{"id":"https://openalex.org/W4406311531","doi":"https://doi.org/10.1093/jsxmed/qdae201","title":"Evaluation of polygenic risk scores for hormones and receptors levels in patients with vestibulodynia: a case\u2013control study","display_name":"Evaluation of polygenic risk scores for hormones and receptors levels in patients with vestibulodynia: a case\u2013control study","publication_year":2025,"publication_date":"2025-01-12","ids":{"openalex":"https://openalex.org/W4406311531","doi":"https://doi.org/10.1093/jsxmed/qdae201","pmid":"https://pubmed.ncbi.nlm.nih.gov/39799433"},"language":"en","primary_location":{"id":"doi:10.1093/jsxmed/qdae201","doi":"https://doi.org/10.1093/jsxmed/qdae201","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jsxmed/qdae201","pdf_url":null,"source":{"id":"https://openalex.org/S159512450","display_name":"The Journal of Sexual Medicine","issn_l":"1743-6095","issn":["1743-6095","1743-6109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Sexual Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069157926","display_name":"Filippo Murina","orcid":"https://orcid.org/0000-0002-9966-6448","observed_orcids":["https://orcid.org/0000-0002-9966-6448"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210140859","display_name":"Ospedale dei Bambini Vittore Buzzi","ror":"https://ror.org/044ycg712","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210140859","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Filippo Murina","raw_affiliation_strings":["Lower Genital Tract Disease Unit, V. Buzzi Hospital\u2014University of the Study of Milan , Via Castelvetro 24-20124, Milan ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lower Genital Tract Disease Unit, V. Buzzi Hospital\u2014University of the Study of Milan , Via Castelvetro 24-20124, Milan ,","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210140859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002480412","display_name":"Cecilia Fochesato","orcid":"https://orcid.org/0000-0002-9612-5646","observed_orcids":["https://orcid.org/0000-0002-9612-5646"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210140859","display_name":"Ospedale dei Bambini Vittore Buzzi","ror":"https://ror.org/044ycg712","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210140859","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cecilia Fochesato","raw_affiliation_strings":["Lower Genital Tract Disease Unit, V. Buzzi Hospital\u2014University of the Study of Milan , Via Castelvetro 24-20124, Milan ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lower Genital Tract Disease Unit, V. Buzzi Hospital\u2014University of the Study of Milan , Via Castelvetro 24-20124, Milan ,","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210140859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021083272","display_name":"Chiara Leo","orcid":"https://orcid.org/0000-0003-0510-2535","observed_orcids":["https://orcid.org/0000-0003-0510-2535"]},"institutions":[{"id":"https://openalex.org/I4210117106","display_name":"Polo d\u2019Innovazione di Genomica","ror":"https://ror.org/0252wp173","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210117106"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Leo","raw_affiliation_strings":["Laboratory of Genomics\u2014Polo d\u2019Innovazione di Genomica, Genetica e Biologia , Strada del Petriccio e Belriguardo 35-53100, Siena ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genomics\u2014Polo d\u2019Innovazione di Genomica, Genetica e Biologia , Strada del Petriccio e Belriguardo 35-53100, Siena ,","institution_ids":["https://openalex.org/I4210117106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060561112","display_name":"Giuseppe Emanuele Condorelli","orcid":"https://orcid.org/0000-0002-8052-0844","observed_orcids":["https://orcid.org/0000-0002-8052-0844"]},"institutions":[{"id":"https://openalex.org/I4210117106","display_name":"Polo d\u2019Innovazione di Genomica","ror":"https://ror.org/0252wp173","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210117106"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe E Condorelli","raw_affiliation_strings":["Genetic and Ecology Research Centre\u2014Polo d\u2019Innovazione di Genomica, Genetica e Biologia , Via Fiorentina 1-05100, Terni ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic and Ecology Research Centre\u2014Polo d\u2019Innovazione di Genomica, Genetica e Biologia , Via Fiorentina 1-05100, Terni ,","institution_ids":["https://openalex.org/I4210117106"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anna Rocchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117106","display_name":"Polo