{"id":"https://openalex.org/W4406001237","doi":"https://doi.org/10.1038/s41467-024-55371-y","title":"Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in Drosophila","display_name":"Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in Drosophila","publication_year":2025,"publication_date":"2025-01-02","ids":{"openalex":"https://openalex.org/W4406001237","doi":"https://doi.org/10.1038/s41467-024-55371-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/39747032","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11696257"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-024-55371-y","doi":"https://doi.org/10.1038/s41467-024-55371-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-55371-y","pdf_url":"https://www.nature.com/articles/s41467-024-55371-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-024-55371-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101815325","display_name":"Muhammad Ahmad","orcid":"https://orcid.org/0000-0003-4909-5760","observed_orcids":["https://orcid.org/0000-0003-4909-5760"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammad Ahmad","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4909-5760","affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112853724","display_name":"Shang Wu","orcid":"https://orcid.org/0009-0004-4868-0065","observed_orcids":["https://orcid.org/0009-0004-4868-0065"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shang Wu","raw_affiliation_strings":["The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114176155","display_name":"Shengyao Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengyao Luo","raw_affiliation_strings":["Yuanpei College, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yuanpei College, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102382257","display_name":"Wenjia Shi","orcid":"https://orcid.org/0009-0004-3006-7940","observed_orcids":["https://orcid.org/0009-0004-3006-7940"]},"institutions":[{"id":"https://openalex.org/I4210131919","display_name":"Xi'an University of Technology","ror":"https://ror.org/038avdt50","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210131919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjia Shi","raw_affiliation_strings":["Department of Applied Physics, Xi'an University of Technology, Xi'an, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Physics, Xi'an University of Technology, Xi'an, Shaanxi, China","institution_ids":["https://openalex.org/I4210131919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061333208","display_name":"Xuan Guo","orcid":"https://orcid.org/0000-0001-5259-7345","observed_orcids":["https://orcid.org/0000-0001-5259-7345"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan Guo","raw_affiliation_strings":["Life Science Institute, Jinzhou Medical University, Jinzhou, Liaoning, China"],"raw_orcid":"https://orcid.org/0000-0001-5259-7345","affiliations":[{"raw_affiliation_string":"Life Science Institute, Jinzhou Medical University, Jinzhou, Liaoning, China","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045174555","display_name":"Yuansheng Cao","orcid":"https://orcid.org/0000-0002-6857-6044","observed_orcids":["https://orcid.org/0000-0002-6857-6044"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuansheng Cao","raw_affiliation_strings":["Department of Physics, Tsinghua University, Beijing, China. yscao@tsinghua.edu.cn","Department of Physics, Tsinghua University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-6857-6044","affiliations":[{"raw_affiliation_string":"Department of Physics, Tsinghua University, Beijing, China. yscao@tsinghua.edu.cn","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Department of Physics, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071083794","display_name":"Norbert Perrimon","orcid":"https://orcid.org/0000-0001-7542-472X","observed_orcids":["https://orcid.org/0000-0001-7542-472X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Norbert Perrimon","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, MA, USA. perrimon@genetics.med.harvard.edu","Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA. perrimon@genetics.med.harvard.edu","Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-7542-472X","affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, MA, USA. perrimon@genetics.med.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA. perrimon@genetics.med.harvard.edu","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037882400","display_name":"Li He","orcid":"https://orcid.org/0000-0003-2155-606X","observed_orcids":["https://orcid.org/0000-0003-2155-606X"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li He","raw_affiliation_strings":["The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. lihe19@ustc.edu.cn","The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China"],"raw_orcid":"https://orcid.org/0000-0003-2155-606X","affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. lihe19@ustc.edu.cn","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China","institution_ids":["https://openalex.org/I126520041"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5037882400","https://openalex.org/A5045174555","https://openalex.org/A5071083794"],"corresponding_institution_ids":["https://openalex.org/I126520041","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I99065089"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":4.9885,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.96389168,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"1","first_page":"247","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.5181000232696533,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.5181000232696533,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.13830000162124634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.09239999949932098,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intercellular-calcium-waves","display_name":"intercellular