{"id":"https://openalex.org/W4406635652","doi":"https://doi.org/10.1126/scisignal.adn9868","title":"Biotin mitigates the development of manganese-induced, Parkinson\u2019s disease\u2013related neurotoxicity in Drosophila and human neurons","display_name":"Biotin mitigates the development of manganese-induced, Parkinson\u2019s disease\u2013related neurotoxicity in Drosophila and human neurons","publication_year":2025,"publication_date":"2025-01-21","ids":{"openalex":"https://openalex.org/W4406635652","doi":"https://doi.org/10.1126/scisignal.adn9868","pmid":"https://pubmed.ncbi.nlm.nih.gov/38045419","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10690230"},"language":"en","primary_location":{"id":"doi:10.1126/scisignal.adn9868","doi":"https://doi.org/10.1126/scisignal.adn9868","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.adn9868","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2023/11/21/2023.11.21.568033.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087794576","display_name":"Yunjia Lai","orcid":"https://orcid.org/0000-0002-1081-0897","observed_orcids":["https://orcid.org/0000-0002-1081-0897"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunjia Lai","raw_affiliation_strings":["Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, USA","Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093312096","display_name":"Pablo Reina-Gonzalez","orcid":"https://orcid.org/0000-0001-5962-4246","observed_orcids":["https://orcid.org/0000-0001-5962-4246"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pablo Reina-Gonzalez","raw_affiliation_strings":["Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071891906","display_name":"Gali Maor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gali Maor","raw_affiliation_strings":["Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069002204","display_name":"Gary W. Miller","orcid":"https://orcid.org/0000-0001-8984-1284","observed_orcids":["https://orcid.org/0000-0001-8984-1284"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary W. Miller","raw_affiliation_strings":["Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, USA","Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002011992","display_name":"Souvarish Sarkar","orcid":"https://orcid.org/0000-0002-7384-0508","observed_orcids":["https://orcid.org/0000-0002-7384-0508"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Souvarish Sarkar","raw_affiliation_strings":["Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA","Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5002011992","https://openalex.org/A5069002204"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I28792581","https://openalex.org/I5388228","https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":13.4226,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.99363644,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"18","issue":"870","first_page":"eadn9868","last_page":"eadn9868"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.6582000255584717,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.6582000255584717,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.2957000136375427,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.020600000396370888,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biotin","display_name":"biotin","score":0.8429999947547913},{"id":"https://openalex.org/keywords/manganese-toxicity","display_name":"manganese toxicity","score":0.7990000247955322},{"id":"https://openalex.org/keywords/manganism","display_name":"manganism","score":0.8999999761581421},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9309999942779541},{"id":"https://openalex.org/keywords/drosophila-model","display_name":"Drosophila model","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8999999761581421},{"id":"https://openalex.org/keywords/lysosomal-dysfunction","display_name":"lysosomal dysfunction","score":0.7580000162124634},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ipsc-derived-neurons","display_name":"iPSC-derived neurons","score":0.8029999732971191},{"id":"https://openalex.org/keywords/biotin-supplementation","display_name":"biotin supplementation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.621999979019165},{"id":"https://openalex.org/keywords/occupational-manganese-exposure","display_name":"occupational manganese exposure","score":0.7269999980926514},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7549999952316284},{"id":"https://openalex.org/keywords/behavioral-deficits","display_name":"behavioral deficits","score":0.43299999833106995},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.6858983039855957},{"id":"https://openalex.org/C2778204606","wikidata":"https://www.wikidata.org/wiki/Q181354","display_name":"Biotin","level":2,"score":0.6712849736213684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6038246154785156},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5809588432312012},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.5474349856376648},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5196015238761902},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.45001569390296936},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.43645572662353516},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.4287397265434265},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3761613368988037},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3676072061061859},