{"id":"https://openalex.org/W4405941972","doi":"https://doi.org/10.1016/j.bone.2024.117386","title":"Multiscale interstitial fluid computation modeling of cortical bone to characterize the hydromechanical stimulation of lacunar-canalicular network","display_name":"Multiscale interstitial fluid computation modeling of cortical bone to characterize the hydromechanical stimulation of lacunar-canalicular network","publication_year":2024,"publication_date":"2024-12-31","ids":{"openalex":"https://openalex.org/W4405941972","doi":"https://doi.org/10.1016/j.bone.2024.117386","pmid":"https://pubmed.ncbi.nlm.nih.gov/39746592"},"language":"en","primary_location":{"id":"doi:10.1016/j.bone.2024.117386","doi":"https://doi.org/10.1016/j.bone.2024.117386","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bone.2024.117386","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039652905","display_name":"Wei\u2010Lun Yu","orcid":"https://orcid.org/0000-0002-6253-576X","observed_orcids":["https://orcid.org/0000-0002-6253-576X"]},"institutions":[{"id":"https://openalex.org/I4210136497","display_name":"Jilin Medical University","ror":"https://ror.org/03mzw7781","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210136497"]},{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"WeiLun Yu","raw_affiliation_strings":["College of Biomedical Engineering, Jilin Medical University, Jilin, Jilin Province, China; Orthopedics, Shanxi Bethune Hospital, Taiyuan, Shanxi Province, China; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedical Engineering, Jilin Medical University, Jilin, Jilin Province, China; Orthopedics, Shanxi Bethune Hospital, Taiyuan, Shanxi Province, China; College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China","institution_ids":["https://openalex.org/I4210136497","https://openalex.org/I9086337"]}]},{"author_position":"middle","author":{"id":null,"display_name":"RenXia Ou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136497","display_name":"Jilin Medical University","ror":"https://ror.org/03mzw7781","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210136497"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"RenXia Ou","raw_affiliation_strings":["College of Biomedical Engineering, Jilin Medical University, Jilin, Jilin Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedical Engineering, Jilin Medical University, Jilin, Jilin Province, China","institution_ids":["https://openalex.org/I4210136497"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qi Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136497","display_name":"Jilin Medical University","ror":"https://ror.org/03mzw7781","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210136497"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Hou","raw_affiliation_strings":["College of Biomedical Engineering, Jilin Medical University, Jilin, Jilin Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedical Engineering, Jilin Medical University, Jilin, Jilin Province, China","institution_ids":["https://openalex.org/I4210136497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100701327","display_name":"Chunming Li","orcid":"https://orcid.org/0000-0002-4159-7048","observed_orcids":["https://orcid.org/0000-0002-4159-7048"]},"institutions":[{"id":"https://openalex.org/I4210109300","display_name":"Jilin City Central Hospital","ror":"https://ror.org/01y87aw49","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109300"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ChunMing Li","raw_affiliation_strings":["Orthopedics, Jilin Central Hospital, Jilin, Jilin Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopedics, Jilin Central Hospital, Jilin, Jilin Province, China","institution_ids":["https://openalex.org/I4210109300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072355181","display_name":"Xiaohang Yang","orcid":"https://orcid.org/0000-0003-3948-1481","observed_orcids":["https://orcid.org/0000-0003-3948-1481"]},"institutions":[{"id":"https://openalex.org/I4210136497","display_name":"Jilin Medical University","ror":"https://ror.org/03mzw7781","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210136497"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"XiaoHang Yang","raw_affiliation_strings":["College of Biomedical Engineering, Jilin Medical University, Jilin, Jilin Province, China. Electronic address: xhyang16@mails.jlu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedical Engineering, Jilin Medical University, Jilin, Jilin Province, China. Electronic address: xhyang16@mails.jlu.edu.cn","institution_ids":["https://openalex.org/I4210136497"]}]},{"author_position":"middle","author":{"id":null,"display_name":"YingHui Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136497","display_name":"Jilin Medical University","ror":"https://ror.org/03mzw7781","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210136497"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YingHui Ma","raw_affiliation_strings":["College of Biomedical Engineering, Jilin Medical University, Jilin, Jilin Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedical Engineering, Jilin Medical University, Jilin, Jilin Province, China","institution_ids":["https://openalex.org/I4210136497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036816100","display_name":"Xiaogang Wu","orcid":"https://orcid.org/0000-0003-3220-8933","observed_orcids":["https://orcid.org/0000-0003-3220-8933"]},"institutions":[{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XiaoGang Wu","raw_affiliation_strings":["College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China","institution_ids":["https://openalex.org/I9086337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100731420","display_name":"Weiyi Chen","orcid":"https://orcid.org/0000-0003-1702-5653","observed_orcids":["https://orcid.org/0000-0003-1702-5653","https://orcid.org/0009-0005-1048-6598","https://orcid.org/0009-0007-1759-4414"]},"institutions":[{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"WeiYi Chen","raw_affiliation_strings":["College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, Shanxi, China","institution_ids":["https://openalex.org/I9086337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072355181"],"corresponding_institution_ids":["https://openalex.org/I4210136497"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":null,"fwci":2.0805,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.83880257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"193","issue":null,"first_page":"117386","last_page":"117386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.6919000148773193,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.6919000148773193,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.08349999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.05609999969601631,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cortical-bone","display_name":"cortical