{"id":"https://openalex.org/W4407181007","doi":"https://doi.org/10.3389/fmicb.2025.1517018","title":"Electroacupuncture alleviates functional constipation by upregulating host-derived miR-205-5p to modulate gut microbiota and tryptophan metabolism","display_name":"Electroacupuncture alleviates functional constipation by upregulating host-derived miR-205-5p to modulate gut microbiota and tryptophan metabolism","publication_year":2025,"publication_date":"2025-02-05","ids":{"openalex":"https://openalex.org/W4407181007","doi":"https://doi.org/10.3389/fmicb.2025.1517018","pmid":"https://pubmed.ncbi.nlm.nih.gov/39973939"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2025.1517018","doi":"https://doi.org/10.3389/fmicb.2025.1517018","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2025.1517018","pdf_url":null,"source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fmicb.2025.1517018","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100364520","display_name":"Lu Wang","orcid":"https://orcid.org/0000-0003-1338-777X","observed_orcids":["https://orcid.org/0000-0003-1338-777X"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Wang","raw_affiliation_strings":["Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","Department of Acupuncture, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]},{"raw_affiliation_string":"Department of Acupuncture, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085772388","display_name":"Menghan Xi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125143","display_name":"Chengdu University","ror":"https://ror.org/034z67559","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210125143"]},{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Menghan Xi","raw_affiliation_strings":["Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","Department of Acupuncture and Moxibustion, Chengdu Pidu District Hospital of TCM/The Third Clinical Medical College of Chengdu University of TCM, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]},{"raw_affiliation_string":"Department of Acupuncture and Moxibustion, Chengdu Pidu District Hospital of TCM/The Third Clinical Medical College of Chengdu University of TCM, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I4210125143","https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115605193","display_name":"Wei Cao","orcid":"https://orcid.org/0000-0002-6878-6164","observed_orcids":["https://orcid.org/0000-0002-6878-6164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Cao","raw_affiliation_strings":["Center of Preventive Medicine, Chengdu Integrated TCM and Western Medicine Hospital, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Preventive Medicine, Chengdu Integrated TCM and Western Medicine Hospital, Chengdu, Sichuan, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066256287","display_name":"Haiyan Qin","orcid":"https://orcid.org/0009-0005-6916-6388","observed_orcids":["https://orcid.org/0009-0005-6916-6388"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyan Qin","raw_affiliation_strings":["Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Di Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Qin","raw_affiliation_strings":["Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100396692","display_name":"Shuai Chen","orcid":"https://orcid.org/0000-0002-9950-6049","observed_orcids":["https://orcid.org/0000-0002-9950-6049","https://orcid.org/0000-0002-6265-7097"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Chen","raw_affiliation_strings":["Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101959260","display_name":"Siyuan Zhou","orcid":"https://orcid.org/0000-0001-5669-0264","observed_orcids":["https://orcid.org/0000-0001-5669-0264"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyuan Zhou","raw_affiliation_strings":["Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085716029","display_name":"Yujun Hou","orcid":"https://orcid.org/0000-0002-7726-910X","observed_orcids":["https://orcid.org/0000-0002-7726-910X"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujun Hou","raw_affiliation_strings":["Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100383000","display_name":"Ying Chen","orcid":"https://orcid.org/0000-0001-6303-5858","observed_orcids":["https://orcid.org/0000-0001-6303-5858","https://orcid.org/0000-0001-6180-1600"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Chen","raw_affiliation_strings":["Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103907204","display_name":"Xianjun Xiao","orcid":"https://orcid.org/0000-0003-1671-5716","observed_orcids":["https://orcid.org/0000-0003-1671-5716"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianjun Xiao","raw_affiliation_strings":["School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087031747","display_name":"Qianhua Zheng","orcid":"https://orcid.org/0000-0001-5489-7034","observed_orcids":["https://orcid.org/0000-0001-5489-7034"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianhua