{"id":"https://openalex.org/W4405802083","doi":"https://doi.org/10.1016/j.canlet.2024.217416","title":"NSUN2-mediated R-loop stabilization as a key driver of bladder cancer progression and cisplatin sensitivity","display_name":"NSUN2-mediated R-loop stabilization as a key driver of bladder cancer progression and cisplatin sensitivity","publication_year":2024,"publication_date":"2024-12-26","ids":{"openalex":"https://openalex.org/W4405802083","doi":"https://doi.org/10.1016/j.canlet.2024.217416","pmid":"https://pubmed.ncbi.nlm.nih.gov/39732321"},"language":"en","primary_location":{"id":"doi:10.1016/j.canlet.2024.217416","doi":"https://doi.org/10.1016/j.canlet.2024.217416","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.canlet.2024.217416","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.canlet.2024.217416","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064904535","display_name":"Yuqing Wu","orcid":"https://orcid.org/0000-0003-4883-5982","observed_orcids":["https://orcid.org/0000-0003-4883-5982","https://orcid.org/0009-0002-7136-7806"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqing Wu","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102971374","display_name":"Yufan Ying","orcid":"https://orcid.org/0000-0002-8552-9557","observed_orcids":["https://orcid.org/0000-0002-8552-9557"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yufan Ying","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address: 12018517@zju.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address: 12018517@zju.edu.cn","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022648020","display_name":"Fenghao Zhang","orcid":"https://orcid.org/0000-0002-5405-590X","observed_orcids":["https://orcid.org/0000-0002-5405-590X"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fenghao Zhang","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080532189","display_name":"Xuan Shu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan Shu","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113111358","display_name":"Zhixiang Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhixiang Qi","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100631348","display_name":"Jiaming Wang","orcid":"https://orcid.org/0000-0002-4834-967X","observed_orcids":["https://orcid.org/0000-0002-4834-967X"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaming Wang","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101818057","display_name":"Zixiang Liu","orcid":"https://orcid.org/0000-0002-6178-4406","observed_orcids":["https://orcid.org/0000-0002-6178-4406"]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zixiang Liu","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 315042, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 315042, China","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yijie Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yijie Tang","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101915491","display_name":"Jiazhu Sun","orcid":"https://orcid.org/0000-0001-8343-1583","observed_orcids":["https://orcid.org/0000-0001-8343-1583"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiazhu Sun","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048866104","display_name":"Jiahe Yi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahe Yi","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043417019","display_name":"Dingheng Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dingheng Lu","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101922058","display_name":"Lin Shen","orcid":"https://orcid.org/0000-0003-2392-3353","observed_orcids":["https://orcid.org/0000-0003-2392-3353"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shen Lin","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sida Hao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sida Hao","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020117680","display_name":"Xueyou Ma","orcid":"https://orcid.org/0000-0002-8146-8611","observed_orcids":["https://orcid.org/0000-0002-8146-8611"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueyou Ma","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055214550","display_name":"Jiangfeng Li","orcid":"https://orcid.org/0000-0001-7838-4858","observed_orcids":["https://orcid.org/0000-0001-7838-4858"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangfeng Li","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao Wang","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address: zjuwangxiao@zju.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address: zjuwangxiao@zju.edu.cn","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028197048","display_name":"Liping Xie","orcid":"https://orcid.org/0000-0002-3287-5536","observed_orcids":["https://orcid.org/0000-0002-3287-5536"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liping Xie","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address: xielp@zju.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address: xielp@zju.edu.cn","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013556663","display_name":"Xiangyi Zheng","orcid":"https://orcid.org/0000-0002-9428-1514","observed_orcids":["https://orcid.org/0000-0002-9428-1514"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiangyi Zheng","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address: zheng_xy@zju.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address: zheng_xy@zju.edu.cn","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013556663","https://openalex.org/A5028197048","https://openalex.org/A5102971374"],"corresponding_institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":{"value":4260,"currency":"USD","value_usd":4260},"fwci":1.2768,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.79701117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"611","issue":null,"first_page":"217416","last_page":"217416"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nsun2","display_name":"NSUN2","score":0.8840000033378601},{"id":"https://openalex.org/keywords/r-loops","display_name":"R-loops","score":0.9330000281333923},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cisplatin-sensitivity","display_name":"cisplatin sensitivity","score":0.9210000038146973},{"id":"https://openalex.org/keywords/5-methylcytosine","display_name":"5-methylcytosine","score":0.847000002861023},{"id":"https://openalex.org/keywords/rna-methyltransferase","display_name":"RNA methyltransferase","score":0.7269999980926514},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.9150000214576721},{"id":"https://openalex.org/keywords/homologous-recombination-repair","display_name":"homologous recombination