{"id":"https://openalex.org/W4406682575","doi":"https://doi.org/10.3389/fphar.2024.1451083","title":"Anti-HSV-1 agents: an update","display_name":"Anti-HSV-1 agents: an update","publication_year":2025,"publication_date":"2025-01-21","ids":{"openalex":"https://openalex.org/W4406682575","doi":"https://doi.org/10.3389/fphar.2024.1451083","pmid":"https://pubmed.ncbi.nlm.nih.gov/39931518","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11808302"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2024.1451083","doi":"https://doi.org/10.3389/fphar.2024.1451083","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1451083","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1451083/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1451083/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wenwen Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenwen Lv","raw_affiliation_strings":["College of Pharmaceutics, Kunming Medical University, Kunming, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutics, Kunming Medical University, Kunming, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101889190","display_name":"Lei Zhou","orcid":"https://orcid.org/0000-0002-8164-0258","observed_orcids":["https://orcid.org/0000-0002-8164-0258"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zhou","raw_affiliation_strings":["College of Pharmaceutics, Kunming Medical University, Kunming, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutics, Kunming Medical University, Kunming, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jia Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Wu","raw_affiliation_strings":["College of Basic Medical, Kunming Medical University, Kunming, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medical, Kunming Medical University, Kunming, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110915841","display_name":"Jishuai Cheng","orcid":"https://orcid.org/0000-0003-0769-858X","observed_orcids":["https://orcid.org/0000-0003-0769-858X"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jishuai Cheng","raw_affiliation_strings":["Department of Experimental Animals, Kunming Medical University, Kunming, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Animals, Kunming Medical University, Kunming, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019437833","display_name":"Yongzhong Duan","orcid":"https://orcid.org/0000-0002-7866-868X","observed_orcids":["https://orcid.org/0000-0002-7866-868X"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongzhong Duan","raw_affiliation_strings":["Academy of Biomedical Engineering, Kunming Medical University, Kunming, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Biomedical Engineering, Kunming Medical University, Kunming, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100687071","display_name":"Wen Hui Qian","orcid":"https://orcid.org/0000-0002-4260-4625","observed_orcids":["https://orcid.org/0000-0002-4260-4625"]},"institutions":[{"id":"https://openalex.org/I4405267551","display_name":"Walvax Biotechnology Co., Ltd. (China)","ror":"https://ror.org/037kzc759","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405267551"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wen Qian","raw_affiliation_strings":["Walvax Biotechnology Co., Ltd., Kunming, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walvax Biotechnology Co., Ltd., Kunming, Yunnan, China","institution_ids":["https://openalex.org/I4405267551"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019437833","https://openalex.org/A5100687071"],"corresponding_institution_ids":["https://openalex.org/I26080491","https://openalex.org/I4405267551"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.6107,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.81789448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"15","issue":null,"first_page":"1451083","last_page":"1451083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.871999979019165},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.9549999833106995},{"id":"https://openalex.org/keywords/helicase-primase-inhibitors","display_name":"helicase-primase inhibitor","score":0.9509999752044678},{"id":"https://openalex.org/keywords/antiviral-resistance","display_name":"antiviral resistance","score":0.7749999761581421},{"id":"https://openalex.org/keywords/herpes-simplex-keratitis","display_name":"herpes simplex keratitis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/herpes-simplex-encephalitis","display_name":"herpes simplex encephalitis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/herpes-labialis","display_name":"oral herpes","score":0.7879999876022339},{"id":"https://openalex.org/keywords/viral-latency","display_name":"viral latency","score":0.7480000257492065},{"id":"https://openalex.org/keywords/antiviral-drug-discovery","display_name":"antiviral drug