{"id":"https://openalex.org/W4407109428","doi":"https://doi.org/10.1158/1078-0432.28332827","title":"Figure 1 from Safety and Tolerability of Letetresgene Autoleucel (GSK3377794): Pilot Studies in Patients with Advanced Non\u2013Small Cell Lung Cancer","display_name":"Figure 1 from Safety and Tolerability of Letetresgene Autoleucel (GSK3377794): Pilot Studies in Patients with Advanced Non\u2013Small Cell Lung Cancer","publication_year":2025,"publication_date":"2025-02-03","ids":{"openalex":"https://openalex.org/W4407109428","doi":"https://doi.org/10.1158/1078-0432.28332827"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.28332827","doi":"https://doi.org/10.1158/1078-0432.28332827","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.28332827","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.28332827","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039160380","display_name":"Mehmet Altan","orcid":"https://orcid.org/0000-0001-9229-156X","observed_orcids":["https://orcid.org/0000-0001-9229-156X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehmet Altan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9229-156X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068401391","display_name":"Gilberto De Lima Lopes Jr.","orcid":"https://orcid.org/0000-0002-1151-9903","observed_orcids":["https://orcid.org/0000-0002-1151-9903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gilberto Lopes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1151-9903","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078862785","display_name":"T. Jeroen N. Hiltermann","orcid":"https://orcid.org/0000-0002-0665-2160","observed_orcids":["https://orcid.org/0000-0002-0665-2160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Jeroen N. Hiltermann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0665-2160","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068824818","display_name":"Ramaswamy Govindan","orcid":"https://orcid.org/0000-0002-6964-9612","observed_orcids":["https://orcid.org/0000-0002-6964-9612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramaswamy Govindan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6964-9612","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082389042","display_name":"Liza Cosca Villaruz","orcid":"https://orcid.org/0000-0001-7456-523X","observed_orcids":["https://orcid.org/0000-0001-7456-523X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liza C. Villaruz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7456-523X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053069942","display_name":"Emiliano Calvo","orcid":"https://orcid.org/0000-0003-4921-829X","observed_orcids":["https://orcid.org/0000-0003-4921-829X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emiliano Calvo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4921-829X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063441489","display_name":"Martin Joseph Edelman","orcid":"https://orcid.org/0000-0002-3752-0726","observed_orcids":["https://orcid.org/0000-0002-3752-0726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin J. Edelman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3752-0726","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083477114","display_name":"Muhammad Furqan","orcid":"https://orcid.org/0000-0003-3137-2053","observed_orcids":["https://orcid.org/0000-0003-3137-2053"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muhammad Furqan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3137-2053","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034377849","display_name":"Joel W. Neal","orcid":"https://orcid.org/0000-0003-3119-9334","observed_orcids":["https://orcid.org/0000-0003-3119-9334"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel Neal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3119-9334","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090324173","display_name":"Enriqueta Felip","orcid":"https://orcid.org/0000-0002-7620-0098","observed_orcids":["https://orcid.org/0000-0002-7620-0098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enriqueta Felip","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7620-0098","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012109523","display_name":"Jennifer Wilkinson Carlisle","orcid":"https://orcid.org/0000-0001-7085-4640","observed_orcids":["https://orcid.org/0000-0001-7085-4640"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer W. Carlisle","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7085-4640","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048380048","display_name":"John Victor Heymach","orcid":"https://orcid.org/0000-0001-9068-8942","observed_orcids":["https://orcid.org/0000-0001-9068-8942"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John V. Heymach","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9068-8942","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053852463","display_name":"Roisin