{"id":"https://openalex.org/W4406428633","doi":null,"title":"MicroRNA Significance in Cancer: An Updated Review on Diagnostic, Prognostic, and Therapeutic Perspectives.","display_name":"MicroRNA Significance in Cancer: An Updated Review on Diagnostic, Prognostic, and Therapeutic Perspectives.","publication_year":2024,"publication_date":"2024-12-01","ids":{"openalex":"https://openalex.org/W4406428633","pmid":"https://pubmed.ncbi.nlm.nih.gov/39810890","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11726331"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11726331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11726331","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11726331/pdf/ejifcc-35-265.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJIFCC","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11726331/pdf/ejifcc-35-265.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102463650","display_name":"Vijay Singh","orcid":"https://orcid.org/0009-0000-7283-6008","observed_orcids":["https://orcid.org/0009-0000-7283-6008"]},"institutions":[{"id":"https://openalex.org/I4405257162","display_name":"All India Institute of Medical Sciences Gorakhpur","ror":"https://ror.org/04yve5w51","country_code":"IN","type":"government","lineage":["https://openalex.org/I4405257162"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vijay Singh","raw_affiliation_strings":["Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India","institution_ids":["https://openalex.org/I4405257162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101966019","display_name":"Aniruddha Sen","orcid":"https://orcid.org/0009-0007-5446-2015","observed_orcids":["https://orcid.org/0009-0007-5446-2015"]},"institutions":[{"id":"https://openalex.org/I4405257162","display_name":"All India Institute of Medical Sciences Gorakhpur","ror":"https://ror.org/04yve5w51","country_code":"IN","type":"government","lineage":["https://openalex.org/I4405257162"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aniruddha Sen","raw_affiliation_strings":["Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India","institution_ids":["https://openalex.org/I4405257162"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sapna Saini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257162","display_name":"All India Institute of Medical Sciences Gorakhpur","ror":"https://ror.org/04yve5w51","country_code":"IN","type":"government","lineage":["https://openalex.org/I4405257162"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sapna Saini","raw_affiliation_strings":["Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India","institution_ids":["https://openalex.org/I4405257162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043045848","display_name":"Shailendra Dwivedi","orcid":"https://orcid.org/0000-0003-2781-1009","observed_orcids":["https://orcid.org/0000-0003-2781-1009"]},"institutions":[{"id":"https://openalex.org/I4405257162","display_name":"All India Institute of Medical Sciences Gorakhpur","ror":"https://ror.org/04yve5w51","country_code":"IN","type":"government","lineage":["https://openalex.org/I4405257162"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shailendra Dwivedi","raw_affiliation_strings":["Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India","institution_ids":["https://openalex.org/I4405257162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112600621","display_name":"Ruchika Agrawal","orcid":"https://orcid.org/0000-0002-0671-2346","observed_orcids":["https://orcid.org/0000-0002-0671-2346"]},"institutions":[{"id":"https://openalex.org/I4405257162","display_name":"All India Institute of Medical Sciences Gorakhpur","ror":"https://ror.org/04yve5w51","country_code":"IN","type":"government","lineage":["https://openalex.org/I4405257162"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ruchika Agrawal","raw_affiliation_strings":["Department of ENT, All India Institute of Medical Sciences Gorakhpur, 273008, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of ENT, All India Institute of Medical Sciences Gorakhpur, 273008, India","institution_ids":["https://openalex.org/I4405257162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072328705","display_name":"Akash Bansal","orcid":"https://orcid.org/0000-0002-9574-9326","observed_orcids":["https://orcid.org/0000-0002-9574-9326"]},"institutions":[{"id":"https://openalex.org/I4405257162","display_name":"All India Institute of Medical Sciences Gorakhpur","ror":"https://ror.org/04yve5w51","country_code":"IN","type":"government","lineage":["https://openalex.org/I4405257162"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akash Bansal","raw_affiliation_strings":["Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India","institution_ids":["https://openalex.org/I4405257162"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040049038","display_name":"Shashank Shekhar","orcid":"https://orcid.org/0000-0001-8720-6690","observed_orcids":["https://orcid.org/0000-0001-8720-6690"]},"institutions":[{"id":"https://openalex.org/I4405257162","display_name":"All India Institute of Medical Sciences