{"id":"https://openalex.org/W4405875207","doi":"https://doi.org/10.1007/s43032-024-01775-6","title":"Evaluation of the In Vivo Efficacy of the JAK Inhibitor AZD1480 in Uterine Leiomyomas Using a Patient-derived Xenograft Murine Model","display_name":"Evaluation of the In Vivo Efficacy of the JAK Inhibitor AZD1480 in Uterine Leiomyomas Using a Patient-derived Xenograft Murine Model","publication_year":2024,"publication_date":"2024-12-29","ids":{"openalex":"https://openalex.org/W4405875207","doi":"https://doi.org/10.1007/s43032-024-01775-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/39738934"},"language":"en","primary_location":{"id":"doi:10.1007/s43032-024-01775-6","doi":"https://doi.org/10.1007/s43032-024-01775-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s43032-024-01775-6","pdf_url":null,"source":{"id":"https://openalex.org/S68157034","display_name":"Reproductive Sciences","issn_l":"1933-7191","issn":["1933-7191","1933-7205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060665355","display_name":"Michael Franklin Neblett","orcid":"https://orcid.org/0000-0002-5377-9308","observed_orcids":["https://orcid.org/0000-0002-5377-9308"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael F. Neblett","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA","Mayo Clinic Alix School of Medicine, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Alix School of Medicine, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083422468","display_name":"Merrick T. Ducharme","orcid":"https://orcid.org/0000-0003-3945-1266","observed_orcids":["https://orcid.org/0000-0003-3945-1266"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Merrick T. Ducharme","raw_affiliation_strings":["Mayo Clinic Alix School of Medicine, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Alix School of Medicine, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024167418","display_name":"Jeffrey A. Meridew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Meridew","raw_affiliation_strings":["Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064053749","display_name":"Andrew J. Haak","orcid":"https://orcid.org/0000-0002-5323-253X","observed_orcids":["https://orcid.org/0000-0002-5323-253X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Haak","raw_affiliation_strings":["Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071191360","display_name":"Sylvie Girard","orcid":"https://orcid.org/0000-0002-5164-5816","observed_orcids":["https://orcid.org/0000-0002-5164-5816"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sylvie Girard","raw_affiliation_strings":["Department of Immunology, Mayo Clinic, Rochester, MN, USA","Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA","Mayo Clinic Alix School of Medicine, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Alix School of Medicine, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040325695","display_name":"Daniel J. Tschumperlin","orcid":"https://orcid.org/0000-0002-5115-9025","observed_orcids":["https://orcid.org/0000-0002-5115-9025"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Tschumperlin","raw_affiliation_strings":["Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA","Mayo Clinic Alix School of Medicine, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Alix School of Medicine, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056214143","display_name":"Elizabeth A. Stewart","orcid":"https://orcid.org/0000-0003-1110-2400","observed_orcids":["https://orcid.org/0000-0003-1110-2400"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth A. Stewart","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA. stewart.elizabeth@mayo.edu","Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. stewart.elizabeth@mayo.edu","Mayo Clinic Alix School of Medicine, Rochester, MN, USA. stewart.elizabeth@mayo.edu","Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA","Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA","Mayo Clinic Alix School of Medicine, Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0003-1110-2400","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA. stewart.elizabeth@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. stewart.elizabeth@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Alix School of Medicine, Rochester, MN, USA. stewart.elizabeth@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Alix School of Medicine, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056214143"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":null,"fwci":0.9887,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.79063515,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"32","issue":"2","first_page":"417","last_page":"427"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10989","display_name":"Uterine Myomas and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10989","display_name":"Uterine Myomas and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uterine-fibroids","display_name":"uterine fibroids","score":0.9480000138282776},{"id":"https://openalex.org/keywords/azd1480","display_name":"AZD1480","score":0.984000027179718},{"id":"https://openalex.org/keywords/jak1-2-inhibitor","display_name":"JAK1/2 