{"id":"https://openalex.org/W4406283471","doi":"https://doi.org/10.1016/j.chroma.2025.465663","title":"Frit-inlet asymmetric flow field-flow fractionation for the analysis of lipid nanoparticle-protein interactions","display_name":"Frit-inlet asymmetric flow field-flow fractionation for the analysis of lipid nanoparticle-protein interactions","publication_year":2025,"publication_date":"2025-01-11","ids":{"openalex":"https://openalex.org/W4406283471","doi":"https://doi.org/10.1016/j.chroma.2025.465663","pmid":"https://pubmed.ncbi.nlm.nih.gov/39826279"},"language":"en","primary_location":{"id":"doi:10.1016/j.chroma.2025.465663","doi":"https://doi.org/10.1016/j.chroma.2025.465663","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chroma.2025.465663","pdf_url":null,"source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.chroma.2025.465663","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007981470","display_name":"Rand Abdulrahman","orcid":"https://orcid.org/0009-0007-1781-0893","observed_orcids":["https://orcid.org/0009-0007-1781-0893"]},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rand Abdulrahman","raw_affiliation_strings":["Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK"],"raw_orcid":"https://orcid.org/0009-0007-1781-0893","affiliations":[{"raw_affiliation_string":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK","institution_ids":["https://openalex.org/I181647926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091965834","display_name":"Panida Punnabhum","orcid":"https://orcid.org/0009-0002-6830-1072","observed_orcids":["https://orcid.org/0009-0002-6830-1072"]},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Panida Punnabhum","raw_affiliation_strings":["Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK"],"raw_orcid":"https://orcid.org/0009-0002-6830-1072","affiliations":[{"raw_affiliation_string":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK","institution_ids":["https://openalex.org/I181647926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088732380","display_name":"Robin Bruno Capomaccio","orcid":"https://orcid.org/0000-0001-7164-2340","observed_orcids":["https://orcid.org/0000-0001-7164-2340"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robin Capomaccio","raw_affiliation_strings":["New Modalities Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New Modalities Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067361587","display_name":"Kevin Edward Treacher","orcid":"https://orcid.org/0000-0002-8705-3476","observed_orcids":["https://orcid.org/0000-0002-8705-3476"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin Treacher","raw_affiliation_strings":["New Modalities Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UK"],"raw_orcid":"https://orcid.org/0000-0002-8705-3476","affiliations":[{"raw_affiliation_string":"New Modalities Product Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011580238","display_name":"Yvonne Perrie","orcid":"https://orcid.org/0000-0001-8497-2541","observed_orcids":["https://orcid.org/0000-0001-8497-2541","https://orcid.org/0009-0007-1248-067X"]},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yvonne Perrie","raw_affiliation_strings":["Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK","institution_ids":["https://openalex.org/I181647926"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059167331","display_name":"Zahra Rattray","orcid":"https://orcid.org/0000-0002-8371-8549","observed_orcids":["https://orcid.org/0000-0002-8371-8549"]},"institutions":[{"id":"https://openalex.org/I181647926","display_name":"University of Strathclyde","ror":"https://ror.org/00n3w3b69","country_code":"GB","type":"education","lineage":["https://openalex.org/I181647926"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Zahra Rattray","raw_affiliation_strings":["Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK. Electronic address: zahra.rattray@strath.ac.uk"],"raw_orcid":"https://orcid.org/0000-0002-8371-8549","affiliations":[{"raw_affiliation_string":"Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK. Electronic address: zahra.rattray@strath.ac.uk","institution_ids":["https://openalex.org/I181647926"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059167331"],"corresponding_institution_ids":["https://openalex.org/I181647926"],"apc_list":{"value":4040,"currency":"USD","value_usd":4040},"apc_paid":{"value":4040,"currency":"USD","value_usd":4040},"fwci":4.2258,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.95817968,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"1743","issue":null,"first_page":"465663","last_page":"465663"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12850","display_name":"Field-Flow