{"id":"https://openalex.org/W4405877413","doi":"https://doi.org/10.1111/aos.17043","title":"Genome-wide association study of anterior uveitis","display_name":"Genome-wide association study of anterior uveitis","publication_year":2024,"publication_date":"2024-12-27","ids":{"openalex":"https://openalex.org/W4405877413","doi":"https://doi.org/10.1111/aos.17043","pmid":"https://pubmed.ncbi.nlm.nih.gov/39732499"},"language":"en","primary_location":{"id":"doi:10.1111/aos.17043","doi":"https://doi.org/10.1111/aos.17043","is_oa":false,"landing_page_url":"https://doi.org/10.1111/aos.17043","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dx.doi.org/10.1101/2024.06.03.24308116","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027340662","display_name":"Fredrika Koskim\u00e4ki","orcid":"https://orcid.org/0000-0001-7171-3217","observed_orcids":["https://orcid.org/0000-0001-7171-3217"]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Fredrika Koskim\u00e4ki","raw_affiliation_strings":["Department of Ophthalmology and Medical Research Center, Oulu University Hospital; Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland fredrika.koskimaki@gmail.com","Department of Ophthalmology and Medical Research Center, Oulu University Hospital","Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland"],"raw_orcid":"https://orcid.org/0000-0001-7171-3217","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Medical Research Center, Oulu University Hospital; Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland fredrika.koskimaki@gmail.com","institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I98381234"]},{"raw_affiliation_string":"Department of Ophthalmology and Medical Research Center, Oulu University Hospital","institution_ids":["https://openalex.org/I2799272722"]},{"raw_affiliation_string":"Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095789912","display_name":"Oona Ahokas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Oona Ahokas","raw_affiliation_strings":["Department of Mathematical Sciences, University of Oulu, Oulu, Finland","Department of Ophthalmology and Medical Research Center, Oulu University Hospital; Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland","Department of Ophthalmology and Medical Research Center, Oulu University Hospital","Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematical Sciences, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Department of Ophthalmology and Medical Research Center, Oulu University Hospital; Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I98381234"]},{"raw_affiliation_string":"Department of Ophthalmology and Medical Research Center, Oulu University Hospital","institution_ids":["https://openalex.org/I2799272722"]},{"raw_affiliation_string":"Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043494315","display_name":"Risto Kajanne","orcid":"https://orcid.org/0000-0002-3405-7115","observed_orcids":["https://orcid.org/0000-0002-3405-7115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Risto Kajanne","raw_affiliation_strings":["FinnGen, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FinnGen, Helsinki, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115691828","display_name":"Krista-Roberta Saviauk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krista-Roberta Saviauk","raw_affiliation_strings":["Estonian Biobank Research Team, Estonia, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Estonian Biobank Research Team, Estonia, Estonia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038065072","display_name":"Abdelrahman G. Elnahas","orcid":"https://orcid.org/0009-0008-3389-0720","observed_orcids":["https://orcid.org/0009-0008-3389-0720"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Abdelrahman Elnahas","raw_affiliation_strings":["Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041008485","display_name":"Anu Reigo","orcid":"https://orcid.org/0009-0008-0226-3396","observed_orcids":["https://orcid.org/0009-0008-0226-3396"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Anu Reigo","raw_affiliation_strings":["Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040675172","display_name":"Kadri Reis","orcid":"https://orcid.org/0000-0002-2144-5856","observed_orcids":["https://orcid.org/0000-0002-2144-5856"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Kadri Reis","raw_affiliation_strings":["Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007189110","display_name":"T\u00f5nu Esko","orcid":"https://orcid.org/0000-0003-1982-6569","observed_orcids":["https://orcid.org/0000-0003-1982-6569","https://orcid.org/0000-0002-6213-793X","https://orcid.org/0000-0002-7511-5684"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"T\u00f5nu Esko","raw_affiliation_strings":["Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066237538","display_name":"Priit Palta","orcid":"https://orcid.org/0000-0001-9320-7008","observed_orcids":["https://orcid.org/0000-0001-9320-7008"]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"Priit Palta","raw_affiliation_strings":["Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070744970","display_name":"Sanna Leinonen","orcid":"https://orcid.org/0000-0002-6067-6972","observed_orcids":["https://orcid.org/0000-0002-6067-6972"]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sanna Leinonen","raw_affiliation_strings":["Tays Eye Centre, Tampere University Hospital, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tays Eye Centre, Tampere University Hospital, Tampere, Finland","institution_ids":["https://openalex.org/I4210126318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022876944","display_name":"Johannes Kettunen","orcid":"https://orcid.org/0000-0002-3345-491X","observed_orcids":["https://orcid.org/0000-0002-3345-491X"]},"institutions":[{"id":"https://openalex.org/I39624965","display_name":"Finnish Institute for Health and Welfare","ror":"https://ror.org/03tf0c761","country_code":"FI","type":"government","lineage":["https://openalex.org/I39624965"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Johannes