bone","score":0.8510000109672546},{"id":"https://openalex.org/keywords/interstitial-fluid-flow","display_name":"interstitial fluid flow","score":0.8159999847412109},{"id":"https://openalex.org/keywords/osteocyte-mechanotransduction","display_name":"osteocyte mechanotransduction","score":0.7710000276565552},{"id":"https://openalex.org/keywords/fluid-shear-stress","display_name":"fluid shear stress","score":0.8220000267028809},{"id":"https://openalex.org/keywords/pore-pressure","display_name":"pore pressure","score":0.9700000286102295},{"id":"https://openalex.org/keywords/poroelasticity","display_name":"poroelasticity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/osteons","display_name":"osteons","score":0.5550000071525574},{"id":"https://openalex.org/keywords/haversian-canals","display_name":"Haversian canals","score":0.746999979019165},{"id":"https://openalex.org/keywords/bone-permeability","display_name":"bone permeability","score":0.6660000085830688},{"id":"https://openalex.org/keywords/flow-velocity","display_name":"flow velocity","score":0.621999979019165},{"id":"https://openalex.org/keywords/bone-mechanotransduction","display_name":"bone mechanotransduction","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.599436342716217},{"id":"https://openalex.org/C2779822359","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Interstitial fluid","level":2,"score":0.5959624648094177},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.56600022315979},{"id":"https://openalex.org/C2781451080","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cortical bone","level":2,"score":0.43695542216300964},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39644965529441833},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3663628101348877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20653638243675232},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.17253154516220093},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.13847994804382324},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09276247024536133},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071538","descriptor_name":"Cortical Bone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006253","descriptor_name":"Haversian System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045604","descriptor_name":"Extracellular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045604","descriptor_name":"Extracellular Fluid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bone.2024.117386","doi":"https://doi.org/10.1016/j.bone.2024.117386","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bone.2024.117386","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"},{"id":"pmid:39746592","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39746592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5267026276","display_name":null,"funder_award_id":"YDZJ2023012YTS142","funder_id":"https://openalex.org/F4320335953","funder_display_name":"Jilin Scientific and Technological Development Program"},{"id":"https://openalex.org/G5556323736","display_name":null,"funder_award_id":"2023JC054","funder_id":"https://openalex.org/F4320330794","funder_display_name":"Health Commission of Jilin Province"},{"id":"https://openalex.org/G6244514065","display_name":null,"funder_award_id":"JJKH20230537KJ","funder_id":"https://openalex.org/F4320326270","funder_display_name":"Education Department of Jilin Province"},{"id":"https://openalex.org/G8287703565","display_name":null,"funder_award_id":"YDZJ202301ZYTS325","funder_id":"https://openalex.org/F4320335953","funder_display_name":"Jilin Scientific and Technological Development Program"}],"funders":[{"id":"https://openalex.org/F4320326270","display_name":"Education Department of Jilin Province","ror":"https://ror.org/05782e512"},{"id":"https://openalex.org/F4320327282","display_name":"Department of Science and Technology of Jilin Province","ror":"https://ror.org/049x38272"},{"id":"https://openalex.org/F4320330794","display_name":"Health Commission of Jilin Province","ror":null},{"id":"https://openalex.org/F4320335953","display_name":"Jilin Scientific and Technological Development Program","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1971322232","https://openalex.org/W1977066211","https://openalex.org/W1993940624","https://openalex.org/W1994189997","https://openalex.org/W2013988230","https://openalex.org/W2022378211","https://openalex.org/W2029810059","https://openalex.org/W2039856754","https://openalex.org/W2045949664","https://openalex.org/W2053462474","https://openalex.org/W2064146852","https://openalex.org/W2066846288","https://openalex.org/W2074349538","https://openalex.org/W2075871350","https://openalex.org/W2088282601","https://openalex.org/W2145937652","https://openalex.org/W2150421312","https://openalex.org/W2160086148","https://openalex.org/W2166079767","https://openalex.org/W2186516255","https://openalex.org/W2991187435","https://openalex.org/W2998639465","https://openalex.org/W3011812953","https://openalex.org/W3044550495","https://openalex.org/W3111952893","https://openalex.org/W3116269626","https://openalex.org/W3126005303","https://openalex.org/W3138595029","https://openalex.org/W3169043779","https://openalex.org/W3171268238","https://openalex.org/W4213365620","https://openalex.org/W4307493982","https://openalex.org/W4312094903","https://openalex.org/W4321188763","https://openalex.org/W4321596595","https://openalex.org/W4327601582","https://openalex.org/W4366368421","https://openalex.org/W4375948003","https://openalex.org/W4379376569","https://openalex.org/W4386245446","https://openalex.org/W4388380023","https://openalex.org/W4391353511","https://openalex.org/W4392697620","https://openalex.org/W4392906060","https://openalex.org/W4393204780","https://openalex.org/W4399533192","https://openalex.org/W4400011688","https://openalex.org/W4400654788","https://openalex.org/W4403922283"],"related_works":["https://openalex.org/W4413998234","https://openalex.org/W2890866361","https://openalex.org/W4414262257","https://openalex.org/W2883168866","https://openalex.org/W1913527393","https://openalex.org/W4224287259","https://openalex.org/W2044657760","https://openalex.org/W2145937652","https://openalex.org/W4407877902","https://openalex.org/W2417412637"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-01-01T00:00:00"}