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3428362011909485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3183162808418274},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22512903809547424},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19879454374313354},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.16729766130447388}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1126/scisignal.adn9868","doi":"https://doi.org/10.1126/scisignal.adn9868","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.adn9868","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},{"id":"doi:10.1101/2023.11.21.568033","doi":"https://doi.org/10.1101/2023.11.21.568033","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.11.21.568033","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/11/21/2023.11.21.568033.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:38045419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38045419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:39836750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39836750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science signaling","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12006901","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12006901/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Signal","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11620608","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12006901","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10690230","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10690230","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2023.11.21.568033","doi":"https://doi.org/10.1101/2023.11.21.568033","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.11.21.568033","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/11/21/2023.11.21.568033.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1635908778","display_name":"Epidemiological Integration of Genetic Variants and Metabolomics Profiles in Washington Heights Columbia Aging Project","funder_award_id":"RF1AG066107","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1703881485","display_name":"National Metabolomics Data Repository - nextgen Metabolomics Workbench","funder_award_id":"U2CDK119886","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2030429064","display_name":"Mega-scale Identification tools for xenobiotic metabolism","funder_award_id":"U2CES030163","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4119845923","display_name":"Genetic Epidemiology and Multi-Omics Analyses in Familial and Sporadic Alzheimer's Disease Among Secular Caribbean Hispanics and Religious Order","funder_award_id":"R01AG067501","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5067816299","display_name":"Biomedical Data Commons Workbench (BDCW)","funder_award_id":"OT2OD030544","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5889996289","display_name":"Metabolomics Consortium Coordinating Center (M3C)","funder_award_id":"U2CDK119889","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6883990589","display_name":"An in vivo multiplex model to study gene-environment interaction in Parkinson's Disease","funder_award_id":"K99ES033723","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000857426","display_name":"Clinical and Translational Science Award","funder_award_id":"UL1TR001873","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000872378","display_name":"Vesicular modulation of dopamine neuron toxicity","funder_award_id":"R01ES023839","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000888856","display_name":"Environmental Agents as Modulators of Disease Processes","funder_award_id":"P30ES001247","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000904057","display_name":"Training in Environmental Toxicology","funder_award_id":"T32ES007026","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000910433","display_name":"An in vivo multiplex model to study gene-environment interaction in Parkinson's Disease","funder_award_id":"R00ES033723","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000920621","display_name":"Center for Environmental Health in Northern Manhattan","funder_award_id":"P30ES009089","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333627","display_name":"Irving Medical Center, Columbia University","ror":"https://ror.org/01esghr10"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406635652.pdf","grobid_xml":"https://content.openalex.org/works/W4406635652.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1543068333","https://openalex.org/W2019638504","https://openalex.org/W2029981647","https://openalex.org/W2044908785","https://openalex.org/W2093922785","https://openalex.org/W2118932150","https://openalex.org/W2120802226","https://openalex.org/W2268479893","https://openalex.org/W2287117443","https://openalex.org/W2322580831","https://openalex.org/W2417395660","https://openalex.org/W2473139211","https://openalex.org/W2511000429","https://openalex.org/W2531872507","https://openalex.org/W2607248985","https://openalex.org/W2611697375","https://openalex.org/W2614680488","https://openalex.org/W2761027295","https://openalex.org/W2771082365","https://openalex.org/W2784304284","https://openalex.org/W2888868590","https://openalex.org/W2889719632","https://openalex.org/W2909458901","https://openalex.org/W2909716959","https://openalex.org/W2910109864","https://openalex