{"id":"https://openalex.org/W4406214719","doi":"https://doi.org/10.1038/s41598-026-51092-y","title":"Whole transcriptome sequencing and ceRNA regulatory network in diabetic peripheral neuropathy","display_name":"Whole transcriptome sequencing and ceRNA regulatory network in diabetic peripheral neuropathy","publication_year":2026,"publication_date":"2026-06-13","ids":{"openalex":"https://openalex.org/W4406214719","doi":"https://doi.org/10.1038/s41598-026-51092-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/42288543","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13521941"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-51092-y","doi":"https://doi.org/10.1038/s41598-026-51092-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-51092-y","pdf_url":"https://www.nature.com/articles/s41598-026-51092-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-51092-y_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101538922","display_name":"Yan Qi","orcid":"https://orcid.org/0000-0002-3168-4332","observed_orcids":["https://orcid.org/0000-0002-3168-4332"]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Yan","raw_affiliation_strings":["The Fourth Clinical Medical College of Xinjiang Medical University, Urumqi, 830000, China","The Fourth Clinical Medical College of Xinjiang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fourth Clinical Medical College of Xinjiang Medical University, Urumqi, 830000, China","institution_ids":["https://openalex.org/I154093214"]},{"raw_affiliation_string":"The Fourth Clinical Medical College of Xinjiang Medical University","institution_ids":["https://openalex.org/I154093214"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ming Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Zhang","raw_affiliation_strings":["The Fourth Clinical Medical College of Xinjiang Medical University, Urumqi, 830000, China","Hospital of Traditional Chinese Medicine Afiliated to Xinjiang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fourth Clinical Medical College of Xinjiang Medical University, Urumqi, 830000, China","institution_ids":["https://openalex.org/I154093214"]},{"raw_affiliation_string":"Hospital of Traditional Chinese Medicine Afiliated to Xinjiang Medical University","institution_ids":["https://openalex.org/I154093214"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li-Juan Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Juan Xu","raw_affiliation_strings":["Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi, 830000, China","Hospital of Traditional Chinese Medicine Afiliated to Xinjiang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi, 830000, China","institution_ids":["https://openalex.org/I154093214"]},{"raw_affiliation_string":"Hospital of Traditional Chinese Medicine Afiliated to Xinjiang Medical University","institution_ids":["https://openalex.org/I154093214"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Ma","raw_affiliation_strings":["Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi, 830000, China","Laboratory of Respiratory Diseases Research, Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi, 830000, China","institution_ids":["https://openalex.org/I154093214"]},{"raw_affiliation_string":"Laboratory of Respiratory Diseases Research, Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University","institution_ids":["https://openalex.org/I154093214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115589198","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-3793-3264","observed_orcids":["https://orcid.org/0000-0002-3793-3264","https://orcid.org/0009-0006-5992-5640"]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Key Laboratory of Respiratory Diseases Research, Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, 830000, China","Hospital of Traditional Chinese Medicine Afiliated to Xinjiang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Respiratory Diseases Research, Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, 830000, China","institution_ids":["https://openalex.org/I154093214"]},{"raw_affiliation_string":"Hospital of Traditional Chinese Medicine Afiliated to Xinjiang Medical University","institution_ids":["https://openalex.org/I154093214"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xian-Min Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xian-Min Wang","raw_affiliation_strings":["Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi, 830000, China","Hospital of Traditional Chinese Medicine Afiliated to Xinjiang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi, 830000, China","institution_ids":["https://openalex.org/I154093214"]},{"raw_affiliation_string":"Hospital of Traditional Chinese Medicine Afiliated to Xinjiang Medical University","institution_ids":["https://openalex.org/I154093214"]}]},{"author_position":"last","author":{"id":null,"display_name":"Li Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li Ma","raw_affiliation_strings":["Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi, 830000, China. malixj322122@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi, 830000, China. malixj322122@163.com","institution_ids":["https://openalex.org/I154093214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154093214"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00238354,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.07020000368356705,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.0471000000834465,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-peripheral-neuropathy","display_name":"diabetic peripheral neuropathy","score":1.0},{"id":"https://openalex.org/keywords/sciatic-nerve","display_name":"sciatic nerve","score":0.8830000162124634},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.968999981880188},{"id":"https://openalex.org/keywords/competitive-endogenous-rna-network","display_name":"competing endogenous RNA network","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.9200000166893005},{"id":"https://openalex.org/keywords/fos","display_name":"FOS","score":0.8640000224113464},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.996999979019165},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/il-17-signaling","display_name":"IL-17 signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.8140000104904175},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.8569999933242798},{"id":"https://openalex.org/keywords/th17-differentiation","display_name":"Th17 