{"id":"https://openalex.org/W4406183771","doi":"https://doi.org/10.1177/03635465241274155","title":"Evaluation of Spin in Clinical Trials of Mesenchymal Stromal Cells for the Treatment of Knee Osteoarthritis: A Systematic Review","display_name":"Evaluation of Spin in Clinical Trials of Mesenchymal Stromal Cells for the Treatment of Knee Osteoarthritis: A Systematic Review","publication_year":2025,"publication_date":"2025-01-08","ids":{"openalex":"https://openalex.org/W4406183771","doi":"https://doi.org/10.1177/03635465241274155","pmid":"https://pubmed.ncbi.nlm.nih.gov/39772944"},"language":"en","primary_location":{"id":"doi:10.1177/03635465241274155","doi":"https://doi.org/10.1177/03635465241274155","is_oa":false,"landing_page_url":"https://doi.org/10.1177/03635465241274155","pdf_url":null,"source":{"id":"https://openalex.org/S154904565","display_name":"The American Journal of Sports Medicine","issn_l":"0363-5465","issn":["0363-5465","1552-3365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Sports Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043325043","display_name":"Katherine A. Woolley","orcid":"https://orcid.org/0000-0002-7262-6999","observed_orcids":["https://orcid.org/0000-0002-7262-6999"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Woolley","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058634631","display_name":"Nesa Milan","orcid":"https://orcid.org/0000-0003-4930-581X","observed_orcids":["https://orcid.org/0000-0003-4930-581X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nesa Milan","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075307321","display_name":"Zubin Master","orcid":"https://orcid.org/0000-0002-3462-4546","observed_orcids":["https://orcid.org/0000-0002-3462-4546"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zubin Master","raw_affiliation_strings":["Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA","Maya Angelou Center for Health Equity, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA","Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Maya Angelou Center for Health Equity, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001653419","display_name":"Brian Thomas Feeley","orcid":"https://orcid.org/0000-0001-9060-6695","observed_orcids":["https://orcid.org/0000-0001-9060-6695","https://orcid.org/0000-0002-4215-9664"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian T. Feeley","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001653419"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":0.7065,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.75615764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"53","issue":"9","first_page":"2264","last_page":"2272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10206","display_name":"Meta-analysis and systematic reviews","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10206","display_name":"Meta-analysis and systematic reviews","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13607","display_name":"Academic Publishing and Open Access","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/3309","display_name":"Library and Information Sciences"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11649","display_name":"Pharmaceutical industry and healthcare","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/2910","display_name":"Issues, ethics and legal aspects"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spin-bias","display_name":"spin bias","score":0.9490000009536743},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/trial-reporting-quality","display_name":"trial reporting quality","score":0.6290000081062317},{"id":"https://openalex.org/keywords/financial-disclosure","display_name":"financial disclosure","score":0.47099998593330383},{"id":"https://openalex.org/keywords/orthopaedic-journals","display_name":"orthopaedic journals","score":0.7459999918937683},{"id":"https://openalex.org/keywords/impact-factor","display_name":"impact factor","score":0.6589999794960022},{"id":"https://openalex.org/keywords/risk-of-bias-assessment","display_name":"risk of bias