{"id":"https://openalex.org/W4406292843","doi":"https://doi.org/10.24873/j.rpemd.2024.12.1264","title":"#035 Impacto da fenilceton\u00faria no desenvolvimento de defeitos de esmalte dent\u00e1rio: Caso cl\u00ednico","display_name":"#035 Impacto da fenilceton\u00faria no desenvolvimento de defeitos de esmalte dent\u00e1rio: Caso cl\u00ednico","publication_year":2024,"publication_date":"2024-12-30","ids":{"openalex":"https://openalex.org/W4406292843","doi":"https://doi.org/10.24873/j.rpemd.2024.12.1264"},"language":"pt","primary_location":{"id":"doi:10.24873/j.rpemd.2024.12.1264","doi":"https://doi.org/10.24873/j.rpemd.2024.12.1264","is_oa":true,"landing_page_url":"https://doi.org/10.24873/j.rpemd.2024.12.1264","pdf_url":null,"source":{"id":"https://openalex.org/S2898265778","display_name":"Revista Portuguesa de Estomatologia Medicina Dent\u00e1ria e Cirurgia Maxilofacial","issn_l":"1646-2890","issn":["1646-2890","1647-6700"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","norway-1","poland-20","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310315687","host_organization_name":"CIG Media Group","host_organization_lineage":["https://openalex.org/P4310315687"],"host_organization_lineage_names":["CIG Media Group"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Portuguesa de Estomatologia, Medicina Dent\u00e1ria e Cirurgia Maxilofacial","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.24873/j.rpemd.2024.12.1264","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jo\u00e3o Louren\u00e7o","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Louren\u00e7o","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"In\u00eas Borges","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"In\u00eas Borges","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115853729","display_name":"Catarina Norte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catarina Norte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143184334","display_name":"Andreia Fernandes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreia Fernandes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Carlos Salgado","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Salgado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112781995","display_name":"Jos\u00e9 Figueiredo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Figueiredo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"s1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenylketonuria","display_name":"phenylketonuria","score":0.9819999933242798},{"id":"https://openalex.org/keywords/enamel-defects","display_name":"enamel defects","score":0.7749999761581421},{"id":"https://openalex.org/keywords/enamel-hypomineralization","display_name":"enamel hypomineralization","score":0.8930000066757202},{"id":"https://openalex.org/keywords/enamel-hypoplasia","display_name":"enamel hypoplasia","score":0.8659999966621399},{"id":"https://openalex.org/keywords/dentin-hypersensitivity","display_name":"dentin hypersensitivity","score":0.8199999928474426},{"id":"https://openalex.org/keywords/phenylalanine-metabolism","display_name":"phenylalanine metabolism","score":0.703000009059906},{"id":"https://openalex.org/keywords/ameloblasts","display_name":"ameloblasts","score":0.734000027179718},{"id":"https://openalex.org/keywords/enamel-matrix-proteins","display_name":"enamel matrix proteins","score":0.7570000290870667},{"id":"https://openalex.org/keywords/primary-dentition","display_name":"primary