{"id":"https://openalex.org/W4406233558","doi":"https://doi.org/10.3103/s0891416824700253","title":"CPG Oligonucleotides as Vaccine Adjuvants for Prevention of Infectious Diseases","display_name":"CPG Oligonucleotides as Vaccine Adjuvants for Prevention of Infectious Diseases","publication_year":2024,"publication_date":"2024-09-01","ids":{"openalex":"https://openalex.org/W4406233558","doi":"https://doi.org/10.3103/s0891416824700253"},"language":"en","primary_location":{"id":"doi:10.3103/s0891416824700253","doi":"https://doi.org/10.3103/s0891416824700253","is_oa":false,"landing_page_url":"https://doi.org/10.3103/s0891416824700253","pdf_url":null,"source":{"id":"https://openalex.org/S200760274","display_name":"Molecular Genetics Microbiology and Virology","issn_l":"0891-4168","issn":["0891-4168","1934-841X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Genetics, Microbiology and Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028951864","display_name":"Andrey Mikhailovich Zhirov","orcid":"https://orcid.org/0000-0002-7698-7361","observed_orcids":["https://orcid.org/0000-0002-7698-7361"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A. M. Zhirov","raw_affiliation_strings":["Stavropol Plague Control Research Institute, 355035, Stavropol, Russia"],"raw_orcid":"https://orcid.org/0000-0002-7698-7361","affiliations":[{"raw_affiliation_string":"Stavropol Plague Control Research Institute, 355035, Stavropol, Russia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017429728","display_name":"\u041a\u043e\u0432\u0430\u043b\u0435\u0432 \u0414\u043c\u0438\u0442\u0440\u0438\u0439 \u0410\u043d\u0430\u0442\u043e\u043b\u044c\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0002-9366-5647","observed_orcids":["https://orcid.org/0000-0002-9366-5647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. A. Kovalev","raw_affiliation_strings":["Stavropol Plague Control Research Institute, 355035, Stavropol, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stavropol Plague Control Research Institute, 355035, Stavropol, Russia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012302189","display_name":"\u0421. \u0410. \u041a\u0443\u0440\u0447\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0002-3564-0791","observed_orcids":["https://orcid.org/0000-0002-3564-0791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. A. Kurcheva","raw_affiliation_strings":["Stavropol Plague Control Research Institute, 355035, Stavropol, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stavropol Plague Control Research Institute, 355035, Stavropol, Russia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073966811","display_name":"\u0414. \u0413. \u041f\u043e\u043d\u043e\u043c\u0430\u0440\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0003-0422-6755","observed_orcids":["https://orcid.org/0000-0003-0422-6755"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. G. Ponomarenko","raw_affiliation_strings":["Stavropol Plague Control Research Institute, 355035, Stavropol, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stavropol Plague Control Research Institute, 355035, Stavropol, Russia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015999333","display_name":"\u0410. \u041d. \u041a\u0443\u043b\u0438\u0447\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0002-9362-3949","observed_orcids":["https://orcid.org/0000-0002-9362-3949"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. N. Kulichenko","raw_affiliation_strings":["Stavropol Plague Control Research Institute, 355035, Stavropol, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stavropol Plague Control Research Institute, 355035, Stavropol, Russia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028951864"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.449,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.52705891,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"39","issue":"3","first_page":"209","last_page":"218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.24789999425411224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cpg-oligodeoxynucleotides","display_name":"CpG oligodeoxynucleotides","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":0.984000027179718},{"id":"https://openalex.org/keywords/innate-immune-activation","display_name":"innate immune activation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/protein-vaccine","display_name":"protein vaccine","score":0.7400000095367432},{"id":"https://openalex.org/keywords/infectious-disease-prevention","display_name":"infectious disease prevention","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8078429102897644},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.7250520586967468},{"id":"https://openalex.org/C3020289777","wikidata":"https://www.wikidata.org/wiki/Q967453","display_name":"Vaccine adjuvant","level":3,"score":0.6190721392631531},{"id":"https://openalex.org/C22801619","wikidata":"https://www.wikidata.org/wiki/Q477471","display_name":"CpG