Eilish O'Cearbhaill","orcid":"https://orcid.org/0000-0001-8217-4554","observed_orcids":["https://orcid.org/0000-0001-8217-4554"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R\u00f3is\u00edn Eilish O\u2019Cearbhaill","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8217-4554","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014084163","display_name":"Marjorie Glass Zauderer","orcid":"https://orcid.org/0000-0002-6109-5790","observed_orcids":["https://orcid.org/0000-0002-6109-5790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marjorie Zauderer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6109-5790","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038887077","display_name":"Michael Jon Chisamore","orcid":"https://orcid.org/0009-0006-8629-8232","observed_orcids":["https://orcid.org/0009-0006-8629-8232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Chisamore","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-8629-8232","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037837058","display_name":"Ellie Corigliano","orcid":"https://orcid.org/0009-0009-7900-7689","observed_orcids":["https://orcid.org/0009-0009-7900-7689"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ellie Corigliano","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-7900-7689","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006847422","display_name":"Ioanna Eleftheriadou","orcid":"https://orcid.org/0000-0002-0278-1061","observed_orcids":["https://orcid.org/0000-0002-0278-1061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ioanna Eleftheriadou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0278-1061","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020043851","display_name":"Stefan C. Zajic","orcid":"https://orcid.org/0000-0002-9844-9951","observed_orcids":["https://orcid.org/0000-0002-9844-9951"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Zajic","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9844-9951","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034976125","display_name":"Ben Jenkins","orcid":"https://orcid.org/0000-0002-2517-3595","observed_orcids":["https://orcid.org/0000-0002-2517-3595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ben Jenkins","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2517-3595","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045208165","display_name":"Sophia Goodison","orcid":"https://orcid.org/0009-0002-1120-751X","observed_orcids":["https://orcid.org/0009-0002-1120-751X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sophia Goodison","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-1120-751X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113855119","display_name":"Sunil Suchindran","orcid":"https://orcid.org/0009-0000-3954-9277","observed_orcids":["https://orcid.org/0009-0000-3954-9277"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunil Suchindran","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-3954-9277","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009933319","display_name":"Natalia Ramos-Hern\u00e1ndez","orcid":"https://orcid.org/0009-0008-2816-3318","observed_orcids":["https://orcid.org/0009-0008-2816-3318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalia Ramos-Hernandez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-2816-3318","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056899264","display_name":"Nidale Tarek","orcid":"https://orcid.org/0000-0003-2643-7887","observed_orcids":["https://orcid.org/0000-0003-2643-7887"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nidale Tarek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2643-7887","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010486958","display_name":"Adam Jacob Schoenfeld","orcid":"https://orcid.org/0000-0002-2644-1416","observed_orcids":["https://orcid.org/0000-0002-2644-1416"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam J. Schoenfeld","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2644-1416","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.6309000253677368,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.6309000253677368,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.17739999294281006,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.05939999967813492,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.7820000052452087},{"id":"https://openalex.org/keywords/ny-eso-1","display_name":"NY-ESO-1","score":0.906000018119812},{"id":"https://openalex.org/keywords/patient-dropout","display_name":"patient dropout","score":0.7680000066757202},{"id":"https://openalex.org/keywords/tumor-marker-expression","display_name":"tumor marker