{"id":"https://openalex.org/W4406984766","doi":"https://doi.org/10.1016/s0031-6997(25)07198-4","title":"D. COENZYMES AND HYDROXYLASES: ASCORBATE AND DOPAMINE-\u03b2-HYDROXYLASE; TETRAHYDROPTERIDINES AND PHENYLALANINE AND TYROSINE HYDROXYLASES","display_name":"D. COENZYMES AND HYDROXYLASES: ASCORBATE AND DOPAMINE-\u03b2-HYDROXYLASE; TETRAHYDROPTERIDINES AND PHENYLALANINE AND TYROSINE HYDROXYLASES","publication_year":1966,"publication_date":"1966-03-01","ids":{"openalex":"https://openalex.org/W4406984766","doi":"https://doi.org/10.1016/s0031-6997(25)07198-4","mag":"2247763195","pmid":"https://pubmed.ncbi.nlm.nih.gov/5904174"},"language":"en","primary_location":{"id":"doi:10.1016/s0031-6997(25)07198-4","doi":"https://doi.org/10.1016/s0031-6997(25)07198-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0031-6997(25)07198-4","pdf_url":null,"source":{"id":"https://openalex.org/S161680845","display_name":"Pharmacological Reviews","issn_l":"0031-6997","issn":["0031-6997","1521-0081"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Reviews","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108437014","display_name":"Seymour Kaufman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Seymour Kaufman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108437014"],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.8576,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.85784314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"18","issue":"1","first_page":"61","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.3792000114917755,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.3792000114917755,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.19419999420642853,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.14090000092983246,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coenzymes","display_name":"coenzymes","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hydroxylase","display_name":"hydroxylase","score":0.9800000190734863},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dopamine-beta-hydroxylase","display_name":"dopamine beta-hydroxylase","score":0.968999981880188},{"id":"https://openalex.org/keywords/tetrahydropteridines","display_name":"tetrahydropteridines","score":0.949999988079071},{"id":"https://openalex.org/keywords/phenylalanine-hydroxylase","display_name":"phenylalanine hydroxylase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/catecholamine-biosynthesis","display_name":"catecholamine synthesis","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.700425386428833},{"id":"https://openalex.org/C207009774","wikidata":"https://www.wikidata.org/wiki/Q420604","display_name":"Phenylalanine hydroxylase","level":4,"score":0.6043806672096252},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.5865182280540466},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5735986232757568},{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.5364362001419067},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5220417976379395},{"id":"https://openalex.org/C2909129545","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine 3-Monooxygenase","level":4,"score":0.4641745090484619},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4520662724971771},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.39592036604881287},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.10751515626907349}],"mesh":[{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003067","descriptor_name":"Coenzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011621","descriptor_name":"Pteridines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0031-6997(25)07198-4","doi":"https://doi.org/10.1016/s0031-6997(25)07198-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0031-6997(25)07198-4","pdf_url":null,"source":{"id":"https://openalex.org/S161680845","display_name":"Pharmacological Reviews","issn_l":"0031-6997","issn":["0031-6997","1521-0081"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Reviews","raw_type":"journal-article"},{"id":"pmid:5904174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5904174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological reviews","raw_type":"Journal Article"},{"id":"mag:2247763195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5904174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2247763195","https://openalex.org/W1978096059","https://openalex.org/W1966146750","https://openalex.org/W2443463614","https://openalex.org/W2897025931","https://openalex.org/W7098362079","https://openalex.org/W2525550930","https://openalex.org/W53964101","https://openalex.org/W2404855663","https://openalex.org/W22445766"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-01-31T00:00:00"}