openalex.org/keywords/child-pugh-score","display_name":"Child-Pugh score","score":0.7710000276565552},{"id":"https://openalex.org/keywords/bclc-stage","display_name":"BCLC stage","score":0.8550000190734863},{"id":"https://openalex.org/keywords/alpha-fetoprotein-response","display_name":"alpha-fetoprotein response","score":0.8949999809265137},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7599999904632568},{"id":"https://openalex.org/keywords/advanced-liver-cancer","display_name":"advanced liver cancer","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9660894870758057},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7090864181518555},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.6127469539642334},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6105208396911621},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5889006853103638},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4906967878341675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46716630458831787},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.4565347135066986},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3402237594127655},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2932087779045105},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.22486743330955505},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.08632773160934448}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/jcm14031034","doi":"https://doi.org/10.3390/jcm14031034","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm14031034","pdf_url":"https://www.mdpi.com/2077-0383/14/3/1034/pdf","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11818670","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11818670","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11818670/pdf/jcm-14-01034.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Med","raw_type":"Text"},{"id":"pmid:39941701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39941701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/jcm14031034","doi":"https://doi.org/10.3390/jcm14031034","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm14031034","pdf_url":"https://www.mdpi.com/2077-0383/14/3/1034/pdf","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407196136.pdf","grobid_xml":"https://content.openalex.org/works/W4407196136.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1587807025","https://openalex.org/W2106600040","https://openalex.org/W2118982785","https://openalex.org/W2502891277","https://openalex.org/W2511951051","https://openalex.org/W2734975816","https://openalex.org/W2766624177","https://openalex.org/W2775356055","https://openalex.org/W2802906787","https://openalex.org/W2969802526","https://openalex.org/W2999675465","https://openalex.org/W3000125713","https://openalex.org/W3006581633","https://openalex.org/W3025022288","https://openalex.org/W3082999141","https://openalex.org/W3083986479","https://openalex.org/W3097803258","https://openalex.org/W3138484572","https://openalex.org/W3196922443","https://openalex.org/W3210474759","https://openalex.org/W3211365788","https://openalex.org/W3212963169","https://openalex.org/W3213277274","https://openalex.org/W4200388794","https://openalex.org/W4200473175","https://openalex.org/W4214704026","https://openalex.org/W4220787479","https://openalex.org/W4283819452","https://openalex.org/W4296797531","https://openalex.org/W4297154641","https://openalex.org/W4313332161","https://openalex.org/W4315780598","https://openalex.org/W4319872581","https://openalex.org/W4366606641","https://openalex.org/W4377011124","https://openalex.org/W4383341840","https://openalex.org/W4386116138","https://openalex.org/W4387016839","https://openalex.org/W4389300283","https://openalex.org/W4398175217","https://openalex.org/W4401100726","https://openalex.org/W4403463844","https://openalex.org/W4406117717"],"related_works":["https://openalex.org/W2999675465","https://openalex.org/W4384661866","https://openalex.org/W3150434687","https://openalex.org/W3120838604","https://openalex.org/W3184978282","https://openalex.org/W4362678485","https://openalex.org/W4317679291","https://openalex.org/W4292756365","https://openalex.org/W4407264177","https://openalex.org/W4414284119"],"abstract_inverted_index":{"Background/Objectives:":[0],"Hepatocellular":[1],"carcinoma":[2],"(HCC)":[3],"is":[4],"the":[5,232],"most":[6,233],"common":[7],"primary":[8,84],"hepatic":[9],"malignancy.":[10],"Barcelona":[11],"Clinic":[12],"Liver":[13],"Cancer":[14],"(BCLC)":[15],"guidelines":[16],"recommend":[17],"antiangiogenic":[18],"agents":[19],"with":[20,38,168,183,228],"immune":[21],"checkpoint":[22],"inhibitors":[23],"as":[24,99],"first-line":[25],"therapy":[26],"for":[27,170],"advanced":[28],"HCC.":[29,138],"We":[30],"present":[31],"our":[32],"experience":[33],"of":[34,63,81,114,189,195,216,236],"treating":[35],"HCC":[36,56],"patients":[37,57,120,133,141,167],"Atezolizumab\u2013Bevacizumab,":[39],"their":[40],"response":[41,47,88,93,97,115,198,239,242],"rates,":[42],"adverse":[43],"events,":[44],"survival,":[45],"and":[46,48,72,75,95,112,116,147,161,177,179,205,243],"survival":[49,107,110,224],"predictors.":[50],"Methods:":[51],"This":[52],"retrospective":[53],"analysis":[54],"included":[55],"diagnosed":[58],"at":[59,77],"All":[60],"India":[61,68],"Institute":[62],"Medical":[64],"Sciences,":[65],"New":[66],"Delhi,":[67],"between":[69],"July":[70],"2021":[71],"April":[73],"2024":[74],"receiving":[76],"least":[78],"one":[79],"dose":[80],"Atezolizumab\u2013Bevacizumab.":[82],"The":[83],"outcome":[85],"was":[86,159,163,174,181],"overall":[87,106],"rate":[89],"(ORR),":[90],"comprising":[91],"complete":[92],"(CR)":[94],"partial":[96],"(PR),":[98],"per":[100],"mRECIST":[101],"criteria.":[102],"Secondary":[103],"outcomes":[104],"were":[105,121,212],"(OS),":[108],"progression-free":[109],"(PFS),":[111],"predictors":[113],"survival.":[117,209,237,245],"Results:":[118],"Sixty-three":[119],"analyzed":[122],"{mean":[123],"age:":[124],"56.0":[125],"+":[126],"12.7":[127],"years;":[128],"82.5%":[129],"males}.":[130],"Forty-three":[131],"(68.2%)":[132],"had":[134],"BCLC":[135,206],"stage":[136,207],"C":[137],"Thirty-five":[139],"(55.5%)":[140],"belonged":[142,150],"to":[143,151],"Child\u2013Pugh":[144,152,203,229],"class":[145,153,204,230],"A":[146],"28":[148],"(44.5%)":[149],"B.":[154],"At":[155],"1":[156],"year,":[157],"OS":[158],"39%":[160],"PFS":[162],"27%.":[164],"Among":[165],"43":[166],"data":[169],"radiological":[171,200,241],"response,":[172,201],"ORR":[173],"48.8%":[175],"(CR\u20149.3%":[176],"PR\u201439.5%)":[178],"DCR":[180],"62.7%":[182],"stable":[184],"disease":[185],"(SD)":[186],"in":[187,193,214],"13.9%":[188],"patients.":[190,196,217],"PD":[191],"occurred":[192],"37.2%":[194],"AFP":[197,238],"predicted":[199,208],"while":[202],"Adverse":[210],"events":[211],"reported":[213],"49.2%":[215],"Conclusions:":[218],"Our":[219],"study":[220],"shows":[221],"slightly":[222],"lower":[223],"than":[225],"previous":[226],"studies":[227],"being":[231],"important":[234],"determinant":[235],"predicts":[240],"not":[244]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-02-06T00:00:00"}