inhibitor","score":0.8550000190734863},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.9330000281333923},{"id":"https://openalex.org/keywords/stat3-phosphorylation","display_name":"STAT3 phosphorylation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9160000085830688},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/non-hormonal-therapy","display_name":"non-hormonal therapy","score":0.8059999942779541},{"id":"https://openalex.org/keywords/leiomyoma-volume-reduction","display_name":"leiomyoma volume reduction","score":0.5740000009536743},{"id":"https://openalex.org/keywords/ki-67-proliferation-index","display_name":"Ki-67 proliferation index","score":0.7179999947547913},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.5690000057220459},{"id":"https://openalex.org/keywords/premenopausal-women","display_name":"premenopausal women","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C3017725331","wikidata":"https://www.wikidata.org/wiki/Q556281","display_name":"Uterine leiomyoma","level":3,"score":0.7827357649803162},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7701242566108704},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5948960781097412},{"id":"https://openalex.org/C2777795800","wikidata":"https://www.wikidata.org/wiki/Q4667534","display_name":"Leiomyoma","level":2,"score":0.5874848365783691},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5122684836387634},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.5041478872299194},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.4718741476535797},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42781874537467957},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.42384085059165955},{"id":"https://openalex.org/C112392421","wikidata":"https://www.wikidata.org/wiki/Q903451","display_name":"Janus kinase","level":3,"score":0.4120294153690338},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36604073643684387},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3402697741985321},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26662832498550415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14999255537986755},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11015883088111877},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075242","descriptor_name":"Janus Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000075242","descriptor_name":"Janus Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007889","descriptor_name":"Leiomyoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007889","descriptor_name":"Leiomyoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007889","descriptor_name":"Leiomyoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s43032-024-01775-6","doi":"https://doi.org/10.1007/s43032-024-01775-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s43032-024-01775-6","pdf_url":null,"source":{"id":"https://openalex.org/S68157034","display_name":"Reproductive Sciences","issn_l":"1933-7191","issn":["1933-7191","1933-7205"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Sciences","raw_type":"journal-article"},{"id":"pmid:39738934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39738934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive sciences (Thousand Oaks, Calif.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W862970225","https://openalex.org/W1952507411","https://openalex.org/W1953263831","https://openalex.org/W1985001876","https://openalex.org/W1986768904","https://openalex.org/W1987267629","https://openalex.org/W1993649166","https://openalex.org/W2017715430","https://openalex.org/W2044227662","https://openalex.org/W2057967312","https://openalex.org/W2058673998","https://openalex.org/W2083802827","https://openalex.org/W2110790636","https://openalex.org/W2117222458","https://openalex.org/W2121929569","https://openalex.org/W2127833800","https://openalex.org/W2129763580","https://openalex.org/W2136977400","https://openalex.org/W2146022028","https://openalex.org/W2157785358","https://openalex.org/W2172133051","https://openalex.org/W2176670122","https://openalex.org/W2180221738","https://openalex.org/W2562358208","https://openalex.org/W2595206985","https://openalex.org/W2770132733","https://openalex.org/W2781007043","https://openalex.org/W2804911874","https://openalex.org/W2807426998","https://openalex.org/W2891305985","https://openalex.org/W2906052725","https://openalex.org/W2942534170","https://openalex.org/W2971575895","https://openalex.org/W2984382213","https://openalex.org/W3005485049","https://openalex.org/W3023436896","https://openalex.org/W3046421095","https://openalex.org/W3047762506","https://openalex.org/W3092484689","https://openalex.org/W4200050711","https://openalex.org/W4210440227","https://openalex.org/W4313826159","https://openalex.org/W4375853754"],"related_works":["https://openalex.org/W4382930705","https://openalex.org/W3005485049","https://openalex.org/W4280579923","https://openalex.org/W2110790636","https://openalex.org/W2157077144","https://openalex.org/W2058673998","https://openalex.org/W2015348909","https://openalex.org/W2057967312","https://openalex.org/W2049510962","https://openalex.org/W1968553594"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-12-29T00:00:00"}