{"id":"https://openalex.org/W4406618596","doi":"https://doi.org/10.3390/molecules30020393","title":"The General Principle of the Warburg Effect as a Possible Approach for Cancer Immunotherapy: The Regulatory Effect of Plant Extracts Could Change the Game","display_name":"The General Principle of the Warburg Effect as a Possible Approach for Cancer Immunotherapy: The Regulatory Effect of Plant Extracts Could Change the Game","publication_year":2025,"publication_date":"2025-01-18","ids":{"openalex":"https://openalex.org/W4406618596","doi":"https://doi.org/10.3390/molecules30020393","pmid":"https://pubmed.ncbi.nlm.nih.gov/39860262","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11767411"},"language":"en","primary_location":{"id":"doi:10.3390/molecules30020393","doi":"https://doi.org/10.3390/molecules30020393","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules30020393","pdf_url":"https://www.mdpi.com/1420-3049/30/2/393/pdf?version=1737185761","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/30/2/393/pdf?version=1737185761","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075432547","display_name":"Donika Ivanova","orcid":"https://orcid.org/0000-0001-7847-4394","observed_orcids":["https://orcid.org/0000-0001-7847-4394"]},"institutions":[{"id":"https://openalex.org/I173112312","display_name":"Trakia University","ror":"https://ror.org/04p2cym91","country_code":"BG","type":"education","lineage":["https://openalex.org/I173112312"]}],"countries":["BG"],"is_corresponding":true,"raw_author_name":"Donika Ivanova","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Faculty of Medicine, Trakia University, 6000 Stara Zagora, Bulgaria","Department of Pharmacology, Animal Physiology Biochemistry and Chemistry, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Faculty of Medicine, Trakia University, 6000 Stara Zagora, Bulgaria","institution_ids":["https://openalex.org/I173112312"]},{"raw_affiliation_string":"Department of Pharmacology, Animal Physiology Biochemistry and Chemistry, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria","institution_ids":["https://openalex.org/I173112312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054669220","display_name":"Severina Semkova","orcid":"https://orcid.org/0000-0002-2373-7713","observed_orcids":["https://orcid.org/0000-0002-2373-7713"]},"institutions":[{"id":"https://openalex.org/I24768866","display_name":"Bulgarian Academy of Sciences","ror":"https://ror.org/01x8hew03","country_code":"BG","type":"government","lineage":["https://openalex.org/I24768866"]},{"id":"https://openalex.org/I4210103918","display_name":"Institute of Biophysics and Biomedical Engineering","ror":"https://ror.org/01dxqkr82","country_code":"BG","type":"facility","lineage":["https://openalex.org/I24768866","https://openalex.org/I4210103918"]}],"countries":["BG"],"is_corresponding":true,"raw_author_name":"Severina Semkova","raw_affiliation_strings":["Department of Electroinduced and Adhesive Properties, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0002-2373-7713","affiliations":[{"raw_affiliation_string":"Department of Electroinduced and Adhesive Properties, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria","institution_ids":["https://openalex.org/I24768866","https://openalex.org/I4210103918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034475152","display_name":"Boncho Grigorov","orcid":"https://orcid.org/0000-0001-6446-9316","observed_orcids":["https://orcid.org/0000-0001-6446-9316"]},"institutions":[{"id":"https://openalex.org/I173112312","display_name":"Trakia University","ror":"https://ror.org/04p2cym91","country_code":"BG","type":"education","lineage":["https://openalex.org/I173112312"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Boncho Grigorov","raw_affiliation_strings":["Department of Molecular Biology, Immunology and Medical Genetics, Faculty of Medicine, Trakia University, 6000 Stara Zagora, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Immunology and Medical Genetics, Faculty of Medicine, Trakia University, 6000 Stara Zagora, Bulgaria","institution_ids":["https://openalex.org/I173112312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112688289","display_name":"Milena Tankova Tzanova","orcid":"https://orcid.org/0000-0002-1306-0905","observed_orcids":["https://orcid.org/0000-0002-1306-0905"]},"institutions":[{"id":"https://openalex.org/I173112312","display_name":"Trakia University","ror":"https://ror.org/04p2cym91","country_code":"BG","type":"education","lineage":["https://openalex.org/I173112312"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Milena Tzanova","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Agriculture, Trakia University, 6000 Stara Zagora, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0002-1306-0905","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Agriculture, Trakia University, 6000 Stara Zagora, Bulgaria","institution_ids":["https://openalex.org/I173112312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051534252","display_name":"A. Georgieva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173112312","display_name":"Trakia