{"id":"https://openalex.org/W4406233379","doi":"https://doi.org/10.1007/s00774-025-01579-x","title":"Osteoporosis and stroke: a bidirectional mendelian randomization study","display_name":"Osteoporosis and stroke: a bidirectional mendelian randomization study","publication_year":2025,"publication_date":"2025-01-10","ids":{"openalex":"https://openalex.org/W4406233379","doi":"https://doi.org/10.1007/s00774-025-01579-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/39792154"},"language":"en","primary_location":{"id":"doi:10.1007/s00774-025-01579-x","doi":"https://doi.org/10.1007/s00774-025-01579-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00774-025-01579-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00774-025-01579-x.pdf","source":{"id":"https://openalex.org/S178027841","display_name":"Journal of Bone and Mineral Metabolism","issn_l":"0914-8779","issn":["0914-8779","1435-5604"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00774-025-01579-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100753921","display_name":"Miao He","orcid":"https://orcid.org/0000-0002-8427-7693","observed_orcids":["https://orcid.org/0000-0002-8427-7693","https://orcid.org/0000-0003-1023-1040"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210135470","display_name":"Chongqing Emergency Medical Center","ror":"https://ror.org/03xhwyc44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135470"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miao He","raw_affiliation_strings":["Department of Orthopedic Surgery, Chongqing Emergency Medical Center (Chongqing University Central Hospital), Jiankang Road 1, Chongqing, 400010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Chongqing Emergency Medical Center (Chongqing University Central Hospital), Jiankang Road 1, Chongqing, 400010, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210135470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057980615","display_name":"Haochuan Yong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210135470","display_name":"Chongqing Emergency Medical Center","ror":"https://ror.org/03xhwyc44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135470"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haochuan Yong","raw_affiliation_strings":["Department of Orthopedic Surgery, Chongqing Emergency Medical Center (Chongqing University Central Hospital), Jiankang Road 1, Chongqing, 400010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Chongqing Emergency Medical Center (Chongqing University Central Hospital), Jiankang Road 1, Chongqing, 400010, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210135470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038776508","display_name":"Zhidong Cao","orcid":"https://orcid.org/0000-0001-5936-6822","observed_orcids":["https://orcid.org/0000-0001-5936-6822"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210135470","display_name":"Chongqing Emergency Medical Center","ror":"https://ror.org/03xhwyc44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135470"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhidong Cao","raw_affiliation_strings":["Department of Orthopedic Surgery, Chongqing Emergency Medical Center (Chongqing University Central Hospital), Jiankang Road 1, Chongqing, 400010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Chongqing Emergency Medical Center (Chongqing University Central Hospital), Jiankang Road 1, Chongqing, 400010, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210135470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044249983","display_name":"Jie Li","orcid":"https://orcid.org/0000-0002-3286-2006","observed_orcids":["https://orcid.org/0000-0002-3286-2006"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210135470","display_name":"Chongqing Emergency Medical Center","ror":"https://ror.org/03xhwyc44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135470"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Li","raw_affiliation_strings":["Department of Orthopedic Surgery, Chongqing Emergency Medical Center (Chongqing University Central Hospital), Jiankang Road 1, Chongqing, 400010, China. renzhitianxinglj@sina.com","Department of Orthopedic Surgery, Chongqing Emergency Medical Center (Chongqing University Central Hospital), Jiankang Road 1, Chongqing, 400010, China"],"raw_orcid":"https://orcid.org/0000-0002-3286-2006","affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Chongqing Emergency Medical Center (Chongqing University Central Hospital), Jiankang Road 1, Chongqing, 400010, China. renzhitianxinglj@sina.com","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210135470"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Chongqing Emergency Medical Center (Chongqing University Central Hospital), Jiankang Road 1, Chongqing, 