{"id":"https://openalex.org/W4406133867","doi":"https://doi.org/10.1007/s11899-024-00749-4","title":"Mutant Calreticulin in MPN: Mechanistic Insights and Therapeutic Implications","display_name":"Mutant Calreticulin in MPN: Mechanistic Insights and Therapeutic Implications","publication_year":2025,"publication_date":"2025-01-07","ids":{"openalex":"https://openalex.org/W4406133867","doi":"https://doi.org/10.1007/s11899-024-00749-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/39775969","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12085081"},"language":"en","primary_location":{"id":"doi:10.1007/s11899-024-00749-4","doi":"https://doi.org/10.1007/s11899-024-00749-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11899-024-00749-4","pdf_url":null,"source":{"id":"https://openalex.org/S35022943","display_name":"Current Hematologic Malignancy Reports","issn_l":"1558-8211","issn":["1558-8211","1558-822X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Hematologic Malignancy Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12085081/pdf/nihms-2076915.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103085165","display_name":"Mifra Faiz","orcid":"https://orcid.org/0000-0001-8681-6286","observed_orcids":["https://orcid.org/0000-0001-8681-6286"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mifra Faiz","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Institute of Medicine, Boston, MA, 02115, USA"],"raw_orcid":"https://orcid.org/0000-0001-8681-6286","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Institute of Medicine, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115797279","display_name":"Merle Riedemann","orcid":"https://orcid.org/0009-0004-5457-7451","observed_orcids":["https://orcid.org/0009-0004-5457-7451"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Merle Riedemann","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Institute of Medicine, Boston, MA, 02115, USA"],"raw_orcid":"https://orcid.org/0009-0004-5457-7451","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Institute of Medicine, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029579545","display_name":"Jonas Samuel Jutzi","orcid":"https://orcid.org/0000-0002-1977-153X","observed_orcids":["https://orcid.org/0000-0002-1977-153X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonas S. Jutzi","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Institute of Medicine, Boston, MA, 02115, USA"],"raw_orcid":"https://orcid.org/0000-0002-1977-153X","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Institute of Medicine, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015102296","display_name":"Ann Mullally","orcid":"https://orcid.org/0000-0001-9727-8495","observed_orcids":["https://orcid.org/0000-0001-9727-8495"]},"institutions":[{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ann Mullally","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA. amullal@stanford.edu","Hematology Division, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA. amullal@stanford.edu","Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA","Hematology Division, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA"],"raw_orcid":"https://orcid.org/0000-0001-9727-8495","affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA. amullal@stanford.edu","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Hematology Division, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA. amullal@stanford.edu","institution_ids":["https://openalex.org/I204866599"]},{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Hematology Division, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA","institution_ids":["https://openalex.org/I204866599"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5015102296"],"corresponding_institution_ids":["https://openalex.org/I204866599","https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":1.3429,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.7740448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"4","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calr-mutation","display_name":"CALR mutation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.9879999756813049},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.5989999771118164},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.8199999928474426},{"id":"https://openalex.org/keywords/proteasome-targeting","display_name":"proteasome targeting","score":0.9020000100135803},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C47450691","wikidata":"https://www.wikidata.org/wiki/Q634510","display_name":"Calreticulin","level":3,"score":0.927975058555603},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7254496216773987},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5357206463813782},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44677144289016724},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24934208393096924},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21615982055664062},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15922784805297852},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.06998315453529358}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009196","descriptor_name":"Myeloproliferative Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D037282","descriptor_name":"Calreticulin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D037282","descriptor_name":"Calreticulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D037282","descriptor_name":"Calreticulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s11899-024-00749-4","doi":"https://doi.org/10.1007/s11899-024-00749-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11899-024-00749-4","pdf_url":null,"source":{"id":"https://openalex.org/S35022943","display_name":"Current