{"id":"https://openalex.org/W4406595628","doi":"https://doi.org/10.1111/aos.17233","title":"Possible necrotizing scleritis and non\u2010infectious vitritis following intravitreal injection of bevacizumab","display_name":"Possible necrotizing scleritis and non\u2010infectious vitritis following intravitreal injection of bevacizumab","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4406595628","doi":"https://doi.org/10.1111/aos.17233"},"language":"en","primary_location":{"id":"doi:10.1111/aos.17233","doi":"https://doi.org/10.1111/aos.17233","is_oa":false,"landing_page_url":"https://doi.org/10.1111/aos.17233","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115941709","display_name":"Patricia Roig Outeiri\u00f1o","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160736","display_name":"Hospital Universitario Infanta Sof\u00eda","ror":"https://ror.org/05dfzd836","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210160736"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Patricia Roig Outeiri\u00f1o","raw_affiliation_strings":["Ophthalmology, Infanta Sof\u00eda Hospital  Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Infanta Sof\u00eda Hospital  Madrid Spain","institution_ids":["https://openalex.org/I4210160736"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria del Mar Esteban Ortega","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160736","display_name":"Hospital Universitario Infanta Sof\u00eda","ror":"https://ror.org/05dfzd836","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210160736"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria del Mar Esteban Ortega","raw_affiliation_strings":["Ophthalmology, Infanta Sof\u00eda Hospital  Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Infanta Sof\u00eda Hospital  Madrid Spain","institution_ids":["https://openalex.org/I4210160736"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sergio Pernas Mart\u00edn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160736","display_name":"Hospital Universitario Infanta Sof\u00eda","ror":"https://ror.org/05dfzd836","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210160736"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergio Pernas Mart\u00edn","raw_affiliation_strings":["Ophthalmology, Infanta Sof\u00eda Hospital  Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Infanta Sof\u00eda Hospital  Madrid Spain","institution_ids":["https://openalex.org/I4210160736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115941708","display_name":"Alejandra Ant\u00f3n Guzm\u00e1n de L\u00e1zaro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160736","display_name":"Hospital Universitario Infanta Sof\u00eda","ror":"https://ror.org/05dfzd836","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210160736"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandra Ant\u00f3n Guzm\u00e1n de L\u00e1zaro","raw_affiliation_strings":["Ophthalmology, Infanta Sof\u00eda Hospital  Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Infanta Sof\u00eda Hospital  Madrid Spain","institution_ids":["https://openalex.org/I4210160736"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113099039","display_name":"Eduardo Conesa Hern\u00e1ndez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160736","display_name":"Hospital Universitario Infanta Sof\u00eda","ror":"https://ror.org/05dfzd836","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210160736"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduardo Conesa Hern\u00e1ndez","raw_affiliation_strings":["Ophthalmology, Infanta Sof\u00eda Hospital  Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Infanta Sof\u00eda Hospital  Madrid Spain","institution_ids":["https://openalex.org/I4210160736"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040804883","display_name":"Manuel Moriche Carretero","orcid":"https://orcid.org/0000-0002-7008-4700","observed_orcids":["https://orcid.org/0000-0002-7008-4700"]},"institutions":[{"id":"https://openalex.org/I4210160736","display_name":"Hospital Universitario Infanta Sof\u00eda","ror":"https://ror.org/05dfzd836","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210160736"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Moriche Carretero","raw_affiliation_strings":["Ophthalmology, Infanta Sof\u00eda Hospital  Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Infanta