{"id":"https://openalex.org/W4406986281","doi":"https://doi.org/10.3390/ijms26031222","title":"The Role of Genetic, Environmental, and Dietary Factors in Alzheimer\u2019s Disease: A Narrative Review","display_name":"The Role of Genetic, Environmental, and Dietary Factors in Alzheimer\u2019s Disease: A Narrative Review","publication_year":2025,"publication_date":"2025-01-30","ids":{"openalex":"https://openalex.org/W4406986281","doi":"https://doi.org/10.3390/ijms26031222","pmid":"https://pubmed.ncbi.nlm.nih.gov/39940989","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11818526"},"language":"en","primary_location":{"id":"doi:10.3390/ijms26031222","doi":"https://doi.org/10.3390/ijms26031222","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26031222","pdf_url":"https://www.mdpi.com/1422-0067/26/3/1222/pdf?version=1738248199","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/26/3/1222/pdf?version=1738248199","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116086472","display_name":"Beyza Merta\u015f","orcid":"https://orcid.org/0009-0009-5162-5864","observed_orcids":["https://orcid.org/0009-0009-5162-5864"]},"institutions":[{"id":"https://openalex.org/I54001450","display_name":"D\u00fczce \u00dcniversitesi","ror":"https://ror.org/04175wc52","country_code":"TR","type":"education","lineage":["https://openalex.org/I54001450"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Beyza Merta\u015f","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmacy, D\u00fczce University, D\u00fczce 81010, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0009-0009-5162-5864","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, D\u00fczce University, D\u00fczce 81010, T\u00fcrkiye","institution_ids":["https://openalex.org/I54001450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031191176","display_name":"\u0130. \u0130pek Bo\u015fgelmez","orcid":"https://orcid.org/0000-0003-2528-1227","observed_orcids":["https://orcid.org/0000-0003-2528-1227"]},"institutions":[{"id":"https://openalex.org/I87673952","display_name":"Erciyes University","ror":"https://ror.org/047g8vk19","country_code":"TR","type":"education","lineage":["https://openalex.org/I87673952"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"\u0130. \u0130pek Bo\u015fgelmez","raw_affiliation_strings":["Department of Toxicology, Faculty of Pharmacy, Erciyes University, Kayseri 38280, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, Faculty of Pharmacy, Erciyes University, Kayseri 38280, T\u00fcrkiye","institution_ids":["https://openalex.org/I87673952"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031191176"],"corresponding_institution_ids":["https://openalex.org/I87673952"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":4.8778,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.9748503,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"26","issue":"3","first_page":"1222","last_page":"1222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8051999807357788,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.8051999807357788,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.19120000302791595,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.8500000238418579},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.8259999752044678},{"id":"https://openalex.org/keywords/environmental-risk-factors","display_name":"environmental risk factors","score":0.9660000205039978},{"id":"https://openalex.org/keywords/dietary-factors","display_name":"dietary factors","score":0.8650000095367432},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.9729999899864197},{"id":"https://openalex.org/keywords/toxic-elements","display_name":"toxic elements","score":0.6200000047683716},{"id":"https://openalex.org/keywords/pesticides","display_name":"pesticides","score":0.8799999952316284},{"id":"https://openalex.org/keywords/infectious-agents","display_name":"infectious agents","score":0.9789999723434448},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tobacco-use","display_name":"tobacco use","score":0.8889999985694885},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.9739999771118164},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9700000286102295},{"id":"https://openalex.org/keywords/dietary-behavior","display_name":"dietary