{"id":"https://openalex.org/W4406780717","doi":"https://doi.org/10.1007/s11845-025-03881-z","title":"Efficacy of Ozurdex implants as second-line therapy for non-responders to anti-VEGF in retinal vein occlusion-associated macular edema: a retrospective cohort study","display_name":"Efficacy of Ozurdex implants as second-line therapy for non-responders to anti-VEGF in retinal vein occlusion-associated macular edema: a retrospective cohort study","publication_year":2025,"publication_date":"2025-01-24","ids":{"openalex":"https://openalex.org/W4406780717","doi":"https://doi.org/10.1007/s11845-025-03881-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/39853533","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12031803"},"language":"en","primary_location":{"id":"doi:10.1007/s11845-025-03881-z","doi":"https://doi.org/10.1007/s11845-025-03881-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11845-025-03881-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11845-025-03881-z.pdf","source":{"id":"https://openalex.org/S117684900","display_name":"Irish Journal of Medical Science (1971 -)","issn_l":"0021-1265","issn":["0021-1265","1863-4362"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Irish Journal of Medical Science (1971 -)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11845-025-03881-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101730610","display_name":"Mahmoud Hammad Eissa","orcid":"https://orcid.org/0009-0001-8298-4634","observed_orcids":["https://orcid.org/0009-0001-8298-4634","https://orcid.org/0009-0005-7932-9611"]},"institutions":[{"id":"https://openalex.org/I2799594651","display_name":"Salisbury District Hospital","ror":"https://ror.org/05bx2yj81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799594651","https://openalex.org/I79209787"]},{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mahmoud Eissa","raw_affiliation_strings":["Salisbury Eye Unit, Salisbury District Hospital, Salisbury, UK","Southampton Eye Unit, University Hospital Southampton, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salisbury Eye Unit, Salisbury District Hospital, Salisbury, UK","institution_ids":["https://openalex.org/I2799594651"]},{"raw_affiliation_string":"Southampton Eye Unit, University Hospital Southampton, Southampton, UK","institution_ids":["https://openalex.org/I2802965805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068960835","display_name":"Dimitrios Kalogeropoulos","orcid":"https://orcid.org/0000-0001-6404-5409","observed_orcids":["https://orcid.org/0000-0001-6404-5409"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dimitrios Kalogeropoulos","raw_affiliation_strings":["Southampton Eye Unit, University Hospital Southampton, Southampton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southampton Eye Unit, University Hospital Southampton, Southampton, UK","institution_ids":["https://openalex.org/I2802965805"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799594651","display_name":"Salisbury District Hospital","ror":"https://ror.org/05bx2yj81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799594651","https://openalex.org/I79209787"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William Evans","raw_affiliation_strings":["Salisbury Eye Unit, Salisbury District Hospital, Salisbury, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salisbury Eye Unit, Salisbury District Hospital, Salisbury, UK","institution_ids":["https://openalex.org/I2799594651"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rashi Arora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799594651","display_name":"Salisbury District Hospital","ror":"https://ror.org/05bx2yj81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799594651","https://openalex.org/I79209787"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rashi Arora","raw_affiliation_strings":["Salisbury Eye Unit, Salisbury District Hospital, Salisbury, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salisbury Eye Unit, Salisbury District Hospital, Salisbury, UK","institution_ids":["https://openalex.org/I2799594651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072541133","display_name":"Andrew John Lotery","orcid":"https://orcid.org/0000-0001-5541-4305","observed_orcids":["https://orcid.org/0000-0001-5541-4305"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andrew John Lotery","raw_affiliation_strings":["Clinical and Experimental Sciences, Faculty of Medicine, South Lab and Path Block, Level D, University of Southampton, University Hospital Southampton, Mailpoint 806, Southampton, SO16 6YD, UK. A.J.Lotery@soton.ac.uk","Southampton Eye Unit, University Hospital Southampton, Southampton, UK. A.J.Lotery@soton.ac.uk","Southampton Eye Unit, University Hospital Southampton, Southampton, UK"],"raw_orcid":"https://orcid.org/0000-0001-5541-4305","affiliations":[{"raw_affiliation_string":"Clinical and Experimental Sciences, Faculty of Medicine, South Lab and Path Block, Level D, University of Southampton, University