Sof\u00eda Hospital  Madrid Spain","institution_ids":["https://openalex.org/I4210160736"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210160736"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"103","issue":"S284","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.02710000053048134,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necrotizing-scleritis","display_name":"necrotizing scleritis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9940000176429749},{"id":"https://openalex.org/keywords/intravitreal-injection","display_name":"intravitreal injection","score":0.9580000042915344},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7684009075164795},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.7355186343193054},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5900712013244629},{"id":"https://openalex.org/C2781053147","wikidata":"https://www.wikidata.org/wiki/Q511000","display_name":"Scleritis","level":3,"score":0.49130192399024963},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22744086384773254},{"id":"https://openalex.org/C2776194053","wikidata":"https://www.wikidata.org/wiki/Q280027","display_name":"Uveitis","level":2,"score":0.13139313459396362},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.05199790000915527}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/aos.17233","doi":"https://doi.org/10.1111/aos.17233","is_oa":false,"landing_page_url":"https://doi.org/10.1111/aos.17233","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7080695932","https://openalex.org/W2089838877","https://openalex.org/W2084582937","https://openalex.org/W7140557740","https://openalex.org/W1979581633","https://openalex.org/W2888854458","https://openalex.org/W2001846805","https://openalex.org/W2396657636","https://openalex.org/W3168513729","https://openalex.org/W2121738011"],"abstract_inverted_index":{"Aims/Purpose:":[0],"This":[1,176],"case":[2,177],"report":[3],"describes":[4],"possible":[5,73,149,173],"necrotizing":[6,74,142],"scleritis":[7,75,143],"and":[8,48,68,102,104,136,183],"non\u2010infectious":[9],"vitritis":[10,106],"in":[11,166],"the":[12,21,29,36,53,57,60,87,97,110,169,179,193,202],"right":[13],"eye":[14],"following":[15],"intravitreal":[16,37,155,190],"injections":[17],"of":[18,23,94,121,181],"bevacizumab":[19,90,125],"for":[20,195],"treatment":[22,88,113,153,170],"postsurgical":[24],"cystic":[25],"macular":[26,95],"edema,":[27,96],"highlighting":[28],"potential":[30],"immune\u2010mediated":[31,123,161],"adverse":[32,150,187],"reactions":[33,188],"associated":[34],"with":[35,46,72,80,89,154,159,168],"treatment.":[38],"Methods:":[39],"An":[40],"ophthalmological":[41],"examination":[42],"was":[43,78,107,126],"performed":[44],"along":[45],"laboratory":[47],"imaging":[49],"tests":[50],"to":[51,92,119,152,189,201],"diagnose":[52],"patient.":[54,203],"Results:":[55],"After":[56],"first":[58],"injection,":[59],"patient":[61,98],"developed":[62],"intense":[63],"ocular":[64],"redness,":[65],"scleral":[66],"thinning,":[67],"pancorneal":[69],"punctate":[70],"keratitis,":[71],"suspected.":[76],"Treatment":[77],"iniciated":[79],"a":[81,148,172],"positive":[82],"progress,":[83],"however,":[84],"after":[85],"resuming":[86],"due":[91,118],"persistence":[93],"experienced":[99],"blurred":[100],"vision":[101],"photophobia,":[103],"mild":[105],"observed":[108],"during":[109],"examination.":[111],"Topical":[112],"produced":[114],"rapid":[115],"improvement,":[116],"but":[117],"suspicion":[120],"an":[122],"reaction,":[124],"discontinued.":[127],"Alternative":[128],"treatments":[129],"were":[130],"considered,":[131],"including":[132],"other":[133],"anti\u2010VEGF":[134],"agents":[135],"topical":[137],"anti\u2010inflammatory":[138],"medications.":[139],"Conclusions:":[140],"Although":[141],"is":[144],"not":[145],"described":[146],"as":[147],"reaction":[151,162],"bevacizumab,":[156],"its":[157],"association":[158],"another":[160],"that":[163,198],"also":[164],"coincides":[165],"time":[167],"suggests":[171],"causal":[174],"relationship.":[175],"highlights":[178],"importance":[180],"recognizing":[182],"managing":[184],"rare":[185],"immune\u2010related":[186],"treatments,":[191],"emphasizing":[192],"need":[194],"alternative":[196],"therapies":[197],"minimize":[199],"risks":[200]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-01-20T00:00:00"}