Oligodeoxynucleotide","level":5,"score":0.5802547335624695},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5747964382171631},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.4523925185203552},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.44095420837402344},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4335029423236847},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3872980773448944},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.21213558316230774},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19989913702011108},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14171454310417175},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.07599470019340515},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3103/s0891416824700253","doi":"https://doi.org/10.3103/s0891416824700253","is_oa":false,"landing_page_url":"https://doi.org/10.3103/s0891416824700253","pdf_url":null,"source":{"id":"https://openalex.org/S200760274","display_name":"Molecular Genetics Microbiology and Virology","issn_l":"0891-4168","issn":["0891-4168","1934-841X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Genetics, Microbiology and Virology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W781277998","https://openalex.org/W1485179699","https://openalex.org/W1524792851","https://openalex.org/W1544722565","https://openalex.org/W1549003425","https://openalex.org/W1596740642","https://openalex.org/W1603446342","https://openalex.org/W1606632249","https://openalex.org/W1696638240","https://openalex.org/W1917892434","https://openalex.org/W1963563273","https://openalex.org/W1965565095","https://openalex.org/W1970291282","https://openalex.org/W1986315531","https://openalex.org/W1987155125","https://openalex.org/W1987237534","https://openalex.org/W1988711597","https://openalex.org/W1993000082","https://openalex.org/W1995744610","https://openalex.org/W1997609395","https://openalex.org/W2006617601","https://openalex.org/W2015645693","https://openalex.org/W2030562643","https://openalex.org/W2033489525","https://openalex.org/W2043697982","https://openalex.org/W2045971655","https://openalex.org/W2047417656","https://openalex.org/W2048069351","https://openalex.org/W2055666891","https://openalex.org/W2059427031","https://openalex.org/W2061812402","https://openalex.org/W2066825944","https://openalex.org/W2068264979","https://openalex.org/W2069179045","https://openalex.org/W2071636826","https://openalex.org/W2072706410","https://openalex.org/W2075789186","https://openalex.org/W2078941471","https://openalex.org/W2079860629","https://openalex.org/W2084229289","https://openalex.org/W2088593344","https://openalex.org/W2090640877","https://openalex.org/W2100620258","https://openalex.org/W2101760818","https://openalex.org/W2117200779","https://openalex.org/W2126214215","https://openalex.org/W2127946778","https://openalex.org/W2137059754","https://openalex.org/W2137564090","https://openalex.org/W2140644802","https://openalex.org/W2142374514","https://openalex.org/W2148356388","https://openalex.org/W2148704093","https://openalex.org/W2158827553","https://openalex.org/W2160775559","https://openalex.org/W2559300437","https://openalex.org/W2899479705","https://openalex.org/W2946603945","https://openalex.org/W4231388637","https://openalex.org/W4244757991","https://openalex.org/W4313398188"],"related_works":["https://openalex.org/W2055456476","https://openalex.org/W2004084345","https://openalex.org/W2110223801","https://openalex.org/W3080132169","https://openalex.org/W2338216867","https://openalex.org/W2049483717","https://openalex.org/W2578825457","https://openalex.org/W2034259068","https://openalex.org/W2349516135","https://openalex.org/W2016629087"],"abstract_inverted_index":{"Abstract":[0],"Synthetic":[1],"oligonucleotides":[2,35,81],"containing":[3],"unmethylated":[4],"CpG":[5,34,80],"motifs":[6],"activate":[7],"the":[8,46,53,76,86],"innate":[9],"immune":[10,40],"system":[11],"by":[12],"binding":[13],"to":[14],"cells":[15,26],"expressing":[16],"Toll-like":[17],"receptor":[18],"9.":[19],"In":[20],"humans,":[21],"these":[22],"include":[23],"plasmacytoid":[24],"dendritic":[25],"and":[27,38,51,57],"B":[28],"cells.":[29],"Research":[30],"results":[31,77],"show":[32],"that":[33],"enhance":[36],"humoral":[37],"cellular":[39],"responses,":[41],"as":[42,44,82],"well":[43],"accelerate":[45],"induction":[47],"of":[48,55,75,78,88],"specific":[49],"immunoglobulins":[50],"promote":[52],"formation":[54],"higher":[56],"more":[58],"persistent":[59],"antibody":[60],"titers":[61],"when":[62],"used":[63],"in":[64],"combination":[65],"with":[66],"protein":[67],"vaccines.":[68],"This":[69],"literature":[70],"review":[71],"presents":[72],"an":[73],"analysis":[74],"using":[79],"vaccine":[83],"adjuvants":[84],"for":[85],"prevention":[87],"infectious":[89],"diseases.":[90]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-01-10T00:00:00"}