{"id":"https://openalex.org/W4405951663","doi":"https://doi.org/10.1002/alz.14371","title":"Microstructural mapping of neural pathways in Alzheimer's disease using macrostructure\u2010informed normative tractometry","display_name":"Microstructural mapping of neural pathways in Alzheimer's disease using macrostructure\u2010informed normative tractometry","publication_year":2024,"publication_date":"2024-12-30","ids":{"openalex":"https://openalex.org/W4405951663","doi":"https://doi.org/10.1002/alz.14371","pmid":"https://pubmed.ncbi.nlm.nih.gov/38712293"},"language":"en","primary_location":{"id":"doi:10.1002/alz.14371","doi":"https://doi.org/10.1002/alz.14371","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.14371","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.14371","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.14371","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056780680","display_name":"Yixue Feng","orcid":"https://orcid.org/0000-0003-1015-4209","observed_orcids":["https://orcid.org/0000-0003-1015-4209"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yixue Feng","raw_affiliation_strings":["Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA"],"raw_orcid":"https://orcid.org/0000-0003-1015-4209","affiliations":[{"raw_affiliation_string":"Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024772201","display_name":"Bramsh Q. Chandio","orcid":"https://orcid.org/0000-0002-8949-4937","observed_orcids":["https://orcid.org/0000-0002-8949-4937"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bramsh Q. Chandio","raw_affiliation_strings":["Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070275145","display_name":"Julio E. Villal\u00f3n\u2010Reina","orcid":"https://orcid.org/0009-0005-9039-4924","observed_orcids":["https://orcid.org/0009-0005-9039-4924"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julio E. Villalon\u2010Reina","raw_affiliation_strings":["Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017365268","display_name":"Sophia I. Thomopoulos","orcid":"https://orcid.org/0000-0002-0046-4070","observed_orcids":["https://orcid.org/0000-0002-0046-4070"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia I. Thomopoulos","raw_affiliation_strings":["Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076060041","display_name":"Talia M. Nir","orcid":"https://orcid.org/0000-0002-7106-7443","observed_orcids":["https://orcid.org/0000-0002-7106-7443"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Talia M. Nir","raw_affiliation_strings":["Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058809330","display_name":"Sebastian M. Benavidez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sebastian Benavidez","raw_affiliation_strings":["Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055654698","display_name":"Emily Laltoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Laltoo","raw_affiliation_strings":["Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074576951","display_name":"Tamoghna Chattopadhyay","orcid":"https://orcid.org/0000-0002-3146-6845","observed_orcids":["https://orcid.org/0000-0002-3146-6845"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamoghna Chattopadhyay","raw_affiliation_strings":["Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015551986","display_name":"Himanshu Joshi","orcid":"https://orcid.org/0000-0003-2624-7821","observed_orcids":["https://orcid.org/0000-0003-2624-7821","https://orcid.org/0009-0005-9057-5741"]},"institutions":[{"id":"https://openalex.org/I699696","display_name":"National Institute of Mental Health and Neurosciences","ror":"https://ror.org/0405n5e57","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I699696"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Himanshu Joshi","raw_affiliation_strings":["Multimodal Brain Image Analysis Laboratory, National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bangalore India","Multimodal Brain Image Analysis Laboratory, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multimodal Brain Image Analysis Laboratory, National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bangalore India","institution_ids":["https://openalex.org/I699696"]},{"raw_affiliation_string":"Multimodal Brain Image Analysis Laboratory, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India","institution_ids":["https://openalex.org/I699696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047157394","display_name":"Ganesan Venkatasubramanian","orcid":"https://orcid.org/0000-0002-0949-898X","observed_orcids":["https://orcid.org/0000-0002-0949-898X"]},"institutions":[{"id":"https://openalex.org/I699696","display_name":"National Institute of Mental Health and Neurosciences","ror":"https://ror.org/0405n5e57","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I699696"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ganesan Venkatasubramanian","raw_affiliation_strings":["Translational Psychiatry Laboratory National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bangalore