{"id":"https://openalex.org/W4406883095","doi":"https://doi.org/10.1002/mas.21925","title":"MS\u2010Based Glycome Characterization of Biotherapeutics With N\u2010 and O\u2010Glycosylation","display_name":"MS\u2010Based Glycome Characterization of Biotherapeutics With N\u2010 and O\u2010Glycosylation","publication_year":2025,"publication_date":"2025-01-27","ids":{"openalex":"https://openalex.org/W4406883095","doi":"https://doi.org/10.1002/mas.21925","pmid":"https://pubmed.ncbi.nlm.nih.gov/39871420"},"language":"en","primary_location":{"id":"doi:10.1002/mas.21925","doi":"https://doi.org/10.1002/mas.21925","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mas.21925","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mas.21925","source":{"id":"https://openalex.org/S69764086","display_name":"Mass Spectrometry Reviews","issn_l":"0277-7037","issn":["0277-7037","1098-2787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mass Spectrometry Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mas.21925","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101412052","display_name":"Myung Jin Oh","orcid":"https://orcid.org/0000-0003-0136-2305","observed_orcids":["https://orcid.org/0000-0003-0136-2305"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myung Jin Oh","raw_affiliation_strings":["Asia-Pacific Glycomics Reference Site, Daejeon, Korea","Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asia-Pacific Glycomics Reference Site, Daejeon, Korea","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027761886","display_name":"Youngsuk Seo","orcid":"https://orcid.org/0000-0002-8934-3290","observed_orcids":["https://orcid.org/0000-0002-8934-3290"]},"institutions":[{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youngsuk Seo","raw_affiliation_strings":["Life Science Institute, Institute for Basic Science, Daejeon, Korea"],"raw_orcid":"https://orcid.org/0000-0002-8934-3290","affiliations":[{"raw_affiliation_string":"Life Science Institute, Institute for Basic Science, Daejeon, Korea","institution_ids":["https://openalex.org/I4210104335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114110498","display_name":"Nari Seo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nari Seo","raw_affiliation_strings":["Asia-Pacific Glycomics Reference Site, Daejeon, Korea","Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asia-Pacific Glycomics Reference Site, Daejeon, Korea","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071147220","display_name":"Hyun Joo An","orcid":"https://orcid.org/0000-0001-5847-7483","observed_orcids":["https://orcid.org/0000-0001-5847-7483"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyun Joo An","raw_affiliation_strings":["Asia-Pacific Glycomics Reference Site, Daejeon, Korea","Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea"],"raw_orcid":"https://orcid.org/0000-0001-5847-7483","affiliations":[{"raw_affiliation_string":"Asia-Pacific Glycomics Reference Site, Daejeon, Korea","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea","institution_ids":["https://openalex.org/I196345858"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071147220"],"corresponding_institution_ids":["https://openalex.org/I196345858"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":0.3798,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.35436098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"45","issue":"4","first_page":"691","last_page":"713"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/o-glycosylation","display_name":"O-glycosylation","score":1.0},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8080000281333923},{"id":"https://openalex.org/keywords/batch-to-batch-consistency","display_name":"batch-to-batch consistency","score":0.8999999761581421},{"id":"https://openalex.org/keywords/maldi-tof-mass-spectrometry","display_name":"MALDI-TOF mass spectrometry","score":0.9039999842643738},{"id":"https://openalex.org/keywords/lc-ms","display_name":"LC-MS","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"tandem mass spectrometry","score":0.953000009059906},{"id":"https://openalex.org/keywords/glycopeptide-analysis","display_name":"glycopeptide analysis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/glycan-analysis","display_name":"glycan analysis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/biopharmaceutical-development","display_name":"biopharmaceutical development","score":0.9129999876022339}],"concepts":[{"id":"https://openalex.org/C158650290","wikidata":"https://www.wikidata.org/wiki/Q3063952","display_name":"Glycome","level":4,"score":0.929732084274292},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.839309573173523},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8070375919342041},{"id":"https://openalex.org/C2781047461","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biopharmaceutical","level":2,"score":0.8052735328674316},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.7987126111984253},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5908119678497314},{"id":"https://openalex.org/C137610392","wikidata":"https://www.wikidata.org/wiki/Q2425020","display_name":"Glycopeptide","level":3,"score":0.5547347664833069},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5305949449539185},{"id":"https://openalex.org/C106686826","wikidata":"https://www.wikidata.org/wiki/Q741206","display_name":"Glycomics","level":4,"score":0.45827221870422