repair","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mre11","display_name":"MRE11","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7919999957084656},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.6551604270935059},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.651721179485321},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4544123411178589},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44618669152259827},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4372238516807556},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.42069071531295776},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3610982894897461},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2792336940765381},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2722755968570709},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2295437753200531},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08776843547821045},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071221","descriptor_name":"Enhancer of Zeste Homolog 2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071221","descriptor_name":"Enhancer of Zeste Homolog 2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000076228","descriptor_name":"MRE11 Homologue Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000076228","descriptor_name":"MRE11 Homologue Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000080870","descriptor_name":"R-Loop Structures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.canlet.2024.217416","doi":"https://doi.org/10.1016/j.canlet.2024.217416","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.canlet.2024.217416","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},{"id":"pmid:39732321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39732321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.canlet.2024.217416","doi":"https://doi.org/10.1016/j.canlet.2024.217416","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.canlet.2024.217416","pdf_url":null,"source":{"id":"https://openalex.org/S106234763","display_name":"Cancer Letters","issn_l":"0304-3835","issn":["0304-3835","1872-7980"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6100000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1325828178","display_name":null,"funder_award_id":"81 972 374","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2829090","display_name":null,"funder_award_id":"82 072 848","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4476606580","display_name":null,"funder_award_id":"82 372 949","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8930383868","display_name":null,"funder_award_id":"82103243","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1972842371","https://openalex.org/W2021087942","https://openalex.org/W2136696487","https://openalex.org/W2606518593","https://openalex.org/W2627064270","https://openalex.org/W2764078489","https://openalex.org/W2804134268","https://openalex.org/W2886727482","https://openalex.org/W2899888410","https://openalex.org/W2903840918","https://openalex.org/W2964438344","https://openalex.org/W2974301258","https://openalex.org/W2992958546","https://openalex.org/W2994940889","https://openalex.org/W3016186661","https://openalex.org/W3033832055","https://openalex.org/W3038967150","https://openalex.org/W3080554914","https://openalex.org/W3088289001","https://openalex.org/W3139686968","https://openalex.org/W3197911804","https://openalex.org/W4220651986","https://openalex.org/W4220981414","https://openalex.org/W4224293621","https://openalex.org/W4225262085","https://openalex.org/W4281259035","https://openalex.org/W4293004809","https://openalex.org/W4293109671","https://openalex.org/W4297102182","https://openalex.org/W4321004288","https://openalex.org/W4324026558","https://openalex.org/W4327898526","https://openalex.org/W4327900625","https://openalex.org/W4365142061","https://openalex.org/W4376115823","https://openalex.org/W4386801569","https://openalex.org/W4387709619","https://openalex.org/W4395076259","https://openalex.org/W4396518630","https://openalex.org/W4399388261"],"related_works":["https://openalex.org/W2091461259","https://openalex.org/W2406608798","https://openalex.org/W2080420195","https://openalex.org/W2406596433","https://openalex.org/W2066496973","https://openalex.org/W2460036924","https://openalex.org/W1971929983","https://openalex.org/W2021865845","https://openalex.org/W2100875939","https://openalex.org/W2366519347"],"abstract_inverted_index":{"R-loops":[0,34,54,184,199],"are":[1,185],"critical":[2],"structures":[3],"that":[4,107],"play":[5],"pivotal":[6],"roles":[7],"in":[8,35,55,142,187],"regulating":[9],"genomic":[10],"stability":[11],"and":[12,33,39,74,146,175],"modulating":[13],"gene":[14,117],"expression.":[15],"This":[16],"study":[17],"investigates":[18],"the":[19,22,36,110,114,130],"interactions":[20],"between":[21],"5-methylcytosine":[23],"(m":[24],"5":[25,85,202],"C)":[26],"methyltransferase":[27,30,91],"NOP2/Sun":[28],"RNA":[29],"2":[31,96],"(NSUN2)":[32],"transcriptional":[37],"dynamics":[38],"damage":[40,149,160],"repair":[41],"process":[42,80],"of":[43,53,69,93,113,132,157,172],"bladder":[44,188,225],"cancer":[45,189,212,226],"(BCa)":[46],"cells.":[47,62,195],"We":[48],"observed":[49],"markedly":[50],"elevated":[51,186],"levels":[52],"BCa":[56,173],"cells":[57,190,227],"relative":[58],"to":[59,72,100,139,159,192,228],"normal":[60,193],"urothelial":[61,194],"NSUN2":[63,108,135,197,210,222],"was":[64,98,152],"identified":[65],"as":[66],"a":[67,79],"regulator":[68],"R-loops,":[70],"acting":[71],"bind":[73],"stabilize":[75],"their":[76,207],"structure":[77],"through":[78,217],"dependent":[81],"on":[82],"its":[83],"m":[84,201],"C":[86,203],"catalytic":[87,204],"activity.":[88],"The":[89],"histone":[90],"Enhancer":[92],"Zeste":[94],"Homolog":[95],"(EZH2)":[97],"found":[99],"interact":[101],"with":[102,154,219],"NSUN2.":[103],"Our":[104],"results":[105],"demonstrated":[106],"facilitates":[109],"epigenetic":[111],"silencing":[112,215],"tumor":[115,144],"suppressor":[116],"PR":[118],"Domain":[119],"Zinc":[120],"Finger":[121],"Protein":[122],"11":[123],"(PRDM11)":[124],"by":[125,214,230],"recruiting":[126],"EZH2,":[127],"thereby":[128,162],"advancing":[129],"progression":[131],"BCa.":[133],"Furthermore,":[134],"knockdown":[136,223],"sensitizes":[137,224],"tumors":[138],"cisplatin,":[140],"resulting":[141],"reduced":[143,155],"growth":[145,213],"increased":[147],"DNA":[148],"levels,":[150],"which":[151],"associated":[153],"recruitment":[156],"MRE11":[158],"sites,":[161],"impairing":[163],"homologous":[164],"recombination":[165],"repair.":[166],"These":[167],"findings":[168],"enhance":[169],"our":[170],"understanding":[171],"pathogenesis":[174],"identify":[176],"new":[177],"potential":[178],"targets":[179],"for":[180],"therapeutic":[181],"intervention.":[182],"\u2022":[183,196,209,221],"compared":[191],"regulates":[198],"via":[200],"activity,":[205],"stabilizing":[206],"structure.":[208],"promotes":[211],"PRDM11":[216],"interaction":[218],"EZH2.":[220],"cisplatin":[229],"reducing":[231],"R-loops.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
