{"id":"https://openalex.org/W4406789320","doi":"https://doi.org/10.1073/pnas.2617783123","title":"Modeling a continuum of drug-induced persistence during targeted cancer therapy","display_name":"Modeling a continuum of drug-induced persistence during targeted cancer therapy","publication_year":2026,"publication_date":"2026-10-27","ids":{"openalex":"https://openalex.org/W4406789320","doi":"https://doi.org/10.1073/pnas.2617783123","pmid":"https://pubmed.ncbi.nlm.nih.gov/42945243","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13732087"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2617783123","doi":"https://doi.org/10.1073/pnas.2617783123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2617783123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2617783123","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004396830","display_name":"Ji Tae Park","orcid":"https://orcid.org/0009-0005-1633-4173","observed_orcids":["https://orcid.org/0009-0005-1633-4173"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]},{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]},{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ji Tae Park","raw_affiliation_strings":["Center for Theoretical Biological Physics, Northeastern University","Department of Physics, Northeastern University"],"raw_orcid":"https://orcid.org/0009-0005-1633-4173","affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics, Northeastern University","institution_ids":["https://openalex.org/I12912129","https://openalex.org/I4210145836","https://openalex.org/I9224756"]},{"raw_affiliation_string":"Department of Physics, Northeastern University","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036939761","display_name":"Herbert Levine","orcid":"https://orcid.org/0000-0002-8819-9055","observed_orcids":["https://orcid.org/0000-0002-8819-9055"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]},{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]},{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Herbert Levine","raw_affiliation_strings":["Center for Theoretical Biological Physics, Northeastern University","Department of Bioengineering, Northeastern University","Department of Physics, Northeastern University"],"raw_orcid":"https://orcid.org/0000-0002-8819-9055","affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics, Northeastern University","institution_ids":["https://openalex.org/I12912129","https://openalex.org/I4210145836","https://openalex.org/I9224756"]},{"raw_affiliation_string":"Department of Bioengineering, Northeastern University","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Department of Physics, Northeastern University","institution_ids":["https://openalex.org/I12912129"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5036939761"],"corresponding_institution_ids":["https://openalex.org/I12912129","https://openalex.org/I4210145836","https://openalex.org/I9224756"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.00529181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"123","issue":"44","first_page":"e2617783123","last_page":"e2617783123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.8140000104904175},{"id":"https://openalex.org/keywords/phenotypic-plasticity","display_name":"phenotypic plasticity","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cellular-quiescence","display_name":"quiescent cells","score":0.640999972820282},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6499999761581421},{"id":"https://openalex.org/keywords/single-cell-clones","display_name":"single-cell clones","score":0.8460000157356262},{"id":"https://openalex.org/keywords/drug-holidays","display_name":"drug holidays","score":0.5659999847412109},{"id":"https://openalex.org/keywords/optimal-drug-concentration","display_name":"optimal drug concentration","score":0.828000009059906},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.772026002407074},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5958924293518066},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.5913305878639221},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4318787753582001},{"id":"https://openalex.org/C3020340455","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer drugs","level":3,"score":0.42423728108406067},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37519416213035583},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2648928165435791},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25569215416908264},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25568944215774536},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1734996736049652},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1712784469127655},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.13398495316505432},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.10472193360328674},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.2617783123","doi":"https://doi.org/10.1073/pnas.2617783123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2617783123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"doi:10.1101/2025.01.21.634165","doi":"https://doi.org/10.1101/2025.01.21.634165","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.01.21.634165","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/01/24/2025.01.21.634165.