{"id":"https://openalex.org/W4406057193","doi":"https://doi.org/10.1016/s0022-3565(24)39243-2","title":"Effects of Volatile Anesthetics on the Direct and Indirect Protein Kinase C-Mediated Enhancement of \u03b11E-Type Ca2+Current in Xenopus Oocytes","display_name":"Effects of Volatile Anesthetics on the Direct and Indirect Protein Kinase C-Mediated Enhancement of \u03b11E-Type Ca2+Current in Xenopus Oocytes","publication_year":2000,"publication_date":"2000-04-01","ids":{"openalex":"https://openalex.org/W4406057193","doi":"https://doi.org/10.1016/s0022-3565(24)39243-2","mag":"1900803465","pmid":"https://pubmed.ncbi.nlm.nih.gov/10773003"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-3565(24)39243-2","doi":"https://doi.org/10.1016/s0022-3565(24)39243-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-3565(24)39243-2","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086846420","display_name":"Ganesan L. Kamatchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ganesan L. Kamatchi","raw_affiliation_strings":["Department of Anesthesiology, University of Virginia Health Science System, Charlottesville, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Virginia Health Science System, Charlottesville, Virginia","institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061757931","display_name":"Shveta N. Tiwari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shveta N. Tiwari","raw_affiliation_strings":["Department of Anesthesiology, University of Virginia Health Science System, Charlottesville, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Virginia Health Science System, Charlottesville, Virginia","institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034538984","display_name":"Marcel E. Durieux","orcid":"https://orcid.org/0000-0003-1479-7666","observed_orcids":["https://orcid.org/0000-0003-1479-7666"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcel E. Durieux","raw_affiliation_strings":["Department of Anesthesiology, University of Virginia Health Science System, Charlottesville, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Virginia Health Science System, Charlottesville, Virginia","institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103371364","display_name":"Carl III Lynch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl Lynch","raw_affiliation_strings":["Department of Anesthesiology, University of Virginia Health Science System, Charlottesville, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, University of Virginia Health Science System, Charlottesville, Virginia","institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086846420"],"corresponding_institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I51556381"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.4981,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.55779705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"293","issue":"2","first_page":"360","last_page":"369"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.5522000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.5522000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.3499000072479248,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/volatile-anesthetics","display_name":"volatile anesthetics","score":1.0},{"id":"https://openalex.org/keywords/halothane","display_name":"halothane","score":0.9430000185966492},{"id":"https://openalex.org/keywords/isoflurane","display_name":"isoflurane","score":1.0},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9959999918937683},{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.828000009059906},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9110000133514404},{"id":"https://openalex.org/keywords/1-2-dioctanoyl-sn-glycerol","display_name":"1,2-dioctanoyl-sn-glycerol","score":0.9190000295639038},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9179999828338623},{"id":"https://openalex.org/keywords/barium-currents","display_name":"barium currents","score":0.8539999723434448},{"id":"https://openalex.org/keywords/pkc-isoforms","display_name":"PKC isoforms","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.9126348495483398},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5625064969062805},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5571797490119934},{"id":"https://openalex.org/C2994138156","wikidata":"https://www.wikidata.org/wiki/Q909194","display_name":"Volatile anesthetic","level":3,"score":0.4726656675338745},{"id":"https://openalex.org/C148043351","wikidata":"https://www.wikidata.org/wiki/Q4456944","display_name":"Current (fluid)","level":2,"score":0.4499748647212982},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4050655663013458},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3226316571235657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31122320890426636},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27228790521621704},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.25755929946899414},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07299497723579407},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06456845998764038},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.04413297772407532},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C2776359302","wikidata":"https://www.wikidata.org/wiki/Q413918","display_name":"Isoflurane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004075","descriptor_name":"Diglycerides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006221","descriptor_name":"Halothane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007530","descriptor_name":"Isoflurane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016210","descriptor_name":"Methacholine Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018721","descriptor_name":"Muscarinic Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020536","descriptor_name":"Enzyme Activators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043643","descriptor_name":"Receptor, Muscarinic M1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-3565(24)39243-2","doi":"https://doi.org/10.1016/s0022-3565(24)39243-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-3565(24)39243-2","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},{"id":"pmid:10773003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10773003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pharmacology and experimental therapeutics","raw_type":"Journal Article"},{"id":"mag:1900803465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10773003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1476895786","display_name":"MOLECULAR STUDIES OF ANESTHETIC-MUSCARINIC INTERACTIONS","funder_award_id":"R29GM052387","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1997662618","display_name":"CALCIUM CURRENT DEPRESSION BY VOLATILE ANESTHETICS","funder_award_id":"R01GM031144","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W220075218","https://openalex.org/W1639006700","https://openalex.org/W1924075688","https://openalex.org/W1963046602","https://openalex.org/W1965846991","https://openalex.org/W1974018894","https://openalex.org/W1981646620","https://openalex.org/W1985686041","https://openalex.org/W1988480635","https://openalex.org/W1992053490","https://openalex.org/W2002668908","https://openalex.org/W2002907216","https://openalex.org/W2012571262","https://openalex.org/W2029008254","https://openalex.org/W2037471264","https://openalex.org/W2038297374","https://openalex.org/W2039788784","https://openalex.org/W2040855186","https://openalex.org/W2050531815","https://openalex.org/W2055989053","https://openalex.org/W2068910592","https://openalex.org/W2079801558","https://openalex.org/W2081025398","https://openalex.org/W2083628540","https://openalex.org/W2085588834","https://openalex.org/W2090100880","https://openalex.org/W2090235849","https://openalex.org/W2091293272","https://openalex.org/W2092401349","https://openalex.org/W2117126341","https://openalex.org/W2128278859","https://openalex.org/W2130950257","https://openalex.org/W2132805001","https://openalex.org/W2148527746","https://openalex.org/W2151632397","https://openalex.org/W2261589407","https://openalex.org/W2407805475","https://openalex.org/W2413511019","https://openalex.org/W2416393487","https://openalex.org/W4210574951"],"related_works":["https://openalex.org/W1900803465","https://openalex.org/W2018767641","https://openalex.org/W2084546632","https://openalex.org/W2025998979","https://openalex.org/W4406066373","https://openalex.org/W2019660971","https://openalex.org/W1988480635","https://openalex.org/W1968092829","https://openalex.org/W2074946128","https://openalex.org/W2010779942"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-01-04T00:00:00"}