{"id":"https://openalex.org/W4406240367","doi":"https://doi.org/10.1016/j.nbd.2025.106803","title":"Peripherally administered TNF inhibitor is not protective against \u03b1-synuclein-induced dopaminergic neuronal death in rats","display_name":"Peripherally administered TNF inhibitor is not protective against \u03b1-synuclein-induced dopaminergic neuronal death in rats","publication_year":2025,"publication_date":"2025-01-10","ids":{"openalex":"https://openalex.org/W4406240367","doi":"https://doi.org/10.1016/j.nbd.2025.106803","pmid":"https://pubmed.ncbi.nlm.nih.gov/39800228"},"language":"en","primary_location":{"id":"doi:10.1016/j.nbd.2025.106803","doi":"https://doi.org/10.1016/j.nbd.2025.106803","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbd.2025.106803","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.nbd.2025.106803","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082209159","display_name":"Josefine R\u00e5g\u00e5rd Christiansen","orcid":"https://orcid.org/0000-0001-9808-9290","observed_orcids":["https://orcid.org/0000-0001-9808-9290"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Josefine R. Christiansen","raw_affiliation_strings":["Department of Biomedicine & Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, 8000 Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine & Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, 8000 Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011493455","display_name":"Sara Almeida Ferreira","orcid":"https://orcid.org/0000-0001-6943-514X","observed_orcids":["https://orcid.org/0000-0001-6943-514X"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Sara A. Ferreira","raw_affiliation_strings":["Department of Biomedicine & Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, 8000 Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine & Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, 8000 Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054821101","display_name":"David E. Szymkowski","orcid":"https://orcid.org/0000-0002-8934-7902","observed_orcids":["https://orcid.org/0000-0002-8934-7902"]},"institutions":[{"id":"https://openalex.org/I4210133987","display_name":"Xencor (United States)","ror":"https://ror.org/03v2jew50","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Szymkowski","raw_affiliation_strings":["Xencor, Inc, Pasadena, CA 91107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xencor, Inc, Pasadena, CA 91107, USA","institution_ids":["https://openalex.org/I4210133987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021760406","display_name":"Johan Jakobsson","orcid":"https://orcid.org/0000-0003-0669-7673","observed_orcids":["https://orcid.org/0000-0003-0669-7673"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Johan Jakobsson","raw_affiliation_strings":["Department of Experimental Medical Science, Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, Lund University, BMC A11 and B10, S-221 84 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medical Science, Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, Lund University, BMC A11 and B10, S-221 84 Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008036209","display_name":"Mal\u00fa G. Tansey","orcid":"https://orcid.org/0000-0002-1719-4708","observed_orcids":["https://orcid.org/0000-0002-1719-4708"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mal\u00fa G\u00e1mez Tansey","raw_affiliation_strings":["Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, United States of America","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019698136","display_name":"Marina Romero\u2010Ramos","orcid":"https://orcid.org/0000-0003-0970-578X","observed_orcids":["https://orcid.org/0000-0003-0970-578X"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Marina Romero-Ramos","raw_affiliation_strings":["Department of Biomedicine & Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, 8000 Aarhus, Denmark. Electronic address: mrr@biomed.au.dk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine & Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, 8000 Aarhus, Denmark. Electronic address: mrr@biomed.au.dk","institution_ids":["https://openalex.org/I204337017"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":{"value":4180,"currency":"USD","value_usd":4180},"fwci":1.6493,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.8067238,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"206","issue":null,"first_page":"106803","last_page":"106803"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.8180000185966492},{"id":"https://openalex.org/keywords/xpro1595","display_name":"XPro1595","score":0.8960000276565552},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.777999997138977},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.8389999866485596},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/nigrostriatal-neurons","display_name":"nigrostriatal