Kettunen","raw_affiliation_strings":["Finnish Institute for Health and Welfare (THL), Helsinki, Finland","Research Unit of Population Health, Faculty of Medicine, University of Oulu; Biocenter Oulu, University of Oulu, Oulu, Finland","Biocenter Oulu, University of Oulu, Oulu, Finland","Research Unit of Population Health, Faculty of Medicine, University of Oulu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Finnish Institute for Health and Welfare (THL), Helsinki, Finland","institution_ids":["https://openalex.org/I39624965"]},{"raw_affiliation_string":"Research Unit of Population Health, Faculty of Medicine, University of Oulu; Biocenter Oulu, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Biocenter Oulu, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Research Unit of Population Health, Faculty of Medicine, University of Oulu","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033398262","display_name":"Johanna Liinamaa","orcid":"https://orcid.org/0000-0003-3424-7207","observed_orcids":["https://orcid.org/0000-0003-3424-7207"]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Johanna Liinamaa","raw_affiliation_strings":["Department of Ophthalmology and Medical Research Center, Oulu University Hospital; Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland","Department of Ophthalmology and Medical Research Center, Oulu University Hospital","Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Medical Research Center, Oulu University Hospital; Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I98381234"]},{"raw_affiliation_string":"Department of Ophthalmology and Medical Research Center, Oulu University Hospital","institution_ids":["https://openalex.org/I2799272722"]},{"raw_affiliation_string":"Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022041636","display_name":"Minna K. Karjalainen","orcid":"https://orcid.org/0000-0003-3184-3775","observed_orcids":["https://orcid.org/0000-0003-3184-3775"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Minna K Karjalainen","raw_affiliation_strings":["Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","Research Unit of Population Health, Faculty of Medicine, University of Oulu; Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland","Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland","Research Unit of Population Health, Faculty of Medicine, University of Oulu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"Research Unit of Population Health, Faculty of Medicine, University of Oulu; Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Research Unit of Population Health, Faculty of Medicine, University of Oulu","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064207133","display_name":"Ville O. Saarela","orcid":"https://orcid.org/0000-0003-3189-7626","observed_orcids":["https://orcid.org/0000-0003-3189-7626"]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ville Saarela","raw_affiliation_strings":["Department of Ophthalmology and Medical Research Center, Oulu University Hospital; Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland","Department of Ophthalmology and Medical Research Center, Oulu University Hospital","Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Medical Research Center, Oulu University Hospital; Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I98381234"]},{"raw_affiliation_string":"Department of Ophthalmology and Medical Research Center, Oulu University Hospital","institution_ids":["https://openalex.org/I2799272722"]},{"raw_affiliation_string":"Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5027340662"],"corresponding_institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I98381234"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":1.7401,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.80606432,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"103","issue":"6","first_page":"660","last_page":"667"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anterior-uveitis","display_name":"anterior uveitis","score":1.0},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6679999828338623},{"id":"https://openalex.org/keywords/nlrp3","display_name":"NLRP3","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nos2","display_name":"NOS2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hla-region","display_name":"HLA region","score":0.7900000214576721},{"id":"https://openalex.org/keywords/erap1","display_name":"ERAP1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/il23r","display_name":"IL23R","score":0.9679999947547913},{"id":"https://openalex.org/keywords/phenome-wide-association-study","display_name":"phenome-wide association study","score":0.7799999713897705},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.859000027179718},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9359999895095825},{"id":"https://openalex.org/keywords/ankylosing-spondylitis","display_name":"ankylosing spondylitis","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.9139746427536011},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7973757982254028},{"id":"https://openalex.org/C2776194053","wikidata":"https://www.wikidata.org/wiki/Q280027","display_name":"Uveitis","level":2,"score":0.5758680105209351},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5703222155570984},{"id":"https://openalex.org/C2992250680","wikidata":"https://www.wikidata.org/wiki/Q280027","display_name":"Anterior