{"id":"https://openalex.org/W4406364933","doi":"https://doi.org/10.2337/figshare.28184291.v1","title":"Cisplatin exposure dysregulates insulin secretion in male and female mice","display_name":"Cisplatin exposure dysregulates insulin secretion in male and female mice","publication_year":2025,"publication_date":"2025-01-14","ids":{"openalex":"https://openalex.org/W4406364933","doi":"https://doi.org/10.2337/figshare.28184291.v1"},"language":"en","primary_location":{"id":"doi:10.2337/figshare.28184291.v1","doi":"https://doi.org/10.2337/figshare.28184291.v1","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.28184291.v1","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2337/figshare.28184291.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021246141","display_name":"Lahari Basu","orcid":"https://orcid.org/0000-0002-6990-3529","observed_orcids":["https://orcid.org/0000-0002-6990-3529"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lahari Basu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107586806","display_name":"Lili Grieco-St-Pierre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lili Grieco-St-Pierre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084129183","display_name":"Ma. Enrica Angela Ching","orcid":"https://orcid.org/0000-0002-8458-8440","observed_orcids":["https://orcid.org/0000-0002-8458-8440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ma. Enrica Angela Ching","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021936585","display_name":"John D. H. Stead","orcid":"https://orcid.org/0000-0002-5726-6809","observed_orcids":["https://orcid.org/0000-0002-5726-6809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John D. H. Stead","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088820828","display_name":"Antonio A. Hanson","orcid":"https://orcid.org/0000-0001-7286-5669","observed_orcids":["https://orcid.org/0000-0001-7286-5669"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio A. Hanson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092536867","display_name":"Jana Palaniyandi","orcid":"https://orcid.org/0009-0005-3956-553X","observed_orcids":["https://orcid.org/0009-0005-3956-553X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jana Palaniyandi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030126018","display_name":"Erin J. Vanzyl","orcid":"https://orcid.org/0000-0001-8360-0340","observed_orcids":["https://orcid.org/0000-0001-8360-0340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erin P. van Zyl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020515512","display_name":"Myriam P Hoyeck","orcid":"https://orcid.org/0000-0003-4021-5770","observed_orcids":["https://orcid.org/0000-0003-4021-5770"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Myriam P. Hoyeck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113406373","display_name":"Kelsea S. McKay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelsea S. McKay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099014763","display_name":"Kyle A. van Allen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyle A. van Allen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100772125","display_name":"Hyo Jin Lee","orcid":"https://orcid.org/0000-0001-8378-3001","observed_orcids":["https://orcid.org/0000-0001-8378-3001"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyojin Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Xiao-Qing Dai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Qing Dai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111089169","display_name":"Austin Bautista","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Austin Bautista","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048655880","display_name":"Evgenia Fadzeyeva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evgenia Fadzeyeva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024168823","display_name":"Erin E. Mulvihill","orcid":"https://orcid.org/0000-0002-3981-0241","observed_orcids":["https://orcid.org/0000-0002-3981-0241"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erin E. Mulvihill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077375577","display_name":"Carole Lyn Yauk","orcid":"https://orcid.org/0000-0002-6725-3454","observed_orcids":["https://orcid.org/0000-0002-6725-3454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carole L. Yauk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012068599","display_name":"Jan Alexander Mennigen","orcid":"https://orcid.org/0000-0003-4117-6654","observed_orcids":["https://orcid.org/0000-0003-4117-6654"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan A. Mennigen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015722444","display_name":"Patrick