neurons","score":0.7820000052452087},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.7940000295639038},{"id":"https://openalex.org/keywords/systemic-drug-administration","display_name":"systemic drug administration","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7988347411155701},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5736641883850098},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5620657205581665},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5356993079185486},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5222744941711426},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.5010776519775391},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.45186737179756165},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44422051310539246},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3516843318939209},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.22198104858398438},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1808173656463623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17852553725242615},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10936442017555237}],"mesh":[{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.nbd.2025.106803","doi":"https://doi.org/10.1016/j.nbd.2025.106803","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbd.2025.106803","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},{"id":"doi:10.1101/2024.10.11.617361","doi":"https://doi.org/10.1101/2024.10.11.617361","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.10.11.617361","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:39800228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39800228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:da7ac3f680864d99b491c3c6bfccb537","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/da7ac3f680864d99b491c3c6bfccb537","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurobiology of Disease, Vol 206, Iss , Pp 106803- (2025)","raw_type":"article"},{"id":"pmh:oai:lup.lub.lu.se:8b30fd74-5d7f-4b2a-8908-e10e6b03825d","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/8b30fd74-5d7f-4b2a-8908-e10e6b03825d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0969-9961","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:openaire/e75731df-306b-493d-928d-001864ca7d11","doi":null,"is_oa":true,"landing_page_url":"https://www.scopus.com/pages/publications/85215077406","pdf_url":null,"source":{"id":"https://openalex.org/S4306400063","display_name":"Scopus (Elsevier)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Christiansen, J R, Ferreira, S A, Szymkowski, D E, Jakobsson, J, Tansey, M G & Romero-Ramos, M 2025, 'Peripherally administered TNF inhibitor is not protective against \u03b1-synuclein-induced dopaminergic neuronal death in rats', Neurobiology of Disease, vol. 206, 106803. https://doi.org/10.1016/j.nbd.2025.106803","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.nbd.2025.106803","doi":"https://doi.org/10.1016/j.nbd.2025.106803","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbd.2025.106803","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.44999998807907104,"display_name":"Zero hunger"},{"id":"https://metadata.un.org/sdg/3","score":0.4399999976158142,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W249845531","https://openalex.org/W1516639618","https://openalex.org/W1588261022","https://openalex.org/W1605537968","https://openalex.org/W1627786998","https://openalex.org/W1965624208","https://openalex.org/W1968117332","https://openalex.org/W1972931472","https://openalex.org/W1974573191","https://openalex.org/W1979480763","https://openalex.org/W1985419351","https://openalex.org/W1989734945","https://openalex.org/W1996650387","https://openalex.org/W1998241928","https://openalex.org/W1998981667","https://openalex.org/W2000580759","https://openalex.org/W2001176185","https://openalex.org/W2002506451","https://openalex.org/W2004205580","https://openalex.org/W2006345152","https://openalex.org/W2010395737","https://openalex.org/W2026413177","https://openalex.org/W2047402066","https://openalex.org/W2065422132","https://openalex.org/W2066734010","https://openalex.org/W2075281870","https://openalex.org/W2075680729","https://openalex.org/W2084334114","https://openalex.org/W2086255604","https://openalex.org/W2100078626","https://openalex.org/W2100898704","https://openalex.org/W2101243397","https://openalex.org/W2102323773","https://openalex.org/W2107646604","https://openalex.org/W2108231900","https://openalex.org/W2110749444","https://openalex.org/W2115643906","https://openalex.org/W2127