{"id":"https://openalex.org/W4406139516","doi":"https://doi.org/10.1136/bmjopen-2024-085142","title":"Developing an adaptive paediatric intensive care unit platform trial with key stakeholders: a qualitative study","display_name":"Developing an adaptive paediatric intensive care unit platform trial with key stakeholders: a qualitative study","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4406139516","doi":"https://doi.org/10.1136/bmjopen-2024-085142","pmid":"https://pubmed.ncbi.nlm.nih.gov/39773799"},"language":"en","primary_location":{"id":"doi:10.1136/bmjopen-2024-085142","doi":"https://doi.org/10.1136/bmjopen-2024-085142","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2024-085142","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/15/1/e085142.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmjopen.bmj.com/content/bmjopen/15/1/e085142.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088401589","display_name":"Tracy Karen Mitchell","orcid":"https://orcid.org/0000-0003-0014-8016","observed_orcids":["https://orcid.org/0000-0003-0014-8016"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Tracy Karen Mitchell","raw_affiliation_strings":["Public Health, Policy and Systems, University of Liverpool, Liverpool, UK"],"raw_orcid":"https://orcid.org/0000-0003-0014-8016","affiliations":[{"raw_affiliation_string":"Public Health, Policy and Systems, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042848288","display_name":"Julie Christine Menzies","orcid":"https://orcid.org/0000-0003-2080-3364","observed_orcids":["https://orcid.org/0000-0003-2080-3364"]},"institutions":[{"id":"https://openalex.org/I2801868026","display_name":"Bristol Royal Hospital for Children","ror":"https://ror.org/01qgecw57","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801868026","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julie C Menzies","raw_affiliation_strings":["Paediatric Intensive Care Unit, Bristol Royal Hospital for Children, Bristol, UK"],"raw_orcid":"https://orcid.org/0000-0003-2080-3364","affiliations":[{"raw_affiliation_string":"Paediatric Intensive Care Unit, Bristol Royal Hospital for Children, Bristol, UK","institution_ids":["https://openalex.org/I2801868026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015882350","display_name":"Padmanabhan Ramnarayan","orcid":"https://orcid.org/0000-0003-0784-8154","observed_orcids":["https://orcid.org/0000-0003-0784-8154"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Padmanabhan Ramnarayan","raw_affiliation_strings":["Department of Surgery and Cancer, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Cancer, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025578011","display_name":"Doug William Gould","orcid":"https://orcid.org/0000-0003-4148-3312","observed_orcids":["https://orcid.org/0000-0003-4148-3312"]},"institutions":[{"id":"https://openalex.org/I4210161081","display_name":"Intensive Care National Audit & Research Centre","ror":"https://ror.org/057b2ek35","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210161081"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Doug William Gould","raw_affiliation_strings":["Intensive Care National Audit and Research Centre, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-4148-3312","affiliations":[{"raw_affiliation_string":"Intensive Care National Audit and Research Centre, London, UK","institution_ids":["https://openalex.org/I4210161081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021015995","display_name":"Elizabeth Deja","orcid":"https://orcid.org/0000-0002-3626-4927","observed_orcids":["https://orcid.org/0000-0002-3626-4927","https://orcid.org/0000-0002-2168-7994"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth Deja","raw_affiliation_strings":["Institute of Population Health, Department of Public Health, Policy and Systems, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Population Health, Department of Public Health, Policy and Systems, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056182089","display_name":"Shelley Marsh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shelley Marsh","raw_affiliation_strings":["Patient and Public Partner, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Patient and Public Partner, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer Ainsworth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157731","display_name":"Alder Hey Children's Hospital","ror":"https://ror.org/04z61sd03","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210094656","https://openalex.org/I4210157731"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jennifer Ainsworth","raw_affiliation_strings":["GenerationR Liverpool Young Person\u2019s Advisory Group, Alder Hey Children's Hospital Clinical Research Facility, Liverpool, UK","GenerationR Liverpool Young Person's Advisory Group, Alder Hey Children's Hospital Clinical Research Facility, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GenerationR Liverpool Young Person\u2019s Advisory Group, Alder Hey Children's Hospital Clinical Research Facility, Liverpool, UK","institution_ids":["https://openalex.org/I4210157731"]},{"raw_affiliation_string":"GenerationR Liverpool Young Person's Advisory Group, Alder Hey Children's Hospital Clinical Research Facility, Liverpool, UK","institution_ids":["https://openalex.org/I4210157731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033339531","display_name":"Jennifer Preston","orcid":"https://orcid.org/0000-0003-4800-234X","observed_orcids":["https://orcid.org/0000-0003-4800-234X"]},"institutions":[{"id":"https://openalex.org/I4210157731","display_name":"Alder Hey Children's Hospital","ror":"https://ror.org/04z61sd03","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210094656","https://openalex.org/I4210157731"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jennifer