behavior","score":0.7910000085830688},{"id":"https://openalex.org/keywords/antibiotics","display_name":"antibiotics","score":0.7289999723434448},{"id":"https://openalex.org/keywords/mind-diet","display_name":"MIND diet","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mediterranean-diet","display_name":"Mediterranean diet","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dash-diet","display_name":"DASH diet","score":0.9089999794960022},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7489869594573975},{"id":"https://openalex.org/C2778962194","wikidata":"https://www.wikidata.org/wiki/Q47564","display_name":"Mediterranean diet","level":2,"score":0.7030969262123108},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5529912114143372},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48064151406288147},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.47751039266586304},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4755525290966034},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4603315591812134},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.42578989267349243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3670797348022461},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3504413366317749},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11310708522796631},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms26031222","doi":"https://doi.org/10.3390/ijms26031222","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26031222","pdf_url":"https://www.mdpi.com/1422-0067/26/3/1222/pdf?version=1738248199","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11818526","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11818526","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11818526/pdf/ijms-26-01222.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:39940989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39940989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:0a70707f-afc8-45e7-8db7-f31993628894","doi":null,"is_oa":false,"landing_page_url":"https://avesis.erciyes.edu.tr/publication/details/0a70707f-afc8-45e7-8db7-f31993628894/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055139","display_name":"Erciyes University - AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/ijms26031222","doi":"https://doi.org/10.3390/ijms26031222","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26031222","pdf_url":"https://www.mdpi.com/1422-0067/26/3/1222/pdf?version=1738248199","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406986281.pdf","grobid_xml":"https://content.openalex.org/works/W4406986281.grobid-xml"},"referenced_works_count":212,"referenced_works":["https://openalex.org/W17963537","https://openalex.org/W222006012","https://openalex.org/W291729710","https://openalex.org/W1544176368","https://openalex.org/W1628868962","https://openalex.org/W1965692917","https://openalex.org/W1974105677","https://openalex.org/W1975216966","https://openalex.org/W1977220166","https://openalex.org/W1988151436","https://openalex.org/W2017016428","https://openalex.org/W2028601946","https://openalex.org/W2034639126","https://openalex.org/W2052667522","https://openalex.org/W2054003482","https://openalex.org/W2055779774","https://openalex.org/W2059278059","https://openalex.org/W2066918975","https://openalex.org/W2069453256","https://openalex.org/W2074423172","https://openalex.org/W2075105426","https://openalex.org/W2097522066","https://openalex.org/W2099514643","https://openalex.org/W2101928861","https://openalex.org/W2105604179","https://openalex.org/W2112354679","https://openalex.org/W2112767940","https://openalex.org/W2113944963","https://openalex.org/W2119621057","https://openalex.org/W2122890373","https://openalex.org/W2123624041","https://openalex.org/W2128903550","https://openalex.org/W2129295604","https://openalex.org/W2129629659","https://openalex.org/W2138649409","https://openalex.org/W2146602519","https://openalex.org/W2166704587","https://openalex.org/W2169299827","https://openalex.org/W2192428444","https://openalex.org/W2299895859","https://openalex.org/W2319269644","https://openalex.org/W2416334527","https://openalex.org/W2465189407","https://openalex.org/W2516855911","https://openalex.org/W2528415721","https://openalex.org/W2560756564","https://openalex.org/W2583083439","https://openalex.org/W2608686430","https://openalex.org/W