Fractionation Techniques","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12850","display_name":"Field-Flow Fractionation Techniques","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":0.9549999833106995},{"id":"https://openalex.org/keywords/bovine-serum-albumin","display_name":"bovine serum albumin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/asymmetric-flow-field-flow-fractionation","display_name":"asymmetrical flow field-flow fractionation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/protein-corona","display_name":"protein corona","score":0.8090000152587891},{"id":"https://openalex.org/keywords/nanoparticle-aggregation","display_name":"nanoparticle aggregation","score":0.718999981880188},{"id":"https://openalex.org/keywords/dynamic-light-scattering","display_name":"dynamic light scattering","score":0.7120000123977661},{"id":"https://openalex.org/keywords/particle-size-distribution","display_name":"particle size distribution","score":0.597000002861023},{"id":"https://openalex.org/keywords/shape-factor","display_name":"shape factor","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9275442361831665},{"id":"https://openalex.org/C68930688","wikidata":"https://www.wikidata.org/wiki/Q383361","display_name":"Frit","level":2,"score":0.9131988286972046},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7260115146636963},{"id":"https://openalex.org/C97428945","wikidata":"https://www.wikidata.org/wiki/Q15305109","display_name":"Fractionation","level":2,"score":0.706826388835907},{"id":"https://openalex.org/C16031182","wikidata":"https://www.wikidata.org/wiki/Q782281","display_name":"Field flow fractionation","level":3,"score":0.6730071902275085},{"id":"https://openalex.org/C201289731","wikidata":"https://www.wikidata.org/wiki/Q1172599","display_name":"Inlet","level":2,"score":0.6333289742469788},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.5800886154174805},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.46246546506881714},{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.4408716857433319},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.21616452932357788},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.13916999101638794},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.13834622502326965},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000067493","descriptor_name":"Dynamic Light Scattering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D031521","descriptor_name":"Fractionation, Field Flow","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D031521","descriptor_name":"Fractionation, Field Flow","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.chroma.2025.465663","doi":"https://doi.org/10.1016/j.chroma.2025.465663","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chroma.2025.465663","pdf_url":null,"source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.4956046","doi":"https://doi.org/10.2139/ssrn.4956046","is_oa":true,"landing_page_url":"http://dx.doi.org/10.2139/ssrn.4956046","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:39826279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39826279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatography. A","raw_type":"Journal Article"},{"id":"pmh:oai:strathprints.strath.ac.uk:91836","doi":null,"is_oa":true,"landing_page_url":"https://strathprints.strath.ac.uk/view/author/1448293.html>","pdf_url":"https://strathprints.strath.ac.uk/91836/7/Abdulrahman-etal-JCA-2025-Frit-inlet-asymmetric-flow-field-flow-fractionation-for-the-analysis-of.pdf","source":{"id":"https://openalex.org/S4306402226","display_name":"Strathprints: The University of Strathclyde institutional repository (University of Strathclyde)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181647926","host_organization_name":"University of Strathclyde","host_organization_lineage":["https://openalex.org/I181647926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.chroma.2025.465663","doi":"https://doi.org/10.1016/j.chroma.2025.465663","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chroma.2025.465663","pdf_url":null,"source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3458228074","display_name":"Multiscale Metrology Suite for Next-Generation Health Nanotechnologies","funder_award_id":"EP/V028960/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406283471.pdf","grobid_xml":"https://content.openalex.org/works/W4406283471.