India","Translational Psychiatry Laboratory, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Psychiatry Laboratory National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bangalore India","institution_ids":["https://openalex.org/I699696"]},{"raw_affiliation_string":"Translational Psychiatry Laboratory, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India","institution_ids":["https://openalex.org/I699696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065718043","display_name":"John P. John","orcid":"https://orcid.org/0000-0001-6756-0297","observed_orcids":["https://orcid.org/0000-0001-6756-0297"]},"institutions":[{"id":"https://openalex.org/I699696","display_name":"National Institute of Mental Health and Neurosciences","ror":"https://ror.org/0405n5e57","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I699696"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"John P. John","raw_affiliation_strings":["Multimodal Brain Image Analysis Laboratory, National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bangalore India","Multimodal Brain Image Analysis Laboratory, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multimodal Brain Image Analysis Laboratory, National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bangalore India","institution_ids":["https://openalex.org/I699696"]},{"raw_affiliation_string":"Multimodal Brain Image Analysis Laboratory, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India","institution_ids":["https://openalex.org/I699696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019781190","display_name":"Neda Jahanshad","orcid":"https://orcid.org/0000-0003-4401-8950","observed_orcids":["https://orcid.org/0000-0003-4401-8950"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neda Jahanshad","raw_affiliation_strings":["Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008693997","display_name":"Robert I. Reid","orcid":"https://orcid.org/0000-0003-2391-8650","observed_orcids":["https://orcid.org/0000-0003-2391-8650"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert I. Reid","raw_affiliation_strings":["Department of Information Technology Mayo Clinic and Foundation  Rochester Minnesota USA","Department of Radiology Mayo Clinic and Foundation  Rochester Minnesota USA","Department of Information Technology, Mayo Clinic and Foundation, Rochester, Minnesota, USA","Department of Radiology, Mayo Clinic and Foundation, Rochester, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Technology Mayo Clinic and Foundation  Rochester Minnesota USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Radiology Mayo Clinic and Foundation  Rochester Minnesota USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Information Technology, Mayo Clinic and Foundation, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Radiology, Mayo Clinic and Foundation, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005099850","display_name":"Clifford R. Jack","orcid":"https://orcid.org/0000-0001-7916-622X","observed_orcids":["https://orcid.org/0000-0001-7916-622X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford R. Jack","raw_affiliation_strings":["Department of Radiology Mayo Clinic and Foundation  Rochester Minnesota USA","Department of Radiology, Mayo Clinic and Foundation, Rochester, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology Mayo Clinic and Foundation  Rochester Minnesota USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Radiology, Mayo Clinic and Foundation, Rochester, Minnesota, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102977342","display_name":"Michael Walter Weiner","orcid":"https://orcid.org/0000-0002-0144-1954","observed_orcids":["https://orcid.org/0000-0002-0144-1954"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210110664","display_name":"University of California San Francisco Medical Center","ror":"https://ror.org/01t8svj65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210110664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W. Weiner","raw_affiliation_strings":["Department of Radiology and Biomedical Imaging UCSF School of Medicine  San Francisco California USA","Department of Radiology and Biomedical Imaging, UCSF School of Medicine, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Biomedical Imaging UCSF School of Medicine  San Francisco California USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]},{"raw_affiliation_string":"Department of Radiology and Biomedical Imaging, UCSF School of Medicine, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210110664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867","observed_orcids":["https://orcid.org/0000-0002-4720-8867","https://orcid.org/0000-0003-2476-2803","https://orcid.org/0000-0002-2305-8438"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul M. Thompson","raw_affiliation_strings":["Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center Mark and Mary Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California  Marina del Rey California USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106733559","display_name":"Alzheimer\u2019s Disease Neuroimaging Initiative","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for the Alzheimer's Disease Neuroimaging Initiative","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5056780680","https://openalex.org/A5100606557"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":{"value":4000,"currency":"USD","value_usd":4000},"fwci":2.9895,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.92138557,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"e14371","last_page":"e14371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.890999972820282},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C44725695","wikidata":"https://www.wikidata.org/wiki/Q288156","display_name":"Normative","level":2,"score":0.77556312084198},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5079696774482727},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.45590561628341675},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44940751791000366},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3457478880882263},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3257884383201599},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2782568037509918},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.260357141494751},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2514825165271759},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.20590198040008545},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.20141366124153137}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1002/alz.14371","doi":"https://doi.org/10.1002/alz.14371","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.14371","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.14371","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},{"id":"doi:10.1101/2024.04.25.591183","doi":"https://doi.org/10.1101/2024.04.25.591183","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.04.25.591183","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:38712293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38712293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:39737627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39737627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & dementia : the journal of the Alzheimer's Association","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt0ht70274","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0ht70274","pdf_url":"https://escholarship.org/content/qt0ht70274/qt0ht70274.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alzheimers & Dementia: The Journal of the Alzheimers Association, vol 21, iss 1","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11782200","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11782200","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11782200/pdf/ALZ-21-e14371.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alzheimers Dement","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:11071453","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11071453","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/alz.14371","doi":"https://doi.org/10.1002/alz.14371","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.14371","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.14371","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2259361616","display_name":null,"funder_award_id":"R01 AG057892","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2957681590","display_name":null,"funder_award_id":"U19-AG024904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3146424788","display_name":null,"funder_award_id":"AG 024904","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7075784216","display_name":"Cortical dMRI microstructure as an early marker of AD pathology","funder_award_id":"AARG-23-1149996","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G8700881871","display_name":null,"funder_award_id":"R01 AG060610","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000055340","display_name":null,"funder_award_id":"U19AG024904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000122335","display_name":null,"funder_award_id":"AG024904","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000276735","display_name":null,"funder_award_id":"R01AG060610","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4405951663.pdf","grobid_xml":"https://content.openalex.org/works/W4405951663.