Preston","raw_affiliation_strings":["GenerationR Liverpool Young Person\u2019s Advisory Group, Alder Hey Children's Hospital Clinical Research Facility, Liverpool, UK","GenerationR Liverpool Young Person's Advisory Group, Alder Hey Children's Hospital Clinical Research Facility, Liverpool, UK"],"raw_orcid":"https://orcid.org/0000-0003-4800-234X","affiliations":[{"raw_affiliation_string":"GenerationR Liverpool Young Person\u2019s Advisory Group, Alder Hey Children's Hospital Clinical Research Facility, Liverpool, UK","institution_ids":["https://openalex.org/I4210157731"]},{"raw_affiliation_string":"GenerationR Liverpool Young Person's Advisory Group, Alder Hey Children's Hospital Clinical Research Facility, Liverpool, UK","institution_ids":["https://openalex.org/I4210157731"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115799211","display_name":"Hannah Sedgwick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161081","display_name":"Intensive Care National Audit & Research Centre","ror":"https://ror.org/057b2ek35","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210161081"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hannah Sedgwick","raw_affiliation_strings":["Intensive Care National Audit and Research Centre, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care National Audit and Research Centre, London, UK","institution_ids":["https://openalex.org/I4210161081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041489112","display_name":"Carly Tibbins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159183","display_name":"NIHR Research Delivery Network","ror":"https://ror.org/05fj7ar22","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210159183"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carly Tibbins","raw_affiliation_strings":["NIHR Clinical Research Network West Midlands, Birmingham, West Midlands, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Clinical Research Network West Midlands, Birmingham, West Midlands, UK","institution_ids":["https://openalex.org/I4210159183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059004773","display_name":"Paul  R. Mouncey","orcid":"https://orcid.org/0000-0002-8510-8517","observed_orcids":["https://orcid.org/0000-0002-8510-8517"]},"institutions":[{"id":"https://openalex.org/I4210161081","display_name":"Intensive Care National Audit & Research Centre","ror":"https://ror.org/057b2ek35","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210161081"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul R Mouncey","raw_affiliation_strings":["Intensive Care National Audit and Research Centre, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-8510-8517","affiliations":[{"raw_affiliation_string":"Intensive Care National Audit and Research Centre, London, UK","institution_ids":["https://openalex.org/I4210161081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050377625","display_name":"Mark John Peters","orcid":"https://orcid.org/0000-0003-3653-4808","observed_orcids":["https://orcid.org/0000-0003-3653-4808"]},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I2800349819","display_name":"Great Ormond Street Hospital for Children NHS Foundation Trust","ror":"https://ror.org/03zydm450","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I4387152181","display_name":"NIHR Great Ormond Street Hospital Biomedical Research Centre","ror":"https://ror.org/033rx1153","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819","https://openalex.org/I34931013","https://openalex.org/I4387152181"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark J Peters","raw_affiliation_strings":["Institute of Child Health, University College London, London, UK","NIHR Biomedical Research Centre, Great Ormond Street Hospital For Children NHS Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Child Health, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"NIHR Biomedical Research Centre, Great Ormond Street Hospital For Children NHS Trust, London, UK","institution_ids":["https://openalex.org/I2800129641","https://openalex.org/I2800349819","https://openalex.org/I4387152181"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069937739","display_name":"Kerry Woolfall","orcid":"https://orcid.org/0000-0002-5726-5304","observed_orcids":["https://orcid.org/0000-0002-5726-5304"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kerry Woolfall","raw_affiliation_strings":["Institute of Population Health, Department of Public Health, Policy and Systems, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Population Health, Department of Public Health, Policy and Systems, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5088401589"],"corresponding_institution_ids":["https://openalex.org/I146655781"],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1500,"currency":"GBP","value_usd":1839},"fwci":5.89,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.96598026,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"e085142","last_page":"e085142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.5576000213623047,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.5576000213623047,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10582","display_name":"Ethics in Clinical Research","score":0.24719999730587006,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14437","display_name":"Ethics and Legal Issues in Pediatric Healthcare","score":0.09080000221729279,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adaptive-platform-trial","display_name":"adaptive platform trial","score":0.7820000052452087},{"id":"https://openalex.org/keywords/pediatric-intensive-care","display_name":"pediatric intensive care","score":0.9860000014305115},{"id":"https://openalex.org/keywords/critically-ill-children","display_name":"critically ill children","score":0.9110000133514404},{"id":"https://openalex.org/keywords/stakeholder-perspectives","display_name":"stakeholder