discovery","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.8198205232620239},{"id":"https://openalex.org/C2911196830","wikidata":"https://www.wikidata.org/wiki/Q2364836","display_name":"Herpes Labialis","level":4,"score":0.7769304513931274},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6065781116485596},{"id":"https://openalex.org/C36372059","wikidata":"https://www.wikidata.org/wiki/Q376492","display_name":"HSL and HSV","level":3,"score":0.5986334681510925},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.5792999863624573},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.5506342649459839},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49759557843208313},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3890051245689392},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3675706386566162},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.30234965682029724}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2024.1451083","doi":"https://doi.org/10.3389/fphar.2024.1451083","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1451083","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1451083/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11808302","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11808302","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11808302/pdf/fphar-15-1451083.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:39931518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39931518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:73dd52237fd44bc9a3bbd80fae1375d2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/73dd52237fd44bc9a3bbd80fae1375d2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 15 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2024.1451083","doi":"https://doi.org/10.3389/fphar.2024.1451083","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2024.1451083","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1451083/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3209117325","display_name":null,"funder_award_id":"82360393","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322268","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259"},{"id":"https://openalex.org/F4320324734","display_name":"Yunnan Provincial Department of Education","ror":"https://ror.org/02yrxdp92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406682575.pdf","grobid_xml":"https://content.openalex.org/works/W4406682575.grobid-xml"},"referenced_works_count":153,"referenced_works":["https://openalex.org/W608355102","https://openalex.org/W1543253558","https://openalex.org/W1582367115","https://openalex.org/W1590734579","https://openalex.org/W1964007399","https://openalex.org/W1964768213","https://openalex.org/W1966015990","https://openalex.org/W1979165307","https://openalex.org/W1979760295","https://openalex.org/W1982012608","https://openalex.org/W1982301628","https://openalex.org/W1991557786","https://openalex.org/W1994217603","https://openalex.org/W1994732210","https://openalex.org/W1999658209","https://openalex.org/W2000671975","https://openalex.org/W2012051375","https://openalex.org/W2012987444","https://openalex.org/W2013130286","https://openalex.org/W2016760321","https://openalex.org/W2019405166","https://openalex.org/W2024678649","https://openalex.org/W2026105127","https://openalex.org/W2027289172","https://openalex.org/W2029772457","https://openalex.org/W2030739472","https://openalex.org/W2033139212","https://openalex.org/W2040873318","https://openalex.org/W2041419602","https://openalex.org/W2043472690","https://openalex.org/W2044753800","https://openalex.org/W2045360603","https://openalex.org/W2045527619","https://openalex.org/W2048747284","https://openalex.org/W2049990321","https://openalex.org/W2053054361","https://openalex.org/W2053754396","https://openalex.org/W2055125497","https://openalex.org/W2064172664","https://openalex.org/W2064313113","https://openalex.org/W2064723120","https://openalex.org/W2065523077","https://openalex.org/W2073679129","https://openalex.org/W2089744711","https://openalex.org/W2089784154","https://openalex.org/W2092901647","https://openalex.org/W2094680194","https://openalex.org/W2097556464","https://openalex.org/W2102715326","https://openalex.org/W2114069528","https://openalex.org/W2132911514","https://openalex.org/W2137186878","https://openalex.org/W2141894134","https://openalex.org/W2148226942","https://openalex.org/W2162674813","https://openalex.org/W2167540878","https://openalex.org/W2186824244","https://openalex.org/W2262468684","https://openalex.org/W2275987487","https://openalex.org/W2314105391","https://openalex.org/W2319866742","https://openalex.org/W2321354409","https://openalex.org/W2324794224","https://openalex.org/W2329354687","https://openalex.org/W2336382764","https://openalex.org/W2394641089","https://openalex.org/W2415322322","https://openalex.org/W2492788507","https://openalex.org/W2509404947","https://openalex.org/W2553197555","https://openalex.org/W2584525