University","ror":"https://ror.org/04p2cym91","country_code":"BG","type":"education","lineage":["https://openalex.org/I173112312"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Ana Georgieva","raw_affiliation_strings":["Trakia University, 6000 Stara Zagora, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trakia University, 6000 Stara Zagora, Bulgaria","institution_ids":["https://openalex.org/I173112312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115949477","display_name":"Dancho Danchev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173112312","display_name":"Trakia University","ror":"https://ror.org/04p2cym91","country_code":"BG","type":"education","lineage":["https://openalex.org/I173112312"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Dancho Danchev","raw_affiliation_strings":["Trakia University, 6000 Stara Zagora, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trakia University, 6000 Stara Zagora, Bulgaria","institution_ids":["https://openalex.org/I173112312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013948005","display_name":"Biliana Nikolova","orcid":"https://orcid.org/0000-0001-9742-9812","observed_orcids":["https://orcid.org/0000-0001-9742-9812"]},"institutions":[{"id":"https://openalex.org/I24768866","display_name":"Bulgarian Academy of Sciences","ror":"https://ror.org/01x8hew03","country_code":"BG","type":"government","lineage":["https://openalex.org/I24768866"]},{"id":"https://openalex.org/I4210103918","display_name":"Institute of Biophysics and Biomedical Engineering","ror":"https://ror.org/01dxqkr82","country_code":"BG","type":"facility","lineage":["https://openalex.org/I24768866","https://openalex.org/I4210103918"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Biliana Nikolova","raw_affiliation_strings":["Department of Electroinduced and Adhesive Properties, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0001-9742-9812","affiliations":[{"raw_affiliation_string":"Department of Electroinduced and Adhesive Properties, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria","institution_ids":["https://openalex.org/I24768866","https://openalex.org/I4210103918"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035565904","display_name":"Zvezdelina Lyubenova Yaneva","orcid":"https://orcid.org/0000-0001-8159-4530","observed_orcids":["https://orcid.org/0000-0001-8159-4530"]},"institutions":[{"id":"https://openalex.org/I173112312","display_name":"Trakia University","ror":"https://ror.org/04p2cym91","country_code":"BG","type":"education","lineage":["https://openalex.org/I173112312"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Zvezdelina Yaneva","raw_affiliation_strings":["Department of Pharmacology, Animal Physiology Biochemistry and Chemistry, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0001-8159-4530","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Animal Physiology Biochemistry and Chemistry, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria","institution_ids":["https://openalex.org/I173112312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054669220","https://openalex.org/A5075432547"],"corresponding_institution_ids":["https://openalex.org/I173112312","https://openalex.org/I24768866","https://openalex.org/I4210103918"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.36,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.35107422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"30","issue":"2","first_page":"393","last_page":"393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.7289999723434448,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.7289999723434448,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.1809999942779541,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":1.0},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.8690000176429749},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.8830000162124634},{"id":"https://openalex.org/keywords/redox-metabolism","display_name":"redox metabolism","score":0.9150000214576721},{"id":"https://openalex.org/keywords/peroxisome-proliferator-activated-receptors","display_name":"peroxisome proliferator-activated receptors","score":0.9309999942779541},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.800000011920929},{"id":"https://openalex.org/keywords/natural-compounds","display_name":"natural compounds","score":0.6520000100135803},{"id":"https://openalex.org/keywords/secondary-metabolites","display_name":"secondary metabolites","score":0.7269999980926514},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C109156525","wikidata":"https://www.wikidata.org/wiki/Q56770304","display_name":"Warburg