Hospital Southampton, Mailpoint 806, Southampton, SO16 6YD, UK. A.J.Lotery@soton.ac.uk","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Southampton Eye Unit, University Hospital Southampton, Southampton, UK. A.J.Lotery@soton.ac.uk","institution_ids":["https://openalex.org/I2802965805"]},{"raw_affiliation_string":"Southampton Eye Unit, University Hospital Southampton, Southampton, UK","institution_ids":["https://openalex.org/I2802965805"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072541133"],"corresponding_institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":{"value":4090,"currency":"USD","value_usd":4090},"fwci":2.9237,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.88067241,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"194","issue":"2","first_page":"745","last_page":"750"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexamethasone-intravitreal-implant","display_name":"intravitreal dexamethasone implant","score":0.8360000252723694},{"id":"https://openalex.org/keywords/becaplermin","display_name":"becaplermin","score":0.6819999814033508},{"id":"https://openalex.org/keywords/retinal-vein-occlusion","display_name":"retinal vein occlusion","score":0.9459999799728394},{"id":"https://openalex.org/keywords/macular-edema","display_name":"macular edema","score":0.9679999947547913},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.8859999775886536},{"id":"https://openalex.org/keywords/intravitreal-implant","display_name":"intravitreal implant","score":0.9200000166893005},{"id":"https://openalex.org/keywords/central-retinal-thickness","display_name":"central retinal thickness","score":0.8820000290870667},{"id":"https://openalex.org/keywords/best-corrected-visual-acuity","display_name":"best-corrected visual acuity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/branch-retinal-vein-occlusion","display_name":"branch retinal vein occlusion","score":0.9539999961853027},{"id":"https://openalex.org/keywords/central-retinal-vein-occlusion","display_name":"central retinal vein occlusion","score":0.9129999876022339},{"id":"https://openalex.org/keywords/treatment-burden","display_name":"treatment burden","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9367964267730713},{"id":"https://openalex.org/C2780347916","wikidata":"https://www.wikidata.org/wiki/Q1813737","display_name":"Macular edema","level":3,"score":0.769498348236084},{"id":"https://openalex.org/C2908732032","wikidata":"https://www.wikidata.org/wiki/Q5062148","display_name":"Retinal Vein","level":3,"score":0.7520719766616821},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6673249006271362},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6537024974822998},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.5806527733802795},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.5617452263832092},{"id":"https://openalex.org/C2778844676","wikidata":"https://www.wikidata.org/wiki/Q190831","display_name":"Central retinal vein occlusion","level":4,"score":0.5330979228019714},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5309846997261047},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.45694786310195923},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3647627830505371},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.21009257435798645},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069579","descriptor_name":"Ranibizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004343","descriptor_name":"Drug Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012170","descriptor_name":"Retinal Vein Occlusion","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012170","descriptor_name":"Retinal Vein Occlusion","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s11845-025-03881-z","doi":"https://doi.org/10.1007/s11845-025-03881-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11845-025-03881-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11845-025-03881-z.pdf","source":{"id":"https://openalex.org/S117684900","display_name":"Irish Journal of Medical Science (1971 -)","issn_l":"0021-1265","issn":["0021-1265","1863-4362"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Irish Journal of Medical Science (1971 -)","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12031803","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12031803","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12031803/pdf/11845_2025_Article_3881.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ir J Med Sci","raw_type":"Text"},{"id":"pmid:39853533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39853533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Irish journal of medical science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s11845-025-03881-z","doi":"https://doi.org/10.1007/s11845-025-03881-z","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11845-025-03881-z","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11845-025-03881-z.pdf","source":{"id":"https://openalex.org/S117684900","display_name":"Irish Journal of Medical Science (1971 -)","issn_l":"0021-1265","issn":["0021-1265","1863-4362"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Irish Journal of Medical Science (1971 -)","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406780717.pdf","grobid_xml":"https://content.openalex.org/works/W4406780717.