{"id":"https://openalex.org/W4406436734","doi":"https://doi.org/10.1001/jamaoncol.2024.5927","title":"Intratumoral Injection of mRNA-2752 and Pembrolizumab for High-Risk Ductal Carcinoma In Situ","display_name":"Intratumoral Injection of mRNA-2752 and Pembrolizumab for High-Risk Ductal Carcinoma In Situ","publication_year":2025,"publication_date":"2025-01-16","ids":{"openalex":"https://openalex.org/W4406436734","doi":"https://doi.org/10.1001/jamaoncol.2024.5927","pmid":"https://pubmed.ncbi.nlm.nih.gov/39821301"},"language":"en","primary_location":{"id":"doi:10.1001/jamaoncol.2024.5927","doi":"https://doi.org/10.1001/jamaoncol.2024.5927","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2024.5927","pdf_url":null,"source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11926637/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073798608","display_name":"Kirithiga Ramalingam","orcid":"https://orcid.org/0000-0002-1774-6891","observed_orcids":["https://orcid.org/0000-0002-1774-6891"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirithiga Ramalingam","raw_affiliation_strings":["Department of Surgery, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002290290","display_name":"Rachel Woody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Woody","raw_affiliation_strings":["Department of Surgery, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065015623","display_name":"Alexa Glencer","orcid":"https://orcid.org/0000-0002-3183-1056","observed_orcids":["https://orcid.org/0000-0002-3183-1056"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexa Glencer","raw_affiliation_strings":["Department of Surgery, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077811687","display_name":"Christopher J. Schwartz","orcid":"https://orcid.org/0000-0002-8086-8429","observed_orcids":["https://orcid.org/0000-0002-8086-8429"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Schwartz","raw_affiliation_strings":["Department of Surgery, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hidetoshi Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hidetoshi Mori","raw_affiliation_strings":["Department of Pathology and Lab Medicine, University of California, Davis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Lab Medicine, University of California, Davis","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021217453","display_name":"Jasmine Wong","orcid":"https://orcid.org/0000-0001-6440-0431","observed_orcids":["https://orcid.org/0000-0001-6440-0431"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasmine Wong","raw_affiliation_strings":["Department of Surgery, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076178845","display_name":"Gillian L. Hirst","orcid":"https://orcid.org/0000-0002-4502-0035","observed_orcids":["https://orcid.org/0000-0002-4502-0035"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gillian Hirst","raw_affiliation_strings":["Department of Surgery, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034246237","display_name":"Jennifer M. Rosenbluth","orcid":"https://orcid.org/0000-0003-1314-6976","observed_orcids":["https://orcid.org/0000-0003-1314-6976"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Rosenbluth","raw_affiliation_strings":["Department of Medicine, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024284558","display_name":"Natsuko Onishi","orcid":"https://orcid.org/0000-0003-4495-9187","observed_orcids":["https://orcid.org/0000-0003-4495-9187"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natsuko Onishi","raw_affiliation_strings":["Dempartment of Radiology, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dempartment of Radiology, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023543805","display_name":"Jessica Gibbs","orcid":"https://orcid.org/0000-0003-1785-0899","observed_orcids":["https://orcid.org/0000-0003-1785-0899"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Gibbs","raw_affiliation_strings":["Dempartment of Radiology, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dempartment of Radiology, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034796205","display_name":"Nola M. Hylton","orcid":"https://orcid.org/0000-0002-6747-1662","observed_orcids":["https://orcid.org/0000-0002-6747-1662"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nola Hylton","raw_affiliation_strings":["Dempartment of Radiology, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dempartment of Radiology, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071350705","display_name":"Alexander D. Borowsky","orcid":"https://orcid.org/0000-0003-3117-9202","observed_orcids":["https://orcid.org/0000-0003-3117-9202"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander D. Borowsky","raw_affiliation_strings":["Department of Pathology and Lab Medicine, University of California, Davis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Lab Medicine, University of