d\u2019Innovazione di Genomica","ror":"https://ror.org/0252wp173","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210117106"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Rocchi","raw_affiliation_strings":["Laboratory of Genomics\u2014Polo d\u2019Innovazione di Genomica, Genetica e Biologia , Strada del Petriccio e Belriguardo 35-53100, Siena ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genomics\u2014Polo d\u2019Innovazione di Genomica, Genetica e Biologia , Strada del Petriccio e Belriguardo 35-53100, Siena ,","institution_ids":["https://openalex.org/I4210117106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045827547","display_name":"Sara Amitrano","orcid":"https://orcid.org/0009-0003-0100-2008","observed_orcids":["https://orcid.org/0009-0003-0100-2008"]},"institutions":[{"id":"https://openalex.org/I4210117106","display_name":"Polo d\u2019Innovazione di Genomica","ror":"https://ror.org/0252wp173","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210117106"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Amitrano","raw_affiliation_strings":["Laboratory of Genomics\u2014Polo d\u2019Innovazione di Genomica, Genetica e Biologia , Strada del Petriccio e Belriguardo 35-53100, Siena ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Genomics\u2014Polo d\u2019Innovazione di Genomica, Genetica e Biologia , Strada del Petriccio e Belriguardo 35-53100, Siena ,","institution_ids":["https://openalex.org/I4210117106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056942303","display_name":"Valerio Napolioni","orcid":"https://orcid.org/0000-0002-4378-6838","observed_orcids":["https://orcid.org/0000-0002-4378-6838"]},"institutions":[{"id":"https://openalex.org/I112859197","display_name":"Universit\u00e0 di Camerino","ror":"https://ror.org/0005w8d69","country_code":"IT","type":"education","lineage":["https://openalex.org/I112859197"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valerio Napolioni","raw_affiliation_strings":["Genomic and Molecular Epidemiology (GAME) Lab, School of Biosciences and Veterinary Medicine, University of Camerino , Camerino, Via Gentile III Da Varano 62032 Camerino (MC) ,","Genomic and Molecular Epidemiology (GAME) Lab, School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Via Gentile III Da Varano 62032 Camerino (MC), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic and Molecular Epidemiology (GAME) Lab, School of Biosciences and Veterinary Medicine, University of Camerino , Camerino, Via Gentile III Da Varano 62032 Camerino (MC) ,","institution_ids":["https://openalex.org/I112859197"]},{"raw_affiliation_string":"Genomic and Molecular Epidemiology (GAME) Lab, School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Via Gentile III Da Varano 62032 Camerino (MC), Italy","institution_ids":["https://openalex.org/I112859197"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029826178","display_name":"Valeria Maria Savasi","orcid":"https://orcid.org/0000-0002-1476-7689","observed_orcids":["https://orcid.org/0000-0002-1476-7689"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210156709","display_name":"ASST Fatebenefratelli Sacco","ror":"https://ror.org/05dy5ab02","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria Savasi","raw_affiliation_strings":["Clinical Obstetric and Gynecological V Buzzi, ASST-FBF-Sacco, Via Castelvetro 24-20124-University of the Study of Milan , Milan ,","Clinical Obstetric and Gynecological V Buzzi, ASST-FBF-Sacco, Via Castelvetro 24-20124-University of the Study of Milan, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Obstetric and Gynecological V Buzzi, ASST-FBF-Sacco, Via Castelvetro 24-20124-University of the Study of Milan , Milan ,","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210156709"]},{"raw_affiliation_string":"Clinical Obstetric and Gynecological V Buzzi, ASST-FBF-Sacco, Via Castelvetro 24-20124-University of the Study of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5069157926"],"corresponding_institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210140859"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.9832,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.70824311,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"22","issue":"3","first_page":"483","last_page":"490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.06620000302791595,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vestibulodynia","display_name":"vestibulodynia","score":0.9070000052452087},{"id":"https://openalex.org/keywords/vulvodynia","display_name":"vulvodynia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.9890000224113464},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7409999966621399},{"id":"https://openalex.org/keywords/sex-hormones","display_name":"sex