{"id":"https://openalex.org/W4406311720","doi":"https://doi.org/10.1016/s0026-895x(24)13270-1","title":"Interleukin-1\u03b2 Induces Bradykinin B2 Receptor Gene Expression through a Prostanoid Cyclic AMP-Dependent Pathway in Human Bronchial Smooth Muscle Cells","display_name":"Interleukin-1\u03b2 Induces Bradykinin B2 Receptor Gene Expression through a Prostanoid Cyclic AMP-Dependent Pathway in Human Bronchial Smooth Muscle Cells","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W4406311720","doi":"https://doi.org/10.1016/s0026-895x(24)13270-1","mag":"1827292456","pmid":"https://pubmed.ncbi.nlm.nih.gov/9614202"},"language":"en","primary_location":{"id":"doi:10.1016/s0026-895x(24)13270-1","doi":"https://doi.org/10.1016/s0026-895x(24)13270-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0026-895x(24)13270-1","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025492450","display_name":"Fabien Schmidlin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabien Schmidlin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025864006","display_name":"Didier Scherrer","orcid":"https://orcid.org/0000-0001-9835-8550","observed_orcids":["https://orcid.org/0000-0001-9835-8550"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Didier Scherrer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047671567","display_name":"Laurent Daeffler","orcid":"https://orcid.org/0000-0001-5871-5082","observed_orcids":["https://orcid.org/0000-0001-5871-5082"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurent Daeffler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049873623","display_name":"Claude Bertrand","orcid":"https://orcid.org/0000-0002-5564-1767","observed_orcids":["https://orcid.org/0000-0002-5564-1767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claude Bertrand","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110274018","display_name":"Yves Landry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yves Landry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5104441935","display_name":"Jean\u2010Pierre Gies","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Pierre Gies","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":4.3292,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.94609805,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"53","issue":"6","first_page":"1009","last_page":"1015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.41429999470710754,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9340000152587891},{"id":"https://openalex.org/keywords/bradykinin-b2-receptor","display_name":"bradykinin B2 receptor","score":1.0},{"id":"https://openalex.org/keywords/bronchial-smooth-muscle-cells","display_name":"bronchial smooth muscle cells","score":0.8560000061988831},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.7639999985694885},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.8270000219345093},{"id":"https://openalex.org/keywords/prostanoids","display_name":"prostanoids","score":0.6990000009536743},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.6930000185966492},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.6790000200271606},{"id":"https://openalex.org/keywords/receptor-mrna-expression","display_name":"receptor mRNA expression","score":0.574999988079071},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9020000100135803},{"id":"https://openalex.org/keywords/inositol-phosphate-formation","display_name":"inositol phosphate formation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.7924333810806274},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.6464723944664001},{"id":"https://openalex.org/C2778266237","wikidata":"https://www.wikidata.org/wiki/Q962217","display_name":"Prostanoid","level":3,"score":0.5991789102554321},{"id":"https://openalex.org/C3017940444","wikidata":"https://www.wikidata.org/wiki/Q287961","display_name":"B2 receptor","level":4,"score":0.5974168181419373},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49705770611763},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48123788833618164},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45742878317832947},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41330695152282715},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35932376980781555},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34811797738075256},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33572083711624146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2935725748538971},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18449532985687256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17165717482566833}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018002","descriptor_name":"Receptors, Bradykinin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043782","descriptor_name":"Receptor, Bradykinin B2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0026-895x(24)13270-1","doi":"https://doi.org/10.1016/s0026-895x(24)13270-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0026-895x(24)13270-1","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmid:9614202","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9614202","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Journal Article"},{"id":"mag:1827292456","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9614202","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W140941701","https://openalex.org/W170281222","https://openalex.org/W1505408758","https://openalex.org/W1513611318","https://openalex.org/W1558437811","https://openalex.org/W1754684850","https://openalex.org/W1802980406","https://openalex.org/W1811025707","https://openalex.org/W1982932317","https://openalex.org/W1983116880","https://openalex.org/W1986077570","https://openalex.org/W1991801112","https://openalex.org/W1992280077","https://openalex.org/W2009716292","https://openalex.org/W2011508883","https://openalex.org/W2021253208","https://openalex.org/W2035862933","https://openalex.org/W2037321781","https://openalex.org/W2042981314","https://openalex.org/W2045246923","https://openalex.org/W2046029794","https://openalex.org/W2050405908","https://openalex.org/W2051674444","https://openalex.org/W2051693853","https://openalex.org/W2062069578","https://openalex.org/W2063641757","https://openalex.org/W2076919558","https://openalex.org/W2080913361","https://openalex.org/W2092427582","https://openalex.org/W2101979009","https://openalex.org/W2104324075","https://openalex.org/W2105429058","https://openalex.org/W2105896882","https://openalex.org/W2134812217","https://openalex.org/W2166781237","https://openalex.org/W2255296690","https://openalex.org/W2261420992","https://openalex.org/W2289305848","https://openalex.org/W2304927850","https://openalex.org/W2318473077","https://openalex.org/W6675725686","https://openalex.org/W6698395855","https://openalex.org/W6830204037"],"related_works":["https://openalex.org/W1827292456","https://openalex.org/W7095992250","https://openalex.org/W1970218372","https://openalex.org/W2289344015","https://openalex.org/W4239512792","https://openalex.org/W2125720205","https://openalex.org/W2002351066","https://openalex.org/W2019545209","https://openalex.org/W2079542777","https://openalex.org/W7001061672"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-01-13T00:00:00"}