{"id":"https://openalex.org/W4406277901","doi":"https://doi.org/10.1016/j.pbb.2025.173958","title":"Differential reductions in alcohol consumption and cue-induced alcohol-seeking behavior following mGlu5 receptor inhibition in the prelimbic vs. infralimbic subregions of the rat prefrontal cortex","display_name":"Differential reductions in alcohol consumption and cue-induced alcohol-seeking behavior following mGlu5 receptor inhibition in the prelimbic vs. infralimbic subregions of the rat prefrontal cortex","publication_year":2025,"publication_date":"2025-01-11","ids":{"openalex":"https://openalex.org/W4406277901","doi":"https://doi.org/10.1016/j.pbb.2025.173958","pmid":"https://pubmed.ncbi.nlm.nih.gov/39805474","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11846690"},"language":"en","primary_location":{"id":"doi:10.1016/j.pbb.2025.173958","doi":"https://doi.org/10.1016/j.pbb.2025.173958","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pbb.2025.173958","pdf_url":null,"source":{"id":"https://openalex.org/S59685179","display_name":"Pharmacology Biochemistry and Behavior","issn_l":"0091-3057","issn":["0091-3057","1873-5177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pharmacology Biochemistry and Behavior","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.pbb.2025.173958","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027920612","display_name":"Jonna M. Leyrer\u2010Jackson","orcid":"https://orcid.org/0000-0001-9460-6641","observed_orcids":["https://orcid.org/0000-0001-9460-6641"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonna M. Leyrer-Jackson","raw_affiliation_strings":["Department of Psychology, Arizona State University, Tempe, AZ 85257, United States of America; Department of Medical Education, School of Medicine, Creighton University, Phoenix, AZ 85012, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Arizona State University, Tempe, AZ 85257, United States of America; Department of Medical Education, School of Medicine, Creighton University, Phoenix, AZ 85012, United States of America","institution_ids":["https://openalex.org/I114493937","https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041754145","display_name":"Peter R. Kufahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter R. Kufahl","raw_affiliation_strings":["Department of Psychology, Arizona State University, Tempe, AZ 85257, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Arizona State University, Tempe, AZ 85257, United States of America","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076836999","display_name":"Michael Foster Olive","orcid":"https://orcid.org/0000-0002-2517-0351","observed_orcids":["https://orcid.org/0000-0002-2517-0351"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. Foster Olive","raw_affiliation_strings":["Department of Psychology, Arizona State University, Tempe, AZ 85257, United States of America. Electronic address: foster.olive@asu.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Arizona State University, Tempe, AZ 85257, United States of America. Electronic address: foster.olive@asu.edu","institution_ids":["https://openalex.org/I55732556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076836999"],"corresponding_institution_ids":["https://openalex.org/I55732556"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":null,"fwci":0.3912,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.49487226,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"248","issue":null,"first_page":"173958","last_page":"173958"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mglu5-receptor","display_name":"mGlu5 receptor","score":0.9319999814033508},{"id":"https://openalex.org/keywords/metabotropic-glutamate-receptors","display_name":"metabotropic glutamate receptors","score":0.8410000205039978},{"id":"https://openalex.org/keywords/mtep","display_name":"MTEP","score":0.902999997138977},{"id":"https://openalex.org/keywords/prelimbic-cortex","display_name":"prelimbic cortex","score":0.8090000152587891},{"id":"https://openalex.org/keywords/infralimbic-cortex","display_name":"infralimbic cortex","score":1.0},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.8949999809265137},{"id":"https://openalex.org/keywords/alcohol-self-administration","display_name":"alcohol self-administration","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alcohol-seeking-behavior","display_name":"alcohol seeking","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cue-induced-reinstatement","display_name":"cue-induced reinstatement","score":0.843999981880188},{"id":"https://openalex.org/keywords/alcohol-relapse","display_name":"alcohol relapse","score":0.7440000176429749},{"id":"https://openalex.org/keywords/glutamatergic-signaling","display_name":"glutamatergic signaling","score":0.7960000038146973},{"id":"https://openalex.org/keywords/alcohol-abuse","display_name":"alcohol abuse","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C2779934784","wikidata":"https://www.wikidata.org/wiki/Q16259058","display_name":"Infralimbic cortex","level":4,"score":0.9013396501541138},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.7392104864120483},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5645179748535156},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.5318388938903809},{"id":"https://openalex.org/C3019635848","wikidata":"https://www.wikidata.org/wiki/Q154","display_name":"Alcohol consumption","level":3,"score":0.5019552707672119},{"id":"https://openalex.org/C3019921246","wikidata":"https://www.wikidata.org/wiki/Q104853310","display_name":"Differential