{"id":"https://openalex.org/W4406024334","doi":"https://doi.org/10.1002/alz.092437","title":"Rapid Identification of Patients with Rapidly Progressive Dementia","display_name":"Rapid Identification of Patients with Rapidly Progressive Dementia","publication_year":2024,"publication_date":"2024-12-01","ids":{"openalex":"https://openalex.org/W4406024334","doi":"https://doi.org/10.1002/alz.092437","pmid":"https://pubmed.ncbi.nlm.nih.gov/39750237"},"language":"en","primary_location":{"id":"doi:10.1002/alz.092437","doi":"https://doi.org/10.1002/alz.092437","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.092437","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.092437","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.092437","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056731983","display_name":"Yoav D. Piura","orcid":"https://orcid.org/0000-0003-1004-4560","observed_orcids":["https://orcid.org/0000-0003-1004-4560"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yoav D Piura","raw_affiliation_strings":["Mayo Clinic, Jacksonville, FL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004861574","display_name":"Philip W. Tipton","orcid":"https://orcid.org/0000-0003-4084-2248","observed_orcids":["https://orcid.org/0000-0003-4084-2248"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip W Tipton","raw_affiliation_strings":["Mayo Clinic, Jacksonville, FL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056157849","display_name":"Steven Richard Dunham","orcid":"https://orcid.org/0000-0003-2840-3955","observed_orcids":["https://orcid.org/0000-0003-2840-3955"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Richard Dunham","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024791032","display_name":"Nihal Satyadev","orcid":"https://orcid.org/0000-0001-7302-2348","observed_orcids":["https://orcid.org/0000-0001-7302-2348"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nihal Satyadev","raw_affiliation_strings":["Mayo Clinic, Jacksonville, FL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091046259","display_name":"Neill R. Graff\u2010Radford","orcid":"https://orcid.org/0000-0001-9847-9096","observed_orcids":["https://orcid.org/0000-0001-9847-9096"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neill R Graff\u2010Radford","raw_affiliation_strings":["Department of Neurology, Mayo Clinic, Jacksonville, FL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic, Jacksonville, FL USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063381985","display_name":"Gregory Scott Day","orcid":"https://orcid.org/0000-0001-5133-5538","observed_orcids":["https://orcid.org/0000-0001-5133-5538"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory S Day","raw_affiliation_strings":["Mayo Clinic, Jacksonville, FL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL USA","institution_ids":["https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056731983"],"corresponding_institution_ids":["https://openalex.org/I4210146710"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":{"value":4000,"currency":"USD","value_usd":4000},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30235758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"S3","first_page":"e092437","last_page":"e092437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rapidly-progressive-dementia","display_name":"rapidly progressive dementia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7921360731124878},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7738335132598877},{"id":"https://openalex.org/C2780906993","wikidata":"https://www.wikidata.org/wiki/Q5133756","display_name":"Clinical Dementia Rating","level":4,"score":0.7122673392295837},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5292826294898987},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4997739791870117},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.47778233885765076},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.4241771697998047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39999496936798096},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3955632448196411},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.36139315366744995}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/alz.092437","doi":"https://doi.org/10.1002/alz.092437","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.092437","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.092437","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},{"id":"pmid:39750237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39750237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & dementia : the journal of the Alzheimer's Association","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11710381","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11710381","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11710381/pdf/ALZ-20-e092437.