{"id":"https://openalex.org/W4406030132","doi":"https://doi.org/10.1002/alz.090886","title":"Seizure\u2010activated neurons facilitate tau spread in 5XFAD mice","display_name":"Seizure\u2010activated neurons facilitate tau spread in 5XFAD mice","publication_year":2024,"publication_date":"2024-12-01","ids":{"openalex":"https://openalex.org/W4406030132","doi":"https://doi.org/10.1002/alz.090886","pmid":"https://pubmed.ncbi.nlm.nih.gov/39750796"},"language":"en","primary_location":{"id":"doi:10.1002/alz.090886","doi":"https://doi.org/10.1002/alz.090886","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.090886","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.090886","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.090886","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037014820","display_name":"Aaron J Barbour","orcid":"https://orcid.org/0000-0002-4880-6797","observed_orcids":["https://orcid.org/0000-0002-4880-6797"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aaron J Barbour","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036387971","display_name":"Abigail Chavez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigail Chavez","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093577823","display_name":"Keegan F. Hoag","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keegan Hoag","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100637085","display_name":"Xiaofan Li","orcid":"https://orcid.org/0000-0002-9885-1289","observed_orcids":["https://orcid.org/0000-0002-9885-1289"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofan Li","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114945232","display_name":"Chloe Hassman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chloe Hassman","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065852445","display_name":"Virginia M.\u2010Y. Lee","orcid":"https://orcid.org/0000-0003-3536-6902","observed_orcids":["https://orcid.org/0000-0003-3536-6902"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia M.\u2010Y. Lee","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039143967","display_name":"Delia M. Talos","orcid":"https://orcid.org/0009-0009-5346-8954","observed_orcids":["https://orcid.org/0009-0009-5346-8954"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Delia M Talos","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059417834","display_name":"Frances E. Jensen","orcid":"https://orcid.org/0000-0001-7844-5518","observed_orcids":["https://orcid.org/0000-0001-7844-5518"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frances E Jensen","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037014820"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":{"value":4000,"currency":"USD","value_usd":4000},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28730187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"S1","first_page":"e090886","last_page":"e090886"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.7456746101379395},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7437486052513123},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5998152494430542},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5876075625419617},{"id":"https://openalex.org/C2776819090","wikidata":"https://www.wikidata.org/wiki/Q412391","display_name":"Pentylenetetrazol","level":4,"score":0.5553998947143555},{"id":"https://openalex.org/C100691959","wikidata":"https://www.wikidata.org/wiki/Q6410625","display_name":"Kindling","level":3,"score":0.5176387429237366},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.4482814371585846},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43545228242874146},{"id":"https://openalex.org/C2778302826","wikidata":"https://www.wikidata.org/wiki/Q1741970","display_name":"Kindling model","level":4,"score":0.4160853922367096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3762528896331787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3561949133872986},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2928478717803955},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.0924949049949646}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007696","descriptor_name":"Kindling, Neurologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007696","descriptor_name":"Kindling, Neurologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010433","descriptor_name":"Pentylenetetrazole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010433","descriptor_name":"Pentylenetetrazole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/alz.090886","doi":"https://doi.org/10.1002/alz.090886","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.090886","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.090886","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},{"id":"pmid:39750796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39750796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & dementia : the journal of the Alzheimer's Association","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11710728","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11710728","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11710728/pdf/ALZ-20-e090886.