E. MacDonald","orcid":"https://orcid.org/0000-0002-5439-6288","observed_orcids":["https://orcid.org/0000-0002-5439-6288"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick E. MacDonald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086759603","display_name":"Jennifer E. Bruin","orcid":"https://orcid.org/0000-0003-2326-7819","observed_orcids":["https://orcid.org/0000-0003-2326-7819"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer E. Bruin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.984000027179718},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cancer-survivors","display_name":"cancer survivors","score":0.7450000047683716},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7950000166893005},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.828000009059906},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7940000295639038},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.8830000162124634},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5450000166893005},{"id":"https://openalex.org/keywords/human-islets","display_name":"human islets","score":0.671999990940094},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6244534254074097},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6217398643493652},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.44910570979118347},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4451330900192261},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4385189116001129},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3441620469093323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.301172137260437},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.14468973875045776}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/figshare.28184291.v1","doi":"https://doi.org/10.2337/figshare.28184291.v1","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.28184291.v1","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2337/figshare.28184291.v1","doi":"https://doi.org/10.2337/figshare.28184291.v1","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.28184291.v1","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4308925338","https://openalex.org/W3039348435","https://openalex.org/W2966842106","https://openalex.org/W2949375004","https://openalex.org/W2031091218","https://openalex.org/W2069724779","https://openalex.org/W2380099415","https://openalex.org/W2150917396","https://openalex.org/W2095114253","https://openalex.org/W4412153856"],"abstract_inverted_index":{"Cancer":[0],"survivors":[1],"have":[2,203],"an":[3],"increased":[4],"risk":[5],"of":[6,43,130,154,176],"developing":[7],"Type":[8,32],"2":[9,33],"diabetes":[10,34],"compared":[11],"to":[12,27,55,73,80,103,122,133],"the":[13,41,128,139,151,157,173],"general":[14],"population.":[15],"Patients":[16],"treated":[17],"with":[18],"cisplatin,":[19],"a":[20,114],"common":[21],"chemotherapeutic":[22],"agent,":[23],"are":[24,184],"more":[25],"likely":[26],"develop":[28],"metabolic":[29],"syndrome":[30],"and":[31,37,90,109,138,181,201],"than":[35],"age-":[36],"sex-matched":[38],"controls.":[39],"Surprisingly,":[40],"impact":[42],"cisplatin":[44,77,101,126,177,193],"on":[45,178,206],"pancreatic":[46],"islets":[47,105],"has":[48],"not":[49],"been":[50],"reported.":[51],"Our":[52,189],"study":[53],"aimed":[54],"determine":[56],"if":[57],"mouse":[58,104,124,163],"islet":[59,207],"function":[60],"is":[61],"adversely":[62],"affected":[63],"by":[64],"systemic":[65],"(in":[66,70],"vivo)":[67],"or":[68],"direct":[69],"vitro)":[71],"exposure":[72,78,102,194],"cisplatin.":[74],"In":[75,99],"vivo":[76],"led":[79],"deficits":[81],"in":[82,87,96,113,161,186,198],"glucose-stimulated":[83],"plasma":[84],"insulin":[85,107,134,158,179,199],"levels":[86],"both":[88],"male":[89,123],"female":[91],"mice,":[92],"despite":[93],"no":[94],"differences":[95],"glucose":[97],"tolerance.":[98],"vitro":[100],"dysregulated":[106],"release":[108],"reduced":[110],"oxygen":[111],"consumption":[112],"non-sex":[115],"specific":[116],"manner.":[117],"When":[118],"shifting":[119],"our":[120],"focus":[121],"islets,":[125],"altered":[127],"expression":[129,148,183],"genes":[131,155],"related":[132],"production,":[135],"oxidative":[136],"stress,":[137],"Bcl-2":[140],"family":[141],"as":[142,144],"early":[143],"6-hours":[145],"post-exposure.":[146],"Genome-wide":[147],"analysis":[149],"confirmed":[150],"pronounced":[152],"downregulation":[153],"within":[156],"secretion":[159,180,200],"pathway":[160],"cisplatin-exposed":[162],"islets.":[164,188],"Data":[165],"from":[166],"3":[167],"human":[168,187],"organ":[169],"donors":[170],"confirms":[171],"that":[172,192],"detrimental":[174],"effects":[175,205],"gene":[182],"reproduced":[185],"findings":[190],"indicate":[191],"causes":[195],"significant":[196],"defects":[197],"may":[202],"lasting":[204],"health.":[208]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-01-15T00:00:00"}