California, Davis","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101867449","display_name":"Michael J. Campbell","orcid":"https://orcid.org/0000-0002-3788-9240","observed_orcids":["https://orcid.org/0000-0002-3788-9240"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Campbell","raw_affiliation_strings":["Department of Surgery, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072789687","display_name":"Laura J. Esserman","orcid":"https://orcid.org/0000-0001-9202-4568","observed_orcids":["https://orcid.org/0000-0001-9202-4568"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura J. Esserman","raw_affiliation_strings":["Department of Surgery, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.1098,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.98910309,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"11","issue":"3","first_page":"288","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.1906999945640564,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ductal-carcinoma-in-situ","display_name":"ductal carcinoma in situ","score":0.8999999761581421},{"id":"https://openalex.org/keywords/intratumoral-immunotherapy","display_name":"intratumoral immunotherapy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9929999709129333},{"id":"https://openalex.org/keywords/il-23","display_name":"IL-23","score":0.8899999856948853},{"id":"https://openalex.org/keywords/interleukin-36gamma","display_name":"interleukin-36\u03b3","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ox40-ligand","display_name":"OX40L","score":0.9430000185966492},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8650000095367432},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.7639999985694885},{"id":"https://openalex.org/keywords/hormone-receptor-negative-breast-cancer","display_name":"hormone receptor-negative breast cancer","score":0.9670000076293945},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8245842456817627},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.6163690686225891},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.57832932472229},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.4778968095779419},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.46646085381507874},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.43549519777297974},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4309077262878418},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.40006202459335327},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39570119976997375},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36512744426727295},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.31592392921447754},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26530683040618896},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.1301259696483612},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11208450794219971},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09013736248016357},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.08821451663970947},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0789230465888977},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1001/jamaoncol.2024.5927","doi":"https://doi.org/10.1001/jamaoncol.2024.5927","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jamaoncol.2024.5927","pdf_url":null,"source":{"id":"https://openalex.org/S2756165422","display_name":"JAMA Oncology","issn_l":"2374-2437","issn":["2374-2437","2374-2445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA Oncology","raw_type":"journal-article"},{"id":"pmid:39821301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39821301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11926637","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11926637/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JAMA Oncol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11926637","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11926637/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JAMA Oncol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1531458427","https://openalex.org/W2108976517","https://openalex.org/W2127644335","https://openalex.org/W2131267314","https://openalex.org/W2141249055","https://openalex.org/W2540499565","https://openalex.org/W2912510115","https://openalex.org/W2970635371","https://openalex.org/W3005738019","https://openalex.org/W3165062659","https://openalex.org/W4283029993","https://openalex.org/W4389296628"],"related_works":["https://openalex.org/W2585407512","https://openalex.org/W1974583777","https://openalex.org/W30847733","https://openalex.org/W3085510013","https://openalex.org/W2269144480","https://openalex.org/W1989903697","https://openalex.org/W196621553","https://openalex.org/W4242046722","https://openalex.org/W2029567565","https://openalex.org/W4240443517"],"abstract_inverted_index":{"Importance:":[0],"Intratumoral":[1],"immunotherapy":[2,40,74],