{"id":"https://openalex.org/W4406139067","doi":"https://doi.org/10.2139/ssrn.5080769","title":"Kdm3b Regulates Post Radiation Fibrotic Responses in Prostate Stroma Via M6a Modification of Lox","display_name":"Kdm3b Regulates Post Radiation Fibrotic Responses in Prostate Stroma Via M6a Modification of Lox","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4406139067","doi":"https://doi.org/10.2139/ssrn.5080769"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.5080769","doi":"https://doi.org/10.2139/ssrn.5080769","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5080769","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.5080769","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046273244","display_name":"Antao Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Antao Dong","raw_affiliation_strings":["Anhui Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anhui Medical University","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107006856","display_name":"Xin Sun","orcid":"https://orcid.org/0000-0002-5573-551X","observed_orcids":["https://orcid.org/0000-0002-5573-551X"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Sun","raw_affiliation_strings":["Anhui Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anhui Medical University","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333590","display_name":"Lei Chen","orcid":"https://orcid.org/0009-0001-1696-5902","observed_orcids":["https://orcid.org/0009-0001-1696-5902"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Chen","raw_affiliation_strings":["Anhui Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anhui Medical University","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014039663","display_name":"Ying Tsai","orcid":"https://orcid.org/0000-0002-6361-9834","observed_orcids":["https://orcid.org/0000-0002-6361-9834"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Tsai","raw_affiliation_strings":["University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090040622","display_name":"Sarah L. Kerns","orcid":"https://orcid.org/0000-0002-6503-0011","observed_orcids":["https://orcid.org/0000-0002-6503-0011"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Kerns","raw_affiliation_strings":["Medical College of Wisconsin","Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074559844","display_name":"Brian Marples","orcid":"https://orcid.org/0000-0002-8684-4372","observed_orcids":["https://orcid.org/0000-0002-8684-4372"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Marples","raw_affiliation_strings":["University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Defu Xing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Defu Xing","raw_affiliation_strings":["Anhui Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anhui Medical University","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016976503","display_name":"Yuhchyau Chen","orcid":"https://orcid.org/0000-0002-8276-1772","observed_orcids":["https://orcid.org/0000-0002-8276-1772"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuhchyau Chen","raw_affiliation_strings":["University of Rochester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112895089","display_name":"Dongdong Xie","orcid":"https://orcid.org/0009-0005-9657-0626","observed_orcids":["https://orcid.org/0009-0005-9657-0626"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongdong Xie","raw_affiliation_strings":["Anhui Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anhui Medical University","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040974046","display_name":"Yin Sun","orcid":"https://orcid.org/0009-0000-8793-3169","observed_orcids":["https://orcid.org/0009-0000-8793-3169"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yin Sun","raw_affiliation_strings":["University of Rochester - George Whipple Lab for Cancer Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester - George Whipple Lab for Cancer Research","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040974046"],"corresponding_institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.11940000206232071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.04919999837875366,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kdm3b","display_name":"KDM3B","score":0.9959999918937683},{"id":"https://openalex.org/keywords/radiation-induced-fibrosis","display_name":"radiation-induced fibrosis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/prostatic-stroma","display_name":"prostate stroma","score":0.8669999837875366},{"id":"https://openalex.org/keywords/lysyl-oxidase","display_name":"lysyl oxidase","score":0.7229999899864197},{"id":"https://openalex.org/keywords/m6a-methylation","display_name":"m6A RNA methylation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/alpha-ketoglutarate","display_name":"alpha-ketoglutarate","score":0.8140000104904175},{"id":"https://openalex.org/keywords/circular-rna","display_name":"circular RNA","score":0.5669999718666077},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7720000147819519},{"id":"https://openalex.org/keywords/collagen-cross-linking","display_name":"collagen cross-linking","score":0.9710000157356262},{"id":"https://openalex.org/keywords/genitourinary-toxicity","display_name":"genitourinary toxicity","score":0.8410000205039978},{"id":"https://openalex.org/keywords/prostate-cancer-radiotherapy","display_name":"prostate cancer radiotherapy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/prime-editing","display_name":"prime editing","score":0.31200000643730164}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7367631196975708},{"id":"https://openalex.org/C193143273","wikidata":"https://www.wikidata.org/wiki/Q419389","display_name":"Lysyl oxidase","level":3,"score":0.6429685950279236},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6330108642578125},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5908029675483704},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5885633230209351},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5690038800239563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4817359745502472},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4213290810585022},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3740466237068176},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26220837235450745},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26112738251686096},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.1273762285709381},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11473128199577332}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.5080769","doi":"https://doi.org/10.2139/ssrn.5080769","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5080769","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.5080769","doi":"https://doi.org/10.2139/ssrn.5080769","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5080769","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1835871681","https://openalex.org/W2018838463","https://openalex.org/W2064709017","https://openalex.org/W2066705793","https://openalex.org/W2067692539","https://openalex.org/W2126763861","https://openalex.org/W2131860315","https://openalex.org/W2149574104","https://openalex.org/W2164428603","https://openalex.org/W2499374012","https://openalex.org/W2616802735","https://openalex.org/W2891055002","https://openalex.org/W2950683108","https://openalex.org/W2953923156","https://openalex.org/W2968558131","https://openalex.org/W2996247621","https://openalex.org/W3012463633","https://openalex.org/W3013209770","https://openalex.org/W3047292488","https://openalex.org/W3048054690","https://openalex.org/W3048845403","https://openalex.org/W3111969163","https://openalex.org/W3127865179","https://openalex.org/W3133117790","https://openalex.org/W3172002214","https://openalex.org/W4205284185","https://openalex.org/W4224278902","https://openalex.org/W4294079598","https://openalex.org/W4309335283","https://openalex.org/W4310121354","https://openalex.org/W4321370235","https://openalex.org/W4365997827","https://openalex.org/W4385157062","https://openalex.org/W4387710332","https://openalex.org/W4387910256","https://openalex.org/W4389001126","https://openalex.org/W4390876452","https://openalex.org/W4390946922","https://openalex.org/W4402498995","https://openalex.org/W4406500920"],"related_works":["https://openalex.org/W4411919599","https://openalex.org/W4389001126","https://openalex.org/W2321377604","https://openalex.org/W2770278593","https://openalex.org/W4416633659","https://openalex.org/W7119577587","https://openalex.org/W3161328142","https://openalex.org/W2899319278","https://openalex.org/W2377464072","https://openalex.org/W2590541532"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-01-08T00:00:00"}