908035","https://openalex.org/W2128833728","https://openalex.org/W2129665374","https://openalex.org/W2137829901","https://openalex.org/W2138685136","https://openalex.org/W2139661803","https://openalex.org/W2141504417","https://openalex.org/W2143604504","https://openalex.org/W2150223407","https://openalex.org/W2154804587","https://openalex.org/W2159272429","https://openalex.org/W2165028896","https://openalex.org/W2233667077","https://openalex.org/W2516694652","https://openalex.org/W2590492263","https://openalex.org/W2607325787","https://openalex.org/W2737283516","https://openalex.org/W2748514674","https://openalex.org/W2806723183","https://openalex.org/W2902812364","https://openalex.org/W3016942694","https://openalex.org/W3044513361","https://openalex.org/W3103631184","https://openalex.org/W3138862697","https://openalex.org/W4214833982","https://openalex.org/W4281629037","https://openalex.org/W4282548171","https://openalex.org/W4294733729","https://openalex.org/W4309409968","https://openalex.org/W4360809405","https://openalex.org/W4380324514","https://openalex.org/W4380366503","https://openalex.org/W4382059965","https://openalex.org/W4388774853","https://openalex.org/W4389686514","https://openalex.org/W4395085502","https://openalex.org/W6650502776","https://openalex.org/W6838625311","https://openalex.org/W6853385555","https://openalex.org/W6873260311"],"related_works":["https://openalex.org/W3119178414","https://openalex.org/W2093078804","https://openalex.org/W2053807370","https://openalex.org/W4401931767","https://openalex.org/W2076034638","https://openalex.org/W4407819105","https://openalex.org/W2029174044","https://openalex.org/W4401621282","https://openalex.org/W2799562270","https://openalex.org/W3009999791"],"abstract_inverted_index":{"The":[0,19],"underlying":[1],"cause":[2],"of":[3,44,71,81,98,126,148,152,170,200,206,237],"neuronal":[4],"loss":[5,147],"in":[6,16,48,84,105,159,175,183,197,241],"Parkinson's":[7],"disease":[8],"(PD)":[9],"remains":[10],"unknown,":[11],"but":[12],"evidence":[13],"implicates":[14],"neuroinflammation":[15],"PD":[17,86,109,136],"pathobiology.":[18],"pro-inflammatory":[20],"cytokine":[21],"soluble":[22,63,238],"tumor":[23],"necrosis":[24],"factor":[25],"(TNF)":[26],"seems":[27],"to":[28,131,220,231],"play":[29],"an":[30,212],"important":[31],"role":[32],"and":[33,155,162,177],"thus":[34],"has":[35],"been":[36],"proposed":[37],"as":[38],"a":[39,99,124],"therapeutic":[40,101,235],"target":[41],"for":[42,91,123],"modulation":[43],"the":[45,68,78,92,95,106,118,168,171,179,184,188,193,198,201,204,234],"neuroinflammatory":[46],"processes":[47],"PD.":[49,242],"In":[50,129],"this":[51,216],"regard,":[52],"dominant-negative":[53],"TNF":[54,64,239],"(DN-TNF)":[55],"agents":[56],"are":[57,229],"promising":[58],"antagonists":[59],"that":[60],"selectively":[61],"inhibit":[62],"signaling,":[65],"while":[66],"preserving":[67],"beneficial":[69],"effects":[70],"transmembrane":[72],"TNF.":[73],"Previous":[74],"studies":[75,133,228],"have":[76],"tested":[77],"protective":[79,96],"potential":[80,97,236],"DN-TNF-based":[82],"therapy":[83],"toxin-based":[85],"models.":[87],"Here":[88],"we":[89,116],"test":[90],"first":[93],"time":[94],"DN-TNF":[100,119],"against":[102,222],"\u03b1-synuclein-driven":[103],"neurodegeneration":[104],"viral":[107,223],"vector-based":[108],"female":[110],"rat":[111],"model.":[112],"To":[113],"do":[114],"so,":[115],"administered":[117],"agent":[120],"XPro1595":[121,144,165],"subcutaneously":[122],"period":[125],"12":[127],"weeks.":[128],"contrast":[130],"previous":[132],"using":[134],"different":[135],"models,":[137],"neuroprotection":[138],"was":[139,157],"not":[140,191,218],"achieved":[141],"by":[142],"systemic":[143],"treatment.":[145],"\u03b1-Synuclein-induced":[146],"nigrostriatal":[149],"neurons,":[150],"accumulation":[151],"pathological":[153],"inclusions":[154],"microgliosis":[156],"detected":[158],"both":[160],"XPro1595-":[161],"saline-treated":[163],"animals.":[164,186],"treatment":[166,189],"increased":[167],"percentage":[169],"hypertrophic/ameboid":[172],"Iba1+":[173],"cells":[174],"SN":[176,199],"reduced":[178],"striatal":[180],"MHCII+":[181],"expression":[182],"\u03b1-synuclein-overexpressing":[185],"However,":[187],"did":[190,217],"prevent":[192],"MHCII":[194],"upregulation":[195],"seen":[196],"model,":[202],"nor":[203],"increase":[205],"CD68+":[207],"phagocytic":[208],"cells.":[209],"Therefore,":[210],"despite":[211],"apparently":[213],"immunomodulatory":[214],"effect,":[215],"suffice":[219],"protect":[221],"vector-derived":[224],"\u03b1-synuclein-induced":[225],"neurotoxicity.":[226],"Further":[227],"warranted":[230],"better":[232],"elucidate":[233],"inhibitors":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}