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1963626891","https://openalex.org/W1972102480","https://openalex.org/W1972211323","https://openalex.org/W1979447309","https://openalex.org/W2000236282","https://openalex.org/W2011927518","https://openalex.org/W2017240503","https://openalex.org/W2030295370","https://openalex.org/W2044968030","https://openalex.org/W2050555000","https://openalex.org/W2056287065","https://openalex.org/W2058913110","https://openalex.org/W2069883932","https://openalex.org/W2075780935","https://openalex.org/W2084850755","https://openalex.org/W2146203027","https://openalex.org/W2179709557","https://openalex.org/W2333755504","https://openalex.org/W2504221004","https://openalex.org/W2608488415","https://openalex.org/W2767858053","https://openalex.org/W2912858829","https://openalex.org/W2942555525","https://openalex.org/W3013087319","https://openalex.org/W4221083079","https://openalex.org/W4224863947","https://openalex.org/W4323657420","https://openalex.org/W4365811185","https://openalex.org/W4376273891","https://openalex.org/W4388163328","https://openalex.org/W4388960367","https://openalex.org/W4389628343","https://openalex.org/W4389803786","https://openalex.org/W4389850751","https://openalex.org/W4390889339"],"related_works":["https://openalex.org/W7134235886","https://openalex.org/W2042088625","https://openalex.org/W4200438079","https://openalex.org/W2797025177","https://openalex.org/W2981488336","https://openalex.org/W2038364050","https://openalex.org/W7164832133","https://openalex.org/W2312868897","https://openalex.org/W3032423858","https://openalex.org/W2795435087"],"abstract_inverted_index":{"PURPOSE:":[0],"Retinal":[1],"vein":[2],"occlusion":[3],"(RVO)":[4],"is":[5],"a":[6,35,56,192],"prevalent":[7],"retinal":[8,13,96],"vascular":[9],"disorder":[10],"characterized":[11],"by":[12],"haemorrhage,":[14],"neovascularization,":[15],"and":[16,26,75,99,135,181,194],"macular":[17,39,199],"edema":[18,40,200],"This":[19],"study":[20,60],"aimed":[21],"to":[22,47,116,205,236],"assess":[23],"the":[24,229],"structural":[25,209],"functional":[27],"effects":[28],"of":[29,65,122,233],"intravitreal":[30],"implant":[31],"(Ozurdex)":[32],"treatment":[33,142,231,248],"as":[34,191],"second-line":[36],"for":[37,167,172,197,243],"RVO-associated":[38],"in":[41,153,201,211,225],"patients":[42,67,81,126,130,184,203,246],"who":[43],"did":[44,150,219],"not":[45,151,220],"respond":[46],"first-line":[48],"anti-VEGF":[49,141,206,237],"therapy.":[50,207],"MATERIALS":[51],"AND":[52],"METHODS:":[53],"We":[54],"conducted":[55],"retrospective":[57],"observational":[58],"cohort":[59],"using":[61,109],"electronic":[62],"health":[63],"records":[64],"RVO":[66,133,202],"at":[68,92],"Salisbury":[69],"District":[70],"Hospital":[71],"between":[72,179],"January":[73],"2014":[74],"December":[76],"2019.":[77],"Inclusion":[78],"criteria":[79],"included":[80],"diagnosed":[82],"with":[83,222],"central":[84,95,138],"or":[85],"branch":[86,132],"RVO.":[87,139],"Patients":[88],"underwent":[89],"ophthalmic":[90],"evaluations":[91],"baseline,":[93],"including":[94],"thickness":[97],"(CRT)":[98],"best-corrected":[100],"visual":[101],"acuity":[102],"(BCVA)":[103],"assessments.":[104],"Statistical":[105],"analysis":[106],"was":[107],"performed":[108],"IBM":[110],"SPSS":[111],"Statistics,":[112],"employing":[113],"various":[114],"tests":[115],"determine":[117],"significance.":[118],"RESULTS:":[119],"Sixteen":[120],"eyes":[121],"16":[123],"White":[124],"British":[125],"were":[127,177,213],"evaluated.":[128],"Most":[129],"had":[131,137],"(52.95%),":[134],"47.05%":[136],"While":[140],"significantly":[143,161],"improved":[144],"BCVA":[145,183],"(p":[146,156,164],"=":[147,157,165,170],"0.0061),":[148],"Ozurdex":[149,189,216,234],"result":[152],"additional":[154,223],"gain":[155,224],"0.747).":[158],"Both":[159],"treatments":[160],"reduced":[162,230],"CRT":[163,212],"0.0055":[166],"anti-VEGF;":[168],"p":[169],"0.0079":[171],"Ozurdex).":[173],"No":[174],"significant":[175],"differences":[176],"observed":[178,214],"diabetic":[180],"non-diabetic":[182],"receiving":[185],"either":[186],"treatment.":[187],"CONCLUSION:":[188],"emerges":[190],"safe":[193],"effective":[195],"option":[196],"persistent":[198],"unresponsive":[204],"Although":[208],"improvements":[210],"following":[215],"treatment,":[217],"they":[218],"correlate":[221],"BCVA.":[226],"Despite":[227],"this,":[228],"frequency":[232],"compared":[235],"injections":[238],"may":[239],"be":[240],"advantageous,":[241],"particularly":[242],"frail":[244],"non-responding":[245],"minimizing":[247],"burden.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-01-24T00:00:00"}