calcium waves","score":0.871999979019165},{"id":"https://openalex.org/keywords/adipokinetic-hormone","display_name":"adipokinetic hormone","score":0.9819999933242798},{"id":"https://openalex.org/keywords/dietary-amino-acids","display_name":"dietary amino acids","score":0.9359999895095825},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.828000009059906},{"id":"https://openalex.org/keywords/fat-body","display_name":"fat body","score":0.8339999914169312},{"id":"https://openalex.org/keywords/neurosecretory-cells","display_name":"neurosecretory cells","score":0.8059999942779541},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7129999995231628},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.746161937713623},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6596167683601379},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.6310719847679138},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5823442339897156},{"id":"https://openalex.org/C2779252662","wikidata":"https://www.wikidata.org/wiki/Q4682938","display_name":"Adipokinetic hormone","level":4,"score":0.5629267692565918},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5608991384506226},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5264875888824463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5264506936073303},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.48076125979423523},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4383660554885864},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43088480830192566},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23706209659576416},{"id":"https://openalex.org/C2993958522","wikidata":"https://www.wikidata.org/wiki/Q7273130","display_name":"Fat body","level":3,"score":0.15442603826522827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08363175392150879},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07740101218223572}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006458","descriptor_name":"Hemolymph","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007301","descriptor_name":"Insect Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007814","descriptor_name":"Larva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008066","descriptor_name":"Lipolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011761","descriptor_name":"Pyrrolidonecarboxylic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011761","descriptor_name":"Pyrrolidonecarboxylic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1038/s41467-024-55371-y","doi":"https://doi.org/10.1038/s41467-024-55371-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-55371-y","pdf_url":"https://www.nature.com/articles/s41467-024-55371-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-4493132/v1","doi":"https://doi.org/10.21203/rs.3.rs-4493132/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-4493132/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"doi:10.1101/2024.03.04.583442","doi":"https://doi.org/10.1101/2024.03.04.583442","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.03.04.583442","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/03/08/2024.03.04.583442.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11696257","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11696257","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11696257/pdf/41467_2024_Article_55371.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:38496667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38496667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:38947048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38947048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Journal Article"},{"id":"pmid:39747032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39747032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11213180","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11213180","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11213180/pdf/nihpp-rs4493132v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Res Sq","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10942355","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10942355","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-024-55371-y","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-024-55371-y","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:0f21c1792c9d4a718783fd18d70b0f6c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0f21c1792c9d4a718783fd18d70b0f6c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 16, Iss 1, Pp 1-16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-024-55371-y","doi":"https://doi.org/10.1038/s41467-024-55371-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-024-55371-y","pdf_url":"https://www.nature.com/articles/s41467-024-55371-y.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1172905597","display_name":"Mapping protein communication between organs in homeostasis and disease","funder_award_id":"R01DK121409","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5768397162","display_name":"CRISPR-Cas9 screens to characterize mechanisms of Lipid Droplet (LD) regulation","funder_award_id":"24PRE1189954","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G6733298462","display_name":null,"funder_award_id":"32070750","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325599","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4406001237.pdf","grobid_xml":"https://content.openalex.org/works/W4406001237.