effect","level":4,"score":0.683692991733551},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6397593021392822},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.6352670788764954},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.6134262681007385},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5550035238265991},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5181518793106079},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.5107593536376953},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4748290479183197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46313005685806274},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44070878624916077},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.4131316840648651},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3447701930999756},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.32703664898872375},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2683805823326111},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23991689085960388},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0916576087474823},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000082802","descriptor_name":"Warburg Effect, Oncologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D047492","descriptor_name":"Peroxisome Proliferator-Activated Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules30020393","doi":"https://doi.org/10.3390/molecules30020393","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules30020393","pdf_url":"https://www.mdpi.com/1420-3049/30/2/393/pdf?version=1737185761","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11767411","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11767411","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11767411/pdf/molecules-30-00393.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmid:39860262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39860262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:04b8cf81ff4843c2957be1840c80bac1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/04b8cf81ff4843c2957be1840c80bac1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 30, Iss 2, p 393 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules30020393","doi":"https://doi.org/10.3390/molecules30020393","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules30020393","pdf_url":"https://www.mdpi.com/1420-3049/30/2/393/pdf?version=1737185761","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326264","display_name":"Trakia University","ror":"https://ror.org/04p2cym91"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406618596.pdf","grobid_xml":"https://content.openalex.org/works/W4406618596.grobid-xml"},"referenced_works_count":149,"referenced_works":["https://openalex.org/W118921147","https://openalex.org/W1511151098","https://openalex.org/W1515730558","https://openalex.org/W1591338264","https://openalex.org/W1649956562","https://openalex.org/W1918028620","https://openalex.org/W1965935659","https://openalex.org/W1966730025","https://openalex.org/W1966813897","https://openalex.org/W1971859682","https://openalex.org/W1973206036","https://openalex.org/W1973248503","https://openalex.org/W1980565960","https://openalex.org/W1981106431","https://openalex.org/W1981314503","https://openalex.org/W1989090840","https://openalex.org/W1992913613","https://openalex.org/W1994993231","https://openalex.org/W1996235861","https://openalex.org/W2005853038","https://openalex.org/W2009170266","https://openalex.org/W2016298359","https://openalex.org/W2018056411","https://openalex.org/W2018576241","https://openalex.org/W2023425329","https://openalex.org/W2024864874","https://openalex.org/W2028170908","https://openalex.org/W2032533550","https://openalex.org/W2033778707","https://openalex.org/W2034131665","https://openalex.org/W2036247576","https://openalex.org/W2039973312","https://openalex.org/W2042081254","https://openalex.org/W2044835625","https://openalex.org/W2047563937","https://openalex.org/W2062952221","https://openalex.org/W2063053561","https://openalex.org/W2067516462","https://openalex.org/W2076272449","https://openalex.org/W2076971614","https://openalex.org/W2094641040","https://openalex.org/W2097080185","https://openalex.org/W2097259163","https://openalex.org/W2107683043","https://openalex.org/W2108587241","https://openalex.org/W2109273931","https://openalex.org/W2110491264","https://openalex.org/W2116765712","https://openalex.org/W2125997801","https://openalex.org/W2131017515","https://openalex.org/W2134228356","https://openalex.org/W2135272175","https://openalex.org/W2146470803","https://openalex.org/W2149598335","https://openalex.org/W2159803625","https://openalex.org/W2163175900","https://openalex.org/W2164736330","https://openalex.org/W2174179366","https://openalex.org/W2204695292","https://openalex.org/W2206617731","https://openalex.org/W2254672185","https://openalex.org/W2275017937","https://openalex.org/W2323052646","https://openalex.org/W2399315353","https://openalex.org/W2410984769","https://openalex.org/W2473969971","https://openalex.org/W2508324947","https://openalex.org/W2522038806","https://openalex.org/W2528720408","https://openalex.org/W2530726117","https://openalex.org/W2534854440","https://openalex.org/W2556661692","https://openalex.org/W2564047037","https://openalex.org/W2588075924","https://openalex.org/W2614504158","https://openalex.org/W2616142271","https://openalex.org/W2625477379","https://openalex.org/W2731613210","https://openalex.org/W2731908234","https://openalex.org/W2735818385","https://openalex.org/W2749353882","https://openalex.org/W2751352835","https://openalex.org/W2758601031","https://openalex.org/W2760780444","https://openalex.org/W2766708677","https://openalex.org/W2769160638","https://openalex.org/W2773924394","https://openalex.org/W2790658373","https://openalex.org/W2791469901","https://openalex.org/W2791680676","https://openalex.org/W2792106006","https://openalex.org/W2795134208","https://openalex.org/W2797947316","https://openalex.org/W2806571973","https://openalex.org/W2891662274","https://openalex.org/W2896474277","https://openalex.org/W2904813088","https://openalex.org/W2917730151","https://openalex.org/W2937947604","https://openalex.org/W2943301094","https://openalex.org/W2948617695","https://openalex.org/W2950687473","https://openalex.org/W2960949990","https://openalex.org/W2969424626","https://openalex.org/W2970831802","https://openalex.org/W2982075716","https://openalex.org/W2984799663","https://openalex.org/W2999832851","https://openalex.org/W3004553757","https://openalex.org/W3004718141","https://openalex.org/W3006150521","https://openalex.org/W3009405970","https://openalex.org/W3038105279","https://openalex.org/W3045740727","https://openalex.org/W3047106569","https://openalex.org/W3047111607","https://openalex.org/W3080144325","https://openalex.org/W3114447894","https://openalex.org/W3121420611","https://openalex.org/W3123407922","https://openalex.org/W3135055431","https://openalex.org/W3136339494","https://openalex.org/W3173665490","https://openalex.org/W3181415681","https://openalex.org/W3196213304","https://openalex.org/W3204693560","https://openalex.org/W3205720294","https://openalex.org/W3209308163","https://openalex.org/W4200193425","https://openalex.org/W4214510073","https://openalex.org/W4220669827","https://openalex.org/W4282931791","https://openalex.org/W4283451643","https://openalex.org/W4283745576","https://openalex.org/W4284690100","https://openalex.org/W4288033227","https://openalex.org/W4316690030","https://openalex.org/W4321167021","https://openalex.org/W4324387366","https://openalex.org/W4362505682","https://openalex.org/W4377206081","https://openalex.org/W4386625232","https://openalex.org/W4389862589","https://openalex.org/W4392852641","https://openalex.org/W4393398071","https://openalex.org/W4402887103","https://openalex.org/W6678672936","https://openalex.org/W6773667172","https://openalex.org/W7074237419"],"related_works":["https://openalex.org/W3197851192","https://openalex.org/W7222760147","https://openalex.org/W3002407564","https://openalex.org/W2049733872","https://openalex.org/W4298087632","https://openalex.org/W4402808802","https://openalex.org/W2983010367","https://openalex.org/W4394820335","https://openalex.org/W4390673726","https://openalex.org/W2754685709"],"abstract_inverted_index":{"The":[0,66],"interpretation":[1],"of":[2,5,15,23,58,72,89,94,100,173,181],"the":[3,21,38,41,45,59,63,70,75,95,131,142,167,184,193,201],"biochemistry":[4],"immune":[6,60,91],"metabolism":[7,33,50],"could":[8,85,199],"be":[9,86,156],"considered":[10],"an":[11,87,159],"attractive":[12],"scientific":[13],"field":[14],"biomedicine":[16],"research.":[17],"In":[18,37,190],"this":[19,191],"review,":[20],"role":[22],"glycolysis":[24],"in":[25,34,106,128,136],"macrophage":[26,52],"polarization":[27],"is":[28,43,162,170,183],"discussed":[29],"together":[30],"with":[31,108,149,177,187],"mitochondrial":[32],"cancer":[35,54,64],"cells.":[36,65],"first":[39],"part,":[40],"focus":[42],"on":[44,74,141],"Warburg":[46,76],"effect":[47,77],"and":[48,56,114],"redox":[49],"during":[51],"polarization,":[53],"development,":[55],"management":[57],"response":[61],"by":[62],"second":[67],"part":[68],"addresses":[69],"possibility":[71],"impacts":[73],"through":[78],"targeting":[79],"peroxisome":[80],"proliferator-activated":[81],"receptors":[82],"(PPARs).":[83],"This":[84],"activator":[88],"native":[90],"responses.":[92],"Because":[93],"reported":[96],"serious":[97],"adverse":[98],"effects":[99],"using":[101],"synthetic":[102],"ligands":[103],"for":[104,111,144],"PPARs":[105],"combination":[107],"chemotherapeutics,":[109],"searches":[110],"less":[112],"toxic":[113],"more":[115],"active":[116],"PPAR":[117,188],"inhibitors,":[118],"as":[119,121,158],"well":[120],"blocking":[122],"undesirable":[123],"cellular":[124],"PPAR-dependent":[125],"processes,":[126],"are":[127],"progress.":[129],"On":[130],"other":[132],"hand,":[133],"recent":[134],"research":[135],"modern":[137],"immunotherapy":[138],"has":[139],"focused":[140],"search":[143],"gentle":[145],"immune-modulating":[146],"natural":[147],"compounds":[148],"harmless":[150],"synergistic":[151],"chemotherapeutic":[152],"efficacy":[153],"that":[154,166],"can":[155],"used":[157],"adjuvant.":[160],"It":[161],"a":[163,171],"well-known":[164],"fact":[165],"plant":[168],"kingdom":[169],"source":[172],"important":[174],"therapeutic":[175],"agents":[176],"multifaceted":[178],"effectiveness.":[179],"One":[180],"these":[182],"known":[185],"association":[186],"activities.":[189],"regard,":[192],"secondary":[194],"metabolites":[195],"extracted":[196],"from":[197],"plants":[198],"change":[200],"game.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-01-21T00:00:00"}