Zheng","raw_affiliation_strings":["Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dehua Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dehua Li","raw_affiliation_strings":["Department of Acupuncture, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Acupuncture, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100414049","display_name":"Ying Li","orcid":"https://orcid.org/0000-0001-7554-0958","observed_orcids":["https://orcid.org/0000-0001-7554-0958"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Li","raw_affiliation_strings":["Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China","institution_ids":["https://openalex.org/I53411278"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100414049"],"corresponding_institution_ids":["https://openalex.org/I53411278"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":2.596,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.87090164,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"16","issue":null,"first_page":"1517018","last_page":"1517018"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.07150000333786011,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electroacupuncture","display_name":"electroacupuncture","score":1.0},{"id":"https://openalex.org/keywords/functional-constipation","display_name":"functional constipation","score":1.0},{"id":"https://openalex.org/keywords/mir-205-5p","display_name":"miR-205-5p","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.9549999833106995},{"id":"https://openalex.org/keywords/limosilactobacillus-reuteri","display_name":"Lactobacillus reuteri","score":0.9509999752044678},{"id":"https://openalex.org/keywords/intestinal-motility","display_name":"intestinal motility","score":0.8899999856948853},{"id":"https://openalex.org/keywords/loperamide-induced-constipation","display_name":"loperamide-induced constipation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/fecal-micrornas","display_name":"fecal microRNAs","score":0.8240000009536743},{"id":"https://openalex.org/keywords/host-microbiota-interactions","display_name":"host-microbiota interactions","score":0.8349999785423279},{"id":"https://openalex.org/keywords/indole-3-acetamide","display_name":"indole-3-acetamide","score":0.8709999918937683},{"id":"https://openalex.org/keywords/indole-3-acetic-acid","display_name":"indole-3-acetic acid","score":0.9639999866485596},{"id":"https://openalex.org/keywords/indole-3-carboxaldehyde","display_name":"indole-3-carboxaldehyde","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C2775898472","wikidata":"https://www.wikidata.org/wiki/Q597078","display_name":"Lactobacillus reuteri","level":4,"score":0.7879767417907715},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.6855511665344238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5794863700866699},{"id":"https://openalex.org/C2777573665","wikidata":"https://www.wikidata.org/wiki/Q423751","display_name":"Loperamide","level":3,"score":0.5676040649414062},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.48516303300857544},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.4503827691078186},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3665957450866699},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.362507164478302},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22417786717414856},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19209066033363342},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15590324997901917},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.15293201804161072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1219465434551239},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.09812557697296143},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmicb.2025.1517018","doi":"https://doi.org/10.3389/fmicb.2025.1517018","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2025.1517018","pdf_url":null,"source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"pmid:39973939","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39973939","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11835812","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11835812","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Microbiol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:32b30d4ce00643c2b2ac67a91cb78555","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/32b30d4ce00643c2b2ac67a91cb78555","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2025.1517018","doi":"https://doi.org/10.3389/fmicb.2025.1517018","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2025.1517018","pdf_url":null,"source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2566037885","display_name":null,"funder_award_id":"82074554","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G435437094","display_name":null,"funder_award_id":"82074554, 