{"id":"https://openalex.org/W4406962772","doi":"https://doi.org/10.1161/str.56.suppl_1.tp341","title":"Abstract TP341: Longitudinal Analysis of Peripheral Blood Dynamics During the First Week after Ischemic Stroke: Biomarkers and Correlation to Functional Outcome","display_name":"Abstract TP341: Longitudinal Analysis of Peripheral Blood Dynamics During the First Week after Ischemic Stroke: Biomarkers and Correlation to Functional Outcome","publication_year":2025,"publication_date":"2025-01-30","ids":{"openalex":"https://openalex.org/W4406962772","doi":"https://doi.org/10.1161/str.56.suppl_1.tp341"},"language":"en","primary_location":{"id":"doi:10.1161/str.56.suppl_1.tp341","doi":"https://doi.org/10.1161/str.56.suppl_1.tp341","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.56.suppl_1.tp341","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067215332","display_name":"Lucy Couture","orcid":"https://orcid.org/0000-0002-1586-988X","observed_orcids":["https://orcid.org/0000-0002-1586-988X"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucy Couture","raw_affiliation_strings":["UTHealth Houston, Houston , Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UTHealth Houston, Houston , Texas, United States","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Trang Do","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trang Do","raw_affiliation_strings":["UTHealth Houston- McGovern Medical, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UTHealth Houston- McGovern Medical, Houston, Texas, United States","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080888653","display_name":"Romeesa Khan","orcid":"https://orcid.org/0000-0002-4129-1612","observed_orcids":["https://orcid.org/0000-0002-4129-1612","https://orcid.org/0000-0001-9733-9593"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Romeesa Khan","raw_affiliation_strings":["UT Health Houston- BRAINS McGovern, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT Health Houston- BRAINS McGovern, Houston, Texas, United States","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114436281","display_name":"Ana E. Cahuiche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Cahuiche","raw_affiliation_strings":["UTHealth Houston, Houston , Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UTHealth Houston, Houston , Texas, United States","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033047164","display_name":"Gary U. Guzman","orcid":"https://orcid.org/0000-0001-8002-9994","observed_orcids":["https://orcid.org/0000-0001-8002-9994"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Guzman","raw_affiliation_strings":["UTHealth Houston, Houston , Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UTHealth Houston, Houston , Texas, United States","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104237751","display_name":"Bryce E. West","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryce West","raw_affiliation_strings":["McGovern Medical School, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGovern Medical School, Houston, Texas, United States","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003872247","display_name":"Patrick Devlin","orcid":"https://orcid.org/0000-0002-0359-4620","observed_orcids":["https://orcid.org/0000-0002-0359-4620"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Devlin","raw_affiliation_strings":["University of Texas at Houston, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Houston, Houston, Texas, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081418182","display_name":"Gabriela Delevati Colpo","orcid":"https://orcid.org/0000-0003-2023-6902","observed_orcids":["https://orcid.org/0000-0003-2023-6902"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriela Delevati Colpo","raw_affiliation_strings":["UTHealth Houston, Houston , Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UTHealth Houston, Houston , Texas, United States","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061776751","display_name":"Rodney M. Ritzel","orcid":"https://orcid.org/0000-0002-0160-2930","observed_orcids":["https://orcid.org/0000-0002-0160-2930"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodney Ritzel","raw_affiliation_strings":["UT-Houston, Houston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT-Houston, Houston, Texas, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"56","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.47269999980926514,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.47269999980926514,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.4699999988079071,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9959999918937683},{"id":"https://openalex.org/keywords/peripheral-blood-biomarkers","display_name":"peripheral blood biomarkers","score":0.8270000219345093},{"id":"https://openalex.org/keywords/lysotracker","display_name":"LysoTracker","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.8619999885559082},{"id":"https://openalex.org/keywords/effector-cd4-t-cells","display_name":"CD4+ effector T cells","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.6539999842643738},{"id":"https://openalex.org/keywords/functional-outcome","display_name":"functional