{"id":"https://openalex.org/W4406433987","doi":"https://doi.org/10.1016/s0022-3565(24)37160-5","title":"Novel Systemically Active Antagonists of the Glycine Site of the N-Methyl-d-aspartate Receptor: Electrophysiological, Biochemical and Behavioral Characterization","display_name":"Novel Systemically Active Antagonists of the Glycine Site of the N-Methyl-d-aspartate Receptor: Electrophysiological, Biochemical and Behavioral Characterization","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W4406433987","doi":"https://doi.org/10.1016/s0022-3565(24)37160-5","mag":"2201538478","pmid":"https://pubmed.ncbi.nlm.nih.gov/9400002"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-3565(24)37160-5","doi":"https://doi.org/10.1016/s0022-3565(24)37160-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-3565(24)37160-5","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071702581","display_name":"Chris G. Parsons","orcid":"https://orcid.org/0000-0002-3122-8572","observed_orcids":["https://orcid.org/0000-0002-3122-8572"]},"institutions":[{"id":"https://openalex.org/I4210113494","display_name":"Merz (Germany)","ror":"https://ror.org/025f1e779","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113494"]},{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["DE","PL"],"is_corresponding":true,"raw_author_name":"Chris G. Parsons","raw_affiliation_strings":["Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)","institution_ids":["https://openalex.org/I4210113494","https://openalex.org/I4210153937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060706996","display_name":"Wojciech Danysz","orcid":"https://orcid.org/0000-0003-2375-0210","observed_orcids":["https://orcid.org/0000-0003-2375-0210"]},"institutions":[{"id":"https://openalex.org/I4210113494","display_name":"Merz (Germany)","ror":"https://ror.org/025f1e779","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113494"]},{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"Wojciech Danysz","raw_affiliation_strings":["Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)","institution_ids":["https://openalex.org/I4210113494","https://openalex.org/I4210153937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110778757","display_name":"G. Quack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113494","display_name":"Merz (Germany)","ror":"https://ror.org/025f1e779","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113494"]},{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"G\u00fcnter Quack","raw_affiliation_strings":["Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)","institution_ids":["https://openalex.org/I4210113494","https://openalex.org/I4210153937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056601420","display_name":"Sabine Hartmann","orcid":"https://orcid.org/0009-0001-5400-2816","observed_orcids":["https://orcid.org/0009-0001-5400-2816"]},"institutions":[{"id":"https://openalex.org/I4210113494","display_name":"Merz (Germany)","ror":"https://ror.org/025f1e779","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113494"]},{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"Sabine Hartmann","raw_affiliation_strings":["Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)","institution_ids":["https://openalex.org/I4210113494","https://openalex.org/I4210153937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000040258","display_name":"B. Lorenz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113494","display_name":"Merz (Germany)","ror":"https://ror.org/025f1e779","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113494"]},{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"Bianke Lorenz","raw_affiliation_strings":["Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)","institution_ids":["https://openalex.org/I4210113494","https://openalex.org/I4210153937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031801089","display_name":"C. Wollenburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113494","display_name":"Merz (Germany)","ror":"https://ror.org/025f1e779","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113494"]},{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"Christine Wollenburg","raw_affiliation_strings":["Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)","institution_ids":["https://openalex.org/I4210113494","https://openalex.org/I4210153937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043083617","display_name":"Leokadia Baran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113494","display_name":"Merz (Germany)","ror":"https://ror.org/025f1e779","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113494"]},{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"Leokadia Baran","raw_affiliation_strings":["Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)","institution_ids":["https://openalex.org/I4210113494","https://openalex.org/I4210153937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013335339","display_name":"Edmund Przegali\u0144ski","orcid":"https://orcid.org/0000-0002-7578-2196","observed_orcids":["https://orcid.org/0000-0002-7578-2196"]},"institutions":[{"id":"https://openalex.org/I4210113494","display_name":"Merz (Germany)","ror":"https://ror.org/025f1e779","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113494"]},{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"Edmund Przegalinski","raw_affiliation_strings":["Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)","institution_ids":["https://openalex.org/I4210113494","https://openalex.org/I4210153937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045544787","display_name":"Wojciech Kostowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113494","display_name":"Merz (Germany)","ror":"https://ror.org/025f1e779","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113494"]},{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"Wojciech Kostowski","raw_affiliation_strings":["Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)","institution_ids":["https://openalex.org/I4210113494","https://openalex.org/I4210153937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050366902","display_name":"Pawe\u0142 Krz\u0105\u015bcik","orcid":"https://orcid.org/0000-0001-8784-7041","observed_orcids":["https://orcid.org/0000-0001-8784-7041"]},"institutions":[{"id":"https://openalex.org/I4210113494","display_name":"Merz (Germany)","ror":"https://ror.org/025f1e779","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113494"]},{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"Pawel Krzascik","raw_affiliation_strings":["Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)","institution_ids":["https://openalex.org/I4210113494","https://openalex.org/I4210153937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111671718","display_name":"Boris A. Chizh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113494","display_name":"Merz (Germany)","ror":"https://ror.org/025f1e779","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113494"]},{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"Boris