cell differentiation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/primary-immunodeficiency","display_name":"primary immunodeficiency","score":0.9409999847412109},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6949999928474426},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.5}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.8705456256866455},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.6724686622619629},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5467280149459839},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.47844958305358887},{"id":"https://openalex.org/C60365752","wikidata":"https://www.wikidata.org/wiki/Q5156306","display_name":"Competing endogenous RNA","level":5,"score":0.46662747859954834},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.430980920791626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3665335178375244},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33285149931907654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3304503262042999},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.31992965936660767},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24158722162246704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21791070699691772},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1748276948928833},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11166733503341675},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.10412415862083435},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000095482","descriptor_name":"RNA, Competitive Endogenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-026-51092-y","doi":"https://doi.org/10.1038/s41598-026-51092-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-51092-y","pdf_url":"https://www.nature.com/articles/s41598-026-51092-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-5673628/v1","doi":"https://doi.org/10.21203/rs.3.rs-5673628/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-5673628/v1","pdf_url":"https://www.researchsquare.com/article/rs-5673628/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13521941","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13521941/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13521941/pdf/41598_2026_Article_51092.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:42288543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42288543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8a787efc3bd640bba72389a118af09a9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8a787efc3bd640bba72389a118af09a9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-51092-y","doi":"https://doi.org/10.1038/s41598-026-51092-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-51092-y","pdf_url":"https://www.nature.com/articles/s41598-026-51092-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8014131584","display_name":null,"funder_award_id":"82060842","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406214719.pdf","grobid_xml":"https://content.openalex.org/works/W4406214719.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3026236880","https://openalex.org/W3027105123","https://openalex.org/W4388620108","https://openalex.org/W2903093435","https://openalex.org/W4389025332","https://openalex.org/W3165465985","https://openalex.org/W4380048621","https://openalex.org/W2941710205","https://openalex.org/W2549886026","https://openalex.org/W4392752423"],"abstract_inverted_index":{"Although":[0],"diabetic":[1],"peripheral":[2],"neuropathy":[3],"(DPN)":[4],"is":[5],"a":[6],"serious":[7],"complication":[8],"of":[9,19,29,235,259,269,274],"diabetes,":[10],"its":[11],"molecular":[12],"causes":[13],"are":[14],"still":[15],"unclear.":[16],"The":[17,135,202,257],"aim":[18],"this":[20,260],"study":[21,216,261],"was":[22,87,110,120,217],"therefore":[23],"to":[24,163,219],"further":[25],"investigate":[26],"the":[27,51,56,62,65,82,90,105,114,128,132,164,174,233,242,248,253,267,272],"pathogenesis":[28,273],"diabetes":[30],"through":[31],"whole":[32,38,52],"transcriptome":[33,39,53],"sequencing.":[34],"METHODS:":[35],"We":[36],"performed":[37],"sequencing":[40,54],"on":[41,50],"sciatic":[42],"nerve":[43],"samples":[44],"from":[45],"Sprague-Dawley":[46],"(SD)":[47],"rats.":[48],"Based":[49],"data,":[55],"differentially":[57],"expressed":[58],"genes":[59,94,109,139,170,223],"(DEGs)":[60],"between":[61,127],"DPN":[63,129,236],"and":[64,70,72,89,131,160,168,197,211,227,252],"control":[66,133],"groups":[67],"were":[68,77,79,95,124,140,171],"identified,":[69],"functions":[71],"pathways":[73,240],"in":[74,232,271],"which":[75],"DEGs":[76,126,167,270],"enriched":[78,172],"analyzed.":[80],"Thereafter,":[81],"protein-protein":[83],"interaction":[84],"(PPI)":[85],"network":[86,119,204],"built,":[88],"top":[91,106,136],"20":[92,107,137],"hub":[93,108,138,169,222],"screened":[96],"via":[97],"STRING":[98],"algorithm.":[99],"In":[100],"addition,":[101],"enrichment":[102,165],"analysis":[103],"for":[104],"subsequently":[111],"performed.":[112],"Finally,":[113],"competing":[115],"endogenous":[116],"RNA":[117],"(ceRNA)":[118],"created.":[121],"RESULTS:":[122],"There":[123],"597":[125],"group":[130],"groups.":[134],"Fos,":[141],"Tnf,":[142],"Jun,":[143],"Cd3e,":[144],"Cd79a,":[145],"Cd27,":[146],"Cd79b,":[147],"Ptprc,":[148],"Cd22,":[149],"Cd40lg,":[150],"Cd19,":[151],"Cr2,":[152],"Sell,":[153],"Il6,":[154],"Pdlim3,":[155],"Actn2,":[156],"Myom2,":[157],"Tnni2,":[158],"Ldb3,":[159],"Myh7.":[161],"According":[162],"analysis,":[166],"into":[173,266],"following:":[175],"'B":[176],"cell":[177,185,190,244],"receptor":[178,186,199,245],"signaling":[179,182,187,193,200,239,246,250,255],"pathway',":[180,183,194],"'TNF":[181],"'T":[184],"pathway'":[188],"'Th17":[189],"differentiation',":[191],"'IL-17":[192],"'primary":[195],"immunodeficiency',":[196],"'toll-like":[198],"pathway'.":[201],"ceRNA":[203],"finally":[205],"contained":[206],"9":[207],"mRNAs,":[208],"23":[209,212],"miRNAs,":[210],"lncRNAs.":[213],"CONCLUSIONS:":[214],"This":[215],"able":[218],"determine":[220],"that":[221],"such":[224],"as":[225],"Fos":[226],"Jun":[228],"may":[229],"be":[230],"involved":[231],"progression":[234],"by":[237],"regulating":[238],"like":[241],"B":[243],"pathway,":[247,251],"TNF":[249],"IL-17":[254],"pathway.":[256],"findings":[258],"could":[262],"provide":[263],"novel":[264],"insights":[265],"roles":[268],"DPN.":[275]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-01-10T00:00:00"}