uveitis","level":3,"score":0.5433365702629089},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4427551031112671},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.42583441734313965},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.41452986001968384},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3544313311576843},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3206906318664551},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.24524790048599243},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.18526995182037354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12544572353363037},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10359877347946167},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014606","descriptor_name":"Uveitis, Anterior","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/aos.17043","doi":"https://doi.org/10.1111/aos.17043","is_oa":false,"landing_page_url":"https://doi.org/10.1111/aos.17043","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"},{"id":"doi:10.1136/bjo-2024-326037","doi":"https://doi.org/10.1136/bjo-2024-326037","is_oa":false,"landing_page_url":"https://doi.org/10.1136/bjo-2024-326037","pdf_url":null,"source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},{"id":"doi:10.1101/2024.06.03.24308116","doi":"https://doi.org/10.1101/2024.06.03.24308116","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2024.06.03.24308116","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:39732499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39732499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of ophthalmology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/2024.06.03.24308116","doi":"https://doi.org/10.1101/2024.06.03.24308116","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2024.06.03.24308116","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1584484141","https://openalex.org/W1678760907","https://openalex.org/W1975909845","https://openalex.org/W1989697230","https://openalex.org/W2001581607","https://openalex.org/W2003328715","https://openalex.org/W2007452107","https://openalex.org/W2015129508","https://openalex.org/W2016827484","https://openalex.org/W2016870529","https://openalex.org/W2022952773","https://openalex.org/W2030826482","https://openalex.org/W2038636068","https://openalex.org/W2053054271","https://openalex.org/W2066922845","https://openalex.org/W2078743381","https://openalex.org/W2082704080","https://openalex.org/W2092413492","https://openalex.org/W2093217973","https://openalex.org/W2094788321","https://openalex.org/W2107412205","https://openalex.org/W2134585221","https://openalex.org/W2139499737","https://openalex.org/W2153860431","https://openalex.org/W2165872127","https://openalex.org/W2209867202","https://openalex.org/W2339267737","https://openalex.org/W2465109134","https://openalex.org/W2606136217","https://openalex.org/W2754234518","https://openalex.org/W2770092353","https://openalex.org/W2784658918","https://openalex.org/W2785711358","https://openalex.org/W2895486342","https://openalex.org/W2930581960","https://openalex.org/W2948290511","https://openalex.org/W2955177623","https://openalex.org/W3031289950","https://openalex.org/W3048245060","https://openalex.org/W3162800482","https://openalex.org/W3202209876","https://openalex.org/W4224988044","https://openalex.org/W4308616307","https://openalex.org/W4309506674","https://openalex.org/W4310588830","https://openalex.org/W4317390883","https://openalex.org/W4319298029","https://openalex.org/W4387144849","https://openalex.org/W4388488603","https://openalex.org/W4403627065"],"related_works":["https://openalex.org/W3031289950","https://openalex.org/W1942289260","https://openalex.org/W3208344678","https://openalex.org/W1191995753","https://openalex.org/W7047594332","https://openalex.org/W4388591912","https://openalex.org/W865623207","https://openalex.org/W2909749373","https://openalex.org/W627863610","https://openalex.org/W2517593543"],"abstract_inverted_index":{"Aims/Purpose:":[0],"The":[1],"purpose":[2],"of":[3,12,39,62,106,141,209,213],"this":[4],"study":[5,18,50,134],"was":[6,51,175],"to":[7,53],"identify":[8],"new":[9],"genetic":[10,166,178,211,218],"associations":[11,55,96,119],"anterior":[13,63,71,127,143,169,193,214,221],"uveitis":[14,64,72,128,144,170,194,215,222],"through":[15],"genome\u2010wide":[16,77,202],"association":[17,49,133],"(GWAS).":[19],"Methods:":[20],"We":[21,68,116,190],"conducted":[22],"a":[23,37,228],"GWAS":[24],"meta\u2010analysis":[25],"combining":[26],"data":[27],"from":[28],"the":[29,142,210,217],"FinnGen,":[30],"Estonian":[31],"Biobank":[32,35],"and":[33,43,58,91,101,130,149,160,171,216,223,233],"UK":[34],"with":[36,76,125,153,201],"total":[38],"12":[40],"205":[41],"cases":[42],"917":[44],"145":[45],"controls.":[46],"A":[47,164],"phenome\u2010wide":[48],"performed":[52],"investigate":[54],"across":[56],"phenotypes":[57],"traits.":[59],"Genetic":[60],"correlations":[61],"were":[65,87,103],"evaluated.":[66],"Results:":[67],"detected":[69],"six":[70,192],"associated":[73,124,145,152,195],"genomic":[74],"regions":[75],"significance":[78],"(p":[79],"<":[80],"5":[81],"\u00d7":[82,187],"10\u20108).":[83],"Three":[84,93],"novel":[85,199],"loci":[86,108,122,146,196,200],"identified:":[88],"INAVA,":[89],"NLRP3":[90],"NOS2.":[92],"previously":[94,123],"reported":[95],"at":[97,120,139],"HLA":[98],"region,":[99],"ERAP1":[100],"TNRC18":[102],"detected.":[104],"All":[105],"these":[107],"had":[109],"biologically":[110],"relevant":[111],"genes":[112],"involved":[113],"in":[114,177],"immunity.":[115],"also":[117],"replicated":[118],"two":[121],"acute":[126],"(IL23R":[129],"HDAC2\u2010AS2).":[131],"Phenome\u2010wide":[132],"indicated":[135],"that":[136],"lead":[137],"SNPs":[138],"three":[140,198],"(ERAP1,":[147],"INAVA":[148],"TNRC18)":[150],"are":[151],"other":[154],"immunity\u2010related":[155],"phenotypes,":[156],"including":[157,197],"ankylosing":[158],"spondylitis":[159],"inflammatory":[161,172],"bowel":[162,173],"disease.":[163],"moderate":[165],"correlation":[167,179],"between":[168,220],"disease":[174],"found":[176],"analysis":[180],"(rg":[181],"=":[182,185],"0.39,":[183],"p":[184],"8":[186],"10\u20105).":[188],"Conclusions:":[189],"identified":[191],"significance.":[203],"Our":[204],"findings":[205],"deepen":[206],"our":[207],"understanding":[208],"basis":[212],"connections":[219],"immune":[224],"related":[225],"disorders,":[226],"providing":[227],"foundation":[229],"for":[230],"further":[231],"research":[232],"potential":[234],"therapeutic":[235],"interventions.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-12-30T00:00:00"}