Gorakhpur","ror":"https://ror.org/04yve5w51","country_code":"IN","type":"government","lineage":["https://openalex.org/I4405257162"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shashank Shekhar","raw_affiliation_strings":["Department of Radiotherapy, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, 273008, India","institution_ids":["https://openalex.org/I4405257162"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405257162"],"apc_list":null,"apc_paid":null,"fwci":2.4031,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.8941425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"35","issue":"4","first_page":"265","last_page":"284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cancer-prognosis","display_name":"cancer prognosis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/microrna-therapy","display_name":"miRNA-based therapy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.9110000133514404},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7269999980926514},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9890000224113464},{"id":"https://openalex.org/keywords/non-invasive-diagnosis","display_name":"non-invasive diagnosis","score":0.6930000185966492},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7071962356567383},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5180197358131409},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4474843442440033},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4084896743297577},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35837411880493164},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3341415822505951},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2954881191253662},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2807600498199463},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08699044585227966},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05753964185714722}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:11726331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11726331","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11726331/pdf/ejifcc-35-265.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJIFCC","raw_type":"Text"},{"id":"pmid:39810890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39810890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJIFCC","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11726331","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11726331","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11726331/pdf/ejifcc-35-265.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJIFCC","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406428633.pdf","grobid_xml":"https://content.openalex.org/works/W4406428633.grobid-xml"},"referenced_works_count":116,"referenced_works":["https://openalex.org/W278034403","https://openalex.org/W1609044025","https://openalex.org/W1794091547","https://openalex.org/W1890576515","https://openalex.org/W1971624340","https://openalex.org/W1977066847","https://openalex.org/W1978337436","https://openalex.org/W1983932066","https://openalex.org/W1989002409","https://openalex.org/W2002347168","https://openalex.org/W2015727577","https://openalex.org/W2015967842","https://openalex.org/W2019812252","https://openalex.org/W2032395102","https://openalex.org/W2036446168","https://openalex.org/W2057650091","https://openalex.org/W2059310361","https://openalex.org/W2064131445","https://openalex.org/W2105679485","https://openalex.org/W2119604948","https://openalex.org/W2122906372","https://openalex.org/W2130823364","https://openalex.org/W2133658633","https://openalex.org/W2140775205","https://openalex.org/W2142352901","https://openalex.org/W2149024246","https://openalex.org/W2149966907","https://openalex.org/W2150712894","https://openalex.org/W2163169932","https://openalex.org/W2207322260","https://openalex.org/W2216943200","https://openalex.org/W2258698362","https://openalex.org/W2472885775","https://openalex.org/W2507120817","https://openalex.org/W2518630307","https://openalex.org/W2546568702","https://openalex.org/W2550146143","https://openalex.org/W2586687721","https://openalex.org/W2588649312","https://openalex.org/W2604757234","https://openalex.org/W2724312978","https://openalex.org/W2736520162","https://openalex.org/W2768567073","https://openalex.org/W2772713217","https://openalex.org/W2793471865","https://openalex.org/W2804641693","https://openalex.org/W2807343509","https://openalex.org/W2808293799","https://openalex.org/W2811212358","https://openalex.org/W2883688299","https://openalex.org/W2883963675","https://openalex.org/W2889792780","https://openalex.org/W2900597665","https://openalex.org/W2910445721","https://openalex.org/W2914072402","https://openalex.org/W2921690682","https://openalex.org/W2921836170","https://openalex.org/W2924908935","https://openalex.org/W2946359529","https://openalex.org/W2964067288","https://openalex.org/W2969078102","https://openalex.org/W2973469696","https://openalex.org/W2974676489","https://openalex.org/W2983138788","https://openalex.org/W2990550529","https://openalex.org/W3001041847","https://openalex.org/W3008665322","https://openalex.org/W3009900067","https://openalex.org/W3011296395","https://openalex.org/W3015098352","https://openalex.org/W3015