Chizh","raw_affiliation_strings":["Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)","institution_ids":["https://openalex.org/I4210113494","https://openalex.org/I4210153937"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112334838","display_name":"P. Max Headley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113494","display_name":"Merz (Germany)","ror":"https://ror.org/025f1e779","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113494"]},{"id":"https://openalex.org/I4210153937","display_name":"Institute of Psychiatry and Neurology","ror":"https://ror.org/0468k6j36","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210153937"]}],"countries":["DE","PL"],"is_corresponding":false,"raw_author_name":"P. Max. Headley","raw_affiliation_strings":["Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Merz and Co., D-60318 Frankfurt am Main, Germany (C.G.P., W.D., G.Q., S.H., B.L., C.W.), Institute of Pharmacology PAN, Smetna 12, Cracow, Poland (L.B., E.P.), Department of Pharmacology, Institute of Psychiatry and Neurology, Sobieskiego 1\u20139, Warsaw, Poland (W.K., P.K.) and Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, England (B.C., P.M.H.)","institution_ids":["https://openalex.org/I4210113494","https://openalex.org/I4210153937"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071702581"],"corresponding_institution_ids":["https://openalex.org/I4210113494","https://openalex.org/I4210153937"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":3.2612,"has_fulltext":false,"cited_by_count":195,"citation_normalized_percentile":{"value":0.93428052,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"283","issue":"3","first_page":"1264","last_page":"1275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.7480000257492065},{"id":"https://openalex.org/keywords/glycine-site-antagonists","display_name":"glycine site antagonists","score":0.8270000219345093},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.7940000295639038},{"id":"https://openalex.org/keywords/anticonvulsant-activity","display_name":"anticonvulsant activity","score":0.8009999990463257},{"id":"https://openalex.org/keywords/pentylenetetrazole-induced-seizures","display_name":"pentylenetetrazole-induced seizures","score":0.7630000114440918},{"id":"https://openalex.org/keywords/maximal-electroshock-seizures","display_name":"maximal electroshock seizures","score":0.9089999794960022},{"id":"https://openalex.org/keywords/probenecid","display_name":"probenecid","score":0.9359999895095825},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.6872642040252686},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.5900825262069702},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5047363042831421},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48510634899139404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45992618799209595},{"id":"https://openalex.org/C35599011","wikidata":"https://www.wikidata.org/wiki/Q426887","display_name":"Glycine receptor","level":4,"score":0.4184555411338806},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34717369079589844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2733633518218994},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.094686359167099}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016202","descriptor_name":"N-Methylaspartate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018009","descriptor_name":"Receptors, Glycine","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018350","descriptor_name":"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0022-3565(24)37160-5","doi":"https://doi.org/10.1016/s0022-3565(24)37160-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-3565(24)37160-5","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},{"id":"pmid:9400002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9400002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pharmacology and experimental therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.570.378","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.570.378","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.chrisparsons.de/Chris/Acrobat/Parsons_1997.pdf","raw_type":"text"},{"id":"mag:2201538478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9400002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1589136255","https://openalex.org/W1775749144","https://openalex.org/W1799745768","https://openalex.org/W1925182157","https://openalex.org/W1963718884","https://openalex.org/W1963895697","https://openalex.org/W1975342713","https://openalex.org/W1978079999","https://openalex.org/W1978446097","https://openalex.org/W1983542896","https://openalex.org/W1985118788","https://openalex.org/W1987017995","https://openalex.org/W1990149170","https://openalex.org/W1995075936","https://openalex.org/W1996216954","https://openalex.org/W1996555027","https://openalex.org/W1996555735","https://openalex.org/W1998883371","https://openalex.org/W2003066583","https://openalex.org/W2011035664","https://openalex.org/W2014281089","https://openalex.org/W2015607927","https://openalex.org/W2016690333","https://openalex.org/W2017974723","https://openalex.org/W2019072693","https://openalex.org/W2020789218","https://openalex.org/W2023657406","https://openalex.org/W2023669826","https://openalex.org/W2024173492","https://openalex.org/W2024922880","https://openalex.org/W2027388429","https://openalex.org/W2028331547","https://openalex.org/W2030463961","https://openalex.org/W2033395644","https://openalex.org/W2035448076","https://openalex.org/W2037380629","https://openalex.org/W2037465347","https://openalex.org/W2038770898","https://openalex.org/W2039092171","https://openalex.org/W2039872800","https://openalex.org/W2048152070","https://openalex.org/W2057009745","https://openalex.org/W2062336842","https://openalex.org/W2069888996","https://openalex.org/W2070275362","https://openalex.org/W2075345533","https://openalex.org/W2077440911","https://openalex.org/W2077942662","https://openalex.org/W2080997656","https://openalex.org/W2081678712","https://openalex.org/W2095171239","https://openalex.org/W2095233711","https://openalex.org/W2100368827","https://openalex.org/W2124192107","https://openalex.org/W2124509140","https://openalex.org/W2149211603","https://openalex.org/W2245679498","https://openalex.org/W2259658508","https://openalex.org/W2259887534","https://openalex.org/W2267979169","https://openalex.org/W2292111191","https://openalex.org/W2316145923","https://openalex.org/W2345451452","https://openalex.org/W2444475331","https://openalex.org/W3037165371"],"related_works":["https://openalex.org/W1799745768","https://openalex.org/W2952682729","https://openalex.org/W2036068251","https://openalex.org/W2096493360","https://openalex.org/W1993065918","https://openalex.org/W1967183301","https://openalex.org/W2075345533","https://openalex.org/W1995075936","https://openalex.org/W2067494870","https://openalex.org/W2009121340"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-01-16T00:00:00"}