402","https://openalex.org/W2594619057","https://openalex.org/W2734874908","https://openalex.org/W2758251544","https://openalex.org/W2761177649","https://openalex.org/W2769459613","https://openalex.org/W2808100742","https://openalex.org/W2884647564","https://openalex.org/W2888480741","https://openalex.org/W2892339436","https://openalex.org/W2897882435","https://openalex.org/W2908827239","https://openalex.org/W2945954368","https://openalex.org/W2946660717","https://openalex.org/W2960909280","https://openalex.org/W2966963897","https://openalex.org/W2968305480","https://openalex.org/W2989199812","https://openalex.org/W3003727413","https://openalex.org/W3012588957","https://openalex.org/W3014603001","https://openalex.org/W3019148405","https://openalex.org/W3022275668","https://openalex.org/W3025426831","https://openalex.org/W3040245042","https://openalex.org/W3069271965","https://openalex.org/W3091285461","https://openalex.org/W3116892956","https://openalex.org/W3132425479","https://openalex.org/W3133088650","https://openalex.org/W3165439000","https://openalex.org/W3175157061","https://openalex.org/W3181150012","https://openalex.org/W3183834857","https://openalex.org/W3184706884","https://openalex.org/W3184974376","https://openalex.org/W3186078572","https://openalex.org/W3200409036","https://openalex.org/W3205045384","https://openalex.org/W3209189529","https://openalex.org/W4205623704","https://openalex.org/W4210551129","https://openalex.org/W4213102702","https://openalex.org/W4221000679","https://openalex.org/W4281879177","https://openalex.org/W4283160605","https://openalex.org/W4284886336","https://openalex.org/W4292452360","https://openalex.org/W4297965042","https://openalex.org/W4309009618","https://openalex.org/W4313364920","https://openalex.org/W4322719970","https://openalex.org/W4323655204","https://openalex.org/W4365144101","https://openalex.org/W4365515535","https://openalex.org/W4377289675","https://openalex.org/W4379471304","https://openalex.org/W4382068692","https://openalex.org/W4382777104","https://openalex.org/W4385399700","https://openalex.org/W4385684607","https://openalex.org/W4385933412","https://openalex.org/W4386319765","https://openalex.org/W4386366496","https://openalex.org/W4386530123","https://openalex.org/W4387185745","https://openalex.org/W4387580839","https://openalex.org/W4387943299","https://openalex.org/W4388017808","https://openalex.org/W4388908194","https://openalex.org/W4389145084","https://openalex.org/W4389312403","https://openalex.org/W4390202208","https://openalex.org/W4390674007","https://openalex.org/W4392594185","https://openalex.org/W4395007024","https://openalex.org/W4399063268","https://openalex.org/W4401486648","https://openalex.org/W4401577502","https://openalex.org/W4402575221","https://openalex.org/W4402825991","https://openalex.org/W4403029849","https://openalex.org/W4403102990"],"related_works":["https://openalex.org/W7214062688","https://openalex.org/W4311621325","https://openalex.org/W2275987487","https://openalex.org/W2102722047","https://openalex.org/W3005801668","https://openalex.org/W2055927452","https://openalex.org/W3150257667","https://openalex.org/W3205433765","https://openalex.org/W2081007549","https://openalex.org/W2899477426"],"abstract_inverted_index":{"Herpes":[0],"simplex":[1,19,25],"virus":[2],"type":[3],"I":[4],"(HSV-1)":[5],"is":[6,14,28,99],"a":[7],"member":[8],"of":[9,16,84,93,105],"the":[10,36,44,77,82,103,114],"\u03b1-herpesvirus":[11],"subfamily":[12],"and":[13,23,39,61,72],"capable":[15],"causing":[17],"herpes":[18,21,24],"keratitis,":[20],"labialis,":[22],"encephalitis.":[26],"HSV-1":[27,85,131],"well":[29],"known":[30],"for":[31,40,81,129],"its":[32],"lytic":[33],"infections":[34,86],"at":[35],"primary":[37],"sites":[38],"establishing":[41],"latency":[42],"in":[43],"sensory":[45],"neuronal":[46],"ganglia,":[47],"with":[48],"occasional":[49],"recurrent":[50],"infections.":[51,132],"To":[52],"date,":[53],"there":[54],"are":[55],"no":[56],"approved":[57],"commercially":[58],"available":[59],"vaccines,":[60],"anti-HSV-1":[62,95,122],"drugs":[63],"such":[64],"as":[65],"specific":[66],"or":[67,97],"non-specific":[68],"nucleotide":[69],"(nucleoside)":[70],"analogs":[71],"helicase-primase":[73],"inhibitors":[74],"have":[75],"become":[76],"main":[78],"clinical":[79],"agents":[80,123],"treatment":[83],"despite":[87],"challenges":[88],"from":[89],"resistance.":[90,106],"Therefore,":[91],"development":[92],"new":[94],"compounds":[96],"therapies":[98],"key":[100],"to":[101],"addressing":[102],"issue":[104],"The":[107],"present":[108],"review":[109],"provides":[110],"an":[111],"update":[112],"on":[113],"progress":[115],"made":[116],"over":[117],"approximately":[118],"60":[119],"years":[120],"regarding":[121],"while":[124],"also":[125],"highlighting":[126],"future":[127],"perspectives":[128],"controlling":[130]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-01-22T00:00:00"}