Hematologic Malignancy Reports","issn_l":"1558-8211","issn":["1558-8211","1558-822X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Hematologic Malignancy Reports","raw_type":"journal-article"},{"id":"pmid:39775969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39775969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current hematologic malignancy reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12085081","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12085081","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12085081/pdf/nihms-2076915.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Hematol Malig Rep","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:12085081","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12085081","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12085081/pdf/nihms-2076915.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Hematol Malig Rep","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G161478333","display_name":"Functional and Molecular Dissection of Mutant Calreticulin in Myeloproliferative Neoplasms","funder_award_id":"R01HL131835","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2067352081","display_name":"Biology and Therapeutic Targeting of Malignant Monocytes in Myeloid Blood Cancers","funder_award_id":"W81XWH-21-1-0909","funder_id":"https://openalex.org/F4320338273","funder_display_name":"Congressionally Directed Medical Research Programs"},{"id":"https://openalex.org/G2555783796","display_name":"BIOLOGY AND THERAPEUTIC TARGETING OF MALIGNANT MONOCYTES IN MYELOID BLOOD CANCERS","funder_award_id":"W81XWH2110909","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5840516970","display_name":null,"funder_award_id":"TRTH112","funder_id":"https://openalex.org/F4320310646","funder_display_name":"European Hematology Association"},{"id":"https://openalex.org/G9000913091","display_name":"Elucidating Mechanisms of Therapy-Resistance to Interferon-alfa in Myeloproliferative Neoplasm Stem Cells","funder_award_id":"R01HL167139","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F3581174656","display_name":"Starr Cancer Consortium","ror":null},{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320310646","display_name":"European Hematology Association","ror":"https://ror.org/05hk0hn26"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320338273","display_name":"Congressionally Directed Medical Research Programs","ror":"https://ror.org/03g2zjp07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406133867.pdf","grobid_xml":"https://content.openalex.org/works/W4406133867.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1980568348","https://openalex.org/W1992604276","https://openalex.org/W2015113479","https://openalex.org/W2049145190","https://openalex.org/W2057360098","https://openalex.org/W2084050646","https://openalex.org/W2116878961","https://openalex.org/W2117986250","https://openalex.org/W2138709799","https://openalex.org/W2144664431","https://openalex.org/W2157694607","https://openalex.org/W2173500616","https://openalex.org/W2230798701","https://openalex.org/W2278646061","https://openalex.org/W2284541528","https://openalex.org/W2295884733","https://openalex.org/W2306779733","https://openalex.org/W2310016096","https://openalex.org/W2344384041","https://openalex.org/W2351294632","https://openalex.org/W2417685891","https://openalex.org/W2509761752","https://openalex.org/W2564597498","https://openalex.org/W2731447759","https://openalex.org/W2778173016","https://openalex.org/W2808824118","https://openalex.org/W2896385413","https://openalex.org/W2901966462","https://openalex.org/W2908952707","https://openalex.org/W2948635289","https://openalex.org/W2954062012","https://openalex.org/W2954384525","https://openalex.org/W2970457608","https://openalex.org/W2972422263","https://openalex.org/W2996973471","https://openalex.org/W3000314328","https://openalex.org/W3095866699","https://openalex.org/W3111369708","https://openalex.org/W3133520808","https://openalex.org/W3134473205","https://openalex.org/W3138777533","https://openalex.org/W3165680939","https://openalex.org/W3195336015","https://openalex.org/W3197283914","https://openalex.org/W4213373081","https://openalex.org/W4223451706","https://openalex.org/W4282914934","https://openalex.org/W4283123366","https://openalex.org/W4283689603","https://openalex.org/W4295073666","https://openalex.org/W4308702374","https://openalex.org/W4309679324","https://openalex.org/W4310937739","https://openalex.org/W4321787519","https://openalex.org/W4362640714","https://openalex.org/W4389219736","https://openalex.org/W4400247344","https://openalex.org/W4402389044","https://openalex.org/W4405043926"],"related_works":["https://openalex.org/W3129937359","https://openalex.org/W2976755053","https://openalex.org/W7223133394","https://openalex.org/W4385660700","https://openalex.org/W4413637580","https://openalex.org/W2909222910","https://openalex.org/W3086140346","https://openalex.org/W7203660746","https://openalex.org/W4415451879","https://openalex.org/W7124197506"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-01-08T00:00:00"}
