{"id":"https://openalex.org/W4406209841","doi":"https://doi.org/10.1002/alz.093319","title":"Predicting Mild Cognitive Impairment in Amyloid Beta Biomarker Positive Individuals Using Automated Speech\u2010Based Testing Procedures","display_name":"Predicting Mild Cognitive Impairment in Amyloid Beta Biomarker Positive Individuals Using Automated Speech\u2010Based Testing Procedures","publication_year":2024,"publication_date":"2024-12-01","ids":{"openalex":"https://openalex.org/W4406209841","doi":"https://doi.org/10.1002/alz.093319"},"language":"en","primary_location":{"id":"doi:10.1002/alz.093319","doi":"https://doi.org/10.1002/alz.093319","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.093319","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.093319","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.093319","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082228880","display_name":"Caroline Skirrow","orcid":"https://orcid.org/0000-0001-8692-7787","observed_orcids":["https://orcid.org/0000-0001-8692-7787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caroline Skirrow","raw_affiliation_strings":["Novoic, London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novoic, London United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062112119","display_name":"Udeepa Meepegama","orcid":"https://orcid.org/0000-0001-8718-7530","observed_orcids":["https://orcid.org/0000-0001-8718-7530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Udeepa Meepegama","raw_affiliation_strings":["Novoic, London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novoic, London United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035488258","display_name":"Michael T. Ropacki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael T. Ropacki","raw_affiliation_strings":["Strategic Global Research &amp; Development, Temecula, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Strategic Global Research &amp; Development, Temecula, CA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003046428","display_name":"Jack Weston","orcid":"https://orcid.org/0000-0001-5344-7840","observed_orcids":["https://orcid.org/0000-0001-5344-7840"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jack Weston","raw_affiliation_strings":["Novoic, London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novoic, London United Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003904755","display_name":"Emil Fristed","orcid":"https://orcid.org/0000-0002-9590-7275","observed_orcids":["https://orcid.org/0000-0002-9590-7275"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emil Fristed","raw_affiliation_strings":["Novoic, London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novoic, London United Kingdom","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003904755"],"corresponding_institution_ids":[],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":{"value":4000,"currency":"USD","value_usd":4000},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32478334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"S2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12848","display_name":"Psychological Testing and Assessment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3202","display_name":"Applied Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9909999966621399},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6435706615447998},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.5947071313858032},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5105177164077759},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.49401789903640747},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.42891865968704224},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.41548609733581543},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.4013090133666992},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3734078109264374},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3003380298614502},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.27986443042755127},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16372662782669067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13326212763786316},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04545918107032776},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/alz.093319","doi":"https://doi.org/10.1002/alz.093319","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.093319","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.093319","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11714835","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11714835","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11714835/pdf/ALZ-20-e093319.