effects","level":2,"score":0.4405752718448639},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4382808208465576},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26297473907470703},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24143263697624207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23166361451148987},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.13840055465698242},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06098097562789917}],"mesh":[{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003463","descriptor_name":"Cues","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012646","descriptor_name":"Self Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058999","descriptor_name":"Drug-Seeking Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D064529","descriptor_name":"Receptor, Metabotropic Glutamate 5","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.pbb.2025.173958","doi":"https://doi.org/10.1016/j.pbb.2025.173958","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pbb.2025.173958","pdf_url":null,"source":{"id":"https://openalex.org/S59685179","display_name":"Pharmacology Biochemistry and Behavior","issn_l":"0091-3057","issn":["0091-3057","1873-5177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pharmacology Biochemistry and Behavior","raw_type":"journal-article"},{"id":"pmid:39805474","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39805474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology, biochemistry, and behavior","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11846690","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11846690/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacol Biochem Behav","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.pbb.2025.173958","doi":"https://doi.org/10.1016/j.pbb.2025.173958","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pbb.2025.173958","pdf_url":null,"source":{"id":"https://openalex.org/S59685179","display_name":"Pharmacology Biochemistry and Behavior","issn_l":"0091-3057","issn":["0091-3057","1873-5177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pharmacology Biochemistry and Behavior","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1750564801","display_name":"Brain endorphin targets of low dose alcohol","funder_award_id":"R01AA025590","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G2409952829","display_name":null,"funder_award_id":"AA025590","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G273431278","display_name":null,"funder_award_id":"AA013852","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G4825366545","display_name":"The role of pro-opiomelanocortin neuronal circuitry in mediating ethanol consumption","funder_award_id":"F32AA027962","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G4948998521","display_name":null,"funder_award_id":"AA013852","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G7123229749","display_name":null,"funder_award_id":"AA025590","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G7520527658","display_name":null,"funder_award_id":"AA030061","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G8087408045","display_name":null,"funder_award_id":"AA030061","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G8366672157","display_name":null,"funder_award_id":"F32AA027962","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G8416825325","display_name":"Control of Ethanol Intake by an mGluR5-PKCe Pathway","funder_award_id":"R01AA013852","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000873511","display_name":"Regulation of binge-like ethanol intake by arcuate POMC projection neurons","funder_award_id":"R01AA030061","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W249845531","https://openalex.org/W1498046084","https://openalex.org/W1614638811","https://openalex.org/W1875588855","https://openalex.org/W1910215401","https://openalex.org/W1934123343","https://openalex.org/W1962536263","https://openalex.org/W1963557453","https://openalex.org/W1967041207","https://openalex.org/W1969953568","https://openalex.org/W1983982251","https://openalex.org/W1984433012","https://openalex.org/W1987916086","https://openalex.org/W1999172222","https://openalex.org/W2003622126","https://openalex.org/W2005019035","https://openalex.org/W2007745798","https://openalex.org/W2009833394","https://openalex.org/W2022746377","https://openalex.org/W2026782481","https://openalex.org/W2037923993","https://openalex.org/W2041828744","https://openalex.org/W2044656761","https://openalex.org/W2057281025","https://openalex.org/W2078530990","https://openalex.org/W2081280243","https://openalex.org/W2091245236","https://openalex.org/W2099858791","https://openalex.org/W2106570464","https://openalex.org/W2111359832","https://openalex.org/W2137227339","https://openalex.org/W2140041201","https://openalex.org/W2590768186","https://openalex.org/W2598781693","https://openalex.org/W2599400127","https://openalex.org/W2609681471","https://openalex.org/W2740032591","https://openalex.org/W2766763196","https://openalex.org/W2768732542","https://openalex.org/W2782662916","https://openalex.org/W2783590820","https://openalex.org/W2785020270","https://openalex.org/W2789955855","https://openalex.org/W2943836719","https://openalex.org/W2972170675","https://openalex.org/W2972517341","https://openalex.org/W3085059467","https://openalex.org/W3172099106","https://openalex.org/W3210459606","https://openalex.org/W4220822678","https://openalex.org/W4223625010","https://openalex.org/W4310670612","https://openalex.org/W4364374924","https://openalex.org/W4398168872","https://openalex.org/W4399567510"],"related_works":["https://openalex.org/W2068883542","https://openalex.org/W7166846536","https://openalex.org/W2009308797","https://openalex.org/W1992195578","https://openalex.org/W2050940101","https://openalex.org/W2124691694","https://openalex.org/W2561379541","https://openalex.org/W2782662916","https://openalex.org/W1984433012","https://openalex.org/W2803719513"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-01-11T00:00:00"}