{"id":"https://openalex.org/W4406483293","doi":"https://doi.org/10.1002/bies.202400111","title":"Nucleic Acid Aptamer\u2010Based Sensors for Bacteria Detection: A Review","display_name":"Nucleic Acid Aptamer\u2010Based Sensors for Bacteria Detection: A Review","publication_year":2025,"publication_date":"2025-01-16","ids":{"openalex":"https://openalex.org/W4406483293","doi":"https://doi.org/10.1002/bies.202400111","pmid":"https://pubmed.ncbi.nlm.nih.gov/39821800"},"language":"en","primary_location":{"id":"doi:10.1002/bies.202400111","doi":"https://doi.org/10.1002/bies.202400111","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bies.202400111","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bies.202400111","source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bies.202400111","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113395242","display_name":"Yalan Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yalan Tang","raw_affiliation_strings":["Department of Biology and Medicine ,college of Chemistry and Chemical Engineering, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Medicine ,college of Chemistry and Chemical Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Li","raw_affiliation_strings":["Department of Biology and Medicine ,college of Chemistry and Chemical Engineering, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Medicine ,college of Chemistry and Chemical Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400297","display_name":"Ping Chen","orcid":"https://orcid.org/0000-0001-8036-0855","observed_orcids":["https://orcid.org/0000-0001-8036-0855"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Chen","raw_affiliation_strings":["Department of Biology and Medicine ,college of Chemistry and Chemical Engineering, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Medicine ,college of Chemistry and Chemical Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015365251","display_name":"Shian Zhong","orcid":"https://orcid.org/0000-0002-0729-2304","observed_orcids":["https://orcid.org/0000-0002-0729-2304"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I165911609","display_name":"Changsha Medical University","ror":"https://ror.org/05dt7z971","country_code":"CN","type":"education","lineage":["https://openalex.org/I165911609"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shian Zhong","raw_affiliation_strings":["Department of Biology and Medicine ,college of Chemistry and Chemical Engineering, Central South University, Changsha, China","Hunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, The \"Double-First Class\" Application Characteristic Discipline of Hunan Province (Pharmaceutical Science), Changsha Medical University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Medicine ,college of Chemistry and Chemical Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Hunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, The \"Double-First Class\" Application Characteristic Discipline of Hunan Province (Pharmaceutical Science), Changsha Medical University, Changsha, China","institution_ids":["https://openalex.org/I165911609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101705569","display_name":"Yanjing Yang","orcid":"https://orcid.org/0009-0007-2113-3354","observed_orcids":["https://orcid.org/0009-0007-2113-3354"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanjing Yang","raw_affiliation_strings":["Department of Biology and Medicine ,college of Chemistry and Chemical Engineering, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0009-0007-2113-3354","affiliations":[{"raw_affiliation_string":"Department of Biology and Medicine ,college of Chemistry and Chemical Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101705569"],"corresponding_institution_ids":["https://openalex.org/I139660479"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":13.0838,"has_fulltext":true,"cited_by_count":160,"citation_normalized_percentile":{"value":0.99693535,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"47","issue":"3","first_page":"e202400111","last_page":"e202400111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aptamers","display_name":"aptamers","score":0.8330000042915344},{"id":"https://openalex.org/keywords/bacterial-detection","display_name":"bacterial detection","score":0.7620000243186951},{"id":"https://openalex.org/keywords/nucleic-acid-biosensors","display_name":"nucleic acid biosensors","score":0.8460000157356262},{"id":"https://openalex.org/keywords/selex","display_name":"SELEX","score":0.9599999785423279},{"id":"https://openalex.org/keywords/optical-biosensors","display_name":"optical