perspectives","score":0.7059999704360962},{"id":"https://openalex.org/keywords/parents-and-caregivers","display_name":"parents and caregivers","score":0.7480000257492065},{"id":"https://openalex.org/keywords/youth","display_name":"youth","score":0.6869999766349792},{"id":"https://openalex.org/keywords/children-s-quality-of-life","display_name":"children's quality of life","score":0.7860000133514404},{"id":"https://openalex.org/keywords/survival-outcomes","display_name":"survival outcomes","score":0.7829999923706055},{"id":"https://openalex.org/keywords/trial-design","display_name":"trial design","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.802416205406189},{"id":"https://openalex.org/C56995899","wikidata":"https://www.wikidata.org/wiki/Q1126687","display_name":"Focus group","level":2,"score":0.7116105556488037},{"id":"https://openalex.org/C74196892","wikidata":"https://www.wikidata.org/wiki/Q7781188","display_name":"Thematic analysis","level":3,"score":0.6897704601287842},{"id":"https://openalex.org/C109359841","wikidata":"https://www.wikidata.org/wiki/Q728944","display_name":"Inclusion (mineral)","level":2,"score":0.594417929649353},{"id":"https://openalex.org/C190248442","wikidata":"https://www.wikidata.org/wiki/Q839486","display_name":"Qualitative research","level":2,"score":0.5596430897712708},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.493024080991745},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4719112515449524},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.46230047941207886},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44918474555015564},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0973484218120575},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000075522","descriptor_name":"Adaptive Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075522","descriptor_name":"Adaptive Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010290","descriptor_name":"Parents","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D010290","descriptor_name":"Parents","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D010290","descriptor_name":"Parents","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D010290","descriptor_name":"Parents","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D010290","descriptor_name":"Parents","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D010290","descriptor_name":"Parents","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D010290","descriptor_name":"Parents","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015278","descriptor_name":"Intensive Care Units, Pediatric","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D015278","descriptor_name":"Intensive Care Units, Pediatric","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D015278","descriptor_name":"Intensive Care Units, Pediatric","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D015278","descriptor_name":"Intensive Care Units, Pediatric","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D015278","descriptor_name":"Intensive Care Units, Pediatric","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D015278","descriptor_name":"Intensive Care Units, Pediatric","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D015278","descriptor_name":"Intensive Care Units, Pediatric","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":true},{"descriptor_ui":"D017144","descriptor_name":"Focus Groups","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017144","descriptor_name":"Focus Groups","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017144","descriptor_name":"Focus Groups","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017144","descriptor_name":"Focus Groups","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017144","descriptor_name":"Focus Groups","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017144","descriptor_name":"Focus Groups","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017144","descriptor_name":"Focus Groups","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036301","descriptor_name":"Qualitative Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036301","descriptor_name":"Qualitative Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036301","descriptor_name":"Qualitative Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036301","descriptor_name":"Qualitative Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036301","descriptor_name":"Qualitative Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036301","descriptor_name":"Qualitative Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036301","descriptor_name":"Qualitative Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1136/bmjopen-2024-085142","doi":"https://doi.org/10.1136/bmjopen-2024-085142","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2024-085142","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/15/1/e085142.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},{"id":"pmid:39773799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39773799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ open","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11749188","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11749188","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11749188/pdf/bmjopen-15-1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ Open","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f434fb78964140cea9303ed67554d862","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f434fb78964140cea9303ed67554d862","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ Open, Vol 15, Iss 1 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/bmjopen-2024-085142","doi":"https://doi.org/10.1136/bmjopen-2024-085142","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2024-085142","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/15/1/e085142.