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1875275023","https://openalex.org/W1979249140","https://openalex.org/W1995704440","https://openalex.org/W2000410329","https://openalex.org/W2021876818","https://openalex.org/W2050886209","https://openalex.org/W2051809212","https://openalex.org/W2083249633","https://openalex.org/W2122046010","https://openalex.org/W2133445717","https://openalex.org/W2138574167","https://openalex.org/W2143743183","https://openalex.org/W2287068442","https://openalex.org/W2335577615","https://openalex.org/W2340665676","https://openalex.org/W2788471465","https://openalex.org/W2792887123","https://openalex.org/W2795918326","https://openalex.org/W2907115174","https://openalex.org/W2936556314","https://openalex.org/W2943930028","https://openalex.org/W2954783697","https://openalex.org/W2989771286","https://openalex.org/W2991326193","https://openalex.org/W3000173939","https://openalex.org/W3074781351","https://openalex.org/W3107052846","https://openalex.org/W3137336075","https://openalex.org/W3207886513","https://openalex.org/W3210990421","https://openalex.org/W4206693046","https://openalex.org/W4220945494","https://openalex.org/W4281384029","https://openalex.org/W4289731877","https://openalex.org/W4378952562","https://openalex.org/W4386736381","https://openalex.org/W4386944448","https://openalex.org/W4387764872","https://openalex.org/W4390446467","https://openalex.org/W4391144896","https://openalex.org/W4392551216","https://openalex.org/W4396674417","https://openalex.org/W4404500442"],"related_works":["https://openalex.org/W4408245256","https://openalex.org/W4405643255","https://openalex.org/W7124930919","https://openalex.org/W3137336075","https://openalex.org/W7029065447","https://openalex.org/W7223225790","https://openalex.org/W4404211713","https://openalex.org/W7060718882","https://openalex.org/W2991326193","https://openalex.org/W4401334300"],"abstract_inverted_index":{"Research":[0],"into":[1],"nanoparticle":[2],"interactions":[3,67],"with":[4,68,80,89,178],"biomolecules":[5],"has":[6],"become":[7],"increasingly":[8],"important":[9],"in":[10,27,31],"nanomedicine.":[11],"While":[12],"lipid":[13],"nanoparticles":[14],"(LNPs)":[15],"are":[16],"widely":[17],"used":[18],"as":[19],"drug":[20],"delivery":[21],"systems,":[22,180],"there":[23],"remains":[24],"a":[25,69,130,138],"gap":[26],"understanding":[28],"their":[29,66],"fate":[30],"circulation,":[32],"which":[33],"is":[34,45],"crucial":[35],"for":[36,125,143,153,181],"selecting":[37],"appropriate":[38],"lipids":[39],"during":[40],"formulation":[41],"development.":[42],"This":[43],"study":[44,169],"the":[46,81,95,171],"first":[47],"to":[48,56,83],"use":[49],"Asymmetric":[50],"Flow":[51,53],"Field":[52],"Fractionation":[54],"(AF4)":[55],"compare":[57],"two":[58,123],"types":[59],"of":[60,97,134,141,173],"LNPs:":[61],"MC3-LNPs":[62],"and":[63,65,101,115,145,147,151,159,189],"SM-102-LNPs,":[64],"model":[70],"protein,":[71],"bovine":[72],"serum":[73],"albumin":[74],"(BSA).":[75],"AF4":[76,120],"offers":[77],"high-resolution":[78],"separation,":[79],"ability":[82],"simultaneously":[84,182],"perform":[85],"multiparametric":[86],"inline":[87,110],"analysis":[88],"multiple":[90],"detectors.":[91],"In":[92],"this":[93,168],"study,":[94],"impact":[96],"LNP":[98],"size,":[99],"morphology":[100],"PDI":[102],"on":[103],"BSA":[104],"corona":[105],"formation":[106],"were":[107],"examined":[108],"using":[109],"multiangle":[111],"light":[112,117],"scattering":[113,118],"(MALS)":[114],"dynamic":[116],"(DLS).":[119],"separation":[121],"revealed":[122],"subpopulations":[124],"MC3-LNPs,":[126],"while":[127],"SM102-LNPs":[128],"exhibited":[129,163],"single":[131],"population.":[132],"Analysis":[133],"shape":[135,139],"factor":[136,140],"indicated":[137],"0.783":[142],"SM-102-BSA":[144],"0.741":[146],"0.795":[148],"(peak":[149],"1":[150],"2)":[152],"MC3-BSA,":[154],"confirming":[155],"interaction":[156],"between":[157],"LNPs":[158,162,184],"BSA.":[160],"Both":[161],"LNP-BSA":[164],"induced":[165],"aggregation.":[166],"Overall,":[167],"demonstrates":[170],"effectiveness":[172],"AF4,":[174],"particularly":[175],"when":[176],"hyphenated":[177],"multidetector":[179],"separating":[183],"from":[185],"complex":[186],"biological":[187],"media":[188],"studying":[190],"LNP-protein":[191],"interactions.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-01-12T00:00:00"}
