{"id":"https://openalex.org/W4405773000","doi":"https://doi.org/10.1021/acsami.4c17852","title":"Copper(II) Oxide Spindle-like Nanomotors Decorated with Calcium Peroxide Nanoshell as a New Nanozyme with Photothermal and Chemodynamic Functions Providing ROS Self-Amplification, Glutathione Depletion, and Cu(I)/Cu(II) Recycling","display_name":"Copper(II) Oxide Spindle-like Nanomotors Decorated with Calcium Peroxide Nanoshell as a New Nanozyme with Photothermal and Chemodynamic Functions Providing ROS Self-Amplification, Glutathione Depletion, and Cu(I)/Cu(II) Recycling","publication_year":2024,"publication_date":"2024-12-25","ids":{"openalex":"https://openalex.org/W4405773000","doi":"https://doi.org/10.1021/acsami.4c17852","pmid":"https://pubmed.ncbi.nlm.nih.gov/39720911"},"language":"en","primary_location":{"id":"doi:10.1021/acsami.4c17852","doi":"https://doi.org/10.1021/acsami.4c17852","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsami.4c17852","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acsami.4c17852","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073401636","display_name":"\u00c7a\u011f\u0131l Zeynep S\u00fcng\u00fc Akdo\u011fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00c7a\u011f\u0131l Zeynep S\u00fcng\u00fc Akdo\u011fan","raw_affiliation_strings":["Bioengineering Division","Graduate School of Science & Engineering","Hacettepe University","Bioengineering Division, Hacettepe University, Ankara 06800, Turkey","Graduate School of Science & Engineering, Hacettepe University, Ankara 06800, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Division","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Science & Engineering","institution_ids":[]},{"raw_affiliation_string":"Hacettepe University","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Bioengineering Division, Hacettepe University, Ankara 06800, Turkey","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Graduate School of Science & Engineering, Hacettepe University, Ankara 06800, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030614303","display_name":"Esin Akbay","orcid":"https://orcid.org/0000-0002-0797-8322","observed_orcids":["https://orcid.org/0000-0002-0797-8322"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Esin Akbay \u00c7etin","raw_affiliation_strings":["Department of Biology","Hacettepe University","Department of Biology, Hacettepe University, Ankara 06800, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology","institution_ids":[]},{"raw_affiliation_string":"Hacettepe University","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Department of Biology, Hacettepe University, Ankara 06800, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068732774","display_name":"Mehmet Ali Onur","orcid":"https://orcid.org/0000-0002-3630-7982","observed_orcids":["https://orcid.org/0000-0002-3630-7982"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Ali Onur","raw_affiliation_strings":["Bioengineering Division","Department of Biology","Hacettepe University","Bioengineering Division, Hacettepe University, Ankara 06800, Turkey","Department of Biology, Hacettepe University, Ankara 06800, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Division","institution_ids":[]},{"raw_affiliation_string":"Department of Biology","institution_ids":[]},{"raw_affiliation_string":"Hacettepe University","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Bioengineering Division, Hacettepe University, Ankara 06800, Turkey","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Department of Biology, Hacettepe University, Ankara 06800, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077462163","display_name":"Selis \u00d6nel","orcid":"https://orcid.org/0000-0001-5184-0323","observed_orcids":["https://orcid.org/0000-0001-5184-0323"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Selis \u00d6nel","raw_affiliation_strings":["Bioengineering Division","Chemical Engineering Department","Hacettepe University","Bioengineering Division, Hacettepe University, Ankara 06800, Turkey","Chemical Engineering Department, Hacettepe University, Ankara 06800, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Division","institution_ids":[]},{"raw_affiliation_string":"Chemical Engineering Department","institution_ids":[]},{"raw_affiliation_string":"Hacettepe University","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Bioengineering Division, Hacettepe University, Ankara 06800, Turkey","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Chemical