teeth","score":0.5730000138282776},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.6330000162124634},{"id":"https://openalex.org/keywords/oral-hygiene-education","display_name":"dental hygiene education","score":0.43299999833106995},{"id":"https://openalex.org/keywords/caries-risk","display_name":"caries risk","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.36572080850601196}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.24873/j.rpemd.2024.12.1264","doi":"https://doi.org/10.24873/j.rpemd.2024.12.1264","is_oa":true,"landing_page_url":"https://doi.org/10.24873/j.rpemd.2024.12.1264","pdf_url":null,"source":{"id":"https://openalex.org/S2898265778","display_name":"Revista Portuguesa de Estomatologia Medicina Dent\u00e1ria e Cirurgia Maxilofacial","issn_l":"1646-2890","issn":["1646-2890","1647-6700"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","norway-1","poland-20","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310315687","host_organization_name":"CIG Media Group","host_organization_lineage":["https://openalex.org/P4310315687"],"host_organization_lineage_names":["CIG Media Group"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Portuguesa de Estomatologia, Medicina Dent\u00e1ria e Cirurgia Maxilofacial","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.24873/j.rpemd.2024.12.1264","doi":"https://doi.org/10.24873/j.rpemd.2024.12.1264","is_oa":true,"landing_page_url":"https://doi.org/10.24873/j.rpemd.2024.12.1264","pdf_url":null,"source":{"id":"https://openalex.org/S2898265778","display_name":"Revista Portuguesa de Estomatologia Medicina Dent\u00e1ria e Cirurgia Maxilofacial","issn_l":"1646-2890","issn":["1646-2890","1647-6700"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","norway-1","poland-20","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310315687","host_organization_name":"CIG Media Group","host_organization_lineage":["https://openalex.org/P4310315687"],"host_organization_lineage_names":["CIG Media Group"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Portuguesa de Estomatologia, Medicina Dent\u00e1ria e Cirurgia Maxilofacial","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2399072620","https://openalex.org/W2019160434","https://openalex.org/W7055808781","https://openalex.org/W2565913527","https://openalex.org/W6891707201","https://openalex.org/W2763417632","https://openalex.org/W6925150401","https://openalex.org/W4405261671","https://openalex.org/W7120512184","https://openalex.org/W2782669410"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o:":[0],"O":[1,264,272,307],"esmalte":[2,51,193],"dent\u00e1rio,":[3],"constitu\u00eddo":[4],"por":[5,13,104,170],"97%":[6],"de":[7,9,30,43,50,76,83,99,128,151,153,164,178,194,199,201,221,228,237,276,284,286,296,345],"cristais":[8],"hidroxiapatite,":[10],"\u00e9":[11,90],"produzido":[12],"c\u00e9lulas":[14],"especializadas":[15],"conhecidas":[16],"como":[17,34,223,235,315],"ameloblastos.":[18],"A":[19,87,288],"sua":[20],"forma\u00e7\u00e3o":[21,67],"divide-":[22],"se":[23],"em":[24,40,71,117,125,184,197,259],"est\u00e1gios":[25,41],"iniciais,":[26],"envolvendo":[27],"a":[28,114,122,267,312,341],"secre\u00e7\u00e3o":[29],"prote\u00ednas":[31],"da":[32,97,107,226,245,274,309,343],"matriz,":[33],"amelogenina,":[35],"ameloblastina":[36],"e":[37,39,45,132,143,156,173,249,311,326,337,339],"enamelina,":[38],"posteriores,":[42],"mineraliza\u00e7\u00e3o":[44,84],"matura\u00e7\u00e3o.":[46],"Defeitos":[47],"no":[48,130,133],"desenvolvimento":[49,152],"(DDE)":[52],"s\u00e3o":[53,319],"comuns":[54],"na":[55,66,74,81,213],"denti\u00e7\u00e3o":[56],"prim\u00e1ria":[57],"e/ou":[58,62],"permanente.":[59],"Fatores":[60],