{"id":"https://openalex.org/W4406825209","doi":"https://doi.org/10.2147/clep.s496579","title":"Risk of Subclinical Hypothyroidism in Breast Cancer Patients Treated With CT-Guided Radiation Therapy: A Prospective Observational Study","display_name":"Risk of Subclinical Hypothyroidism in Breast Cancer Patients Treated With CT-Guided Radiation Therapy: A Prospective Observational Study","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4406825209","doi":"https://doi.org/10.2147/clep.s496579","pmid":"https://pubmed.ncbi.nlm.nih.gov/39882159"},"language":"en","primary_location":{"id":"doi:10.2147/clep.s496579","doi":"https://doi.org/10.2147/clep.s496579","is_oa":true,"landing_page_url":"https://doi.org/10.2147/clep.s496579","pdf_url":"https://www.dovepress.com/article/download/99621","source":{"id":"https://openalex.org/S2736481244","display_name":"Clinical Epidemiology","issn_l":"1179-1349","issn":["1179-1349"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epidemiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/99621","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045531949","display_name":"Lau Amdisen","orcid":"https://orcid.org/0000-0002-5575-9255","observed_orcids":["https://orcid.org/0000-0002-5575-9255"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lau Amdisen","raw_affiliation_strings":["Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-5575-9255","affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056342588","display_name":"Carsten Brink","orcid":"https://orcid.org/0000-0003-3906-1962","observed_orcids":["https://orcid.org/0000-0003-3906-1962"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Carsten Brink","raw_affiliation_strings":["Department of Clinical Research, University of Southern Denmark, Odense, Denmark","Laboratory of Radiation Physics, Department of Oncology, Odense University Hospital, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-3906-1962","affiliations":[{"raw_affiliation_string":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Laboratory of Radiation Physics, Department of Oncology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073947915","display_name":"Ebbe Laugaard Lorenzen","orcid":"https://orcid.org/0000-0003-1895-733X","observed_orcids":["https://orcid.org/0000-0003-1895-733X"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ebbe Lorenzen","raw_affiliation_strings":["Department of Clinical Research, University of Southern Denmark, Odense, Denmark","Laboratory of Radiation Physics, Department of Oncology, Odense University Hospital, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-1895-733X","affiliations":[{"raw_affiliation_string":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]},{"raw_affiliation_string":"Laboratory of Radiation Physics, Department of Oncology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094302403","display_name":"Jeanette Dupont R\u00f8nlev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jeanette Roenlev","raw_affiliation_strings":["Department of Oncology, Odense University Hospital, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027517833","display_name":"Marianne Ewertz","orcid":"https://orcid.org/0000-0002-5965-969X","observed_orcids":["https://orcid.org/0000-0002-5965-969X"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Marianne Ewertz","raw_affiliation_strings":["Department of Clinical Research, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066076502","display_name":"Deirdre P Cronin-Fenton","orcid":"https://orcid.org/0000-0001-9738-2284","observed_orcids":["https://orcid.org/0000-0001-9738-2284"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Deirdre Cronin-Fenton","raw_affiliation_strings":["Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-9738-2284","affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2802335433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.5339,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55684441,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"Volume 17","issue":null,"first_page":"41","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.35030001401901245,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.35030001401901245,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.1817999929189682,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.179299995303154,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subclinical-hypothyroidism","display_name":"subclinical hypothyroidism","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8709999918937683},{"id":"https://openalex.org/keywords/thyroid-dose","display_name":"thyroid dose","score":0.6240000128746033},{"id":"https://openalex.org/keywords/supraclavicular-lymph-nodes","display_name":"supraclavicular lymph nodes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/radiation-induced-thyroid-dysfunction","display_name":"radiation-induced thyroid dysfunction","score":0.652999997138977},{"id":"https://openalex.org/keywords/organs-at-risk","display_name":"organs at risk","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9245687127113342},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.8011240363121033},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.7915580868721008},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.698132336139679},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6612415313720703},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.49626094102859497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4211539924144745},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3883785605430603},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.347596138715744},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.32318568229675293}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.2147/clep.s496579","doi":"https://doi.org/10.2147/clep.s496579","is_oa":true,"landing_page_url":"https://doi.org/10.2147/clep.s496579","pdf_url":"https://www.dovepress.com/article/download/99621","source":{"id":"https://openalex.org/S2736481244","display_name":"Clinical Epidemiology","issn_l":"1179-1349","issn":["1179-1349"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epidemiology","raw_type":"journal-article"},{"id":"pmid:39882159","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39882159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical epidemiology","raw_type":"Journal Article"},{"id":"pmh:oai:sdu.dk:openaire/f86d7b3e-aa8e-4685-add4-9345318a5902","doi":null,"is_oa":true,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/f86d7b3e-aa8e-4685-add4-9345318a5902","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amdisen, L, Brink, C, Lorenzen, E L, Roenlev, J D, Ewertz, M & Cronin-Fenton, D 2025, 'Risk of Subclinical Hypothyroidism in Breast Cancer Patients Treated With CT-Guided Radiation Therapy : A Prospective Observational Study', Clinical Epidemiology, vol. 17, pp. 41-49. https://doi.org/10.2147/clep.s496579","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11776524","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11776524","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11776524/pdf/clep-17-41.