{"id":"https://openalex.org/W4406410741","doi":"https://doi.org/10.1016/j.jaad.2025.01.015","title":"Establishing minimally important difference thresholds for lesion counts in acne clinical studies","display_name":"Establishing minimally important difference thresholds for lesion counts in acne clinical studies","publication_year":2025,"publication_date":"2025-01-16","ids":{"openalex":"https://openalex.org/W4406410741","doi":"https://doi.org/10.1016/j.jaad.2025.01.015","pmid":"https://pubmed.ncbi.nlm.nih.gov/39824353","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12009204"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaad.2025.01.015","doi":"https://doi.org/10.1016/j.jaad.2025.01.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaad.2025.01.015","pdf_url":null,"source":{"id":"https://openalex.org/S58727509","display_name":"Journal of the American Academy of Dermatology","issn_l":"0190-9622","issn":["0190-9622","1097-6787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of the American Academy of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.jaad.2025.01.015","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037026685","display_name":"John S. Barbieri","orcid":"https://orcid.org/0000-0002-5467-4102","observed_orcids":["https://orcid.org/0000-0002-5467-4102"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John S. Barbieri","raw_affiliation_strings":["Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address: jbarbieri@bwh.harvard.edu","Department of Dermatology, Brigham and Women's Hospital, Boston, MA. Electronic address: jbarbieri@bwh.harvard.edu"],"raw_orcid":"https://orcid.org/0000-0002-5467-4102","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address: jbarbieri@bwh.harvard.edu","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Department of Dermatology, Brigham and Women's Hospital, Boston, MA. Electronic address: jbarbieri@bwh.harvard.edu","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031001812","display_name":"Susan S. Ellenberg","orcid":"https://orcid.org/0000-0002-2364-5253","observed_orcids":["https://orcid.org/0000-0002-2364-5253"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan S. Ellenberg","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania","Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029517825","display_name":"Ann M. Tierney","orcid":"https://orcid.org/0000-0002-6912-4197","observed_orcids":["https://orcid.org/0000-0002-6912-4197"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Tierney","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania","Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Suzette Baez VanderBeek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzette Baez VanderBeek","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania","Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067109526","display_name":"Maryte Papadopoulos","orcid":"https://orcid.org/0000-0003-3410-6922","observed_orcids":["https://orcid.org/0000-0003-3410-6922"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryte Papadopoulos","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania","Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005014754","display_name":"Jennifer B. Mason","orcid":"https://orcid.org/0009-0001-0765-3579","observed_orcids":["https://orcid.org/0009-0001-0765-3579"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Mason","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania","Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113308083","display_name":"Anabel C. Mason","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anabel Mason","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania","Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023035293","display_name":"James Dattilo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Dattilo","raw_affiliation_strings":["Clinical Research Collaboration Unit, University of Pennsylvania, Philadelphia, Pennsylvania","Clinical Research Collaboration Unit, University of Pennsylvania, PhiladelphiaPA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Collaboration Unit, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Clinical Research Collaboration Unit, University of Pennsylvania, PhiladelphiaPA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057661348","display_name":"David J. Margolis","orcid":"https://orcid.org/0000-0002-0506-8085","observed_orcids":["https://orcid.org/0000-0002-0506-8085"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J. Margolis","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania","Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia PA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037026685"],"corresponding_institution_ids":["https://openalex.org/I1283280774"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":2.4831,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.86224665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"92","issue":"5","first_page":"1117","last_page":"1119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.12080000340938568,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.777999997138977},{"id":"https://openalex.org/keywords/minimally-important-difference","display_name":"minimally important difference","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lesion-count","display_name":"lesion count","score":0.9359999895095825},{"id":"https://openalex.org/keywords/inflammatory-lesions","display_name":"inflammatory lesions","score":0.8690000176429749},{"id":"https://openalex.org/keywords/comedones","display_name":"comedones","score":0.8479999899864197},{"id":"https://openalex.org/keywords/clinical-trial-endpoints","display_name":"clinical trial endpoints","score":0.4269999861717224},{"id":"https://openalex.org/keywords/treatment-effectiveness","display_name":"treatment effectiveness","score":0.5220000147819519},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9461098909378052},{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.6897449493408203},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5815876126289368},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.47925329208374023},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3273681402206421}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jaad.2025.01.015","doi":"https://doi.org/10.1016/j.jaad.2025.01.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaad.2025.01.015","pdf_url":null,"source":{"id":"https://openalex.org/S58727509","display_name":"Journal of the American Academy of Dermatology","issn_l":"0190-9622","issn":["0190-9622","1097-6787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of the American Academy of Dermatology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12009204","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12009204/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12009204/pdf/nihms-2049920.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Acad Dermatol","raw_type":"Text"},{"id":"pmid:39824353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39824353","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Academy of Dermatology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jaad.2025.01.015","doi":"https://doi.org/10.1016/j.jaad.2025.01.015","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaad.2025.01.015","pdf_url":null,"source":{"id":"https://openalex.org/S58727509","display_name":"Journal of the American Academy of Dermatology","issn_l":"0190-9622","issn":["0190-9622","1097-6787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Journal of the American Academy of Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000917792","display_name":"A randomized, double-blind, multi-center comparative effectiveness study of spironolactone versus doxycycline hyclate for the treatment of acne in women","funder_award_id":"U01AR079752","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406410741.pdf","grobid_xml":"https://content.openalex.org/works/W4406410741.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W1977733462","https://openalex.org/W2059034217","https://openalex.org/W3141739482","https://openalex.org/W4401051466"],"related_works":["https://openalex.org/W2107380584","https://openalex.org/W2022620402","https://openalex.org/W4388212993","https://openalex.org/W4288064942","https://openalex.org/W2342945504","https://openalex.org/W2626692862","https://openalex.org/W2789164638","https://openalex.org/W4206074865","https://openalex.org/W2164547764","https://openalex.org/W7098392421"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-01-16T00:00:00"}