2616705824","https://openalex.org/W2621695716","https://openalex.org/W2694487218","https://openalex.org/W2754663667","https://openalex.org/W2756959977","https://openalex.org/W2783049018","https://openalex.org/W2790037954","https://openalex.org/W2793455642","https://openalex.org/W2798230823","https://openalex.org/W2799497060","https://openalex.org/W2799884346","https://openalex.org/W2802157723","https://openalex.org/W2805312237","https://openalex.org/W2805321653","https://openalex.org/W2807761032","https://openalex.org/W2892109408","https://openalex.org/W2912555658","https://openalex.org/W2914620404","https://openalex.org/W2914888345","https://openalex.org/W2920516237","https://openalex.org/W2920551324","https://openalex.org/W2940493085","https://openalex.org/W2940845035","https://openalex.org/W2944415973","https://openalex.org/W2944552216","https://openalex.org/W2947959068","https://openalex.org/W2948101883","https://openalex.org/W2973204012","https://openalex.org/W2985050537","https://openalex.org/W2986852893","https://openalex.org/W2995475690","https://openalex.org/W3001336685","https://openalex.org/W3003231031","https://openalex.org/W3003241500","https://openalex.org/W3010004390","https://openalex.org/W3016127017","https://openalex.org/W3021520174","https://openalex.org/W3034639723","https://openalex.org/W3036226369","https://openalex.org/W3039498906","https://openalex.org/W3045806571","https://openalex.org/W3084974110","https://openalex.org/W3097498234","https://openalex.org/W3102150527","https://openalex.org/W3109937594","https://openalex.org/W3124558446","https://openalex.org/W3129034325","https://openalex.org/W3134348444","https://openalex.org/W3135336060","https://openalex.org/W3172151408","https://openalex.org/W3183562257","https://openalex.org/W3187285026","https://openalex.org/W3190853618","https://openalex.org/W3199937150","https://openalex.org/W3205749467","https://openalex.org/W4200372152","https://openalex.org/W4206055706","https://openalex.org/W4206549883","https://openalex.org/W4206661596","https://openalex.org/W4225524810","https://openalex.org/W4229006902","https://openalex.org/W4241051658","https://openalex.org/W4280591287","https://openalex.org/W4281554374","https://openalex.org/W4281616414","https://openalex.org/W4283794354","https://openalex.org/W4285396243","https://openalex.org/W4286515542","https://openalex.org/W4288702326","https://openalex.org/W4290673668","https://openalex.org/W4291397316","https://openalex.org/W4297183188","https://openalex.org/W4297235746","https://openalex.org/W4313252318","https://openalex.org/W4313828769","https://openalex.org/W4318982690","https://openalex.org/W4319288677","https://openalex.org/W4319826203","https://openalex.org/W4322761776","https://openalex.org/W4323666031","https://openalex.org/W4324309277","https://openalex.org/W4362506921","https://openalex.org/W4366162838","https://openalex.org/W4377019867","https://openalex.org/W4382651980","https://openalex.org/W4384665281","https://openalex.org/W4384830037","https://openalex.org/W4386568406","https://openalex.org/W4386637821","https://openalex.org/W4386931548","https://openalex.org/W4386945073","https://openalex.org/W4387392099","https://openalex.org/W4387598708","https://openalex.org/W4388615774","https://openalex.org/W4388825554","https://openalex.org/W4388851620","https://openalex.org/W4389151516","https://openalex.org/W4390227061","https://openalex.org/W4390562552","https://openalex.org/W4390570554","https://openalex.org/W4390610579","https://openalex.org/W4390707092","https://openalex.org/W4390782434","https://openalex.org/W4390842851","https://openalex.org/W4391198233","https://openalex.org/W4391270071","https://openalex.org/W4391830477","https://openalex.org/W4392465195","https://openalex.org/W4392752937","https://openalex.org/W4392915125","https://openalex.org/W4394797979","https://openalex.org/W4394916509","https://openalex.org/W4394954046","https://openalex.org/W4395957060","https://openalex.org/W4396625050","https://openalex.org/W4396673676","https://openalex.org/W4396887532","https://openalex.org/W4396888965","https://openalex.org/W4397046612","https://openalex.org/W4399042241","https://openalex.org/W4399375757","https://openalex.org/W4399576740","https://openalex.org/W4399670156","https://openalex.org/W4400059967","https://openalex.org