82274652","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5974164519","display_name":null,"funder_award_id":"82274652","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W2042394891","https://openalex.org/W2062620141","https://openalex.org/W2162871918","https://openalex.org/W2233291722","https://openalex.org/W2582934264","https://openalex.org/W2743071411","https://openalex.org/W2795389370","https://openalex.org/W2807927929","https://openalex.org/W2900788029","https://openalex.org/W2905592162","https://openalex.org/W2912152411","https://openalex.org/W2931017645","https://openalex.org/W2987715292","https://openalex.org/W2998466833","https://openalex.org/W2999367391","https://openalex.org/W3004904380","https://openalex.org/W3012095940","https://openalex.org/W3032932190","https://openalex.org/W3106720814","https://openalex.org/W3112255441","https://openalex.org/W3116491627","https://openalex.org/W3125294206","https://openalex.org/W3127276677","https://openalex.org/W3174024147","https://openalex.org/W3193784544","https://openalex.org/W4205663465","https://openalex.org/W4213018287","https://openalex.org/W4221095311","https://openalex.org/W4280502862","https://openalex.org/W4281929034","https://openalex.org/W4294741274","https://openalex.org/W4296117667","https://openalex.org/W4309884182","https://openalex.org/W4312187802","https://openalex.org/W4313857529","https://openalex.org/W4320732021","https://openalex.org/W4323045445","https://openalex.org/W4360993636","https://openalex.org/W4362664359","https://openalex.org/W4377090569","https://openalex.org/W4377157399","https://openalex.org/W4378982356","https://openalex.org/W4385330641","https://openalex.org/W4386374832","https://openalex.org/W4387757174","https://openalex.org/W4388074202","https://openalex.org/W4390535825","https://openalex.org/W4390744999","https://openalex.org/W4390908427","https://openalex.org/W4391888630","https://openalex.org/W4394008701","https://openalex.org/W4394758909","https://openalex.org/W4394792829","https://openalex.org/W4395085270","https://openalex.org/W4396701752","https://openalex.org/W4396760211","https://openalex.org/W4400521142","https://openalex.org/W4402538274"],"related_works":["https://openalex.org/W2089596534","https://openalex.org/W2075916674","https://openalex.org/W3011976842","https://openalex.org/W1972498426","https://openalex.org/W2104879839","https://openalex.org/W2361575911","https://openalex.org/W2788932760","https://openalex.org/W2085483894","https://openalex.org/W1995269232","https://openalex.org/W1967041568"],"abstract_inverted_index":{"Electroacupuncture":[0],"(EA)":[1],"has":[2],"shown":[3],"promise":[4],"as":[5,24],"a":[6,129],"treatment":[7],"for":[8],"Functional":[9],"constipation":[10],"(FC),":[11],"with":[12,46,78,95],"growing":[13],"evidence":[14],"suggesting":[15],"it":[16],"may":[17],"enhance":[18,183],"gut":[19,83,97],"motility.":[20,84],"MicroRNAs":[21],"(miRNAs)":[22],"serve":[23],"key":[25,48],"regulatory":[26],"molecules":[27],"mediating":[28],"host-microbiota":[29],"interactions.":[30],"However,":[31],"the":[32,96,106,135,142,169],"specific":[33],"fecal":[34,54,117],"miRNAs":[35,73],"regulating":[36],"microbiota":[37,98],"composition":[38,178],"and":[39,58,66,74,82,88,99,118,154,161,179],"metabolism":[40],"in":[41,62,102,116,128,141,175],"EA-treated":[42,67,122],"constipated":[43,64,123],"mice,":[44,124,146],"along":[45],"their":[47,76],"targets,":[49],"remain":[50],"unidentified.":[51],"We":[52],"examined":[53],"microbiome":[55],"composition,":[56],"metabolism,":[57,81],"colonic":[59,119],"miRNA":[60,101],"expression":[61],"loperamide-induced":[63,164],"mice":[65,68],"to":[69,93,182],"identify":[70],"differentially":[71],"expressed":[72],"assess":[75],"relationships":[77],"microbial":[79,177],"abundance,":[80],"An":[85],"antibiotic":[86],"cocktail":[87],"adeno-associated":[89],"virus":[90],"were":[91],"employed":[92],"interfere":[94],"target":[100],"vivo,":[103],"thereby":[104],"validating":[105],"proposed":[107],"mechanism.":[108],"Our":[109],"results":[110],"indicate":[111],"that":[112],"miR-205-5p,":[113],"significantly":[114],"upregulated":[115],"tissues":[120],"of":[121,137,144,172],"promotes":[125],"intestinal":[126,184],"motility":[127,185],"microbiome-dependent":[130],"manner.":[131],"Specifically,":[132],"EA":[133],"promoted":[134],"growth":[136],"Lactobacillus":[138,152],"reuteri,":[139],"enriched":[140],"feces":[143],"constipation-recovered":[145],"through":[147,186],"host-derived":[148,173],"miR-205-5p":[149,174],"regulation.":[150],"Furthermore,":[151],"reuteri":[153],"its":[155],"tryptophan":[156,180],"metabolites":[157,181],"(indole-3-acetamide,":[158],"indole-3-acetic":[159],"acid,":[160],"indole-3-carboxaldehyde)":[162],"alleviated":[163],"constipation.":[165],"These":[166],"findings":[167],"underscore":[168],"pivotal":[170],"role":[171],"modulating":[176],"EA.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}