{"id":"https://openalex.org/W4406463374","doi":"https://doi.org/10.1038/s44321-024-00185-0","title":"Gut microbiota interact with breast cancer therapeutics to modulate efficacy","display_name":"Gut microbiota interact with breast cancer therapeutics to modulate efficacy","publication_year":2025,"publication_date":"2025-01-16","ids":{"openalex":"https://openalex.org/W4406463374","doi":"https://doi.org/10.1038/s44321-024-00185-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/39820166","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11822015"},"language":"en","primary_location":{"id":"doi:10.1038/s44321-024-00185-0","doi":"https://doi.org/10.1038/s44321-024-00185-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44321-024-00185-0","pdf_url":"https://link.springer.com/content/pdf/10.1038/s44321-024-00185-0.pdf","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1038/s44321-024-00185-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089785249","display_name":"Alana A. Arnone","orcid":"https://orcid.org/0000-0001-8881-0726","observed_orcids":["https://orcid.org/0000-0001-8881-0726"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alana A Arnone","raw_affiliation_strings":["Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047945687","display_name":"Katherine Cox Ansley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Ansley","raw_affiliation_strings":["Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA","Department of Internal Medicine, Section on Hematology and Oncology, Wake Forest University School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4387930303"]},{"raw_affiliation_string":"Department of Internal Medicine, Section on Hematology and Oncology, Wake Forest University School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089293098","display_name":"Arielle Lutterman Heeke","orcid":"https://orcid.org/0000-0001-7809-2564","observed_orcids":["https://orcid.org/0000-0001-7809-2564"]},"institutions":[{"id":"https://openalex.org/I4210100342","display_name":"Levine Cancer Institute","ror":"https://ror.org/0174nh398","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334069289","https://openalex.org/I4210100342"]},{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arielle L Heeke","raw_affiliation_strings":["Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA","Department of Solid Tumor Oncology and Investigational Therapeutics, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4387930303"]},{"raw_affiliation_string":"Department of Solid Tumor Oncology and Investigational Therapeutics, Levine Cancer Institute, Atrium Health, Charlotte, NC, USA","institution_ids":["https://openalex.org/I4210100342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036048438","display_name":"Marissa Michelle Howard-McNatt","orcid":"https://orcid.org/0000-0003-1228-3223","observed_orcids":["https://orcid.org/0000-0003-1228-3223"]},"institutions":[{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marissa Howard-McNatt","raw_affiliation_strings":["Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA","Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4387930303"]},{"raw_affiliation_string":"Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025967603","display_name":"Katherine Loree Cook","orcid":"https://orcid.org/0000-0001-6241-0214","observed_orcids":["https://orcid.org/0000-0001-6241-0214"]},"institutions":[{"id":"https://openalex.org/I4387930303","display_name":"Wake Forest Baptist Comprehensive Cancer Center","ror":"https://ror.org/0512csj88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I4387930303","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katherine L Cook","raw_affiliation_strings":["Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA. klcook@wakehealth.edu","Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA. klcook@wakehealth.edu","Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA. klcook@wakehealth.edu"],"raw_orcid":"https://orcid.org/0000-0001-6241-0214","affiliations":[{"raw_affiliation_string":"Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA. klcook@wakehealth.edu","institution_ids":["https://openalex.org/I4387930303"]},{"raw_affiliation_string":"Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, USA. klcook@wakehealth.edu","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, USA. klcook@wakehealth.edu","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025967603"],"corresponding_institution_ids":["https://openalex.org/I4387930303","https://openalex.org/I4405269449","https://openalex.org/I47251452"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":{"value":7990,"currency":"USD","value_usd":7990},"fwci":2.9439,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.93737713,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"17","issue":"2","first_page":"219","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8389999866485596},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9639999866485596},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.5370000004768372},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9259999990463257},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.6949999928474426},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.9419999718666077},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.847000002861023},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9190000295639038},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