biosensors","score":0.8579999804496765},{"id":"https://openalex.org/keywords/electrochemical-biosensor","display_name":"electrochemical biosensor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/signal-amplification","display_name":"signal amplification","score":0.9139999747276306},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8700000047683716},{"id":"https://openalex.org/keywords/infectious-disease-diagnosis","display_name":"infectious disease diagnosis","score":0.5580000281333923},{"id":"https://openalex.org/keywords/sensor-stability","display_name":"sensor stability","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.9005448818206787},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.7063306570053101},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.6424230337142944},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44511258602142334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4064498543739319},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36945706605911255},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3600153923034668},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21849346160888672},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.20413002371788025},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1127278208732605}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D052156","descriptor_name":"SELEX Aptamer Technique","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055664","descriptor_name":"Electrochemical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/bies.202400111","doi":"https://doi.org/10.1002/bies.202400111","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bies.202400111","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bies.202400111","source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},{"id":"pmid:39821800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39821800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays : news and reviews in molecular, cellular and developmental biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/bies.202400111","doi":"https://doi.org/10.1002/bies.202400111","is_oa":true,"landing_page_url":"https://doi.org/10.1002/bies.202400111","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bies.202400111","source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4277239280","display_name":null,"funder_award_id":"22278445)","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6162478703","display_name":null,"funder_award_id":"2020JJ4686","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406483293.pdf","grobid_xml":"https://content.openalex.org/works/W4406483293.grobid-xml"},"referenced_works_count":125,"referenced_works":["https://openalex.org/W39067297","https://openalex.org/W407041135","https://openalex.org/W1648483769","https://openalex.org/W1963256408","https://openalex.org/W1973265413","https://openalex.org/W1974092758","https://openalex.org/W1984662034","https://openalex.org/W1988469102","https://openalex.org/W1996566248","https://openalex.org/W1997511581","https://openalex.org/W1997899213","https://openalex.org/W1999378775","https://openalex.org/W2000685674","https://openalex.org/W2000843982","https://openalex.org/W2004198567","https://openalex.org/W2008678639","https://openalex.org/W2026226265","https://openalex.org/W2035017448","https://openalex.org/W2036386954","https://openalex.org/W2043137047","https://openalex.org/W2045274981","https://openalex.org/W2046296237","https://openalex.org/W2048622358","https://openalex.org/W2051371200","https://openalex.org/W2051773802","https://openalex.org/W2053860199","https://openalex.org/W2056580919","https://openalex.org/W2058220293","https://openalex.org/W2059946298","https://openalex.org/W2068488189","https://openalex.org/W2071865653","https://openalex.org/W2072282398","https://openalex.org/W2073520688","https://openalex.org/W2083254410","https://openalex.org/W2089306901","https://openalex.org/W2097098036","https://openalex.org/W2099034302","https://openalex.org/W2104525153","https://openalex.org/W2127029141","https://openalex.org/W2137363733","https://openalex.org/W2175466446","https://openalex.org/W2218023941","https://openalex.org/W2313188394","https://openalex.org/W2340052055","https://openalex.org/W2340915099","https://openalex.org/W2343535183","https://openalex.org/W2381277861","https://openalex.org/W2410503029","https://openalex.org/W2510518579","https://openalex.org/W2550586991","https://openalex.org/W2560192434","https://openalex.org/W2569053735","https://openalex.org/W2569960621","https://openalex.org/W2592728060","https://openalex.org/W2606640982","https://openalex.org/W2622861420","https