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alzheimers Dement","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/alz.093319","doi":"https://doi.org/10.1002/alz.093319","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.093319","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.093319","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/4","display_name":"Quality education","score":0.6600000262260437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406209841.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2533581028","https://openalex.org/W2090817358","https://openalex.org/W2111160383","https://openalex.org/W2056890439","https://openalex.org/W2606891670","https://openalex.org/W2092424613","https://openalex.org/W3158074726","https://openalex.org/W2944730934","https://openalex.org/W2168190449","https://openalex.org/W2525776475"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"New":[2],"disease":[3,316],"modifying":[4,317],"treatments":[5,318],"for":[6,25,50,62,189,197,252,265,275,300,312,314,320],"Alzheimer\u2019s":[7,228],"Disease":[8],"(AD)":[9],"require":[10],"confirmation":[11],"of":[12,17,44,149,178,203,271],"amyloid":[13,79],"biomarkers":[14,27,39],"and":[15,52,99,122,172,191,201,225,244,257,273,277,290,319,323],"evidence":[16],"clinical":[18,331],"and/or":[19],"cognitive":[20,45,54],"AD":[21,26],"symptoms.":[22],"Blood":[23],"tests":[24],"are":[28],"poised":[29],"to":[30,60,70,86,174],"enter":[31],"routine":[32,330],"care.":[33],"However,":[34],"at\u2010risk":[35,304],"individuals":[36,83,138],"with":[37,103,216,231,248,269,326],"positive":[38,81],"vary":[40],"in":[41,95,160,303],"their":[42],"level":[43],"impairment,":[46],"raising":[47],"the":[48,96,184,206,209,217,226],"need":[49],"sensitive":[51],"scalable":[53],"assessments.":[55],"Fully":[56],"automated":[57],"speech\u2010based":[58],"testing":[59],"screen":[61],"Mild":[63],"Cognitive":[64,229],"Impairment":[65],"(MCI)":[66],"has":[67],"shown":[68,268],"promise":[69],"bridge":[71],"this":[72],"gap,":[73],"but":[74],"its":[75],"efficacy":[76],"specifically":[77],"within":[78],"beta":[80],"(A\u03b2+)":[82],"is":[84],"yet":[85],"be":[87],"fully":[88],"established.":[89],"Method":[90],"Data":[91],"from":[92,114,127,135],"A\u03b2+":[93,137,151],"participants":[94,152,247],"AMYPRED\u2010UK":[97],"(NCT04828122)":[98],"AMYPRED\u2010US":[100],"studies":[101],"(NCT04928976)":[102],"Clinical":[104],"Dementia":[105],"Score":[106],"(CDR\u2010G)":[107],"between":[108,242,287],"0\u20100.5":[109],"were":[110,133,169,235,285],"analyzed.":[111],"Speech":[112],"recordings":[113],"Storyteller,":[115],"a":[116,161,176],"test":[117,224],"battery":[118],"leveraging":[119],"two":[120],"immediate":[121],"one":[123],"delayed":[124],"recall":[125,186],"conditions":[126],"Automated":[128],"Story":[129],"Recall":[130,222],"Task":[131],"(ASRT),":[132],"collected":[134],"84":[136],"(n=38":[139],"MCI;":[140,154],"n=46":[141],"unimpaired)":[142,156],"who":[143],"completed":[144,158,334],"in\u2010clinic":[145,190,254,276],"visits.":[146],"A":[147],"subsample":[148],"46":[150],"(n=17":[153],"n=29":[155],"also":[157,236],"Storyteller":[159],"separate":[162],"optional":[163],"remote":[164,192,258,278],"assessment":[165],"session.":[166],"Spoken":[167],"responses":[168],"automatically":[170],"transcribed":[171],"analysed":[173],"obtain":[175],"measure":[177],"proportional":[179],"recall,":[180],"\u201cG\u2010match\u201d,":[181],"averaged":[182],"over":[183],"three":[185],"trials":[187],"separately":[188],"sessions.":[193],"Analyses":[194],"included":[195],"T\u2010test":[196],"quantifying":[198],"group":[199],"differences,":[200],"prediction":[202],"MCI":[204,243,266,302],"using":[205],"Area":[207],"Under":[208],"Receiver":[210],"Operating":[211],"Characteristic":[212],"curve":[213],"(AUC).":[214],"Correlations":[215],"Wechsler":[218],"Logical":[219],"Memory":[220],"Delayed":[221],"(LMDR)":[223],"Preclinical":[227],"Composite":[230],"semantic":[232],"processing":[233],"(PACC5)":[234],"evaluated.":[237],"Result":[238],"G\u2010match":[239],"scores":[240],"differed":[241],"cognitively":[245],"unimpaired":[246],"large":[249],"effect":[250],"sizes":[251],"both":[253],"(Cohen\u2019s":[255],"d=1.36)":[256],"assessments":[259,279,327],"(d=2.07),":[260],"Figure":[261],"1.":[262],"Predictive":[263],"ability":[264],"was":[267],"AUC":[270],"0.83":[272],"0.92":[274],"respectively":[280],"(Figure":[281],"2).":[282],"Moderate\u2010to\u2010high":[283],"correlations":[284],"observed":[286],"G\u2010match,":[288],"LMDR,":[289],"PACC5":[291],"outcomes":[292],"(r=0.73\u20100.84).":[293],"Conclusion":[294],"Speech\u2010based":[295],"screening":[296,311],"shows":[297],"good":[298],"sensitivity":[299],"detecting":[301],"populations.":[305],"This":[306],"approach":[307],"could":[308],"support":[309],"at\u2010scale":[310],"suitability":[313],"new":[315,321],"treatment":[322],"prevention":[324],"trials,":[325],"incorporated":[328],"into":[329],"visits":[332],"or":[333],"remotely":[335],"at":[336],"home.":[337]},"counts_by_year":[],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2025-10-10T00:00:00"}