assessment","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8308253288269043},{"id":"https://openalex.org/C2771230","wikidata":"https://www.wikidata.org/wiki/Q4926699","display_name":"Blinding","level":3,"score":0.7617058753967285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6745545864105225},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5868181586265564},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.502009391784668},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4603651762008667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37353813648223877},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33195817470550537},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23906975984573364},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.19804829359054565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0685110092163086}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/03635465241274155","doi":"https://doi.org/10.1177/03635465241274155","is_oa":false,"landing_page_url":"https://doi.org/10.1177/03635465241274155","pdf_url":null,"source":{"id":"https://openalex.org/S154904565","display_name":"The American Journal of Sports Medicine","issn_l":"0363-5465","issn":["0363-5465","1552-3365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Sports Medicine","raw_type":"journal-article"},{"id":"pmid:39772944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39772944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of sports medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W429083659","https://openalex.org/W1650284538","https://openalex.org/W1790126255","https://openalex.org/W2011170585","https://openalex.org/W2022419394","https://openalex.org/W2028046200","https://openalex.org/W2028089243","https://openalex.org/W2088256967","https://openalex.org/W2113235638","https://openalex.org/W2116153150","https://openalex.org/W2139826506","https://openalex.org/W2151455227","https://openalex.org/W2156231583","https://openalex.org/W2174154237","https://openalex.org/W2239058448","https://openalex.org/W2346277674","https://openalex.org/W2397516852","https://openalex.org/W2511760972","https://openalex.org/W2561110482","https://openalex.org/W2762693505","https://openalex.org/W2771555348","https://openalex.org/W2791908943","https://openalex.org/W2792653798","https://openalex.org/W2793010650","https://openalex.org/W2793285640","https://openalex.org/W2795229610","https://openalex.org/W2800802679","https://openalex.org/W2885408945","https://openalex.org/W2885527831","https://openalex.org/W2897706271","https://openalex.org/W2902115786","https://openalex.org/W2907679499","https://openalex.org/W2910783311","https://openalex.org/W2912040253","https://openalex.org/W2919999424","https://openalex.org/W2939203249","https://openalex.org/W2947662386","https://openalex.org/W2963431377","https://openalex.org/W2974225693","https://openalex.org/W2975596940","https://openalex.org/W2977829144","https://openalex.org/W2981766064","https://openalex.org/W2997765108","https://openalex.org/W2998423630","https://openalex.org/W3000685522","https://openalex.org/W3001803326","https://openalex.org/W3006370171","https://openalex.org/W3009013307","https://openalex.org/W3011510658","https://openalex.org/W3020407728","https://openalex.org/W3020650885","https://openalex.org/W3023626526","https://openalex.org/W3027947701","https://openalex.org/W3039073311","https://openalex.org/W3043275884","https://openalex.org/W3043376281","https://openalex.org/W3043761436","https://openalex.org/W3046392261","https://openalex.org/W3087236206","https://openalex.org/W3123461228","https://openalex.org/W3146197744","https://openalex.org/W3155823099","https://openalex.org/W3161367245","https://openalex.org/W3162659619","https://openalex.org/W3194015306","https://openalex.org/W3210740564","https://openalex.org/W3213485372","https://openalex.org/W3214954886","https://openalex.org/W4200281892","https://openalex.org/W4200482251","https://openalex.org/W4225120952","https://openalex.org/W4226057576","https://openalex.org/W4285993208","https://openalex.org/W4296210801","https://openalex.org/W4296619963","https://openalex.org/W4307889043","https://openalex.org/W4310461667","https://openalex.org/W4312113679","https://openalex.org/W4365816065","https://openalex.org/W4376134444","https://openalex.org/W4380683659","https://openalex.org/W4381598611","https://openalex.org/W4382182200","https://openalex.org/W4386168199","https://openalex.org/W4386274944","https://openalex.org/W4386279047"],"related_works":["https://openalex.org/W7118166530","https://openalex.org/W4410108765","https://openalex.org