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alzheimers Dement","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/alz.092437","doi":"https://doi.org/10.1002/alz.092437","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.092437","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.092437","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4406024334.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1481122508","https://openalex.org/W4390605164","https://openalex.org/W2208745537","https://openalex.org/W2012773090","https://openalex.org/W3021640140","https://openalex.org/W4210903696","https://openalex.org/W4313682950","https://openalex.org/W2156078606","https://openalex.org/W1975698825","https://openalex.org/W2465537596"],"abstract_inverted_index":{"BACKGROUND:":[0],"Patients":[1,47,103,179],"with":[2,29,106,143,148,162,180,196,275,294,322,331],"the":[3,33,50],"precipitous":[4],"onset":[5],"of":[6,52,129,326,343],"cognitive":[7],"symptoms":[8],"(i.e.,":[9],"suspected":[10,53,170,332],"rapid":[11],"progressive":[12],"dementia":[13,94,112],"[RPD])":[14],"may":[15,22,334],"continue":[16],"to":[17,38,62,111,158,193,222,292],"decline":[18],"(true":[19],"RPD)":[20],"or":[21,24,122,199,208,231],"stabilize":[23],"improve":[25],"(non-RPD).":[26],"Recognizing":[27],"patients":[28,142,167,293,330],"RPD":[30,54,107,144,181,333],"early":[31],"in":[32,44,68,78,329,340],"disease":[34,198,224],"course":[35],"is":[36],"important":[37],"support":[39],"clinical":[40,98,136,336],"care":[41,337],"and":[42,58,75,138,145,190,260,282,312,338],"enrollment":[43,339],"research.":[45],"METHOD:":[46],"referred":[48,168],"for":[49,60,169,177,246],"evaluation":[51],"were":[55,89,104,150,182,218,272,290,319],"prospectively":[56],"enrolled":[57],"followed":[59],"up":[61],"2":[63,127],"years":[64,128,185],"at":[65],"Mayo":[66],"Clinic":[67],"Florida":[69],"(Jacksonville,":[70],"FL;":[71],"Jan-2020":[72],"-":[73,85],"Oct-2023)":[74],"Washington":[76],"University":[77],"St.":[79],"Louis":[80],"(Saint":[81],"Louis,":[82],"MO;":[83],"Jun-2016":[84],"Dec-2019).":[86],"Clinical":[87,114],"data":[88],"independently":[90,273,320],"reviewed":[91],"by":[92],"two":[93],"specialists":[95],"who":[96],"established":[97],"diagnoses,":[99],"referencing":[100],"published":[101],"criteria.":[102],"diagnosed":[105,195],"if":[108],"they":[109],"progressed":[110],"(global":[113],"Dementia":[115],"Rating\u00ae":[116],"[CDR]":[117],"\u22651)":[118],"within":[119,126],"1":[120],"year":[121],"incapacitation":[123],"(CDR":[124],"\u22652)":[125],"symptom":[130],"onset.":[131],"Univariate":[132],"statistics":[133],"compared":[134],"demographics,":[135],"details,":[137],"test":[139],"results":[140],"between":[141],"non-RPD.":[146],"Variables":[147],"p<0.1":[149],"entered":[151],"into":[152],"a":[153],"multivariate":[154],"logistic":[155],"regression":[156],"model":[157],"identify":[159],"factors":[160],"associated":[161,274,321],"RPD.":[163,178,276,323,344],"RESULT:":[164],"Of":[165],"248":[166],"RPD,":[171,295],"187":[172],"(75.4%)":[173],"met":[174],"stated":[175],"criteria":[176],"older":[183],"(62.6\u00b114.4":[184],"vs":[186,203,211,226,239],"55.0\u00b118.3":[187],"years;":[188],"p<0.001),":[189],"more":[191,219],"likely":[192],"be":[194],"Alzheimer":[197],"related":[200],"dementias":[201],"(28.3%":[202],"9.8%;":[204],"p":[205,213,228,241],"=":[206,214,229,242],"0.003)":[207],"Creutzfeldt-Jakob":[209],"(19.1%":[210],"4.6%;":[212],"0.008).":[215],"Non-RPD":[216],"cases":[217],"often":[220],"attributed":[221],"autoimmune/inflammatory":[223],"(42.6%":[225],"29.4%,":[227],"0.061)":[230],"other":[232],"causes":[233],"(e.g.,":[234],"psychiatric,":[235],"neoplasms,":[236],"toxic/metabolic;":[237],"34.4%":[238],"16.6%,":[240],"0.006).":[243],"After":[244],"controlling":[245],"age,":[247],"hallucinations":[248],"(OR,":[249,256,268],"2.81;":[250],"95%CI:":[251,258,270],"1.21-6.52),":[252],"elevated":[253,309],"CSF":[254,261,310,314],"protein":[255],"2.43;":[257],"1.17-5.03),":[259],"white":[262,315],"blood":[263,316],"cell":[264,317],"count":[265,318],"<5":[266],"cells/mm3":[267],"2.77;":[269],"1.32-5.85)":[271],"Cortical":[277],"visual":[278,303],"loss":[279],"(15/183,":[280],"8.2%)":[281],"substantial":[283,305],"brain":[284],"atrophy":[285,306],"on":[286,307],"MRI":[287],"(27/184,":[288],"14.7%)":[289],"specific":[291],"representing":[296],"additional":[297],"distinguishing":[298],"features.":[299],"CONCLUSION:":[300],"Hallucinations,":[301],"cortical":[302],"loss,":[304],"MRI,":[308],"protein,":[311],"normal":[313],"Early":[324],"detection":[325],"these":[327],"features":[328],"inform":[335],"research":[341],"studies":[342]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-01-03T00:00:00"}