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W840778854","https://openalex.org/W1595045726","https://openalex.org/W1832920476","https://openalex.org/W1877112462","https://openalex.org/W1898922522","https://openalex.org/W1935060748","https://openalex.org/W1958372829","https://openalex.org/W1965495036","https://openalex.org/W1970151075","https://openalex.org/W1978045340","https://openalex.org/W1978967901","https://openalex.org/W1979270142","https://openalex.org/W1996802229","https://openalex.org/W1997443428","https://openalex.org/W1997958161","https://openalex.org/W2002193324","https://openalex.org/W2002233209","https://openalex.org/W2002356275","https://openalex.org/W2003752999","https://openalex.org/W2017158148","https://openalex.org/W2018236958","https://openalex.org/W2021628915","https://openalex.org/W2036056595","https://openalex.org/W2051178873","https://openalex.org/W2056302193","https://openalex.org/W2058397178","https://openalex.org/W2060869324","https://openalex.org/W2066994356","https://openalex.org/W2074326067","https://openalex.org/W2078382877","https://openalex.org/W2090634740","https://openalex.org/W2090728253","https://openalex.org/W2092700428","https://openalex.org/W2100687920","https://openalex.org/W2115337061","https://openalex.org/W2118590728","https://openalex.org/W2120132994","https://openalex.org/W2121870259","https://openalex.org/W2124134528","https://openalex.org/W2131129193","https://openalex.org/W2138711839","https://openalex.org/W2141180468","https://openalex.org/W2148760078","https://openalex.org/W2155783580","https://openalex.org/W2157587269","https://openalex.org/W2235807586","https://openalex.org/W2274260151","https://openalex.org/W2280539066","https://openalex.org/W2288588250","https://openalex.org/W2314093641","https://openalex.org/W2411093910","https://openalex.org/W2508701503","https://openalex.org/W2526020947","https://openalex.org/W2526128409","https://openalex.org/W2580040741","https://openalex.org/W2580678460","https://openalex.org/W2582347726","https://openalex.org/W2589971096","https://openalex.org/W2737864209","https://openalex.org/W2885992664","https://openalex.org/W2910010284","https://openalex.org/W2922873188","https://openalex.org/W2937667220","https://openalex.org/W2965537029","https://openalex.org/W2969834369","https://openalex.org/W2977304035","https://openalex.org/W2981706918","https://openalex.org/W3014509110","https://openalex.org/W3020892767","https://openalex.org/W3023704375","https://openalex.org/W3159072427","https://openalex.org/W3185349695","https://openalex.org/W3208811784","https://openalex.org/W4250756743","https://openalex.org/W4281632180","https://openalex.org/W4281665512","https://openalex.org/W4295038126","https://openalex.org/W4365446488","https://openalex.org/W4367175069","https://openalex.org/W4383868382","https://openalex.org/W4386022028","https://openalex.org/W4386826855","https://openalex.org/W4387344382","https://openalex.org/W4387440153","https://openalex.org/W4393220151","https://openalex.org/W4399127314"],"related_works":["https://openalex.org/W4392578316","https://openalex.org/W7167755928","https://openalex.org/W4394769236","https://openalex.org/W2761893168","https://openalex.org/W1978967901","https://openalex.org/W4200508760","https://openalex.org/W2083032108","https://openalex.org/W2149200224","https://openalex.org/W3217748236","https://openalex.org/W2286326724"],"abstract_inverted_index":{"Abstract":[0],"Propagation":[1],"of":[2,19,34,51],"intercellular":[3,35,102,156],"calcium":[4,21,36,80,103,157],"waves":[5,22,37,81,104,158],"through":[6],"tissues":[7],"has":[8],"been":[9],"found":[10],"to":[11,92,125],"coordinate":[12],"different":[13],"multicellular":[14],"responses.":[15],"Nevertheless,":[16],"our":[17],"understanding":[18],"how":[20],"operate":[23],"remains":[24],"limited.":[25],"In":[26,95],"this":[27],"study,":[28],"we":[29,114,134],"explore":[30],"the":[31,47,54,72,75,83,96,120,141,145,150],"real-time":[32],"dynamics":[33],"in":[38,61,82,149,159],"Drosophila":[39],"adipose":[40,62,160],"tissues.":[41],"We":[42,64],"identify":[43],"Adipokinetic":[44],"Hormone":[45],"(AKH),":[46],"fly":[48],"functional":[49],"homolog":[50],"glucagon,":[52],"as":[53],"key":[55],"factor":[56],"driving":[57],"Ca":[58,128],"2+":[59,129],"activities":[60],"tissue.":[63],"find":[65],"that":[66,116,136],"AKH,":[67],"which":[68,152],"is":[69],"released":[70],"into":[71],"hemolymph":[73],"from":[74,144],"AKH-producing":[76,121,146],"neurosecretory":[77,122,147],"cells,":[78,123],"stimulates":[79,154],"larval":[84],"fat":[85,98],"by":[86,107],"a":[87,108],"previously":[88],"unrecognized":[89],"gap-junction-independent":[90,155],"mechanism":[91],"promote":[93],"lipolysis.":[94],"adult":[97],"body,":[99],"however,":[100],"gap-junction-dependent":[101],"are":[105],"triggered":[106],"presumably":[109],"uniformly":[110],"diffused":[111],"AKH.":[112],"Additionally,":[113],"discover":[115],"amino":[117,138],"acids":[118,139],"activate":[119],"leading":[124],"increased":[126],"intracellular":[127],"and":[130],"AKH":[131,142],"secretion.":[132],"Altogether,":[133],"show":[135],"dietary":[137],"regulate":[140],"release":[143],"cells":[148],"brain,":[151],"subsequently":[153],"tissue,":[161],"enhancing":[162],"lipid":[163],"metabolism.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-01-03T00:00:00"}