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alzheimers Dement","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/alz.090886","doi":"https://doi.org/10.1002/alz.090886","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.090886","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.090886","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5899999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406030132.pdf","grobid_xml":"https://content.openalex.org/works/W4406030132.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2060703234","https://openalex.org/W2156493939","https://openalex.org/W1875008998","https://openalex.org/W2350113219","https://openalex.org/W2373305394","https://openalex.org/W2021112246","https://openalex.org/W2360426185","https://openalex.org/W2465639006","https://openalex.org/W2887962889","https://openalex.org/W2060534207"],"abstract_inverted_index":{"BACKGROUND:":[0],"Seizures":[1,142],"are":[2],"highly":[3],"comorbid":[4],"with":[5,22,106,146],"Alzheimer's":[6],"disease":[7],"(AD).":[8],"We":[9,70,120,210],"and":[10,16,25,78,90,127,139,154,181,197,203,237,268,335,338],"others":[11],"have":[12,85],"demonstrated":[13],"worsened":[14],"pathological":[15,346],"cognitive":[17],"outcomes":[18],"in":[19,29,109,137,222,249,256,260,332],"AD":[20,30,35,54,347],"patients":[21],"seizure":[23,27,245],"history":[24],"after":[26],"induction":[28,254],"mouse":[31,104,333],"models.":[32],"Central":[33],"to":[34,88,115,159,192,220,226,282,344],"progression":[36],"is":[37,68],"the":[38,64,102,125,163,193,230,250,266],"spread":[39,65,77,259,331],"of":[40,52,66,135,166,244],"tau":[41,57,67,76,93,204,217,258,320,330],"along":[42],"neuronal":[43],"connections,":[44],"which":[45],"can":[46],"be":[47],"modelled":[48],"by":[49],"intracerebral":[50],"injection":[51],"human":[53],"brain":[55,187,263],"derived":[56],"lysate":[58],"(AD-tau),":[59],"but":[60],"whether":[61],"seizures":[62,73,83,328,337],"impact":[63],"unknown.":[69],"hypothesized":[71],"that":[72,79,212,313,327],"would":[74,84],"worsen":[75],"neurons":[80,156,201,283,292,306,317,340],"activated":[81],"during":[82],"increased":[86,216,257,295],"susceptibility":[87],"develop":[89],"possibly":[91],"transmit":[92],"pathology.":[94],"METHODS:":[95],"To":[96],"investigate":[97],"seizure-tau":[98],"interactions,":[99],"we":[100,278],"crossed":[101],"5XFAD":[103,287,308],"model":[105],"targeted":[107],"recombination":[108],"active":[110],"populations":[111],"mice":[112,214,309],"(TRAP;":[113],"5X-/WT-TRAP)":[114],"permanently":[116],"label":[117],"seizure-activated":[118,155,200,290,316,339],"neurons.":[119],"injected":[121],"AD-tau":[122,174,227],"unilaterally":[123],"into":[124],"hippocampus":[126],"overlying":[128],"cortex":[129],"(1":[130],"\u00b5g/site)":[131],"at":[132],"three":[133],"months":[134,172],"age":[136],"5X-TRAP":[138,213],"WT-TRAP":[140,221],"littermates.":[141],"were":[143,157,178,189],"then":[144,190],"induced":[145,158],"pentylenetetrazol":[147],"(PTZ)":[148],"kindling":[149,167],"2-3":[150],"weeks":[151],"following":[152,173],"surgery":[153],"express":[160],"tdTomato":[161],"on":[162],"final":[164],"day":[165],"via":[168],"4-hydroxytamoxifen":[169],"administration.":[170],"Three":[171],"seeding,":[175],"5X-/WT-TRAP":[176],"brains":[177],"serially":[179],"sectioned":[180],"underwent":[182],"immunofluorescent":[183],"slide":[184],"scanning.":[185],"Scanned":[186],"images":[188],"registered":[191],"Allen":[194],"Brain":[195],"Atlas":[196],"mapped":[198],"for":[199],"(tdTomato+)":[202,291],"pathology":[205,218],"(phospho-tau":[206],"Ser202/Ser205;":[207],"AT8).":[208],"RESULTS:":[209],"found":[211,279],"had":[215],"compared":[219,281],"hippocampal":[223],"subregions":[224],"ipsilateral":[225,267],"injection,":[228],"including":[229,265],"dentate":[231],"gyrus":[232],"(p<0.05,":[233,272,299],"n":[234,240,273,300],"=":[235,241,274,301],"5-10/group)":[236],"subiculum":[238],"(p<0.01,":[239],"5-9/group),":[242],"regardless":[243],"kindling,":[246],"without":[247],"changes":[248],"contralateral":[251,269],"hippocampus.":[252],"Seizure":[253],"resulted":[255],"remote":[261],"interconnected":[262],"regions,":[264],"thalamo-cortical":[270],"regions":[271],"5-9/group).":[275],"In":[276],"addition,":[277],"that,":[280],"from":[284,307],"a":[285],"saline-treated":[286],"mouse,":[288],"thalamic":[289],"showed":[293],"significantly":[294],"somatic":[296],"AT8":[297],"levels":[298],"8-11),":[302],"while":[303],"surrounding":[304],"(tdTomato-)":[305],"did":[310],"not,":[311],"suggesting":[312],"these":[314],"thalamic,":[315],"preferentially":[318],"facilitate":[319],"spread.":[321],"CONCLUSION:":[322],"Together,":[323],"our":[324],"data":[325],"demonstrate":[326],"increase":[329],"models":[334],"identify":[336],"as":[341],"therapeutic":[342],"targets":[343],"slow":[345],"progression.":[348]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-01-03T00:00:00"}