6279592514038086},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5440707206726074},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4981691837310791},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46612170338630676},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45569908618927},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.45163801312446594},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41612663865089417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3868686258792877},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35031914710998535},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24582278728485107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22038471698760986}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s44321-024-00185-0","doi":"https://doi.org/10.1038/s44321-024-00185-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44321-024-00185-0","pdf_url":"https://link.springer.com/content/pdf/10.1038/s44321-024-00185-0.pdf","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11822015","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11822015","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11822015/pdf/44321_2024_Article_185.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Mol Med","raw_type":"Text"},{"id":"pmid:39820166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39820166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:63b544d4b6334d698af65df215286d70","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/63b544d4b6334d698af65df215286d70","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EMBO Molecular Medicine, Vol 17, Iss 2, Pp 219-234 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s44321-024-00185-0","doi":"https://doi.org/10.1038/s44321-024-00185-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s44321-024-00185-0","pdf_url":"https://link.springer.com/content/pdf/10.1038/s44321-024-00185-0.pdf","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1368002558","display_name":null,"funder_award_id":"BC230701","funder_id":"https://openalex.org/F4320338273","funder_display_name":"Congressionally Directed Medical Research Programs"},{"id":"https://openalex.org/G3058200945","display_name":null,"funder_award_id":"BC210715","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G3413648724","display_name":null,"funder_award_id":"BC230701","funder_id":"https://openalex.org/F4320337656","funder_display_name":"U.S. Army Medical Command"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5422894801","display_name":null,"funder_award_id":"BC210715","funder_id":"https://openalex.org/F4320337656","funder_display_name":"U.S. Army Medical Command"},{"id":"https://openalex.org/G5647900472","display_name":null,"funder_award_id":"24-40-12-ARNO","funder_id":"https://openalex.org/F4320306091","funder_display_name":"American Association for Cancer Research"},{"id":"https://openalex.org/G5905890976","display_name":null,"funder_award_id":"BC210715","funder_id":"https://openalex.org/F4320338273","funder_display_name":"Congressionally Directed Medical Research Programs"},{"id":"https://openalex.org/G6088487405","display_name":null,"funder_award_id":"D2024-014","funder_id":"https://openalex.org/F4320306536","funder_display_name":"V Foundation for Cancer Research"},{"id":"https://openalex.org/G9000875213","display_name":"Determining the contribution of microbial-derived metabolites to protective immunity in obesity-driven cancer risk.","funder_award_id":"U01CA272541","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000896304","display_name":"Role of microbially-derived metabolites in anti-tumor immunity in breast cancer","funder_award_id":"R01CA253329","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306091","display_name":"American Association for Cancer Research","ror":"https://ror.org/02fnpv153"},{"id":"https://openalex.org/F4320306536","display_name":"V Foundation for Cancer Research","ror":"https://ror.org/00kbbk236"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337656","display_name":"U.S. Army Medical Command","ror":"https://ror.org/04vrzee53"},{"id":"https://openalex.org/F4320338273","display_name":"Congressionally Directed Medical Research Programs","ror":"https://ror.org/03g2zjp07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406463374.pdf","grobid_xml":"https://content.openalex.org/works/W4406463374.grobid-xml"},"referenced_works_count":125,"referenced_works":["https://openalex.org/W587932429","https://openalex.org/W1245681932","https://openalex.org/W1420654867","https://openalex.org/W2030323580","https://openalex.org/W2032230795","https://openalex.org/W2054588910","https://openalex.org/W2059128083","https://openalex.org/W2061099728","https://openalex.org/W2078224825","https://openalex.org/W2095863850","https://openalex.org/W2110235509","https://openalex.org/W2116846792","https://openalex.org/W2124632458","https://openalex.org/W2140145798","https://openalex.org/W2151277589","https://openalex.org/W2155634297","https://openalex.org/W2157570303","https://openalex.org/W2165003751","https://openalex.org/W2171437158","https://openalex.org/W2185075416","https://openalex.org/W2323331306","https://openalex.org/W2328023807","https://openalex.org/W2341191157","https://openalex.org/W2498698309","https://openalex.org/W2517943671","https://openalex.org/W2528306813","https://openalex.org/W2605334862","https://openalex.org/W2640