"ambientais":[61],"gen\u00e9ticos":[63],"podem":[64],"interferir":[65],"do":[68,95,160,215,347],"esmalte,":[69,222],"resultando":[70],"hipoplasia":[72],"(altera\u00e7\u00e3o":[73,80],"fase":[75,82],"secre\u00e7\u00e3o)":[77],"ou":[78,85,205],"hipomineraliza\u00e7\u00e3o":[79],"matura\u00e7\u00e3o).":[86],"fenilceton\u00faria":[88],"(PKU)":[89],"um":[91,138,238,323,327],"defeito":[92],"cong\u00e9nito":[93],"raro":[94],"metabolismo":[96],"fenilalanina,":[98],"heran\u00e7a":[100],"autoss\u00f3mica":[101],"recessiva,":[102],"causado":[103],"uma":[105,224],"defici\u00eancia":[106],"enzima":[108,112],"fenilalanina":[109,115],"hidroxilase.":[110],"Esta":[111],"converte":[113],"(PHE)":[116],"tirosina.":[118],"Se":[119],"n\u00e3o":[120],"tratada,":[121],"PKU":[123,254],"resulta":[124],"concentra\u00e7\u00f5es":[126],"elevadas":[127],"PHE":[129],"sangue":[131],"c\u00e9rebro,":[134],"o":[135,243,305],"que":[136],"provoca":[137],"grave":[139],"d\u00e9fice":[140],"cognitivo,":[141],"epilepsia":[142],"altra\u00e7\u00f5es":[144],"comportamentais.":[145],"Estes":[146],"doentes":[147,252,291],"apresentam":[148,255],"ainda":[149],"risco":[150],"DDE,":[154,258],"c\u00e1ries":[155,204,277],"doen\u00e7a":[157,227],"periodontal.":[158],"Descri\u00e7\u00e3o":[159],"Caso":[161],"Cl\u00ednico:":[162],"Menino":[163],"11":[165],"anos,":[166],"referenciado":[167],"\u00e0":[168,281],"consulta":[169],"altera\u00e7\u00f5es":[171,207,220],"dent\u00e1rias":[172],"sensibilidade":[174],"dent\u00e1ria.":[175],"Antecedente":[176],"pessoal":[177],"PKU.":[179],"Ao":[180],"Exame":[181],"Objectivo,":[182],"apresentava,":[183],"todos":[185],"os":[186,333],"dentes,":[187],"\u00e1reas":[188],"brancas":[189],"opacas,":[190],"intercaladas":[191],"com":[192,240,253,261,300],"colora\u00e7\u00e3o":[195],"normal,":[196],"aspecto":[198],"\u00b4c\u00f3digo":[200],"barras\u00b4.":[202],"Sem":[203],"outras":[206],"relevantes.":[208],"Os":[209,251],"achados":[210],"cl\u00ednicos,":[211],"contextualizados":[212],"hist\u00f3ria":[214],"doente,":[216],"permitem":[217],"enquadrar":[218],"as":[219],"manifesta\u00e7\u00e3o":[225],"base.":[229],"Foram":[230],"refor\u00e7adas":[231],"medidas":[232],"higieno-diet\u00e9ticas,":[233],"bem":[234],"prescri\u00e7\u00e3o":[236],"dent\u00edfrico":[239],"arginina":[241],"para":[242,303,321],"tratamento":[244,328],"hipersensiblidade":[246],"dentin\u00e1ria.":[247],"Discuss\u00e3o":[248],"Conclus\u00f5es:":[250],"significativamente":[256],"mais":[257],"compara\u00e7\u00e3o":[260],"indiv\u00edduos":[262],"saud\u00e1veis.":[263],"mecanismo":[265],"subjacente":[266],"esta":[268],"altera\u00e7\u00e3o":[269],"permanece":[270],"inconclusivo.":[271],"aumento":[273],"preval\u00eancia":[275],"pode":[278],"estar":[279],"ligado":[280],"elevada":[282],"ingest\u00e3o":[283],"hidratos":[285],"carbono.":[287],"dieta":[289],"destes":[290],"inclui":[292],"substitutos":[293],"proteicos":[294],"isentos":[295],"PHE,":[297],"frequentemente":[298],"misturados":[299],"bebidas":[301],"a\u00e7ucaradas":[302],"melhorar":[304],"sabor.":[306],"reconhecimento":[308],"patologia":[310],"investiga\u00e7\u00e3o":[313],"cl\u00ednica,":[314],"demonstrado":[316],"neste":[317],"caso,":[318],"fundamentais":[320],"assegurar":[322],"diagn\u00f3stico":[324],"precoce":[325],"apropriado,":[329],"reduzindo":[330],"ao":[331],"m\u00ednimo":[332],"danos":[334],"biol\u00f3gicos,":[335],"psicol\u00f3gicos":[336],"sociais,":[338],"promovendo":[340],"restaura\u00e7\u00e3o":[342],"qualidade":[344],"vida":[346],"utente.":[348]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-01-12T00:00:00"}