outcome","score":0.5429999828338623},{"id":"https://openalex.org/keywords/disability","display_name":"disability","score":0.5680000185966492},{"id":"https://openalex.org/keywords/acute-phase","display_name":"acute phase","score":0.3869999945163727},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9665012955665588},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.6027518510818481},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5782651305198669},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.49968624114990234},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.4978446960449219},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.49411752820014954},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48267248272895813},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3023239076137543},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/str.56.suppl_1.tp341","doi":"https://doi.org/10.1161/str.56.suppl_1.tp341","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.56.suppl_1.tp341","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3173491961","https://openalex.org/W4406992582","https://openalex.org/W3096756498","https://openalex.org/W3133975250","https://openalex.org/W2762663064","https://openalex.org/W2901404586","https://openalex.org/W2905225295","https://openalex.org/W2079637914","https://openalex.org/W3080873401","https://openalex.org/W3082499391"],"abstract_inverted_index":{"Introduction:":[0],"Peripheral":[1],"blood-based":[2],"biomarker":[3],"development":[4],"for":[5,352],"neurological":[6],"diseases":[7],"such":[8],"as":[9,61],"ischemic":[10,49,91],"stroke":[11,92,137,187,286,306],"has":[12,296],"traditionally":[13],"focused":[14],"on":[15,79],"measuring":[16],"alterations":[17,32],"in":[18,68,136,152,177,208,216,242,278,291,339,343],"leukocyte":[19,281],"number":[20],"and":[21,35,59,71,89,97,133,226,323],"composition.":[22],"Deeper":[23],"immunophenotyping":[24,315],"of":[25,42,46,56,104,112,155,180,325,334],"cells":[26,83,115,159,230],"using":[27],"fluorescent":[28],"probes":[29,63],"that":[30],"detect":[31],"among":[33,195,305],"organelles":[34],"structures":[36],"can":[37],"provide":[38,269,317],"a":[39,149,172,288,350],"better":[40],"understanding":[41],"the":[43,54,101,144,153,250,273,279,332,340],"biological":[44,321],"function":[45,324],"leukocytes":[47,327],"after":[48,117,125,160,186,231,262,283,328],"stroke.":[50,126,232,284],"Methods:":[51],"We":[52,108,127],"evaluated":[53],"utility":[55],"BODIPY":[57],"493/503":[58],"LysoTracker":[60],"fluorogenic":[62],"to":[64,99,140,272,302,345],"assess":[65],"cellular":[66,292],"changes":[67,277,337],"lipid":[69,178,247],"content":[70,179,198,248,295],"lysosomal":[72],"burden.":[73],"Flow":[74],"cytometric":[75,314],"assessments":[76],"were":[77,131],"performed":[78],"peripheral":[80],"mononuclear":[81],"blood":[82,280],"from":[84,90],"healthy":[85],"volunteers":[86],"(HV,":[87],"N=31),":[88],"patients":[93,138],"(N=43)":[94],"at":[95,123,184,244,249,259],"3d":[96,116],"7d":[98,124,185],"capture":[100],"temporal":[102],"profile":[103],"these":[105,335],"biomarkers.":[106],"Results:":[107],"found":[109,128,148],"decreased":[110,214],"frequency":[111,154],"CD3+":[113],"T":[114,158,211,229],"stroke,":[118,161],"which":[119],"was":[120,192,199,253],"also":[121,297],"seen":[122,338],"CD4:CD8":[129],"ratios":[130],"significantly":[132,254,299],"persistently":[134],"increased":[135,206,257],"compared":[139,188],"HV":[141],"controls.":[142,189],"Within":[143],"CD4":[145,157,209,217],"subset,":[146],"we":[147,170,234],"persistent":[150],"increase":[151,176,241,290],"effector":[156,227],"this":[162],"finding":[163],"is":[164],"consistent":[165],"with":[166,205,240,256,312],"previous":[167],"literature.":[168],"Interestingly,":[169],"noted":[171],"delayed,":[173],"but":[174,213],"profound":[175],"all":[181],"cell":[182,203],"types":[183],"This":[190],"difference":[191],"more":[193],"pronounced":[194],"females.":[196],"Lysosomal":[197,294],"differentially":[200],"altered":[201],"by":[202],"type,":[204],"levels":[207,215],"na\u00efve":[210],"cells,":[212],"central":[218,225],"memory,":[219],"CD8":[220,222,224],"na\u00efve,":[221],"effector,":[223],"memory":[228],"While":[233],"did":[235],"not":[236],"see":[237],"an":[238],"association":[239],"severity":[243],"admission,":[245],"high":[246],"acute":[251,341],"phase":[252,342],"associated":[255],"disability":[258,304],"3":[260],"months":[261],"hospitalization.":[263],"Conclusion:":[264],"Taken":[265],"together,":[266],"our":[267],"findings":[268],"greater":[270],"context":[271],"previously":[274],"documented":[275],"compositional":[276,336],"compartment":[282],"Ischemic":[285],"causes":[287],"pervasive":[289],"lipidosis.":[293],"been":[298],"positively":[300],"correlated":[301],"functional":[303,310,346],"patients.":[307],"Using":[308],"cell-based":[309],"assays":[311],"flow":[313],"may":[316],"meaningful":[318],"insights":[319],"into":[320],"health":[322],"circulating":[326],"brain":[329],"injury.":[330],"Understanding":[331],"effects":[333],"respect":[344],"outcomes":[347],"should":[348],"be":[349],"priority":[351],"researchers":[353],"moving":[354],"forward.":[355]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2025-01-30T00:00:00"}