491768","https://openalex.org/W3025605341","https://openalex.org/W3033941268","https://openalex.org/W3047743354","https://openalex.org/W3048404543","https://openalex.org/W3081631801","https://openalex.org/W3081980722","https://openalex.org/W3112060241","https://openalex.org/W3118146391","https://openalex.org/W3120487598","https://openalex.org/W3125907883","https://openalex.org/W3135324519","https://openalex.org/W3137090744","https://openalex.org/W3137321937","https://openalex.org/W3141563085","https://openalex.org/W3168395491","https://openalex.org/W3182630913","https://openalex.org/W3190093674","https://openalex.org/W3190872957","https://openalex.org/W3196939291","https://openalex.org/W3199373095","https://openalex.org/W3205473828","https://openalex.org/W4207020783","https://openalex.org/W4211200072","https://openalex.org/W4220788436","https://openalex.org/W4224980584","https://openalex.org/W4226225780","https://openalex.org/W4229334923","https://openalex.org/W4238531085","https://openalex.org/W4283692078","https://openalex.org/W4286433636","https://openalex.org/W4293536424","https://openalex.org/W4294225748","https://openalex.org/W4297977882","https://openalex.org/W4303859182","https://openalex.org/W4305015474","https://openalex.org/W4318052967","https://openalex.org/W4321611957","https://openalex.org/W4324146626","https://openalex.org/W4328127096","https://openalex.org/W4382400397","https://openalex.org/W4383820630","https://openalex.org/W4387134181","https://openalex.org/W4388854107","https://openalex.org/W4389040026","https://openalex.org/W4400872999"],"related_works":["https://openalex.org/W2334443293","https://openalex.org/W2780924192","https://openalex.org/W7128017557","https://openalex.org/W4393387364","https://openalex.org/W2111471857","https://openalex.org/W2408707838","https://openalex.org/W2039528004","https://openalex.org/W2473914314","https://openalex.org/W2922187344","https://openalex.org/W2126753949"],"abstract_inverted_index":{"The":[0,32,161,233,264],"article":[1,78,234],"provides":[2,163],"a":[3,48,110,193],"thorough":[4],"and":[5,99,120,226,241,248,274],"up-to-date":[6],"analysis":[7],"of":[8,17,54,75,84,102,128,159,166,169,195,269],"the":[9,15,38,52,67,73,81,100,156,167,230,238,250,267],"role":[10],"that":[11,42,62,70,146,261],"microRNAs":[12,85],"(miRNAs)":[13],"within":[14],"realm":[16],"cancer":[18,87,96,119,185,283],"therapy,":[19],"paying":[20],"specific":[21,124,225],"attention":[22],"to":[23,72,94,115,125,150,171,176,203,245],"their":[24,92,152,174,189],"diagnostic,":[25],"prognostic":[26],"as":[27,29,113,141,143,180,182,214,256,258,285,287],"well":[28,142,181,257,286],"therapeutic":[30,190],"capabilities.":[31],"miRNAs":[33,170],"(small":[34],"non-coding":[35],"RNAs)":[36],"are":[37,47,57,131,277],"current":[39,231,239],"major":[40],"genes":[41,98],"regulate":[43],"gene":[44],"expression.":[45],"They":[46,56],"key":[49,64],"factor":[50],"in":[51,66,117,154,201,279],"genesis":[53],"cancer.":[55,76,129,160,219],"oncogenes,":[58],"or":[59,210],"tumor":[60,178],"suppressors":[61],"play":[63,255],"functions":[65,253],"signaling":[68],"pathway":[69],"contribute":[71],"development":[74],"This":[77,89],"focuses":[79,236],"on":[80,237],"double":[82],"importance":[83,168],"for":[86,109,184,218,271],"oncogenesis.":[88],"includes":[90],"both":[91],"ability":[93,175],"inhibit":[95],"suppressor":[97],"stimulation":[101],"cancer-causing":[103],"oncogenes.":[104],"MicroRNAs":[105],"have":[106,121,147],"been":[107,148],"identified":[108],"long":[111],"time":[112],"biomarkers":[114],"help":[116],"diagnosing":[118],"distinct":[122],"signatures":[123],"different":[126],"kinds":[127],"There":[130],"many":[132],"detection":[133],"strategies":[134],"including":[135,207],"RT-qPCR,":[136],"Next":[137],"Generation":[138],"Sequencing":[139],"(NGS)":[140],"Microarray":[144],"Analysis":[145],"evaluated":[149],"prove":[151],"effectiveness":[153],"aiding":[155],"non-invasive":[157],"diagnosis":[158],"paper":[162],"an":[164],"overview":[165],"prognosis,":[172],"highlighting":[173],"forecast":[177],"progression":[179],"outcomes":[183],"patients.":[186],"In":[187],"addition,":[188],"value":[191],"remains":[192],"subject":[194],"research.":[196],"Research":[197],"is":[198,266],"being":[199],"conducted":[200],"order":[202],"investigate":[204],"miRNA-targeting":[205],"therapy":[206],"antisense":[208],"oligonucleotides,":[209],"small":[211],"molecules":[212],"inhibitors":[213],"possible":[215],"treatment":[216],"options":[217],"These":[220],"methods":[221],"could":[222],"favor":[223],"more":[224],"individualized":[227],"approaches":[228],"than":[229],"techniques.":[232],"also":[235],"challenges":[240],"future":[242],"prospects":[243],"linked":[244],"miRNA":[246],"research":[247,284],"demonstrates":[249],"complex":[251],"biological":[252],"they":[254],"clinical":[259],"applications":[260],"require":[262],"investigation.":[263],"review":[265],"source":[268],"information":[270],"researchers,":[272],"clinicians":[273],"scientists":[275],"who":[276],"interested":[278],"advancing":[280],"studies":[281],"into":[282],"personalized":[288],"treatments.":[289]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-01-16T00:00:00"}