{"id":"https://openalex.org/W4406311666","doi":"https://doi.org/10.1016/s0026-895x(24)13284-1","title":"Glycosylation within the Cysteine Loop and Six Residues Near Conserved Cys192/Cys193 Are Determinants of Neuronal Bungarotoxin Sensitivity on the Neuronal Nicotinic Receptor \u03b13 Subunit","display_name":"Glycosylation within the Cysteine Loop and Six Residues Near Conserved Cys192/Cys193 Are Determinants of Neuronal Bungarotoxin Sensitivity on the Neuronal Nicotinic Receptor \u03b13 Subunit","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W4406311666","doi":"https://doi.org/10.1016/s0026-895x(24)13284-1","mag":"1878991926","pmid":"https://pubmed.ncbi.nlm.nih.gov/9614216"},"language":"en","primary_location":{"id":"doi:10.1016/s0026-895x(24)13284-1","doi":"https://doi.org/10.1016/s0026-895x(24)13284-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0026-895x(24)13284-1","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063326564","display_name":"Charles W. Luetje","orcid":"https://orcid.org/0000-0002-7192-6674","observed_orcids":["https://orcid.org/0000-0002-7192-6674"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles W. Luetje","raw_affiliation_strings":["Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101 Current affiliation: Eli Lilly and Co., Lilly Corporate Center, Indianapolis, IN 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101 Current affiliation: Eli Lilly and Co., Lilly Corporate Center, Indianapolis, IN 46285","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067469475","display_name":"Floyd N. Maddox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Floyd N. Maddox","raw_affiliation_strings":["Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101 Current affiliation: Eli Lilly and Co., Lilly Corporate Center, Indianapolis, IN 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101 Current affiliation: Eli Lilly and Co., Lilly Corporate Center, Indianapolis, IN 46285","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I168537998"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103894751","display_name":"Scott C. Harvey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott C. Harvey","raw_affiliation_strings":["Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101 Current affiliation: Eli Lilly and Co., Lilly Corporate Center, Indianapolis, IN 46285"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101 Current affiliation: Eli Lilly and Co., Lilly Corporate Center, Indianapolis, IN 46285","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I168537998"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063326564"],"corresponding_institution_ids":["https://openalex.org/I145608581","https://openalex.org/I168537998"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.6782,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.66042497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"53","issue":"6","first_page":"1112","last_page":"1119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuronal-nicotinic-acetylcholine-receptors","display_name":"neuronal nicotinic acetylcholine receptors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/alpha3-subunit","display_name":"alpha3 subunit","score":0.875},{"id":"https://openalex.org/keywords/glycosylation","display_name":"glycosylation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/toxin-sensitivity","display_name":"toxin sensitivity","score":0.4099999964237213},{"id":"https://openalex.org/keywords/competitive-antagonists","display_name":"competitive antagonists","score":0.5170000195503235},{"id":"https://openalex.org/keywords/chimeric-receptors","display_name":"chimeric receptors","score":0.6399999856948853},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2777186327","wikidata":"https://www.wikidata.org/wiki/Q4997624","display_name":"Bungarotoxin","level":4,"score":0.6541091203689575},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6222403049468994},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5910556316375732},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.586513102054596},{"id":"https://openalex.org/C19876734","wikidata":"https://www.wikidata.org/wiki/Q5201170","display_name":"Cys-loop receptors","level":5,"score":0.5487526059150696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5054144859313965},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4929828345775604},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.489477276802063},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.463407039642334},{"id":"https://openalex.org/C2779570518","wikidata":"https://www.wikidata.org/wiki/Q412256","display_name":"Nicotinic acetylcholine receptor","level":4,"score":0.32246285676956177},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09827154874801636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002038","descriptor_name":"Bungarotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0026-895x(24)13284-1","doi":"https://doi.org/10.1016/s0026-895x(24)13284-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0026-895x(24)13284-1","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmid:9614216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9614216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Journal Article"},{"id":"mag:1878991926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9614216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2079073367","display_name":"Training Program in Cardiovascular Signaling","funder_award_id":"T32HL007188","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7775554894","display_name":"BINDING SITE STRUCTURE OF NEURONAL NICOTINIC RECEPTORS","funder_award_id":"R01DA008102","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W50917975","https://openalex.org/W185073285","https://openalex.org/W1531561158","https://openalex.org/W1571879661","https://openalex.org/W1577347730","https://openalex.org/W1608817464","https://openalex.org/W1799536240","https://openalex.org/W1970423878","https://openalex.org/W1997408992","https://openalex.org/W2011852440","https://openalex.org/W2011958145","https://openalex.org/W2018885303","https://openalex.org/W2020270595","https://openalex.org/W2022817121","https://openalex.org/W2037097116","https://openalex.org/W2038733372","https://openalex.org/W2043116166","https://openalex.org/W2043976254","https://openalex.org/W2051606745","https://openalex.org/W2052725697","https://openalex.org/W2057949770","https://openalex.org/W2058986020","https://openalex.org/W2061569848","https://openalex.org/W2061675635","https://openalex.org/W2065713456","https://openalex.org/W2088084661","https://openalex.org/W2089840974","https://openalex.org/W2091512475","https://openalex.org/W2093245980","https://openalex.org/W2116249462","https://openalex.org/W2116846032","https://openalex.org/W2125651649","https://openalex.org/W2138311296","https://openalex.org/W2162504777","https://openalex.org/W2338619556","https://openalex.org/W2340050369","https://openalex.org/W3022669110","https://openalex.org/W4237042838","https://openalex.org/W4241749677","https://openalex.org/W4319053089"],"related_works":["https://openalex.org/W1878991926","https://openalex.org/W2074976584","https://openalex.org/W2947861116","https://openalex.org/W2074422599","https://openalex.org/W4319053089","https://openalex.org/W1629345179","https://openalex.org/W2340050369","https://openalex.org/W2046988292","https://openalex.org/W2145071444","https://openalex.org/W2051894306"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-01-13T00:00:00"}