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clin Epidemiol","raw_type":"Text"},{"id":"pmh:oai:dovepress.com/99621","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/risk-of-subclinical-hypothyroidism-in-breast-cancer-patients-treated-w-peer-reviewed-fulltext-article-CLEP","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire/e883d67b-cf88-41d0-9bbc-abf092c5cb57","doi":null,"is_oa":true,"landing_page_url":"https://pure.au.dk/portal/en/publications/e883d67b-cf88-41d0-9bbc-abf092c5cb57","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Amdisen, L, Brink, C, Lorenzen, E, Roenlev, J, Ewertz, M & Cronin-Fenton, D 2025, 'Risk of Subclinical Hypothyroidism in Breast Cancer Patients Treated With CT-Guided Radiation Therapy: A Prospective Observational Study', Clinical Epidemiology, vol. 17, pp. 41\u201349. https://doi.org/10.2147/clep.s496579","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/clep.s496579","doi":"https://doi.org/10.2147/clep.s496579","is_oa":true,"landing_page_url":"https://doi.org/10.2147/clep.s496579","pdf_url":"https://www.dovepress.com/article/download/99621","source":{"id":"https://openalex.org/S2736481244","display_name":"Clinical Epidemiology","issn_l":"1179-1349","issn":["1179-1349"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Epidemiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406825209.pdf","grobid_xml":"https://content.openalex.org/works/W4406825209.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1593887937","https://openalex.org/W1798696526","https://openalex.org/W1971159425","https://openalex.org/W1973191339","https://openalex.org/W1984483689","https://openalex.org/W1985769916","https://openalex.org/W1986985118","https://openalex.org/W2016980154","https://openalex.org/W2023982075","https://openalex.org/W2025917584","https://openalex.org/W2043015190","https://openalex.org/W2062616726","https://openalex.org/W2063068406","https://openalex.org/W2071269831","https://openalex.org/W2089986314","https://openalex.org/W2103885433","https://openalex.org/W2107116656","https://openalex.org/W2113210661","https://openalex.org/W2113289463","https://openalex.org/W2115192621","https://openalex.org/W2133547068","https://openalex.org/W2143488211","https://openalex.org/W2148113299","https://openalex.org/W2148501322","https://openalex.org/W2151980294","https://openalex.org/W2167806706","https://openalex.org/W2168058600","https://openalex.org/W2303243595","https://openalex.org/W2334885135","https://openalex.org/W2470919610","https://openalex.org/W2556816196","https://openalex.org/W2610799208","https://openalex.org/W2614083440","https://openalex.org/W2617856049","https://openalex.org/W3091894482","https://openalex.org/W3119349984","https://openalex.org/W3210775467","https://openalex.org/W4247010434"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W4206182164","https://openalex.org/W1952985933","https://openalex.org/W2374354250","https://openalex.org/W3148222271","https://openalex.org/W2023982075","https://openalex.org/W81046588","https://openalex.org/W3015280878","https://openalex.org/W2799349880","https://openalex.org/W2574728513"],"abstract_inverted_index":{"Purpose:":[0],"The":[1],"thyroid":[2,31,90,97,158,180,199,224],"gland":[3,32,91],"is":[4],"an":[5],"organ":[6],"at":[7,67,80,208,232],"risk":[8,204],"in":[9,38,76,122,138],"breast":[10,40,59],"cancer":[11,41,60],"survivors":[12],"who":[13],"receive":[14],"radiation":[15,27,46,100,154,176,195,220,236],"therapy":[16,237],"to":[17,29,95,102,150,156,178,197,222,240],"the":[18,24,30,34,89,103,123,143,157,179,198,223],"supraclavicular":[19],"lymph":[20],"nodes.":[21],"We":[22,51,87,129,145],"investigated":[23],"effect":[25],"of":[26,36,115,125,183,205,212],"dose":[28,101,155,177,196,221],"on":[33],"incidence":[35,182],"hypothyroidism":[37,106,207],"early-stage":[39],"patients":[42],"treated":[43],"with":[44,58,134,202,228],"CT-guided":[45],"therapy.":[47],"Patients":[48],"and":[49,84,99,159,181],"Methods:":[50],"recruited":[52],"women":[53],"aged":[54],"\u226475":[55],"years":[56],"diagnosed":[57],"from":[61],"March":[62],"2016":[63],"through":[64],"August":[65],"2017":[66],"Odense":[68],"University":[69],"Hospital,":[70],"Denmark.":[71],"Thyroid":[72],"function":[73],"was":[74,107,171,189,200,225],"measured":[75],"blood":[77],"samples":[78],"drawn":[79],"baseline,":[81],"6,":[82],"12,":[83],"18":[85],"months.":[86],"delineated":[88],"using":[92],"CT":[93],"scans":[94],"estimate":[96,151],"volume":[98],"thyroid.":[104],"Subclinical":[105],"defined":[108],"as":[109],"a":[110,132,135,187,209],"thyroid-stimulating":[111],"hormone":[112],"(TSH)":[113],"level":[114],">4":[116],"milli-international":[117],"units":[118],"per":[119],"liter":[120],"(mIU/l)":[121],"presence":[124],"normal":[126],"free":[127],"thyroxine.":[128],"also":[130],"conducted":[131],"subanalysis":[133],"threshold":[136,211],"resulting":[137],"approximately":[139],"20%":[140],"events":[141],"within":[142],"cohort.":[144],"used":[146],"mixed":[147],"logistic":[148],"regression":[149],"associations":[152],"between":[153,174],"subclinical":[160,168,184,206,229],"hypothyroidism.":[161,169,185,241],"Results:":[162],"Among":[163],"102":[164],"patients,":[165],"four":[166],"developed":[167],"There":[170],"no":[172],"association":[173],"increasing":[175,219],"However,":[186],"trend":[188],"observed":[190],"suggesting":[191],"that":[192],"higher":[193],"mean":[194],"associated":[201,227],"elevated":[203],"TSH":[210,234],">2.5mIU/l.":[213],"Conclusion:":[214],"Using":[215],"current":[216],"reference":[217],"levels,":[218],"not":[226],"hypothyroidism,":[230],"but":[231],"lower":[233],"thresholds,":[235],"may":[238],"predispose":[239]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}