expression","score":0.5410000085830688},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.7459999918937683},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.6359999775886536},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6324599385261536},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.513282299041748},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.47590646147727966},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43929699063301086},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4292190968990326},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37768301367759705},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3465091288089752},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2580490708351135},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.28332827","doi":"https://doi.org/10.1158/1078-0432.28332827","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.28332827","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.28332827","doi":"https://doi.org/10.1158/1078-0432.28332827","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.28332827","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404637088","https://openalex.org/W4407110151","https://openalex.org/W4407109402","https://openalex.org/W4407109702","https://openalex.org/W4407109383","https://openalex.org/W4407109611","https://openalex.org/W4407110162","https://openalex.org/W4407109610","https://openalex.org/W3213302180","https://openalex.org/W2978615859"],"abstract_inverted_index":{"Patient":[0,13],"attrition":[1,14],"and":[2,4,29,77,96,124,137,200,267,329,339],"NY-ESO-1":[3,52,87,133,153,169,328,338],"LAGE-1a":[5,228,246,318,330,340,342],"expression":[6,66,154,171,230,325],"profiles":[7],"in":[8,23,60,114,117,121,126,146,160,175,190,193,197,202,221,236,250,265,271,287,349],"the":[9,24,31,61,147,161,176,180,215,222,237,252,256,288,302,364],"multiarm":[10,16,25,62,162,238],"study.":[11,17,63,163,239],"A,":[12],"for":[15,245,354],"A":[18],"total":[19],"of":[20,36,56,92,112,156,188,232,242],"1,698":[21],"patients":[22,59,83,129,159,205,220,235,243,276,280],"study":[26],"were":[27,81,283,298],"screened":[28,57],"signed":[30],"informed":[32],"consent":[33],"form.":[34],"Out":[35],"13":[37],"dosed":[38,157,281],"patients,":[39],"six":[40],"withdrew":[41],"prior":[42],"to":[43,351],"meeting":[44],"interventional":[45],"phase":[46],"completion":[47],"criteria,":[48],"per":[49],"protocol.":[50],"B,":[51],"IHC":[53,110,170,186],"P-score":[54,181],"distribution":[55,74,231],"NY-ESO-1\u2013positive":[58,64,158],"protein":[65],"was":[67,344,357],"detected":[68],"as":[69,300],"a":[70,89,103,291,334],"continuous":[71],"variable":[72],"with":[73,88,98,179,261,290,295],"between":[75],"10%":[76],"100%":[78],"expression.":[79],"There":[80],"62":[82],"whose":[84,130],"tumors":[85,131],"expressed":[86,132],"P":[90,209],"score":[91,319],"\u226510%,":[93],"1+,":[94,135],"2+,":[95,136],"3+,":[97],"each":[99],"vertical":[100,177,310],"bar":[101,335],"representing":[102],"unique":[104,361],"tumor":[105],"sample":[106],"depicted":[107,264,270],"by":[108,184,208,214,307,321],"contributing":[109,185],"intensity":[111,187],"0+":[113,189],"blue,":[115,119,191,195],"1+":[116,192],"light":[118,122,194,198],"2+":[120,196],"orange,":[123,199],"3+":[125,138,201],"orange":[127],"(425":[128],"<10%,":[134],"are":[139,206,285],"not":[140,225,368],"displayed).":[141],"One":[142],"patient":[143],"(ID":[144],"#61":[145],"figure)":[148],"had":[149],"two":[150,279],"samples.":[151],"C,":[152],"profile":[155],"The":[164,204,240,278,309],"mITT":[165,223],"population":[166,224],"based":[167],"on":[168,346],"is":[172,212,312,315,333],"individually":[173],"represented":[174],"bars":[178],"broken":[182],"down":[183],"orange.":[203],"ordered":[207],"score,":[210],"which":[211,251],"indicated":[213],"red":[216,253,266,292],"line.":[217],"NY-ESO-1\u2013negative,":[218],"LAGE-1a\u2013positive":[219,284],"shown.":[226],"D,":[227],"RNA":[229,248],"all":[233,275],"tested":[234,244],"plot":[241],"RT-PCR":[247,322],"expression,":[249],"line":[254],"indicates":[255],"cutoff":[257],"=":[258],"4":[259],"\u0394CT,":[260],"positive":[262],"cases":[263,269],"negative":[268],"blue.":[272],"Triangles":[273],"represent":[274],"screened.":[277],"who":[282],"distinguished":[286],"figure":[289],"circle.":[293],"Patients":[294],"\u201cno":[296],"expression\u201d":[297],"imputed":[299],"having":[301],"lowest":[303],"observable":[304],"value":[305],"divided":[306],"3.":[308],"axis":[311],"reversed":[313],"(zero":[314],"higher);":[316],"lower":[317],"measured":[320],"represents":[323],"higher":[324],"levels.":[326],"E,":[327],"prevalence.":[331,341],"This":[332],"chart":[336],"displaying":[337],"testing":[343],"performed":[345],"tissue":[347,356],"samples":[348,362],"reflex":[350],"NY-ESO-1\u2013negative":[352],"status":[353],"when":[355],"available.":[358],"Prevalence":[359],"includes":[360],"from":[363],"same":[365],"patient.":[366],"NE,":[367],"evaluable.":[369]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-02-04T00:00:00"}