475594","https://openalex.org/W2756403351","https://openalex.org/W2765314233","https://openalex.org/W2769500005","https://openalex.org/W2782333299","https://openalex.org/W2795464178","https://openalex.org/W2798109075","https://openalex.org/W2804340576","https://openalex.org/W2811485525","https://openalex.org/W2892357173","https://openalex.org/W2914650183","https://openalex.org/W2924917805","https://openalex.org/W2927581250","https://openalex.org/W2939256238","https://openalex.org/W2970888800","https://openalex.org/W2982037499","https://openalex.org/W3003912482","https://openalex.org/W3006930853","https://openalex.org/W3011898129","https://openalex.org/W3012289493","https://openalex.org/W3018670839","https://openalex.org/W3035321842","https://openalex.org/W3037222958","https://openalex.org/W3038702366","https://openalex.org/W3049052172","https://openalex.org/W3097890239","https://openalex.org/W3120729122","https://openalex.org/W3122301327","https://openalex.org/W3130439606","https://openalex.org/W3133259633","https://openalex.org/W3158071568","https://openalex.org/W3164246975","https://openalex.org/W3166484721","https://openalex.org/W3174561819","https://openalex.org/W3175536848","https://openalex.org/W3182490035","https://openalex.org/W3188062919","https://openalex.org/W3193946879","https://openalex.org/W3194260045","https://openalex.org/W3194435434","https://openalex.org/W3195237310","https://openalex.org/W3201516608","https://openalex.org/W3207102704","https://openalex.org/W3211231475","https://openalex.org/W4200001874","https://openalex.org/W4200129285","https://openalex.org/W4211110828","https://openalex.org/W4213253758","https://openalex.org/W4223638903","https://openalex.org/W4225117821","https://openalex.org/W4225125644","https://openalex.org/W4245948191","https://openalex.org/W4281614790","https://openalex.org/W4283745189","https://openalex.org/W4285392079","https://openalex.org/W4285992810","https://openalex.org/W4294189863","https://openalex.org/W4301477243","https://openalex.org/W4303621924","https://openalex.org/W4307233918","https://openalex.org/W4307722719","https://openalex.org/W4309192274","https://openalex.org/W4309456809","https://openalex.org/W4311077877","https://openalex.org/W4315568014","https://openalex.org/W4315647618","https://openalex.org/W4318215304","https://openalex.org/W4320489657","https://openalex.org/W4323031394","https://openalex.org/W4323844326","https://openalex.org/W4363672402","https://openalex.org/W4372197300","https://openalex.org/W4376641871","https://openalex.org/W4376954607","https://openalex.org/W4379341255","https://openalex.org/W4380290618","https://openalex.org/W4381187234","https://openalex.org/W4381236312","https://openalex.org/W4385202195","https://openalex.org/W4385664805","https://openalex.org/W4386390703","https://openalex.org/W4386543643","https://openalex.org/W4387136498","https://openalex.org/W4387598250","https://openalex.org/W4388095229","https://openalex.org/W4388705011","https://openalex.org/W4389003343","https://openalex.org/W4389143587","https://openalex.org/W4390311611","https://openalex.org/W4390730449","https://openalex.org/W4391138223","https://openalex.org/W4392756796","https://openalex.org/W4394685401","https://openalex.org/W4394842195","https://openalex.org/W4396602385","https://openalex.org/W4396611892","https://openalex.org/W4402576844","https://openalex.org/W4403921179"],"related_works":["https://openalex.org/W4229069325","https://openalex.org/W4407660327","https://openalex.org/W4410791961","https://openalex.org/W4416851692","https://openalex.org/W7117704734","https://openalex.org/W4321457105","https://openalex.org/W4405293114","https://openalex.org/W4403945632","https://openalex.org/W4409217093","https://openalex.org/W3194435434"],"abstract_inverted_index":{"The":[0,43],"gut":[1,29,65,98],"microbiome,":[2],"or":[3],"the":[4,10,26,48,64,77,86,93,97,128],"community":[5],"of":[6,28,41,50,79,88],"microorganisms":[7],"residing":[8],"in":[9,19,46],"gastrointestinal":[11],"tract,":[12],"has":[13],"emerged":[14],"as":[15],"an":[16,38],"important":[17],"factor":[18],"breast":[20,33,89,101,132],"cancer":[21,34,102,133],"etiology":[22],"and":[23,52,59,72,82,100,120],"treatment.":[24],"Specifically,":[25],"impact":[27,109],"bacterial":[30],"populations":[31],"on":[32],"therapeutic":[35,124],"outcomes":[36],"is":[37,110],"emerging":[39],"area":[40],"research.":[42],"microbiota's":[44],"role":[45],"modifying":[47],"pharmacokinetics":[49],"chemotherapy":[51],"endocrine-targeting":[53],"therapies":[54,103],"can":[55],"alter":[56],"drug":[57],"efficacy":[58],"toxicity":[60],"profiles.":[61],"In":[62],"addition,":[63],"microbiome's":[66],"capacity":[67],"to":[68,126,130],"regulate":[69],"systemic":[70],"inflammation":[71],"immune":[73],"responses":[74],"may":[75,115],"influence":[76],"effectiveness":[78],"both":[80],"conventional":[81],"immunotherapeutic":[83],"strategies":[84,125],"for":[85],"treatment":[87,134],"cancer.":[90],"Overall,":[91],"while":[92],"bidirectional":[94],"interactions":[95],"between":[96],"microbiome":[99,129],"are":[104],"still":[105],"being":[106],"studied,":[107],"its":[108],"increasingly":[111],"recognized.":[112],"Future":[113],"research":[114],"provide":[116],"more":[117],"definitive":[118],"insights":[119],"help":[121],"develop":[122],"personalized":[123],"harness":[127],"improve":[131],"outcomes.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-01-17T00:00:00"}
