{"id":"https://openalex.org/W4406866044","doi":"https://doi.org/10.6019/s-biad1581","title":"Subacute Exposure of Male Adolescent Rats to 2,2',5,5'-Tetrachlorobiphenyl-4-ol via a Polymeric Implant Causes Gene Expression Changes in the Brain and Metabolomic Disruption in Serum","display_name":"Subacute Exposure of Male Adolescent Rats to 2,2',5,5'-Tetrachlorobiphenyl-4-ol via a Polymeric Implant Causes Gene Expression Changes in the Brain and Metabolomic Disruption in Serum","publication_year":2025,"publication_date":"2025-01-27","ids":{"openalex":"https://openalex.org/W4406866044","doi":"https://doi.org/10.6019/s-biad1581"},"language":"en","primary_location":{"id":"doi:10.6019/s-biad1581","doi":"https://doi.org/10.6019/s-biad1581","is_oa":false,"landing_page_url":"https://doi.org/10.6019/s-biad1581","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioStudies Database","raw_type":"dataset"},"volume":null,"type":"dataset","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100460801","display_name":"Hui Wang","orcid":"https://orcid.org/0000-0002-5132-0077","observed_orcids":["https://orcid.org/0000-0002-5132-0077"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Wang","raw_affiliation_strings":["University of Iowa"],"raw_orcid":"https://orcid.org/0000-0002-5132-0077","affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059263229","display_name":"Amanda J. Bullert","orcid":"https://orcid.org/0000-0002-4288-3142","observed_orcids":["https://orcid.org/0000-0002-4288-3142"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda J Bullert","raw_affiliation_strings":["University of Iowa"],"raw_orcid":"https://orcid.org/0000-0002-4288-3142","affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107741892","display_name":"Morgan J Linahon","orcid":"https://orcid.org/0009-0002-5841-6159","observed_orcids":["https://orcid.org/0009-0002-5841-6159"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan Linahon","raw_affiliation_strings":["University of Iowa"],"raw_orcid":"https://orcid.org/0009-0002-5841-6159","affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074145684","display_name":"Michael E. Dailey","orcid":"https://orcid.org/0000-0003-2962-4661","observed_orcids":["https://orcid.org/0000-0003-2962-4661"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Dailey","raw_affiliation_strings":["University of Iowa"],"raw_orcid":"https://orcid.org/0000-0003-2962-4661","affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040748951","display_name":"Jonathan A. Doorn","orcid":"https://orcid.org/0000-0001-9646-9871","observed_orcids":["https://orcid.org/0000-0001-9646-9871"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan A. Doorn","raw_affiliation_strings":["University of Iowa"],"raw_orcid":"https://orcid.org/0000-0001-9646-9871","affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052858229","display_name":"Aloysius John Klingelhutz","orcid":"https://orcid.org/0000-0003-4258-5046","observed_orcids":["https://orcid.org/0000-0003-4258-5046"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aloysius J Klingelhut","raw_affiliation_strings":["University of Iowa"],"raw_orcid":"https://orcid.org/0000-0003-4258-5046","affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062054709","display_name":"James A. Ankrum","orcid":"https://orcid.org/0000-0003-3959-6158","observed_orcids":["https://orcid.org/0000-0003-3959-6158"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A Ankrum","raw_affiliation_strings":["University of Iowa"],"raw_orcid":"https://orcid.org/0000-0003-3959-6158","affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024042726","display_name":"Hans\u2010Joachim Lehmler","orcid":"https://orcid.org/0000-0001-9163-927X","observed_orcids":["https://orcid.org/0000-0001-9163-927X"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans-Joachim Lehmler","raw_affiliation_strings":["University of Iowa"],"raw_orcid":"https://orcid.org/0000-0001-9163-927X","affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.698199987411499,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.698199987411499,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.26510000228881836,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polychlorinated-biphenyls","display_name":"polychlorinated biphenyls","score":0.9079999923706055},{"id":"https://openalex.org/keywords/subacute-exposure","display_name":"subacute exposure","score":0.6589999794960022},{"id":"https://openalex.org/keywords/adolescent-rats","display_name":"adolescent rats","score":0.75},{"id":"https://openalex.org/keywords/polymeric-implants","display_name":"polymer implants","score":0.7369999885559082},{"id":"https://openalex.org/keywords/gene-expression-in-brain","display_name":"brain gene expression","score":0.7549999952316284},{"id":"https://openalex.org/keywords/serum-metabolomics","display_name":"serum metabolomics","score":0.9229999780654907},{"id":"https://openalex.org/keywords/developmental-neurotoxicity","display_name":"developmental neurotoxicity","score":0.781000018119812},{"id":"https://openalex.org/keywords/endocrine-disruption","display_name":"endocrine disruption","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5565866827964783},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.4810245633125305},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.4805110692977905},{"id":"https://openalex.org/C166345560","wikidata":"https://www.wikidata.org/wiki/Q555840","display_name":"Brain implant","level":2,"score":0.4723607003688812},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4245645999908447},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4185616075992584},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4142942726612091},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4053393304347992},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3103221654891968},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30456116795539856},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26419705152511597},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18412554264068604},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.14710912108421326},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.10106518864631653}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.6019/s-biad1581","doi":"https://doi.org/10.6019/s-biad1581","is_oa":false,"landing_page_url":"https://doi.org/10.6019/s-biad1581","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioStudies Database","raw_type":"dataset"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7203606614","https://openalex.org/W6945952936","https://openalex.org/W4388906571","https://openalex.org/W6908253483","https://openalex.org/W7099450129","https://openalex.org/W2058100740","https://openalex.org/W2564292298","https://openalex.org/W7208174242","https://openalex.org/W2181644208","https://openalex.org/W6960046488"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-01-28T00:00:00"}