"that":[3,291,396],"leverages":[4],"the":[5,20,68,86,175,202,336,393],"biological":[6],"characteristics":[7],"of":[8,22,72,85,137,179,182,250,295,322,399,410],"high-risk":[9,49,78,211,411],"ductal":[10],"carcinoma":[11],"in":[12,75,201,335],"situ":[13],"(DCIS)":[14],"may":[15,406],"be":[16],"able":[17],"to":[18,30,45,130,149,156,161,173,190,253,284,319,354,362,367],"reduce":[19],"extent":[21],"surgical":[23],"treatment":[24,313],"and":[25,53,70,114,133,141,167,177,184,193,196,198,241,255,279,298,333,359,384,401,405,422],"provide":[26],"an":[27],"alternative":[28],"approach":[29],"improve":[31,368],"patient":[32,339],"outcomes.":[33],"Objective:":[34],"To":[35],"determine":[36],"if":[37],"combination":[38,136,373],"intratumoral":[39,73,180,397],"can":[41],"activate":[42],"immune":[43,415],"cells":[44,304],"shrink":[46],"or":[47,105,261,306],"eliminate":[48],"DCIS.":[50,263],"Design,":[51],"Setting,":[52],"Participants:":[54],"This":[55],"phase":[56,388],"1":[57,147,242,283,320,363,381,389],"open-label":[58],"nonrandomized":[59,390],"clinical":[60,391],"trial":[61],"at":[62,82],"a":[63,311],"single":[64],"academic":[65],"center":[66],"tested":[67],"safety":[69,176],"efficacy":[71],"patients":[76,209,258,265,270,316],"with":[77,154,210,271,310,379,413],"DCIS,":[79],"defined":[80],"as":[81],"least":[83],"2":[84,128,155,160,235,238,285,355],"following":[87],"present:":[88],"younger":[89],"than":[90,96],"45":[91],"years,":[92],"tumor":[93,204,224],"size":[94,225],"greater":[95],"5":[97],"cm,":[98],"high-grade,":[99],"palpable":[100],"mass,":[101],"hormone":[102],"receptor":[103],"(HR)-negative,":[104],"ERBB2-positive.":[106,244],"Patients":[107],"were":[108,189,219,232,308],"enrolled":[109],"between":[110],"June":[111],"8,":[112],"2021,":[113],"December":[115],"13,":[116],"2022.":[117],"Intervention:":[118],"Pembrolizumab":[119],"(anti-programmed":[120],"cell":[121,300],"death":[122,301],"protein":[123],"1),":[124],"dose":[125,144,347,374],"ranging":[126,145],"from":[127,146,351],"mg":[129,148,353,356,361,364],"8":[131,249,257,352],"mg,":[132,151,378],"mRNA-2752":[134,366,402],"(a":[135],"interleukin":[138],"[IL]-23,":[139],"IL-36\u03b3,":[140],"OX40L":[142],"mRNAs),":[143],"4":[150,157,360,377],"delivered":[152],"intratumorally,":[153],"doses":[158],"given":[159],"3":[162,344],"weeks":[163],"apart.":[164],"Main":[165],"Outcomes":[166],"Measures:":[168],"The":[169,186,221,346,370],"primary":[170],"objective":[171],"was":[172,226,348],"evaluate":[174],"tolerability":[178],"injections":[181,398],"pembrolizumab":[183,358,400],"mRNA-2752.":[185],"secondary":[187],"objectives":[188],"assess":[191],"radiologic":[192],"pathological":[194],"responses":[195],"immunological":[197],"histological":[199],"differences":[200],"posttreatment":[203,273],"microenvironment.":[205],"Results:":[206],"Ten":[207],"female":[208],"DCIS":[212,412],"(median":[213],"[range]":[214],"age,":[215],"46":[216],"[35-80]":[217],"years)":[218],"enrolled.":[220],"median":[222],"(range)":[223],"5.3":[227],"(1.0-10.0)":[228],"cm.":[229],"Five":[230],"tumors":[231],"HR-negative":[233,236,262],"ERBB2-positive;":[234],"ERBB2-negative;":[237,240],"HR-positive":[239,243],"Of":[245],"all":[246,256],"treated":[247],"patients,":[248],"10":[251],"responded":[252],"treatment,":[254],"had":[259,266,340],"ERBB2-positive":[260],"Three":[264,269],"complete":[267],"responses.":[268],"negative":[272],"core":[274],"biopsy":[275],"results":[276,394],"declined":[277],"surgery":[278],"remained":[280],"disease-free":[281],"after":[282],"years.":[286],"Multiplex":[287],"immunofluorescence":[288],"staining":[289],"demonstrated":[290],"high":[292,414],"baseline":[293],"levels":[294],"tumor-infiltrating":[296],"lymphocytes":[297],"programmed":[299],"ligand":[302],"1-positive":[303],"(immune":[305],"tumor)":[307],"associated":[309],"better":[312],"response.":[314],"All":[315],"experienced":[317],"up":[318],"week":[321],"fever,":[323],"malaise,":[324],"flulike":[325],"symptoms,":[326],"axillary":[327],"adenopathy,":[328],"erythema,":[329],"injection":[330],"site":[331],"swelling,":[332],"swelling":[334],"breast.":[337],"One":[338],"intermittent":[341],"urticaria":[342],"for":[343,357,365],"months.":[345],"serially":[349],"reduced":[350],"tolerability.":[369],"final":[371],"recommended":[372],"is":[375],"pembrolizumab,":[376],"mRNA-2752,":[380],"mg.":[382],"Conclusions":[383],"Relevance:":[385],"In":[386],"this":[387],"trial,":[392],"suggest":[395],"are":[403,424],"safe":[404],"induce":[407],"rapid":[408],"regression":[409],"infiltrates.":[416],"These":[417],"findings":[418],"warrant":[419],"additional":[420],"investigation,":[421],"studies":[423],"ongoing.":[425],"Trial":[426],"Registration:":[427],"ClinicalTrials.gov":[428],"Identifier:":[429],"NCT02872025.":[430]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":8}],"updated_date":"2026-10-20T09:52:01.089006","created_date":"2025-01-16T00:00:00"}