hormones","score":0.6060000061988831},{"id":"https://openalex.org/keywords/hormone-receptors","display_name":"hormone receptors","score":0.9169999957084656},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.746999979019165},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.7419999837875366},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.5820000171661377},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor","display_name":"mineralocorticoid receptor","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pain-sensitivity","display_name":"pain sensitivity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/current-perception-threshold","display_name":"current perception threshold","score":0.6190000176429749},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C187869287","wikidata":"https://www.wikidata.org/wiki/Q2032061","display_name":"Endophenotype","level":3,"score":0.6072452068328857},{"id":"https://openalex.org/C2780549859","wikidata":"https://www.wikidata.org/wiki/Q1571008","display_name":"Vulvodynia","level":3,"score":0.5714728236198425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5462262034416199},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.522119402885437},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.470878928899765},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4174412488937378},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.41169121861457825},{"id":"https://openalex.org/C2780136519","wikidata":"https://www.wikidata.org/wiki/Q7161805","display_name":"Pelvic pain","level":2,"score":0.15430378913879395},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.07372826337814331},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000096442","descriptor_name":"Genetic Risk Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056650","descriptor_name":"Vulvodynia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D056650","descriptor_name":"Vulvodynia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/jsxmed/qdae201","doi":"https://doi.org/10.1093/jsxmed/qdae201","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jsxmed/qdae201","pdf_url":null,"source":{"id":"https://openalex.org/S159512450","display_name":"The Journal of Sexual Medicine","issn_l":"1743-6095","issn":["1743-6095","1743-6109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Sexual Medicine","raw_type":"journal-article"},{"id":"pmid:39799433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39799433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of sexual medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubblicazioni.unicam.it:11581/489063","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11581/489063","pdf_url":null,"source":{"id":"https://openalex.org/S4306400819","display_name":"Unicam Scientific Publications (University of Camerino)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I112859197","host_organization_name":"Universit\u00e0 di Camerino","host_organization_lineage":["https://openalex.org/I112859197"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1780466535","https://openalex.org/W1974260271","https://openalex.org/W1978948448","https://openalex.org/W1980115211","https://openalex.org/W1980195037","https://openalex.org/W2000770184","https://openalex.org/W2010203828","https://openalex.org/W2023517643","https://openalex.org/W2029142389","https://openalex.org/W2048163077","https://openalex.org/W2067690802","https://openalex.org/W2099085143","https://openalex.org/W2103380138","https://openalex.org/W2103441770","https://openalex.org/W2104549677","https://openalex.org/W2104803376","https://openalex.org/W2131271579","https://openalex.org/W2132807638","https://openalex.org/W2147963214","https://openalex.org/W2288293986","https://openalex.org/W2309188086","https://openalex.org/W2547433976","https://openalex.org/W2549627926","https://openalex.org/W2582743722","https://openalex.org/W2805983714","https://openalex.org/W2891826632","https://openalex.org/W2904771133","https://openalex.org/W3033232396","https://openalex.org/W3034916530","https://openalex.org/W3039522688","https://openalex.org/W3048245060","https://openalex.org/W3120048360","https://openalex.org/W3120295425","https://openalex.org/W3130945356","https://openalex.org/W3198348572","https://openalex.org/W4240924657","https://openalex.org/W4304136406","https://openalex.org/W4318753639","https://openalex.org/W4320497588","https://openalex.org/W4367834336","https://openalex.org/W4382631461","https://openalex.org/W4385613394","https://openalex