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42945243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42945243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13732087","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42945243/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1073/pnas.2617783123","doi":"https://doi.org/10.1073/pnas.2617783123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2617783123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6001776492","display_name":"Center for Theoretical Biological Physics","funder_award_id":"2019745","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406789320.pdf","grobid_xml":"https://content.openalex.org/works/W4406789320.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W38225241","https://openalex.org/W2005745339","https://openalex.org/W2009001778","https://openalex.org/W2019990270","https://openalex.org/W2032206080","https://openalex.org/W2102573876","https://openalex.org/W2105279356","https://openalex.org/W2106391833","https://openalex.org/W2108734747","https://openalex.org/W2115124007","https://openalex.org/W2129970266","https://openalex.org/W2272802268","https://openalex.org/W2275679174","https://openalex.org/W2324745658","https://openalex.org/W2466745957","https://openalex.org/W2555771555","https://openalex.org/W2754364682","https://openalex.org/W2795656576","https://openalex.org/W2810440784","https://openalex.org/W2897570149","https://openalex.org/W2901933835","https://openalex.org/W2933258121","https://openalex.org/W2936025729","https://openalex.org/W2948866156","https://openalex.org/W2955057587","https://openalex.org/W2969552506","https://openalex.org/W2988773550","https://openalex.org/W2995793704","https://openalex.org/W2997788212","https://openalex.org/W2999859696","https://openalex.org/W3000834598","https://openalex.org/W3037793680","https://openalex.org/W3099461365","https://openalex.org/W3119987272","https://openalex.org/W3184907113","https://openalex.org/W3185872641","https://openalex.org/W3187309064","https://openalex.org/W3189724491","https://openalex.org/W3199319849","https://openalex.org/W3201292455","https://openalex.org/W3202460917","https://openalex.org/W3206973939","https://openalex.org/W3213092776","https://openalex.org/W4200561137","https://openalex.org/W4214741816","https://openalex.org/W4220823647","https://openalex.org/W4251104453","https://openalex.org/W4283643602","https://openalex.org/W4285013480","https://openalex.org/W4287510485","https://openalex.org/W4288704531","https://openalex.org/W4291283009","https://openalex.org/W4293464027","https://openalex.org/W4311631231","https://openalex.org/W4313545884","https://openalex.org/W4321783263","https://openalex.org/W4362737356","https://openalex.org/W4383265707","https://openalex.org/W4384819865","https://openalex.org/W4387017277","https://openalex.org/W4387233041","https://openalex.org/W4391747436","https://openalex.org/W4393852532","https://openalex.org/W4393935425","https://openalex.org/W4394764204","https://openalex.org/W4399049069","https://openalex.org/W4400492066","https://openalex.org/W4401593571","https://openalex.org/W4402602280","https://openalex.org/W4404860416","https://openalex.org/W4406452417","https://openalex.org/W4409287059","https://openalex.org/W4410584534","https://openalex.org/W4413484444","https://openalex.org/W4414406694","https://openalex.org/W4414705922","https://openalex.org/W7118075505","https://openalex.org/W7138869841","https://openalex.org/W7154497051","https://openalex.org/W7155004376"],"related_works":["https://openalex.org/W4410358732","https://openalex.org/W4293464027","https://openalex.org/W2794707316","https://openalex.org/W3164747206","https://openalex.org/W3190476904","https://openalex.org/W4414367238","https://openalex.org/W4285013480","https://openalex.org/W4402344119","https://openalex.org/W4410584534","https://openalex.org/W4402602280"],"abstract_inverted_index":{"We":[0],"introduce":[1],"a":[2],"general":[3],"phenomenological":[4],"framework":[5,43],"for":[6],"understanding":[7],"how":[8],"phenotypic":[9],"plasticity":[10],"gives":[11],"rise":[12],"to":[13,24,37,89],"drug":[14,62,79,86],"persisters.":[15],"These":[16],"persisters,":[17],"often":[18],"quiescent":[19],"but":[20],"which":[21],"sometimes":[22],"return":[23],"cycling,":[25],"survive":[26],"in":[27,64],"the":[28,57,61,66,74,91],"presence":[29],"of":[30,60,70,76],"targeted":[31],"therapy":[32],"and":[33,52,56],"eventually":[34],"can":[35],"lead":[36],"mutants":[38],"with":[39],"true":[40],"resistance.":[41],"Our":[42],"builds":[44],"on":[45],"recent":[46],"experimental":[47],"observations":[48],"regarding":[49],"variations":[50],"between":[51],"among":[53],"single-cell":[54],"clones":[55],"possible":[58],"role":[59],"itself":[63],"enhancing":[65],"survival":[67],"strategy.":[68],"Predictions":[69],"our":[71],"approach":[72],"include":[73],"existence":[75],"an":[77,84],"optimum":[78,85],"concentration":[80],"as":[81,83],"well":[82],"holiday":[87],"schedule":[88],"minimize":[90],"persistence-based":[92],"threat.":[93]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-01-25T00:00:00"}