{"id":"https://openalex.org/W4406605958","doi":"https://doi.org/10.1055/s-0044-1800997","title":"Hepatocarcinogenesis and metabolic control of immunosuppression by ATF6a-driven ER-stress","display_name":"Hepatocarcinogenesis and metabolic control of immunosuppression by ATF6a-driven ER-stress","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4406605958","doi":"https://doi.org/10.1055/s-0044-1800997"},"language":"de","primary_location":{"id":"doi:10.1055/s-0044-1800997","doi":"https://doi.org/10.1055/s-0044-1800997","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0044-1800997","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Xin Li","raw_affiliation_strings":["German Cancer Research Center (DKFZ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Cancer Research Center (DKFZ)","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027317832","display_name":"Cynthia Lebeaupin","orcid":"https://orcid.org/0000-0003-1609-5676","observed_orcids":["https://orcid.org/0000-0003-1609-5676"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia Lebeaupin","raw_affiliation_strings":["Sanford Burnham Prebys Medical Discovery Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanford Burnham Prebys Medical Discovery Institute","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015378855","display_name":"Randal J. Kaufman","orcid":"https://orcid.org/0000-0003-4277-316X","observed_orcids":["https://orcid.org/0000-0003-4277-316X"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randal J. Kaufman","raw_affiliation_strings":["Sanford Burnham Prebys Medical Discovery Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanford Burnham Prebys Medical Discovery Institute","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022155277","display_name":"Mathias F Heikenw\u00e4lder","orcid":"https://orcid.org/0000-0002-3135-2274","observed_orcids":["https://orcid.org/0000-0002-3135-2274"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias Heikenw\u00e4lder","raw_affiliation_strings":["German Cancer Research Center (DKFZ)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Cancer Research Center (DKFZ)","institution_ids":["https://openalex.org/I17937529"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00338983,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"63","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atf6alpha","display_name":"ATF6\u03b1","score":0.8259999752044678},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9599999785423279},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.972000002861023},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8379999995231628},{"id":"https://openalex.org/keywords/liver-metabolism","display_name":"hepatic metabolism","score":0.7490000128746033},{"id":"https://openalex.org/keywords/chronic-hepatitis","display_name":"chronic hepatitis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.5329999923706055},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6069999933242798},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.7836672067642212},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.4297355115413666},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4104287922382355},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27854034304618835},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.25403788685798645},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08777892589569092}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0044-1800997","doi":"https://doi.org/10.1055/s-0044-1800997","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0044-1800997","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7127575740","https://openalex.org/W6903296472","https://openalex.org/W2070649240","https://openalex.org/W7161411993","https://openalex.org/W2084944302","https://openalex.org/W4386133606","https://openalex.org/W7222344831","https://openalex.org/W4381187092","https://openalex.org/W4367557617","https://openalex.org/W4200475244"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)":[2],"is":[3,63],"the":[4,20,29,32,46],"fastest":[5],"growing":[6],"cause":[7],"of":[8,31,49,94,135],"cancer-related":[9],"mortality":[10],"with":[11,84,88,103,110,156],"limited":[12],"therapy.":[13],"While":[14],"endoplasmic":[15],"reticulum":[16],"(ER)":[17],"stress":[18],"and":[19,80,86,106,122],"unfolded":[21],"protein":[22],"response":[23,54],"(UPR)":[24],"are":[25],"implicated":[26],"in":[27,70,77,96,120,139,158],"HCC,":[28,81],"role":[30,48],"UPR-transducer":[33],"activating":[34],"transcription":[35],"factor":[36],"6":[37],"alpha":[38],"(ATF6\u03b1)":[39],"remains":[40],"unclear.":[41],"In":[42],"sharp":[43],"contrast":[44],"to":[45,55,117,149],"well-characterized":[47],"ATF6\u03b1":[50,95],"as":[51],"an":[52,123],"adaptive":[53],"ER-stress,":[56,104,151],"we":[57,145],"here":[58],"demonstrate":[59],"that":[60],"chronic":[61,147],"ATF6\u03b1-activation":[62,76,112],"a":[64],"hitherto":[65],"unknown":[66],"immune-metabolic":[67],"master":[68],"regulator":[69],"driving":[71],"liver":[72,101,154],"cancer:":[73],"We":[74],"establish":[75],"human":[78],"chronic-hepatitis":[79],"unexpectedly":[82],"associated":[83],"tumor-progression":[85],"correlated":[87],"reduced":[89],"patient-survival.":[90],"Chronic,":[91],"hepatocyte-specific":[92,111],"activation":[93],"mice":[97,109],"induced":[98],"early":[99],"onset":[100],"injury":[102],"DNA-damage,":[105],"hepatocyte-proliferation.":[107],"Aged":[108],"developed":[113],"spontaneous":[114],"liver-cancer":[115,142],"due":[116],"oncogenic":[118],"signaling":[119],"hepatocytes":[121],"immunosuppressive":[124],"microenvironment.":[125],"Targeting":[126],"Atf6":[127],"via":[128],"germline,":[129],"hepatocyte-specifically":[130],"or":[131],"by":[132],"therapeutic":[133],"hepatocyte-delivery":[134],"antisense-oligonucleotides":[136],"dampened":[137],"HCC":[138],"distinct":[140],"preclinical":[141],"models.":[143],"Here,":[144],"identify":[146],"ATF6a-activation":[148],"drive":[150],"bridging":[152],"aberrant":[153],"metabolism":[155],"immunosuppression":[157],"hepatocarcinogenesis.":[159],"Publication":[160],"History":[161],"Article":[162],"published":[163],"online:":[164],"20":[165],"January":[166],"2025":[167],"\u00a9":[168],"2025.":[169],"Thieme.":[170],"All":[171],"rights":[172],"reserved.":[173],"Georg":[174],"Thieme":[175],"Verlag":[176],"KG":[177],"Oswald-Hesse-Stra\u00dfe":[178],"50,":[179],"70469":[180],"Stuttgart,":[181],"Germany":[182]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-01-21T00:00:00"}