.org/W4393094122","https://openalex.org/W4404485850"],"related_works":["https://openalex.org/W4411566646","https://openalex.org/W2911377320","https://openalex.org/W3043134366","https://openalex.org/W2542857811","https://openalex.org/W4246063373","https://openalex.org/W4410616563","https://openalex.org/W2413154625","https://openalex.org/W3130945356","https://openalex.org/W2056331704","https://openalex.org/W4414667819"],"abstract_inverted_index":{"BACKGROUND:":[0],"Vulvodynia":[1],"is":[2,16],"a":[3,38,68,196,337,349],"multifactorial":[4],"disease":[5,330,385],"affecting":[6],"7%-16%":[7],"of":[8,76,126,153,202,235,257,272,299,315,329,336],"reproductive-aged":[9],"women":[10,159],"in":[11,37,45,304],"general":[12],"population;":[13],"however,":[14],"little":[15],"still":[17],"known":[18],"about":[19],"the":[20,74,124,216,241,327,334],"genetics":[21],"underlying":[22],"this":[23],"complex":[24],"disease.":[25],"AIM:":[26],"To":[27],"compare":[28],"polygenic":[29,99,127,225,300,353],"risk":[30,100,128,226,301,321,354],"scores":[31,129,227,302,322],"for":[32,175],"hormones":[33,138],"and":[34,47,62,73,86,98,119,121,139,150,162,171,188,237,240,248,259,279,282,290,311,323,332,352,376,379,387],"receptors":[35,140],"levels":[36,90,201,234,256,271],"case-control":[39,55],"study":[40,56],"to":[41,110,122,137,199,209,360,371,383],"investigate":[42,123],"their":[43,48,224],"role":[44],"vulvodynia":[46],"correlation":[49],"with":[50,59,130,143,160,228],"clinical":[51,131,144,217,230,305,324,375],"phenotypes.":[52],"METHODS:":[53],"Our":[54],"included":[57],"patients":[58],"vestibulodynia":[60],"(VBD)":[61],"healthy":[63],"women.":[64],"All":[65],"participants":[66],"underwent":[67],"vestibular":[69,80,83,179,182,242],"cotton":[70],"swab":[71],"test":[72],"assessment":[75],"their:":[77],"pelvic":[78,185],"floor,":[79],"trophism,":[81],"ultrasound":[82],"mucosa":[84,180,243],"thickness,":[85,181],"current":[87],"perception":[88],"threshold":[89],"(Neurometer":[91],"CPT":[92],"device).":[93],"Shallow":[94],"whole":[95],"genome":[96],"sequencing":[97],"score":[101,355],"calculations":[102],"were":[103,108,165,173,389],"performed.":[104],"Linear":[105],"regression":[106],"models":[107],"applied":[109],"predict":[111],"whether":[112],"genomic":[113,135,197,233,255,270],"predisposition":[114,136,198],"varied":[115],"significantly":[116],"between":[117,169,223],"cases":[118,170,219],"controls,":[120],"relationship":[125],"endophenotypes.":[132],"OUTCOMES:":[133],"The":[134],"levels,":[141],"together":[142],"endophenotypes,":[145,218],"can":[146,307],"support":[147],"VBD":[148,161],"diagnosis":[149,310],"personalized":[151,312,338],"treatment":[152,314,388],"related":[154],"pain":[155,189],"condition.":[156],"RESULTS:":[157],"Thirty":[158],"30":[163],"controls":[164,172,210,372],"recruited.":[166],"Significant":[167],"differences":[168,369],"observed":[174],"body":[176],"mass":[177],"index,":[178],"trophic":[183],"health,":[184],"floor":[186],"hypertone":[187],"sensitivity":[190],"(P":[191,211],"<":[192,212,252,267,294],".05).":[193,213,295],"Cases":[194,366],"showed":[195,220,367],"higher":[200],"membrane-associated":[203,274],"progesterone":[204,275],"receptor":[205,239,276,281],"component":[206,277],"1":[207],"compared":[208,370],"When":[214],"considering":[215],"significant":[221,368],"correlations":[222],"several":[229],"measures:":[231],"predicted":[232,254,269],"testosterone":[236],"estrogen":[238],"thickness":[244],"values":[245],"(estimates:":[246],"9.74E-09":[247],"9.16E-08,":[249],"respectively;":[250,292],"P":[251,266,293],".05);":[253,268],"prolactin":[258],"Neurometer":[260,283],"data":[261,284,325,344,378],"at":[262,285],"250":[263],"Hz":[264,287],"(-2.15E-07;":[265],"prolactin,":[273],"2":[278],"mineralocorticoid":[280],"5":[286],"(-3.75E-07,":[288],"-3.43E-07":[289],"-3.06E-07,":[291],"CLINICAL":[296],"IMPLICATIONS:":[297],"Introduction":[298],"evaluation":[303],"practice":[306],"assist":[308],"early":[309],"therapeutic":[313,339],"VBD.":[316],"STRENGTHS":[317],"AND":[318],"LIMITATIONS:":[319],"Polygenic":[320],"allowed":[326],"identification":[328],"endophenotypes":[331,381],"highlighted":[333],"possibility":[335],"approach.":[340],"As":[341],"limitations,":[342],"these":[343],"should":[345,357],"be":[346,358],"confirmed":[347],"on":[348,373],"larger":[350],"cohort":[351],"calculation":[356],"adapted":[359],"ancestries":[361],"other":[362],"than":[363],"European.":[364],"CONCLUSION:":[365],"both":[374],"genetic":[377],"specific":[380],"necessary":[382],"classify":[384],"development":[386],"identified.":[390]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-01-13T00:00:00"}