363},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.45326751470565796},{"id":"https://openalex.org/C130361206","wikidata":"https://www.wikidata.org/wiki/Q908443","display_name":"Calnexin","level":4,"score":0.4220716655254364},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3496691584587097},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.19136103987693787},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.10462254285812378},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07436692714691162},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C47450691","wikidata":"https://www.wikidata.org/wiki/Q634510","display_name":"Calreticulin","level":3,"score":0.0},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006020","descriptor_name":"Glycopeptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006020","descriptor_name":"Glycopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D054794","descriptor_name":"Glycomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/mas.21925","doi":"https://doi.org/10.1002/mas.21925","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mas.21925","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mas.21925","source":{"id":"https://openalex.org/S69764086","display_name":"Mass Spectrometry Reviews","issn_l":"0277-7037","issn":["0277-7037","1098-2787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mass Spectrometry Reviews","raw_type":"journal-article"},{"id":"pmid:39871420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39871420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mass spectrometry reviews","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/mas.21925","doi":"https://doi.org/10.1002/mas.21925","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mas.21925","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mas.21925","source":{"id":"https://openalex.org/S69764086","display_name":"Mass Spectrometry Reviews","issn_l":"0277-7037","issn":["0277-7037","1098-2787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mass Spectrometry Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2969301613","display_name":null,"funder_award_id":"22-CM-EC-18","funder_id":"https://openalex.org/F4320321681","funder_display_name":"Ministry of Trade, Industry and Energy"},{"id":"https://openalex.org/G8543952245","display_name":null,"funder_award_id":"22-CM-EC-18","funder_id":"https://openalex.org/F4320329473","funder_display_name":"Institute of Civil-Military Technology Cooperation"}],"funders":[{"id":"https://openalex.org/F4320321204","display_name":"Chungnam National University","ror":"https://ror.org/0227as991"},{"id":"https://openalex.org/F4320321681","display_name":"Ministry of Trade, Industry and Energy","ror":"https://ror.org/008nkqk13"},{"id":"https://openalex.org/F4320322014","display_name":"Ministry of Food and Drug Safety","ror":"https://ror.org/01f7dp456"},{"id":"https://openalex.org/F4320329473","display_name":"Institute of Civil-Military Technology Cooperation","ror":"https://ror.org/027331q77"},{"id":"https://openalex.org/F4320334874","display_name":"Defense Acquisition Program Administration","ror":"https://ror.org/04bjg9m96"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406883095.pdf","grobid_xml":"https://content.openalex.org/works/W4406883095.grobid-xml"},"referenced_works_count":158,"referenced_works":["https://openalex.org/W210162112","https://openalex.org/W798616579","https://openalex.org/W1547997448","https://openalex.org/W1602462303","https://openalex.org/W1671460938","https://openalex.org/W1966227539","https://openalex.org/W1967252259","https://openalex.org/W1972640464","https://openalex.org/W1978124145","https://openalex.org/W1979045457","https://openalex.org/W1980770700","https://openalex.org/W1981132421","https://openalex.org/W1986436077","https://openalex.org/W1988400338","https://openalex.org/W1989015529","https://openalex.org/W1991045019","https://openalex.org/W1993838215","https://openalex.org/W1994205197","https://openalex.org/W1994251377","https://openalex.org/W1996898871","https://openalex.org/W1997984454","https://openalex.org/W1998653677","https://openalex.org/W2001607896","https://openalex.org/W2007058937","https://openalex.org/W2007116319","https://openalex.org/W2016999730","https://openalex.org/W2017355698","https://openalex.org/W2017515622","https://openalex.org/W2027894892","https://openalex.org/W2028019069","https://openalex.org/W2031268693","https://openalex.org/W2038282126","https://openalex.org/W2038706294","https://openalex.org/W2048182696","https://openalex.org/W2050528115","https://openalex.org/W2057390178","https://openalex.org/W2061518680","https://openalex.org/W2065595227","https://openalex.org/W2066648049","https://openalex.org/W2075166329","https://openalex.org/W2076709027","https://openalex.org/W2077285487","https://openalex.org/W2080105457","https://openalex.org/W2083780169","https://openalex.org/W2085027550","https://openalex.org/W2085141423","https://openalex.org/W2086627779","https://openalex.org/W2094406292","https://openalex.org/W2102647446","https://openalex.org/W2106419402","https://openalex.org/W2120533079","https://openalex.org/W2122447210","https://openalex.org/W2125845245","https://openalex.org/W2135819931","https://openalex.org/W2136482421","https://openalex.org/W2137354517","https://openalex.org/W2140035322","https://openalex.org/W2159397356","https://openalex.org/W2168618030","https://openalex.org/W2175291039","https://openalex.org/W2181199764","https://openalex.org/W2239052723","https://openalex.org/W2250334067","https://openalex.org/W2286149763","https://openalex.org/W2294527235","https://openalex.org/W2329169489","https://openalex.org/W2330451514","https://openalex.org/W2336611928","https://openalex.org/W2409718956","https://openalex.org/W2414358272","https://openalex.org/W2467554648","https://openalex.org/W2478409189","https://openalex.org/W2506249512","https://openalex.org/W2516808437","https://openalex.org/W2551001349","https://openalex.org/W2555495562","https://openalex.org/W2566273342","https://openalex.org/W2590064181","https://openalex.org/W2591498323","https://openalex.org/W2608656888","https://openalex.org/W2754873435","https://openalex.org/W2755333779","https://openalex.org/W2756221472","https://openalex.org/W2764109483","https://openalex.org/W2770525211","https://openalex.org/W2770668672","https://openalex.org/W2789682399","https://openalex.org/W2793655673","https://openalex.org/W2802194796","https://openalex.org/W2805894928","https://openalex.org/W2806737555","https://openalex.org/W2884507766","https://openalex.org/W2885085301","https://openalex.org/W2885484520","https://openalex.org/W2889050507","https://openalex.org/W2889655504","https://openalex.org/W2896911000","https://openalex.org/W2902334680","https://openalex.org/W2908981512","https://openalex.org/W2925160632","https://openalex.org/W2938363660","https://openalex.org/W2941449740","https://openalex.org/W2979940307","https://openalex.org/W2981215620","https://openalex.org/W2995723120","https://openalex.org/W2995755986","https://openalex.org/W2999431220","https://openalex.org/W3002426589","https://openalex.org/W3022116762","https://openalex.org/W3024508204","https://openalex.org/W3025275867","https://openalex.org/W3034064336","https://openalex.org/W3038130589","https://openalex.org/W3040058332","https://openalex.org/W3040435520","https://openalex.org/W3042289739","https://openalex.org/W3082935063","https://openalex.org/W3083707005","https://openalex.org/W3084278307","https://openalex.org/W3087237332","https://openalex.org/W3087481505","https://openalex.org/W3109975779","https://openalex.org/W3111535139","https://openalex.org/W3112689085","https://openalex.org/W3119024742","https://openalex.org/W3137806655","https://openalex.org/W3139839046","https://openalex.org/W3155838997","https://openalex.org/W3164855231","https://openalex.org/W3170359867","https://openalex.org/W3173807452","https://openalex.org/W3181046949","https://openalex.org/W3184378743","https://openalex.org/W3197930186","https://openalex.org/W3199048439","https://openalex.org/W3199754521","https://openalex.org/W4221043595","https://openalex.org/W4225464502","https://openalex.org/W4283216796","https://openalex.org/W4284895787","https://openalex.org/W4290960441","https://openalex.org/W4304117484","https://openalex.org/W4306247807","https://openalex.org/W4311277055","https://openalex.org/W4319068602","https://openalex.org/W4319827662","https://openalex.org/W4382395821","https://openalex.org/W4385330944","https://openalex.org/W4387661655","https://openalex.org/W4387816740","https://openalex.org/W4390755113","https://openalex.org/W4391814070","https://openalex.org/W4392959252","https://openalex.org/W4394845195","https://openalex.org/W4400079504","https://openalex.org/W4400208210","https://openalex.org/W4400279547","https://openalex.org/W4402534241"],"related_works":["https://openalex.org/W2221488325","https://openalex.org/W7049124169","https://openalex.org/W2294527235","https://openalex.org/W4382395821","https://openalex.org/W2770668672","https://openalex.org/W3100103555","https://openalex.org/W3025275867","https://openalex.org/W7172108788","https://openalex.org/W2011399134","https://openalex.org/W2941449740"],"abstract_inverted_index":{"With":[0],"the":[1,15,30,39,50,61,76,107],"increasing":[2],"FDA":[3],"approvals":[4],"of":[5,17,33,41,65,79,113],"glycoprotein-based":[6],"biotherapeutics":[7,42],"including":[8,68],"monoclonal":[9],"antibodies,":[10],"cytokines,":[11],"and":[12,23,46,56,63,72,89,101,110],"enzyme":[13],"treatments,":[14],"significance":[16],"glycosylation":[18,54],"in":[19,37,75],"modulating":[20],"drug":[21],"efficacy":[22],"safety":[24],"becomes":[25],"central.":[26],"This":[27],"review":[28,94],"highlights":[29,95],"crucial":[31],"role":[32],"mass":[34],"spectrometry":[35],"(MS)":[36],"elucidating":[38],"glycome":[40],"that":[43],"feature":[44],"N-":[45],"O-glycosylation,":[47],"directly":[48],"addressing":[49],"challenges":[51],"posed":[52],"by":[53],"complexity":[55],"heterogeneity.":[57],"We":[58],"have":[59],"detailed":[60],"advancements":[62],"application":[64],"MS":[66,74],"technologies":[67],"MALDI-TOF":[69],"MS,":[70],"LC-MS,":[71],"tandem":[73],"precise":[77],"characterization":[78],"glycoprotein":[80],"therapeutics.":[81],"Emphasizing":[82],"MS-based":[83],"strategies":[84],"for":[85,98],"detecting":[86],"immunogenic":[87],"glycans":[88],"ensuring":[90],"batch-to-batch":[91],"consistency,":[92],"this":[93],"targeted":[96],"approaches":[97],"glycoprotein,":[99],"glycopeptide,":[100],"glycan":[102],"analysis":[103],"tailored":[104],"to":[105],"meet":[106],"stringent":[108],"analytical":[109],"regulatory":[111],"demands":[112],"biopharmaceutical":[114],"development.":[115]},"counts_by_year":[{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-01-29T00:00:00"}