{"id":"https://openalex.org/W4407087445","doi":"https://doi.org/10.1212/con.0000000000001528","title":"Surgical Treatments, Devices, and Nonmedical Management of Epilepsy","display_name":"Surgical Treatments, Devices, and Nonmedical Management of Epilepsy","publication_year":2025,"publication_date":"2025-02-01","ids":{"openalex":"https://openalex.org/W4407087445","doi":"https://doi.org/10.1212/con.0000000000001528","pmid":"https://pubmed.ncbi.nlm.nih.gov/39899100"},"language":"en","primary_location":{"id":"doi:10.1212/con.0000000000001528","doi":"https://doi.org/10.1212/con.0000000000001528","is_oa":false,"landing_page_url":"https://doi.org/10.1212/con.0000000000001528","pdf_url":null,"source":{"id":"https://openalex.org/S4210206818","display_name":"CONTINUUM Lifelong Learning in Neurology","issn_l":"1080-2371","issn":["1080-2371","1538-6899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CONTINUUM: Lifelong Learning in Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071565453","display_name":"Daniel J. Friedman","orcid":"https://orcid.org/0000-0003-1068-1797","observed_orcids":["https://orcid.org/0000-0003-1068-1797","https://orcid.org/0000-0002-3442-7454"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniel Friedman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5071565453"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0067,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.83891184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"31","issue":"1","first_page":"165","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epilepsy-surgery","display_name":"epilepsy surgery","score":0.7559999823570251},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.9800000190734863},{"id":"https://openalex.org/keywords/resective-epilepsy-surgery","display_name":"resective epilepsy surgery","score":0.9639999866485596},{"id":"https://openalex.org/keywords/minimally-invasive-epilepsy-surgery","display_name":"minimally invasive epilepsy surgery","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neurostimulation","display_name":"neurostimulation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/ketogenic-diet","display_name":"ketogenic diet","score":0.984000027179718},{"id":"https://openalex.org/keywords/dietary-therapy","display_name":"dietary therapy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/sudden-unexpected-death-in-epilepsy","display_name":"sudden unexpected death in epilepsy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/nocturnal-seizures","display_name":"nocturnal seizures","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pediatric-epilepsy","display_name":"pediatric epilepsy","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.8825775384902954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.761002779006958},{"id":"https://openalex.org/C2776443511","wikidata":"https://www.wikidata.org/wiki/Q1724687","display_name":"Neurostimulation","level":3,"score":0.6487245559692383},{"id":"https://openalex.org/C2778587478","wikidata":"https://www.wikidata.org/wiki/Q1070684","display_name":"Ketogenic diet","level":3,"score":0.6297098994255066},{"id":"https://openalex.org/C2780803581","wikidata":"https://www.wikidata.org/wiki/Q1347108","display_name":"Epilepsy surgery","level":3,"score":0.6207033395767212},{"id":"https://openalex.org/C2910833928","wikidata":"https://www.wikidata.org/wiki/Q18975053","display_name":"Drug Resistant Epilepsy","level":3,"score":0.5877180099487305},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5367525815963745},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.15788644552230835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11177095770835876},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000069279","descriptor_name":"Drug Resistant Epilepsy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019635","descriptor_name":"Neurosurgical Procedures","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055423","descriptor_name":"Diet, Ketogenic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1212/con.0000000000001528","doi":"https://doi.org/10.1212/con.0000000000001528","is_oa":false,"landing_page_url":"https://doi.org/10.1212/con.0000000000001528","pdf_url":null,"source":{"id":"https://openalex.org/S4210206818","display_name":"CONTINUUM Lifelong Learning in Neurology","issn_l":"1080-2371","issn":["1080-2371","1538-6899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CONTINUUM: Lifelong Learning in Neurology","raw_type":"journal-article"},{"id":"doi:10.1212/cont.0000000000001528","doi":"https://doi.org/10.1212/cont.0000000000001528","is_oa":false,"landing_page_url":"https://doi.org/10.1212/cont.0000000000001528","pdf_url":null,"source":{"id":"https://openalex.org/S4210206818","display_name":"CONTINUUM Lifelong Learning in Neurology","issn_l":"1080-2371","issn":["1080-2371","1538-6899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Continuum","raw_type":"journal-article"},{"id":"pmid:39899100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39899100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Continuum (Minneapolis, Minn.