Engineering Department, Hacettepe University, Ankara 06800, Turkey","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002346256","display_name":"Al\u00ef Tuncel","orcid":"https://orcid.org/0000-0002-4341-1286","observed_orcids":["https://orcid.org/0000-0002-4341-1286"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ali Tuncel","raw_affiliation_strings":["Bioengineering Division","Chemical Engineering Department","Hacettepe University","Bioengineering Division, Hacettepe University, Ankara 06800, Turkey","Chemical Engineering Department, Hacettepe University, Ankara 06800, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-4341-1286","affiliations":[{"raw_affiliation_string":"Bioengineering Division","institution_ids":[]},{"raw_affiliation_string":"Chemical Engineering Department","institution_ids":[]},{"raw_affiliation_string":"Hacettepe University","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Bioengineering Division, Hacettepe University, Ankara 06800, Turkey","institution_ids":["https://openalex.org/I66514158"]},{"raw_affiliation_string":"Chemical Engineering Department, Hacettepe University, Ankara 06800, Turkey","institution_ids":["https://openalex.org/I66514158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002346256"],"corresponding_institution_ids":["https://openalex.org/I66514158"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":2.584,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.91781169,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"17","issue":"1","first_page":"632","last_page":"649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12302","display_name":"Advanced Nanomaterials in Catalysis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12302","display_name":"Advanced Nanomaterials in Catalysis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11486","display_name":"Micro and Nano Robotics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3104","display_name":"Condensed Matter Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanozymes","display_name":"nanozymes","score":0.7490000128746033},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hydrogen-peroxide-production","display_name":"hydrogen peroxide production","score":0.640999972820282},{"id":"https://openalex.org/keywords/peroxidase-like-activity","display_name":"peroxidase-like activity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/catalase-like-activity","display_name":"catalase-like activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.7409999966621399},{"id":"https://openalex.org/keywords/chemodynamic-therapy","display_name":"chemodynamic therapy","score":0.7260000109672546},{"id":"https://openalex.org/keywords/photothermal-therapy","display_name":"photothermal therapy","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.746999979019165},{"id":"https://openalex.org/keywords/hypoxia-alleviation","display_name":"hypoxia alleviation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/near-infrared-laser","display_name":"near-infrared laser","score":0.5550000071525574},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.7179999947547913},{"id":"https://openalex.org/keywords/hydrothermal-oxidation","display_name":"hydrothermal oxidation","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C33197981","wikidata":"https://www.wikidata.org/wiki/Q2891289","display_name":"Nanoshell","level":3,"score":0.8655496835708618},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7155847549438477},{"id":"https://openalex.org/C182606246","wikidata":"https://www.wikidata.org/wiki/Q7187926","display_name":"Photothermal therapy","level":2,"score":0.5894122123718262},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.5356288552284241},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.49160653352737427},{"id":"https://openalex.org/C2781183027","wikidata":"https://www.wikidata.org/wiki/Q106920642","display_name":"Copper