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W239929985","https://openalex.org/W1823166105","https://openalex.org/W1847168837","https://openalex.org/W1895268124","https://openalex.org/W1953027527","https://openalex.org/W1964802316","https://openalex.org/W1969637629","https://openalex.org/W1984453610","https://openalex.org/W1986969837","https://openalex.org/W1987990850","https://openalex.org/W1991952617","https://openalex.org/W2001611992","https://openalex.org/W2028748733","https://openalex.org/W2032254014","https://openalex.org/W2060171712","https://openalex.org/W2062791478","https://openalex.org/W2067240723","https://openalex.org/W2069494733","https://openalex.org/W2110065044","https://openalex.org/W2115424422","https://openalex.org/W2124525546","https://openalex.org/W2127309075","https://openalex.org/W2129841144","https://openalex.org/W2137679584","https://openalex.org/W2151712416","https://openalex.org/W2162723250","https://openalex.org/W2198859253","https://openalex.org/W2345496677","https://openalex.org/W2735700022","https://openalex.org/W2766639217","https://openalex.org/W2796762894","https://openalex.org/W2803837136","https://openalex.org/W2892140621","https://openalex.org/W2901906577","https://openalex.org/W2942611003","https://openalex.org/W2944607361","https://openalex.org/W2950030754","https://openalex.org/W2951488689","https://openalex.org/W2966232329","https://openalex.org/W2970898057","https://openalex.org/W2977883299","https://openalex.org/W2993515580","https://openalex.org/W3005550859","https://openalex.org/W3017063260","https://openalex.org/W3092593892","https://openalex.org/W3100850306","https://openalex.org/W3128346820","https://openalex.org/W3158161776","https://openalex.org/W3172893236","https://openalex.org/W3187100106","https://openalex.org/W4205639396","https://openalex.org/W4226203773","https://openalex.org/W4281288063","https://openalex.org/W4310060332","https://openalex.org/W4310461604","https://openalex.org/W4312278544","https://openalex.org/W4323309574","https://openalex.org/W4377103901","https://openalex.org/W4380793055","https://openalex.org/W4384154364","https://openalex.org/W4385191001","https://openalex.org/W4389078794","https://openalex.org/W4389685319","https://openalex.org/W4390489203","https://openalex.org/W4390489229","https://openalex.org/W4392232009","https://openalex.org/W4392472568","https://openalex.org/W4393561336","https://openalex.org/W4400089962","https://openalex.org/W4401525845","https://openalex.org/W4405488993","https://openalex.org/W4410124432","https://openalex.org/W6716082084"],"related_works":["https://openalex.org/W1989297139","https://openalex.org/W2342143608","https://openalex.org/W2496755843","https://openalex.org/W4213090964","https://openalex.org/W892323923","https://openalex.org/W952030982","https://openalex.org/W2128789995","https://openalex.org/W3038899278","https://openalex.org/W3106689948","https://openalex.org/W3210985794"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Diffusion-weighted":[1],"magnetic":[2],"resonance":[3],"imaging":[4,80,161],"(dMRI)":[5],"is":[6],"sensitive":[7],"to":[8,53,83,124,141,166],"the":[9,21,39,90,139,146,152],"microstructural":[10,109],"properties":[11],"of":[12,23,35,92,108,148,174,188],"brain":[13],"tissues":[14],"and":[15,60,70,102,110,116,136,143,193,204],"shows":[16],"great":[17],"promise":[18],"in":[19,65,114,158,177],"detecting":[20],"effects":[22,147],"degenerative":[24,149],"diseases.":[25],"However,":[26],"many":[27],"approaches":[28],"analyze":[29],"single":[30],"measures":[31],"averaged":[32],"over":[33],"regions":[34],"interest":[36],"without":[37],"considering":[38],"underlying":[40],"fiber":[41,86,189],"geometry.":[42,190],"METHODS:":[43],"We":[44,72,127],"propose":[45],"a":[46],"novel":[47],"macrostructure-informed":[48],"normative":[49],"tractometry":[50],"(MINT)":[51],"framework":[52],"investigate":[54],"how":[55,85],"white":[56],"matter":[57],"(WM)":[58],"microstructure":[59,192],"macrostructure":[61,194],"are":[62,195],"jointly":[63,132],"altered":[64],"mild":[66],"cognitive":[67],"impairment":[68],"(MCI)":[69],"dementia.":[71,125],"compared":[73],"MINT-derived":[74],"metrics":[75,82,162,176],"with":[76,197],"univariate":[77],"diffusion":[78,121,159,175],"tensor":[79,160],"(DTI)":[81],"examine":[84],"geometry":[87],"may":[88,163],"impact":[89],"interpretation":[91],"microstructure.":[93],"RESULTS:":[94],"In":[95],"two":[96],"multisite":[97],"cohorts":[98],"from":[99],"North":[100],"America":[101],"India,":[103],"we":[104,118],"find":[105],"consistent":[106],"patterns":[107,187],"macrostructural":[111],"anomalies":[112],"implicated":[113],"MCI":[115],"dementia;":[117],"also":[119],"rank":[120],"metrics'":[122],"sensitivity":[123],"DISCUSSION:":[126],"show":[128],"that":[129],"MINT,":[130],"by":[131],"modeling":[133],"tract":[134],"shape":[135],"microstructure,":[137],"has":[138],"potential":[140],"disentangle":[142],"better":[144],"interpret":[145],"disease":[150],"on":[151,183],"brain's":[153],"neural":[154],"pathways.":[155],"HIGHLIGHTS:":[156],"Changes":[157],"be":[164],"due":[165],"macroscopic":[167],"changes.":[168],"Normative":[169],"models":[170],"encode":[171],"normal":[172],"variability":[173],"healthy":[178],"controls.":[179],"Variational":[180],"autoencoder":[181],"applied":[182],"tractography":[184],"can":[185],"learn":[186],"WM":[191],"modeled":[196],"multivariate":[198],"methods.":[199],"Transfer":[200],"learning":[201],"uses":[202],"pretraining":[203],"fine-tuning":[205],"for":[206],"increased":[207],"efficiency.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}