/W3101588167","https://openalex.org/W2779631004","https://openalex.org/W4387052177","https://openalex.org/W4412080648","https://openalex.org/W3020650885","https://openalex.org/W4403631762","https://openalex.org/W3045287222","https://openalex.org/W3038039221"],"abstract_inverted_index":{"Background:":[0],"The":[1,59],"regenerative":[2],"potential":[3,353],"of":[4,52,61,91,140,203,215,223,243,265,286,348,355],"mesenchymal":[5],"stromal":[6],"cells":[7],"(MSCs)":[8],"has":[9],"sparked":[10],"interest":[11],"in":[12,26,73,88,201,221,227,232,239,283,326],"their":[13],"use":[14],"for":[15,46,93,330],"knee":[16,94,331],"osteoarthritis.":[17,95],"Concurrently,":[18],"there":[19],"have":[20],"been":[21],"investigations":[22],"on":[23,254,270],"how":[24,32],"data":[25],"scientific":[27],"journals":[28,292],"are":[29,43],"reported":[30],"and":[31,54,84,102,115,120,137,155,175,211,229,263,290,297,314,346],"they":[33],"may":[34,70],"influence":[35],"readers\u2019":[36],"interpretations,":[37],"or":[38,57,113,118,122,124,135,168],"\u201cspin":[39],"bias.\u201d":[40],"These":[41],"studies":[42],"at":[44,189],"risk":[45,60],"bias,":[47],"given":[48],"the":[49,66,108,172,176,184,195,240,247,284,301,344],"limited":[50],"number":[51],"patients":[53],"inconsistent":[55],"blinding":[56],"controls.":[58],"spin":[62,86,131,198,266,287,313,349],"bias":[63,87,323],"also":[64],"complicates":[65],"interpretation,":[67],"as":[68,132,138,152,166],"results":[69,151],"be":[71],"presented":[72],"a":[74,78,260,334],"way":[75],"that":[76,339],"favors":[77],"particular":[79],"outcome.":[80],"Purpose:":[81],"To":[82],"quantify":[83],"characterize":[85],"clinical":[89],"trials":[90,329],"MSCs":[92,256,271],"Study":[96],"Design:":[97],"Systematic":[98],"review.":[99],"Methods:":[100],"PubMed":[101],"Embase":[103],"searches":[104],"were":[105,164,180,257],"conducted":[106],"using":[107],"terms":[109],"\u201cmesenchymal":[110],"stem":[111],"cells\u201d":[112],"\u201cMSCs\u201d":[114],"\u201cknee":[116],"arthritis\u201d":[117],"\u201costeoarthritis\u201d":[119],"\u201ctherapy\u201d":[121],"\u201ctreatment\u201d":[123],"\u201cregeneration.\u201d":[125],"Overall,":[126],"2":[127,226],"independent":[128],"reviewers":[129],"classified":[130],"high,":[133,208],"moderate,":[134,210],"low":[136,213],"1":[139,218],"3":[141,231],"types:":[142],"(1)":[143],"emphasizing":[144],"statistically":[145],"significant":[146],"results,":[147],"(2)":[148],"interpreting":[149],"nonsignificant":[150,161],"treatment":[153,158],"effectiveness,":[154],"(3)":[156],"claiming":[157],"benefits":[159],"despite":[160],"results.":[162],"Journals":[163],"categorized":[165],"orthopaedic":[167,289],"nonorthopaedic.":[169],"Descriptive":[170],"statistics,":[171],"chi-square":[173],"test,":[174],"Fisher":[177],"exact":[178],"test":[179],"used":[181],"to":[182],"analyze":[183],"data,":[185],"with":[186,205,246,259,268,300,333],"alpha":[187],"set":[188],"P":[190,250,276,294,305,318],"<":[191],".05.":[192],"Results:":[193],"Among":[194],"54":[196],"studies,":[197],"was":[199,219,235,280,309,324],"found":[200,220],"80.0%":[202],"articles,":[204,224],"14.5%":[206],"having":[207],"25.5%":[209],"40.0%":[212],"levels":[214],"spin.":[216],"Type":[217],"54.5%":[222],"type":[225,230],"18.2%,":[228],"29.1%.":[233],"Spin":[234,322],"less":[236],"frequently":[237],"observed":[238],"Methods":[241],"section":[242],"articles":[244],"compared":[245,267],"abstract":[248],"(17.52;":[249],"=":[251,277,295,306,319],".003).":[252],"Reports":[253],"adipose-derived":[255,341],"associated":[258],"higher":[261,335],"frequency":[262,285,336],"level":[264],"reports":[269],"from":[272],"other":[273],"sources":[274],"(18.92;":[275],".026).":[278],"There":[279,308],"no":[281,298,310],"difference":[282],"between":[288,312],"nonorthopaedic":[291],"(0.48;":[293],".49)":[296],"association":[299,311],"impact":[302],"factor":[303],"(5.34;":[304],".07).":[307],"financial":[315],"disclosures":[316],"(0.02;":[317],".577).":[320],"Conclusion:":[321],"present":[325],"most":[327],"MSC-related":[328],"osteoarthritis,":[332],"among":[337],"those":[338],"utilized":[340],"MSCs.":[342],"Understanding":[343],"prevalence":[345],"strategies":[347],"can":[350],"mitigate":[351],"any":[352],"misinterpretations":[354],"study":[356],"outcomes.":[357]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-01-09T00:00:00"}