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W1491112993","https://openalex.org/W1514406599","https://openalex.org/W1913024560","https://openalex.org/W1920696238","https://openalex.org/W1934102085","https://openalex.org/W1968288733","https://openalex.org/W1971447049","https://openalex.org/W1974648457","https://openalex.org/W1985122316","https://openalex.org/W1986533481","https://openalex.org/W2020888576","https://openalex.org/W2025179558","https://openalex.org/W2025304637","https://openalex.org/W2038606869","https://openalex.org/W2046259291","https://openalex.org/W2058784056","https://openalex.org/W2059497817","https://openalex.org/W2080438790","https://openalex.org/W2090276138","https://openalex.org/W2096042849","https://openalex.org/W2098788339","https://openalex.org/W2104880100","https://openalex.org/W2106511344","https://openalex.org/W2117378831","https://openalex.org/W2119130526","https://openalex.org/W2121709831","https://openalex.org/W2122431110","https://openalex.org/W2126727507","https://openalex.org/W2134394857","https://openalex.org/W2135629133","https://openalex.org/W2135733572","https://openalex.org/W2154214065","https://openalex.org/W2192749205","https://openalex.org/W2278320166","https://openalex.org/W2317495993","https://openalex.org/W2401185702","https://openalex.org/W2402111156","https://openalex.org/W2460220103","https://openalex.org/W2531930448","https://openalex.org/W2534734816","https://openalex.org/W2605063596","https://openalex.org/W2608920670","https://openalex.org/W2623957986","https://openalex.org/W2735733017","https://openalex.org/W2765511579","https://openalex.org/W2777270043","https://openalex.org/W2787779804","https://openalex.org/W2796228083","https://openalex.org/W2805331050","https://openalex.org/W2896867509","https://openalex.org/W2898439257","https://openalex.org/W2900384992","https://openalex.org/W2918972315","https://openalex.org/W2955310318","https://openalex.org/W2965091406","https://openalex.org/W2971780928","https://openalex.org/W2984893531","https://openalex.org/W2987077350","https://openalex.org/W3007790220","https://openalex.org/W3015681370","https://openalex.org/W3040749770","https://openalex.org/W3044132865","https://openalex.org/W3080378203","https://openalex.org/W3089447640","https://openalex.org/W3094056583","https://openalex.org/W3133716463","https://openalex.org/W3134624933","https://openalex.org/W3137221047","https://openalex.org/W3171779398","https://openalex.org/W3184028360","https://openalex.org/W3185000708","https://openalex.org/W3188198900","https://openalex.org/W3192640784","https://openalex.org/W3200703650","https://openalex.org/W3203431666","https://openalex.org/W3208234271","https://openalex.org/W3213678476","https://openalex.org/W4200229659","https://openalex.org/W4200266028","https://openalex.org/W4200534392","https://openalex.org/W4205785472","https://openalex.org/W4206567149","https://openalex.org/W4210410746","https://openalex.org/W4210597369","https://openalex.org/W4210739950","https://openalex.org/W4224242000","https://openalex.org/W4226205043","https://openalex.org/W4280516165","https://openalex.org/W4285676872","https://openalex.org/W4289130896","https://openalex.org/W4294325390","https://openalex.org/W4296120056","https://openalex.org/W4298619728","https://openalex.org/W4306983916","https://openalex.org/W4311157678","https://openalex.org/W4313555460","https://openalex.org/W4327577377","https://openalex.org/W4375950286","https://openalex.org/W4377140662","https://openalex.org/W4386922554","https://openalex.org/W4388157550","https://openalex.org/W4388687049","https://openalex.org/W4389485075","https://openalex.org/W4412909386"],"related_works":["https://openalex.org/W2925382703","https://openalex.org/W2091349748","https://openalex.org/W4225503349","https://openalex.org/W7115074681","https://openalex.org/W7160205259","https://openalex.org/W4384297348","https://openalex.org/W4244696154","https://openalex.org/W3129579234","https://openalex.org/W2112149692","https://openalex.org/W2940138010"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Many":[1],"patients":[2,44,54,92],"with":[3,12,45,64,93,119],"epilepsy":[4,35,70,114,121,127],"are":[5],"unable":[6],"to":[7,125,129,138],"achieve":[8],"optimal":[9],"seizure":[10,24,86,98],"control":[11],"medical":[13],"therapy.":[14],"This":[15],"article":[16],"focuses":[17],"on":[18],"surgical":[19,49],"approaches,":[20],"dietary":[21],"therapies,":[22,76],"and":[23,72,104,144,147],"detection":[25,99],"devices.":[26],"LATEST":[27],"DEVELOPMENTS:":[28],"For":[29,91],"more":[30],"than":[31],"a":[32,39],"century,":[33],"resective":[34],"surgery":[36,71],"has":[37],"been":[38],"treatment":[40,136],"option":[41],"for":[42,53,55,134],"some":[43],"drug-resistant":[46,120],"epilepsy.":[47],"Other":[48],"options":[50,137],"have":[51],"emerged":[52],"whom":[56],"resection":[57],"is":[58,62],"not":[59],"possible":[60],"or":[61],"associated":[63],"unacceptable":[65],"risks,":[66],"including":[67],"minimally":[68],"invasive":[69],"neurostimulation":[73],"therapies.":[74],"Dietary":[75],"such":[77],"as":[78],"the":[79,107,140],"ketogenic":[80],"diet,":[81],"can":[82,101],"also":[83],"help":[84],"improve":[85,148],"control,":[87],"especially":[88],"in":[89,113],"children.":[90],"ongoing":[94],"nocturnal":[95],"convulsive":[96],"seizures,":[97],"devices":[100],"alert":[102],"caregivers":[103],"potentially":[105],"reduce":[106,139],"risk":[108,141],"of":[109,142,150],"sudden":[110],"unexpected":[111],"death":[112,146],"(SUDEP).":[115],"ESSENTIAL":[116],"POINTS:":[117],"Patients":[118],"should":[122],"be":[123],"referred":[124],"comprehensive":[126],"centers":[128],"determine":[130],"if":[131],"they":[132],"qualify":[133],"nonpharmacologic":[135],"seizures":[143],"premature":[145],"quality":[149],"life.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-02-03T00:00:00"}