/W4400089962","https://openalex.org/W4400385825","https://openalex.org/W4400624566","https://openalex.org/W4400725217","https://openalex.org/W4400772417","https://openalex.org/W4400868718","https://openalex.org/W4400954726","https://openalex.org/W4400994374","https://openalex.org/W4401101543","https://openalex.org/W4401121841","https://openalex.org/W4401164724","https://openalex.org/W4401565271","https://openalex.org/W4401633661","https://openalex.org/W4401888492","https://openalex.org/W4402395619","https://openalex.org/W4402400766","https://openalex.org/W4402413408","https://openalex.org/W4402466398","https://openalex.org/W4402664594","https://openalex.org/W4402892702","https://openalex.org/W4402945887","https://openalex.org/W4403087827","https://openalex.org/W4403090924","https://openalex.org/W4403156424","https://openalex.org/W4403267370","https://openalex.org/W4403790644","https://openalex.org/W4404024063","https://openalex.org/W4404296400","https://openalex.org/W4404321720","https://openalex.org/W4404332306","https://openalex.org/W4404423857","https://openalex.org/W4404449308","https://openalex.org/W4404579888","https://openalex.org/W4404643481","https://openalex.org/W4404672055","https://openalex.org/W4404890608","https://openalex.org/W4405030651","https://openalex.org/W4405035908","https://openalex.org/W4405092049","https://openalex.org/W4405247957"],"related_works":["https://openalex.org/W2024424148","https://openalex.org/W2607530994","https://openalex.org/W2893251021","https://openalex.org/W4413623269","https://openalex.org/W2883541950","https://openalex.org/W2105557181","https://openalex.org/W3045208599","https://openalex.org/W1443942943","https://openalex.org/W4298140123","https://openalex.org/W3012828832"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,107],"(AD)":[2],"is":[3,30,51,64,109],"one":[4,72],"of":[5,12,45,73,77,84,102,124,195],"the":[6,27,35,43,74,81,90,100,192,201],"most":[7],"common":[8],"and":[9,14,89,148,166,169,177,184,197,208],"severe":[10],"forms":[11],"dementia":[13],"neurodegenerative":[15],"disease.":[16],"As":[17,54],"life":[18],"expectancy":[19],"increases":[20],"in":[21,25,34,42],"line":[22],"with":[23],"developments":[24],"medicine,":[26],"elderly":[28],"population":[29],"projected":[31],"to":[32,66],"increase":[33,41],"next":[36],"few":[37],"decades;":[38],"therefore,":[39],"an":[40],"prevalence":[44],"some":[46],"diseases,":[47],"such":[48,141,180,199],"as":[49,71,142,151,153,181,200],"AD,":[50,88],"also":[52,188],"expected.":[53],"a":[55,58,85,134],"result,":[56],"until":[57],"radical":[59],"treatment":[60],"becomes":[61],"available,":[62],"AD":[63],"expected":[65],"be":[67],"more":[68],"frequently":[69],"recorded":[70],"top":[75],"causes":[76],"death":[78],"worldwide.":[79],"Given":[80],"current":[82],"lack":[83],"cure":[86],"for":[87,204],"only":[91],"treatments":[92],"available":[93],"being":[94],"ones":[95],"that":[96,105,171],"alleviate":[97],"major":[98],"symptoms,":[99],"identification":[101],"contributing":[103],"factors":[104,140,155,163],"influence":[106],"incidence":[108],"crucial.":[110],"In":[111,129],"this":[112,130],"context,":[113],"genetic":[114,178],"and/or":[115],"epigenetic":[116],"factors,":[117,126,179],"mainly":[118],"environmental,":[119],"disease-related,":[120],"dietary,":[121],"or":[122],"combinations/interactions":[123],"these":[125],"are":[127,172],"assessed.":[128],"review,":[131],"we":[132],"conducted":[133],"literature":[135],"search":[136],"focusing":[137],"on":[138,191],"environmental":[139,176],"air":[143],"pollution,":[144],"toxic":[145],"elements,":[146],"pesticides,":[147],"infectious":[149],"agents,":[150],"well":[152],"dietary":[154,182],"including":[156],"various":[157],"diets,":[158,198],"vitamin":[159],"D":[160],"deficiency,":[161],"social":[162],"(e.g.,":[164],"tobacco":[165],"alcohol":[167],"use),":[168],"variables":[170],"affected":[173],"by":[174],"both":[175],"behavior":[183],"gut":[185],"microbiota.":[186],"We":[187],"evaluated":[189],"studies":[190],"beneficial":[193],"effects":[194],"antibiotics":[196],"Mediterranean-DASH":[202],"Intervention":[203],"Neurodegenerative":[205],"Delay":[206],"(MIND)":[207],"Mediterranean":[209],"diets.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":14}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-01-31T00:00:00"}