400010, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210135470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044249983"],"corresponding_institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210135470"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.541,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56599076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"43","issue":"3","first_page":"256","last_page":"264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":1.0},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9879999756813049},{"id":"https://openalex.org/keywords/bidirectional-causality","display_name":"bidirectional causality","score":0.7609999775886536},{"id":"https://openalex.org/keywords/causal-relationship","display_name":"causal relationship","score":0.621999979019165},{"id":"https://openalex.org/keywords/stroke-subtypes","display_name":"stroke subtypes","score":0.8109999895095825},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.5189999938011169},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pleiotropy","display_name":"pleiotropy","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9434599876403809},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6237442493438721},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5731640458106995},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5460571646690369},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.49650031328201294},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4780057966709137},{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.4649193584918976},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4358464181423187},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.42043086886405945},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.39408981800079346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37527912855148315},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3325836658477783},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2468491792678833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18361049890518188},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.09535440802574158},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.09390723705291748},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0776408314704895},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.07623380422592163},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057182","descriptor_name":"Mendelian Randomization Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00774-025-01579-x","doi":"https://doi.org/10.1007/s00774-025-01579-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00774-025-01579-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00774-025-01579-x.pdf","source":{"id":"https://openalex.org/S178027841","display_name":"Journal of Bone and Mineral Metabolism","issn_l":"0914-8779","issn":["0914-8779","1435-5604"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Metabolism","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-4855698/v1","doi":"https://doi.org/10.21203/rs.3.rs-4855698/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-4855698/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:39792154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39792154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12089162","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12089162","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12089162/pdf/774_2025_Article_1579.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Bone Miner Metab","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s00774-025-01579-x","doi":"https://doi.org/10.1007/s00774-025-01579-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00774-025-01579-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00774-025-01579-x.pdf","source":{"id":"https://openalex.org/S178027841","display_name":"Journal of Bone and Mineral Metabolism","issn_l":"0914-8779","issn":["0914-8779","1435-5604"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406233379.pdf","grobid_xml":"https://content.openalex.org/works/W4406233379.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1490939418","https://openalex.org/W1774542004","https://openalex.org/W1868237212","https://openalex.org/W1932099837","https://openalex.org/W1966766074","https://openalex.org/W1970516435","https://openalex.org/W1981969102","https://openalex.org/W1995773136","https://openalex.org/W2007415523","https://openalex.org/W2012212705","https://openalex.org/W2013152609","https://openalex.org/W2031838708","https://openalex.org/W2039057018","https://openalex.org/W2040524107","https://openalex.org/W2042318129","https://openalex.org/W2060427223","https://openalex.org/W2068218731","https://openalex.org/W2079037416","https://openalex.org/W2079043243","https://openalex.org/W2084478135","https://openalex.org/W2084530881","https://openalex.org/W2085742735","https://openalex.org/W2087707547","https://openalex.org/W2095155444","https://openalex.org/W2101334610","https://openalex.org/W2108182492","https://openalex.org/W2111014636","https://openalex.org/W2113699335","https://openalex.org/W2114599804","https://openalex.org/W2115447165","https://openalex.org/W2118264464","https://openalex.org/W2119394719","https://openalex.org/W2125634783","https://openalex.org/W2128515857","https://openalex.org/W2131552966","https://openalex.org/W2133246960","https://openalex.org/W2141528524","https://openalex.org/W2143731448","https://openalex.org/W2158553348","https://openalex.org/W2169594686","https://openalex.org/W2213513919","https://openalex.org/W2311649616","https://openalex.org/W2315124452","https://openalex.org/W2324862792","https://openalex.org/W2489658084","https://openalex.org/W2564636747","https://openalex.org/W2614566443","https://openalex.org/W2743772055","https://openalex.org/W2765391558","https://openalex.org/W2801660253","https://openalex.org/W2803072880","https://openalex.org/W2805983714","https://openalex.org/W2905938170","https://openalex.org/W2916538789","https://openalex.org/W2929242478","https://openalex.org/W2982255856","https://openalex.org/W2990517472","https://openalex.org/W3011810078","https://openalex.org/W3089834684","https://openalex.org/W3196859858","https://openalex.org/W4206046172","https://openalex.org/W4206774749","https://openalex.org/W4211191293","https://openalex.org/W4255815262","https://openalex.org/W4296466828","https://openalex.org/W4313340340","https://openalex.org/W4391764936","https://openalex.org/W6940453849"],"related_works":["https://openalex.org/W3202647813","https://openalex.org/W4307953159","https://openalex.org/W2784614321","https://openalex.org/W4396219410","https://openalex.org/W2945740433","https://openalex.org/W3041584880","https://openalex.org/W2508244144","https://openalex.org/W4400475119","https://openalex.org/W3105571484","https://openalex.org/W2941148476"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Numerous":[1],"observational":[2],"studies":[3,81],"have":[4],"identified":[5],"a":[6,25,46],"link":[7,232],"between":[8,17,37,58,178,215],"osteoporosis":[9,38,59,68,179,216],"and":[10,39,60,69,97,168,180,198,217],"stroke.":[11,40],"However,":[12],"the":[13,34,54,143,155,158,162,187,196],"causal":[14,35,56,176,213],"genetic":[15],"relationship":[16,36,57,177,214],"these":[18,201],"conditions":[19],"remains":[20],"unclear.":[21],"This":[22],"study":[23,51,205],"employs":[24],"two-sample":[26,47],"bidirectional":[27,175],"Mendelian":[28,48],"randomization":[29,49],"(MR)":[30,50],"approach":[31],"to":[32,52,121,153],"ascertain":[33],"MATERIALS":[41],"AND":[42],"METHODS:":[43],"We":[44],"conducted":[45],"investigate":[53],"potential":[55,190],"stroke,":[61,70],"including":[62],"its":[63,183,220],"subtypes.":[64],"Genetic":[65],"data":[66],"for":[67,104],"along":[71],"with":[72,124],"their":[73],"subtypes,":[74,184],"were":[75,102],"sourced":[76],"from":[77],"published":[78],"genome-wide":[79,88],"association":[80],"(GWAS).":[82],"Single":[83],"nucleotide":[84],"polymorphisms":[85],"(SNPs)":[86],"demonstrating":[87],"significance":[89],"(p":[90],"<":[91,100],"5":[92],"\u00d7":[93],"10^":[94],"-":[95],"8)":[96],"independence":[98],"(r^2":[99],"0.001)":[101],"selected":[103],"further":[105],"analysis,":[106],"provided":[107],"they":[108],"had":[109],"an":[110],"F-statistic":[111],"\u2265":[112],"10.":[113],"The":[114],"inverse-variance":[115],"weighted":[116],"(IVW)":[117],"method":[118],"was":[119,132,140,151,233],"employed":[120],"evaluate":[122],"causality,":[123],"results":[125],"reported":[126],"as":[127],"odds":[128],"ratios":[129],"(ORs).":[130],"Heterogeneity":[131],"assessed":[133],"using":[134,142],"Cochran's":[135],"Q":[136],"test,":[137],"while":[138],"pleiotropy":[139],"tested":[141],"MR-Egger":[144],"intercept":[145],"test.":[146],"A":[147],"leave-one-out":[148],"sensitivity":[149],"analysis":[150],"performed":[152],"ensure":[154],"robustness":[156],"of":[157,186,189,200],"results.":[159],"RESULTS:":[160],"Employing":[161],"IVW":[163],"method,":[164,167,170],"MR":[165],"Egger":[166],"median-weighted":[169],"we":[171],"found":[172],"no":[173,211,230],"significant":[174],"stroke":[181,218],"or":[182,219],"irrespective":[185],"inclusion":[188],"pleiotropic":[191],"SNPs.":[192],"Sensitivity":[193],"analyses":[194],"affirmed":[195],"reliability":[197],"stability":[199],"findings.":[202],"CONCLUSION:":[203],"Our":[204],"findings":[206],"indicate":[207],"that":[208],"there":[209],"is":[210],"direct":[212,231],"subtypes":[221],"in":[222],"either":[223],"direction.":[224],"Based":[225],"on":[226],"our":[227],"results,":[228],"although":[229],"found,":[234],"secondary":[235],"effects":[236],"do":[237],"exist.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