://openalex.org/W2623697933","https://openalex.org/W2704983557","https://openalex.org/W2734506631","https://openalex.org/W2749899164","https://openalex.org/W2750408941","https://openalex.org/W2755823505","https://openalex.org/W2766091793","https://openalex.org/W2767388255","https://openalex.org/W2773742670","https://openalex.org/W2778854211","https://openalex.org/W2790857770","https://openalex.org/W2794432918","https://openalex.org/W2802402709","https://openalex.org/W2807806879","https://openalex.org/W2826066809","https://openalex.org/W2885652434","https://openalex.org/W2889203012","https://openalex.org/W2896770224","https://openalex.org/W2898613994","https://openalex.org/W2900901801","https://openalex.org/W2909463619","https://openalex.org/W2909780708","https://openalex.org/W2934657556","https://openalex.org/W2946324232","https://openalex.org/W2949816023","https://openalex.org/W2957068253","https://openalex.org/W2959285133","https://openalex.org/W2965761395","https://openalex.org/W2968171716","https://openalex.org/W3013651760","https://openalex.org/W3033668031","https://openalex.org/W3034130666","https://openalex.org/W3036526676","https://openalex.org/W3043661953","https://openalex.org/W3047337067","https://openalex.org/W3088529973","https://openalex.org/W3122316126","https://openalex.org/W3126160864","https://openalex.org/W3133467073","https://openalex.org/W3137805526","https://openalex.org/W3159236049","https://openalex.org/W3201622883","https://openalex.org/W3208818509","https://openalex.org/W4200535451","https://openalex.org/W4220681130","https://openalex.org/W4220926613","https://openalex.org/W4223639412","https://openalex.org/W4224951871","https://openalex.org/W4224992813","https://openalex.org/W4284664968","https://openalex.org/W4285403939","https://openalex.org/W4285605446","https://openalex.org/W4301187545","https://openalex.org/W4303024289","https://openalex.org/W4306399257","https://openalex.org/W4307216241","https://openalex.org/W4308722870","https://openalex.org/W4312141187","https://openalex.org/W4377290332","https://openalex.org/W4377826842","https://openalex.org/W4386295589","https://openalex.org/W4386910068","https://openalex.org/W4389246448","https://openalex.org/W4395033764","https://openalex.org/W4398171186","https://openalex.org/W4400493229","https://openalex.org/W4400774902","https://openalex.org/W4401418646","https://openalex.org/W4403187478"],"related_works":["https://openalex.org/W4395033764","https://openalex.org/W4391572670","https://openalex.org/W3126160864","https://openalex.org/W4224951871","https://openalex.org/W118542724","https://openalex.org/W1992580121","https://openalex.org/W4410914766","https://openalex.org/W4388857243","https://openalex.org/W7171497990","https://openalex.org/W4410352793"],"abstract_inverted_index":{"Bacteria":[0],"have":[1,36,117],"a":[2],"significant":[3],"impact":[4],"on":[5,132,141],"human":[6,11,25],"production":[7],"and":[8,13,53,60,80,86,96,108,112,137],"life,":[9],"endangering":[10],"life":[12],"health,":[14],"so":[15],"rapid":[16],"detection":[17,43],"of":[18,31,114,126],"infectious":[19],"agents":[20],"is":[21],"essential":[22],"to":[23,39,45],"improve":[24],"health.":[26],"Aptamers,":[27],"which":[28],"are":[29,103],"pieces":[30],"oligonucleotides":[32],"(DNA":[33],"or":[34],"RNA)":[35],"been":[37,119],"applied":[38],"biosensors":[40],"for":[41],"bacteria":[42],"due":[44],"their":[46,54,133,142],"high":[47],"affinity,":[48],"selectivity,":[49],"robust":[50],"chemical":[51],"stability,":[52],"compatibility":[55],"with":[56],"various":[57],"signal":[58,61],"amplification":[59],"transduction":[62],"mechanisms.":[63],"In":[64,91],"this":[65],"review,":[66],"we":[67],"summarize":[68],"the":[69,82,93,110,115,124],"different":[70],"bacterial":[71,88,99,128],"aptamers":[72],"selected":[73],"in":[74,84,98],"recent":[75],"years":[76],"using":[77],"SELEX":[78],"technology":[79,102],"discuss":[81],"differences":[83],"optical":[85],"electrochemical":[87],"aptamer":[89,100,129],"sensors.":[90],"addition":[92],"technological":[94],"developments":[95],"innovations":[97],"sensor":[101],"introduced.":[104],"Combining":[105],"new":[106],"materials":[107],"methods,":[109],"efficiency":[111],"stability":[113],"sensors":[116,130],"also":[118],"improved.":[120],"This":[121],"review":[122],"summarizes":[123],"progress":[125],"current":[127],"based":[131],"practical":[134],"application":[135],"status":[136],"provides":[138],"an":[139],"outlook":[140],"future":[143],"development.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":116},{"year":2025,"cited_by_count":44}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-01-17T00:00:00"}