oxide","level":3,"score":0.482681542634964},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4462679922580719},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.43289855122566223},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.41443705558776855},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.40981072187423706},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.22402027249336243},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18264910578727722},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18218016624450684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1652263104915619},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.09288585186004639},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010545","descriptor_name":"Peroxides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010545","descriptor_name":"Peroxides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010545","descriptor_name":"Peroxides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010545","descriptor_name":"Peroxides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010545","descriptor_name":"Peroxides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010545","descriptor_name":"Peroxides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057145","descriptor_name":"Nanoshells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057145","descriptor_name":"Nanoshells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057145","descriptor_name":"Nanoshells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057145","descriptor_name":"Nanoshells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057145","descriptor_name":"Nanoshells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D057145","descriptor_name":"Nanoshells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acsami.4c17852","doi":"https://doi.org/10.1021/acsami.4c17852","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsami.4c17852","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},{"id":"pmid:39720911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39720911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied materials & interfaces","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11783533","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11783533","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Appl Mater Interfaces","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acsami.4c17852","doi":"https://doi.org/10.1021/acsami.4c17852","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsami.4c17852","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials & Interfaces","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W1972899481","https://openalex.org/W2003771811","https://openalex.org/W2004588202","https://openalex.org/W2021565293","https://openalex.org/W2109325117","https://openalex.org/W2218975746","https://openalex.org/W2771160707","https://openalex.org/W2790126114","https://openalex.org/W2804032347","https://openalex.org/W2903659409","https://openalex.org/W2907996121","https://openalex.org/W2915273448","https://openalex.org/W2928630271","https://openalex.org/W2939510535","https://openalex.org/W2969760640","https://openalex.org/W2982894973","https://openalex.org/W3002981626","https://openalex.org/W3004241287","https://openalex.org/W3011697548","https://openalex.org/W3037805328","https://openalex.org/W3045527635","https://openalex.org/W3084717795","https://openalex.org/W3109134796","https://openalex.org/W3111158231","https://openalex.org/W3172263921","https://openalex.org/W3173325092","https://openalex.org/W3177677237","https://openalex.org/W3189780824","https://openalex.org/W3191253130","https://openalex.org/W3198675921","https://openalex.org/W3204456652","https://openalex.org/W3206769968","https://openalex.org/W3215764719","https://openalex.org/W4207071956","https://openalex.org/W4213243872","https://openalex.org/W4221040243","https://openalex.org/W4224299072","https://openalex.org/W4225264044","https://openalex.org/W4281493841","https://openalex.org/W4282974745","https://openalex.org/W4287838297","https://openalex.org/W4287921460","https://openalex.org/W4290628352","https://openalex.org/W4293574643","https://openalex.org/W4294225580","https://openalex.org/W4298126272","https://openalex.org/W4306391007","https://openalex.org/W4306831109","https://openalex.org/W4308370900","https://openalex.org/W4310259017","https://openalex.org/W4312117810","https://openalex.org/W4313991528","https://openalex.org/W4319659757","https://openalex.org/W4321435687","https://openalex.org/W4322581019","https://openalex.org/W4360595563","https://openalex.org/W4366133848","https://openalex.org/W4379980763","https://openalex.org/W4381470045","https://openalex.org/W4383501061","https://openalex.org/W4383710776","https://openalex.org/W4385074550","https://openalex.org/W4385623593","https://openalex.org/W4385827895","https://openalex.org/W4386384307","https://openalex.org/W4389209503","https://openalex.org/W4390840837","https://openalex.org/W4391232323","https://openalex.org/W4391239017","https://openalex.org/W4391539516","https://openalex.org/W4391998105","https://openalex.org/W4393941451","https://openalex.org/W4393975746","https://openalex.org/W4394008313","https://openalex.org/W4394913029","https://openalex.org/W4395697789","https://openalex.org/W4396690957","https://openalex.org/W4399157539","https://openalex.org/W4399510695","https://openalex.org/W4400324135","https://openalex.org/W4401430003","https://openalex.org/W4401539068","https://openalex.org/W4401586743","https://openalex.org/W4401731291","https://openalex.org/W4404649337"],"related_works":["https://openalex.org/W3170869511","https://openalex.org/W1591514266","https://openalex.org/W2890356550","https://openalex.org/W1980257336","https://openalex.org/W2244430641","https://openalex.org/W4200417099","https://openalex.org/W2966538135","https://openalex.org/W2914492766","https://openalex.org/W2173601912","https://openalex.org/W2080318840"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Uniform,":[7],"mesoporous":[8],"copper(II)":[9],"oxide":[10],"nanospindles":[11],"(CuO":[12],"NSs)":[13,53],"were":[14,143,293],"synthesized":[15],"via":[16,155,211],"a":[17,47,55,88,120,126,156,205,237,255],"method":[18],"based":[19],"on":[20],"templated":[21],"hydrothermal":[22],"oxidation":[23],"of":[24,29,43,58,63,101,109,125,145,147,167,178,185,207,213,240,259,302],"copper":[25],"in":[26,119,152,222,263,314,321],"the":[27,64,75,105,160,168,175,183,193,197,223,264,280,288],"presence":[28],"monodisperse":[30],"poly(glycerol":[31],"dimethacrylate-":[32],"co":[33,38],"-methacrylic":[34],"acid)":[35],"nanoparticles":[36],"(poly(GDMA-":[37],"-MAA)":[39],"NPs).":[40],"Subsequent":[41],"decoration":[42],"CuO":[44,97],"NSs":[45,86,117,181,231,285,312],"with":[46,236,287],"CaO":[48,76,161],"2":[49,52,71,73,77,85,111,113,116,128,130,149,151,162,171,173,180,210,215,217,230,249,251,284,310],"nanoshell":[50,78,163],"(CuO@CaO":[51],"yielded":[54],"nanozyme":[56],"capable":[57,144],"Cu(I)/Cu(II)":[59,65],"redox":[60],"cycling.":[61],"Activation":[62],"cycle":[66],"by":[67,114,174,274],"exogenously":[68],"generated":[69],"H":[70,110,127,148,170,214,248],"O":[72,112,129,150,172,209,216,250],"from":[74],"significantly":[79],"enhanced":[80,273],"glutathione":[81],"(GSH)":[82],"depletion.":[83],"CuO@CaO":[84,115,179,229,283,309],"exhibited":[87,135,232],"2-fold":[89],"higher":[90,317],"GSH":[91,245],"depletion":[92,246],"rate":[93],"compared":[94],"to":[95,104,218,254],"pristine":[96],"NSs.":[98],"The":[99,201,243,268,299],"generation":[100,184,252],"oxygen":[102],"due":[103],"catalase":[106],"(CAT)-like":[107],"decomposition":[108,212],"resulted":[118,313],"self-propelled":[121],"diffusion":[122],"behavior,":[123],"characteristic":[124],"fueled":[131],"nanomotor.":[132],"These":[133],"nanostructures":[134],"both":[136],"peroxidase":[137],"(POD)-like":[138],"and":[139,142,164,247,305],"CAT-like":[140,202],"activities":[141],"self-production":[146],"aqueous":[153],"media":[154],"chemical":[157],"reaction":[158],"between":[159],"water.":[165],"Usage":[166],"self-supplied":[169,208],"POD-like":[176],"activity":[177,203],"amplified":[182],"toxic":[186],"hydroxyl":[187],"(":[188],"\u2022":[189,260],"OH)":[190],"radicals,":[191],"enhancing":[192],"chemodynamic":[194,269,306],"effect":[195],"within":[196],"tumor":[198],"microenvironment":[199],"(TME).":[200],"provided":[204],"source":[206],"alleviate":[219],"hypoxic":[220],"conditions":[221],"TME.":[224],"Under":[225],"near-infrared":[226],"laser":[227],"irradiation,":[228],"photothermal":[233],"conversion":[234],"properties,":[235],"temperature":[238],"elevation":[239],"25":[241],"\u00b0C.":[242],"combined":[244],"led":[253],"more":[256],"effective":[257],"production":[258],"OH":[261],"radicals":[262],"cell":[265,315],"culture":[266],"medium.":[267],"function":[270],"was":[271],"further":[272],"an":[275],"elevated":[276],"temperature.":[277],"To":[278],"assess":[279],"therapeutic":[281],"potential,":[282],"loaded":[286],"photosensitizer,":[289],"chlorine":[290],"e6":[291],"(Ce6),":[292],"evaluated":[294],"against":[295],"T98G":[296],"glioblastoma":[297],"cells.":[298],"synergistic":[300],"combination":[301],"photodynamic,":[303],"photohermal,":[304],"modalities":[307],"using":[308],"@Ce6":[311],"death":[316],"than":[318],"90%":[319],"under":[320],"vitro":[322],"conditions.":[323]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":9}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2025-10-10T00:00:00"}