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6100000143051147,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1502393134","display_name":"Development of a Platform Trial in Paediatric Intensive Care","funder_award_id":"NIHR155476","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G8710429689","display_name":null,"funder_award_id":"NIHR 155476","funder_id":"https://openalex.org/F4320334661","funder_display_name":"Health Technology Assessment Programme"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320334661","display_name":"Health Technology Assessment Programme","ror":"https://ror.org/0187kwz08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406139516.pdf","grobid_xml":"https://content.openalex.org/works/W4406139516.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1979290264","https://openalex.org/W1988091012","https://openalex.org/W2034329675","https://openalex.org/W2044115095","https://openalex.org/W2072019641","https://openalex.org/W2086805083","https://openalex.org/W2100648787","https://openalex.org/W2138664283","https://openalex.org/W2226322964","https://openalex.org/W2305278139","https://openalex.org/W2726405642","https://openalex.org/W2749485654","https://openalex.org/W2807669236","https://openalex.org/W2950504429","https://openalex.org/W2955652745","https://openalex.org/W2982152932","https://openalex.org/W3007773658","https://openalex.org/W3026023260","https://openalex.org/W3030403894","https://openalex.org/W3047077230","https://openalex.org/W3091935749","https://openalex.org/W3133152905","https://openalex.org/W3134381075","https://openalex.org/W3141957935","https://openalex.org/W3182129217","https://openalex.org/W4229062673","https://openalex.org/W4285078528","https://openalex.org/W4308409819","https://openalex.org/W4319455326","https://openalex.org/W4366598133","https://openalex.org/W4384695924","https://openalex.org/W4388294055","https://openalex.org/W4389486608","https://openalex.org/W4390595410","https://openalex.org/W4399897203","https://openalex.org/W6657425063"],"related_works":["https://openalex.org/W3185553570","https://openalex.org/W2155401483","https://openalex.org/W3045247719","https://openalex.org/W2102102835","https://openalex.org/W2757130632","https://openalex.org/W1774155268","https://openalex.org/W2997034443","https://openalex.org/W3170131249","https://openalex.org/W3166510378","https://openalex.org/W4392833314"],"abstract_inverted_index":{"Objectives":[0],"Platform":[1],"trials":[2,22],"were":[3,90],"used":[4],"successfully":[5],"in":[6,69,126,275],"adult":[7],"populations":[8],"during":[9],"the":[10,26,57,60,70,139,159,179,192,202,223,226,243,257,290,300],"COVID-19":[11],"pandemic.":[12],"By":[13],"testing":[14],"multiple":[15],"treatments":[16,29],"within":[17],"a":[18,170,268,276],"single":[19],"trial,":[20,181],"platform":[21,63,142,161,180,246,262,302],"can":[23,229,272,284],"help":[24],"identify":[25],"most":[27],"effective":[28],"(and":[30],"any":[31,220],"interactions":[32],"between":[33,132],"treatments)":[34],"for":[35,43,65,176,188,264],"patients":[36,44],"more":[37,196],"quickly":[38],"and":[39,45,76,100,104,134,144,166,172,185,200,209,216,239,288],"with":[40,72,182,194,256],"less":[41],"burden":[42],"their":[46],"families.":[47],"The":[48,108],"aim":[49],"of":[50,59,113,128,146,204,207,225,259,292],"this":[51],"qualitative":[52],"research":[53,105,147],"was":[54],"to":[55,151,222,248,279],"inform":[56],"design":[58,258],"first":[61],"adaptive":[62,261],"trial":[64,143,162,193,228,247,263,303],"paediatric":[66,77],"intensive":[67,78],"care":[68,79],"UK":[71],"young":[73,117],"people,":[74,98,237],"parents/carers":[75,238],"unit":[80],"(PICU)":[81],"staff.":[82,106],"Design":[83],"Qualitative":[84],"semistructured":[85],"focus":[86,130],"group":[87],"study.":[88],"Data":[89],"analysed":[91],"using":[92],"reflexive":[93],"thematic":[94],"analysis.":[95],"Participants":[96,137],"Young":[97,236],"parents/carers,":[99],"PICU":[101,122,141,160,240,245,265,301],"medical,":[102],"nursing":[103],"Setting":[107],"UK.":[109],"Results":[110],"A":[111],"total":[112],"86":[114],"participants":[115],"(18":[116],"people;":[118],"15":[119],"parents/carers;":[120],"53":[121],"staff)":[123],"took":[124],"part":[125],"1":[127],"10":[129],"groups":[131],"May":[133],"September":[135],"2023.":[136],"viewed":[138,242],"proposed":[140,244],"use":[145],"without":[148],"prior":[149],"consent":[150],"be":[152,164,230,249,273],"acceptable.":[153,250],"Findings":[154],"provide":[155,280],"insight":[156],"into":[157],"how":[158,219],"should":[163],"designed":[165],"operationalised,":[167],"including":[168],"having":[169],"broad":[171],"inclusive":[173],"population":[174],"eligible":[175],"inclusion":[177,184],"onto":[178],"different":[183],"exclusion":[186],"criteria":[187],"each":[189],"domain;":[190],"starting":[191],"no":[195],"than":[197],"three":[198],"domains":[199],"prioritising":[201],"outcomes":[203],"Child":[205],"quality":[206],"life":[208],"Survival":[210],"(all":[211],"participants).":[212],"Optimal":[213],"governance":[214],"structure":[215],"suggestions":[217],"about":[218],"challenges":[221],"success":[224],"full":[227],"overcome":[231],"are":[232],"also":[233],"presented.":[234],"Conclusions":[235],"staff":[241],"These":[251],"key":[252],"stakeholders":[253],"supported":[254],"us":[255],"an":[260],"that":[266,283],"has":[267],"rigorous":[269],"methodology,":[270],"yet":[271],"operationalised":[274],"family-centred":[277],"way,":[278],"high-quality":[281],"evidence":[282],"support":[285],"clinical":[286],"decision-making":[287],"guide":[289],"treatment":[291],"critically":[293],"ill":[294],"children.":[295],"Our":[296],"findings":[297],"have":[298],"informed":[299],"protocol.":[304]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}
