{"id":"https://openalex.org/W4406572891","doi":"https://doi.org/10.1016/j.mad.2025.112036","title":"Deciphering the role of cytokines in aging: Biomarker potential and effective targeting","display_name":"Deciphering the role of cytokines in aging: Biomarker potential and effective targeting","publication_year":2025,"publication_date":"2025-01-18","ids":{"openalex":"https://openalex.org/W4406572891","doi":"https://doi.org/10.1016/j.mad.2025.112036","pmid":"https://pubmed.ncbi.nlm.nih.gov/39832637"},"language":"en","primary_location":{"id":"doi:10.1016/j.mad.2025.112036","doi":"https://doi.org/10.1016/j.mad.2025.112036","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mad.2025.112036","pdf_url":null,"source":{"id":"https://openalex.org/S6761461","display_name":"Mechanisms of Ageing and Development","issn_l":"0047-6374","issn":["0047-6374","1872-6216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of Ageing and Development","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066651198","display_name":"Panagiotis Poulios","orcid":"https://orcid.org/0000-0003-2337-3638","observed_orcids":["https://orcid.org/0000-0003-2337-3638"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis Poulios","raw_affiliation_strings":["Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece","Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115932786","display_name":"Stamoulis Skampouras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Stamoulis Skampouras","raw_affiliation_strings":["Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece","Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017473942","display_name":"Christina Piperi","orcid":"https://orcid.org/0000-0002-2701-0618","observed_orcids":["https://orcid.org/0000-0002-2701-0618"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Christina Piperi","raw_affiliation_strings":["Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece. Electronic address: cpiperi@med.uoa.gr","Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece. Electronic address: cpiperi@med.uoa.gr"],"raw_orcid":"https://orcid.org/0000-0002-2701-0618","affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece. Electronic address: cpiperi@med.uoa.gr","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Department of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece. Electronic address: cpiperi@med.uoa.gr","institution_ids":["https://openalex.org/I200777214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017473942"],"corresponding_institution_ids":["https://openalex.org/I200777214"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.1921,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.22222222,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"224","issue":null,"first_page":"112036","last_page":"112036"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.4966000020503998,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.4966000020503998,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.24619999527931213,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.048500001430511475,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9819999933242798},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.921999990940094},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9309999942779541},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8610000014305115},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7850000262260437},{"id":"https://openalex.org/keywords/senolytics","display_name":"senolytics","score":0.8040000200271606},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.6570000052452087},{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.7680000066757202},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9190000295639038},{"id":"https://openalex.org/keywords/stress-management","display_name":"stress management","score":0.8040000200271606},{"id":"https://openalex.org/keywords/diet","display_name":"diet","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7257938385009766},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.5059270262718201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4464800953865051},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39739474654197693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3686336278915405},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3602793216705322},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1881662905216217}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.mad.2025.112036","doi":"https://doi.org/10.1016/j.mad.2025.112036","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.mad.2025.112036","pdf_url":null,"source":{"id":"https://openalex.org/S6761461","display_name":"Mechanisms of Ageing and Development","issn_l":"0047-6374","issn":["0047-6374","1872-6216"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of Ageing and Development","raw_type":"journal-article"},{"id":"pmid:39832637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39832637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of ageing and development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":135,"referenced_works":["https://openalex.org/W1504167407","https://openalex.org/W1594981111","https://openalex.org/W1721778868","https://openalex.org/W1766200742","https://openalex.org/W1895277992","https://openalex.org/W1908141864","https://openalex.org/W1971629816","https://openalex.org/W1991295722","https://openalex.org/W1996083201","https://openalex.org/W1997458644","https://openalex.org/W2006992975","https://openalex.org/W2030772730","https://openalex.org/W2037391150","https://openalex.org/W2050609154","https://openalex.org/W2056109592","https://openalex.org/W2082626794","https://openalex.org/W2092333751","https://openalex.org/W2108746950","https://openalex.org/W2108904980","https://openalex.org/W2111522975","https://openalex.org/W2128807350","https://openalex.org/W2141720706","https://openalex.org/W2142515355","https://openalex.org/W2157432178","https://openalex.org/W2210634983","https://openalex.org/W2228820348","https://openalex.org/W2267945682","https://openalex.org/W2270526877","https://openalex.org/W2290227671","https://openalex.org/W2303714942","https://openalex.org/W2324460417","https://openalex.org/W2404993483","https://openalex.org/W2414766522","https://openalex.org/W2484881635","https://openalex.org/W2538366370","https://openalex.org/W2566497735","https://openalex.org/W2591983504","https://openalex.org/W2593337891","https://openalex.org/W2599353531","https://openalex.org/W2604923378","https://openalex.org/W2662694802","https://openalex.org/W2725924697","https://openalex.org/W2748400555","https://openalex.org/W2750254726","https://openalex.org/W2754394790","https://openalex.org/W2755877600","https://openalex.org/W2763387947","https://openalex.org/W2765166506","https://openalex.org/W2765749162","https://openalex.org/W2775698961","https://openalex.org/W2783874580","https://openalex.org/W2799474346","https://openalex.org/W2799526478","https://openalex.org/W2809593089","https://openalex.org/W2889290358","https://openalex.org/W2892906130","https://openalex.org/W2894579895","https://openalex.org/W2897981765","https://openalex.org/W2899052178","https://openalex.org/W2900046418","https://openalex.org/W2902965685","https://openalex.org/W2903805590","https://openalex.org/W2908816590","https://openalex.org/W2911326189","https://openalex.org/W2914147828","https://openalex.org/W2922251729","https://openalex.org/W2933130235","https://openalex.org/W2935612876","https://openalex.org/W2940991134","https://openalex.org/W2944128273","https://openalex.org/W2945404218","https://openalex.org/W2947489838","https://openalex.org/W2954122547","https://openalex.org/W2954914708","https://openalex.org/W2959497269","https://openalex.org/W2979902447","https://openalex.org/W2980465010","https://openalex.org/W2981285387","https://openalex.org/W2981616250","https://openalex.org/W2990337693","https://openalex.org/W2990849135","https://openalex.org/W2997403414","https://openalex.org/W3007131188","https://openalex.org/W3007256318","https://openalex.org/W3008216313","https://openalex.org/W3024921279","https://openalex.org/W3028115663","https://openalex.org/W3035876959","https://openalex.org/W3042236956","https://openalex.org/W3045572480","https://openalex.org/W3088742563","https://openalex.org/W3088858746","https://openalex.org/W3092560102","https://openalex.org/W3123881069","https://openalex.org/W3124211138","https://openalex.org/W3124906490","https://openalex.org/W3127671140","https://openalex.org/W3129040230","https://openalex.org/W3156068899","https://openalex.org/W3157190253","https://openalex.org/W3170771910","https://openalex.org/W3172144992","https://openalex.org/W3190882738","https://openalex.org/W3195255856","https://openalex.org/W3201433964","https://openalex.org/W3206785112","https://openalex.org/W3210952369","https://openalex.org/W4206607707","https://openalex.org/W4206799195","https://openalex.org/W4213157453","https://openalex.org/W4220762948","https://openalex.org/W4224315395","https://openalex.org/W4225285596","https://openalex.org/W4225392821","https://openalex.org/W4229075517","https://openalex.org/W4229864839","https://openalex.org/W4299302962","https://openalex.org/W4303579210","https://openalex.org/W4304688887","https://openalex.org/W4327621583","https://openalex.org/W4366523541","https://openalex.org/W4367299631","https://openalex.org/W4372293780","https://openalex.org/W4380451817","https://openalex.org/W4386143134","https://openalex.org/W4387787869","https://openalex.org/W4389472389","https://openalex.org/W4391040698","https://openalex.org/W4391753892","https://openalex.org/W4392353613","https://openalex.org/W4392947937","https://openalex.org/W4403733067","https://openalex.org/W4404924559","https://openalex.org/W6758013207","https://openalex.org/W6769417516"],"related_works":["https://openalex.org/W4404924559","https://openalex.org/W2748460873","https://openalex.org/W1504167407","https://openalex.org/W7171703243","https://openalex.org/W2790056846","https://openalex.org/W2030772730","https://openalex.org/W7165035594","https://openalex.org/W2730787845","https://openalex.org/W2105996529","https://openalex.org/W4211031119"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-01-19T00:00:00"}