.org/W2921671377","https://openalex.org/W2948676018","https://openalex.org/W2953534538","https://openalex.org/W2953791151","https://openalex.org/W3003877215","https://openalex.org/W3006012411","https://openalex.org/W3036895273","https://openalex.org/W3037123232","https://openalex.org/W3042050487","https://openalex.org/W3095385778","https://openalex.org/W3110777349","https://openalex.org/W3111805946","https://openalex.org/W3126648904","https://openalex.org/W3165720650","https://openalex.org/W3194397640","https://openalex.org/W3206687244","https://openalex.org/W3207459105","https://openalex.org/W4206679594","https://openalex.org/W4229015642","https://openalex.org/W4281832698","https://openalex.org/W4283017342","https://openalex.org/W4287511920","https://openalex.org/W4309109636","https://openalex.org/W4318981447","https://openalex.org/W4379051588","https://openalex.org/W4398160665"],"related_works":["https://openalex.org/W4388880190","https://openalex.org/W2001003591","https://openalex.org/W7065786976","https://openalex.org/W2120802226","https://openalex.org/W1577255033","https://openalex.org/W2760961786","https://openalex.org/W2674021548","https://openalex.org/W1992468909","https://openalex.org/W4383961567","https://openalex.org/W2411415343"],"abstract_inverted_index":{"Abstract":[0],"Occupational":[1],"exposure":[2,244],"to":[3,18,63,118,197,245,358],"manganese":[4,246],"(Mn)":[5,247],"induces":[6],"manganism":[7,238],"and":[8,32,44,73,77,91,135,172,227,239,287,317],"has":[9],"been":[10],"widely":[11],"linked":[12],"as":[13,103,204,219,299,324,355],"a":[14,104,205,220,300,325,356],"contributing":[15],"environmental":[16],"factor":[17],"Parkinson\u2019s":[19,253,278],"disease":[20,254],"(PD),":[21],"featuring":[22,303],"dramatic":[23],"signature":[24],"overlaps":[25],"between":[26],"the":[27,36,95,119,163,250,257,261,292,308,330,360],"two":[28,262],"in":[29,75,114,139,152,209,280,307,340,348],"motor":[30],"symptoms":[31],"clinical":[33],"hallmarks.":[34],"However,":[35],"molecular":[37],"mechanism":[38],"underlying":[39],"such":[40],"link":[41,362],"remains":[42,263],"elusive,":[43],"for":[45,182,233,252,363],"combating":[46,364],"PD,":[47],"effective":[48,235],"mechanism-based":[49],"therapies":[50],"are":[51],"lacking.":[52],"Here,":[53],"we":[54,126],"developed":[55],"an":[56,86],"adult":[57,266],"Drosophila":[58,270],"model":[59,272],"of":[60,89,94,188,193,224,273,327],"Mn":[61,108,225,274],"toxicity":[62,90,109,226,275],"recapitulate":[64],"key":[65,206,277,301,357],"parkinsonian":[66,228,331],"features,":[67],"spanning":[68,282],"behavioral":[69,283],"deficits,":[70,284],"neuronal":[71,169,285],"loss,":[72,170,286],"dysfunctions":[74],"lysosome":[76],"mitochondria.":[78],"We":[79,149],"performed":[80],"global":[81],"metabolomics":[82],"on":[83],"flies":[84],"at":[85],"early":[87],"stage":[88],"identified":[92,215,291],"metabolism":[93],"B":[96,100,295],"vitamin,":[97],"biotin":[98,129,143,165,189,202,217,293,305,323,336,345,353],"(vitamin":[99,294],"7":[101,296],"),":[102],"master":[105],"pathway":[106,218,298,354],"underpinning":[107],"with":[110,329,342],"systemic,":[111],"body\u2013brain":[112],"increases":[113,306],"Mn-treated":[115],"groups":[116],"compared":[117,196],"controls.":[120],"Using":[121],"Btnd":[122],"RNAi":[123],"mutant":[124],"flies,":[125,142,314,316],"show":[127,151,181],"that":[128,162],"depletion":[130],"exacerbates":[131],"Mn-induced":[132,168],"neurotoxicity,":[133],"parkinsonism,":[134],"mitochondrial":[136,173,288],"dysfunction;":[137],"while":[138],"Mn-exposed":[140],"wild-type":[141,315],"feeding":[144],"dramatically":[145,333],"ameliorates":[146],"these":[147],"pathophenotypes.":[148],"further":[150],"human":[153,176,318],"induced":[154],"stem":[155],"cells":[156],"(iPSCs)-":[157],"differentiated":[158],"midbrain":[159],"dopaminergic":[160,320],"neurons":[161,321],"supplemented":[164],"protects":[166],"against":[167,237],"cytotoxicity,":[171],"dysregulation.":[174],"Finally,":[175],"data":[177],"profiling":[178],"biotin-related":[179],"proteins":[180],"PD":[183,349],"cases":[184],"elevated":[185],"circulating":[186,344],"levels":[187],"transporters":[190,346],"but":[191],"not":[192],"metabolic":[194],"enzymes":[195],"healthy":[198],"controls,":[199],"suggesting":[200],"humoral":[201],"transport":[203],"event":[207],"involved":[208],"PD.":[210,240],"Taken":[211],"together,":[212],"our":[213],"findings":[214],"compensatory":[216,352],"convergent,":[221],"systemic":[222,304],"driver":[223,326],"pathology,":[229],"providing":[230],"new":[231],"basis":[232,259],"devising":[234],"countermeasures":[236],"Significance":[241],"Statement":[242],"Environmental":[243],"may":[248],"increase":[249],"risk":[251],"(PD);":[255],"however,":[256],"mechanistic":[258],"linking":[260],"unclear.":[264],"Our":[265,338],"fruit":[267],"fly":[268],"(":[269],")":[271,297],"recapitulated":[276],"hallmarks":[279],"vivo":[281],"dysfunction.":[289],"Metabolomics":[290],"mediator,":[302],"flies.":[309],"Rescue":[310],"trials":[311],"leveraging":[312],"biotin-deficient":[313],"iPSC-derived":[319],"determined":[322],"manganism,":[328],"phenotypes":[332],"reversed":[334],"through":[335],"supplementation.":[337],"findings,":[339],"line":[341],"overexpressed":[343],"observed":[347],"patients,":[350],"suggest":[351],"untangle":[359],"Mn-PD":[361],"neurodegenerative":[365],"disease.":[366]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-01-21T00:00:00"}